He nui rawa te gastrin i roto i tō puku? Me kōrero tātou mō te (Hypergastrinemia)!

He maha ngā wā ka pāngia koe e te mamae o te puku, te kī tonu, me ētahi atu raruraru nakunaku? I ētahi wā, ko te take pea o tēnei he nui ake te taumata o te homoni e kiia nei ko te `(Gastrin)` i hangaia i roto i tō tinana i te mea noa. I tēnei rā, ka kōrerohia e tātou tēnei āhuatanga e kiia nei ko te `(Hypergastrinemia)` me te taipitopito me te tino māmā.

He aha te `(Hypergastrinemia)`? Kia mārama tātou!

Ki te kī ngāwari, ko te tikanga o te `(Hypergastrinemia)` ko te taumata o te `(Gastrin)`, he homoni e āwhina ana i te tinana ki te nakunaku kai, he nui ake i te mea e tika ana. Ka hangaia tēnei homoni `(Gastrin)` e tētahi momo pūtau motuhake i roto i te pakitara puku i te wāhanga o raro o tō tātou puku, arā, e tata ana ki te whekau iti. Ka karangatia tēnei e tātou ko ngā `(G cells)`.

Titiro mai, ko tēnei homoni `(Gastrin)` te mea e kī ana ki tō tātou puku, "Āe, whakaputahia te waikawa." He mea tino nui tēnei waikawa puku, arā, `(gastric acid), ki a tātou. Nā te mea, ka āwhina tēnei waikawa puku i a tātou ki te nakunaku i te kai e kainga ana e tātou, me te mimiti i ngā matūkai o taua kai, hei tauira `(amino acids)` me ngā pūmua.

Heoi, he uaua ake te āhua o te `(Hypergastrinemia)`. I ētahi wā ka nui rawa te waikawa o te puku (`hyperchlorhydria`), ā, i ētahi wā ka iti rawa te waikawa o te puku (`hypochlorhydria`). Nō reira, ko te pānga o te `(Hypergastrinemia)` ki a koe, ka whakawhirinaki ki ētahi atu mate hauora kei a koe, ki ngā pokanga kua mahia e koe, me ngā rongoā e tangohia ana e koe.

Ko wai te mea ka nui ake te tūponotanga ka pāngia e tēnei mate?

Ina hoki, ka pā tēnei āhuatanga e kiia nei ko te "Hypergastrinemia" ki te tangata katoa, ahakoa te pakeke, te ira tangata rānei. Nō reira, he mea pai kia mōhio tātou katoa ki tēnei.

He aha ngā take o te `(Hypergastrinemia)`?

He maha ngā take mō tēnei mate, tae atu ki te "Hypergastrinemia." Ko ētahi take ka whakaiti i te hanga waikawa o te puku, ko ētahi ka whakanui ake i te hanga waikawa o te puku. Me titiro motuhake tātou ki ngā mea e rua.

Ngā take o te heke o te waikawa o te puku

Ina puta te "Hypergastrinemia", ka heke pea te hanga noa o te waikawa o te puku nā ēnei take:

• Ngā rongoā antacid mō te mamae o te puku, te GERD rānei (Gastroesophageal Reflux Disease): Mena kei te whakamahi tonu koe i ēnei momo rongoā, tera pea tētahi o ngā take.
• Te gastritis atrophic mau tonu: Koinei te wā e ngoikore haere ai te pakitara o te puku, ka mumura hoki i roto i te wā.
• Matepukupuku repeure: Ka pāngia hoki tēnei.
• Mate pāwera `(H. pylori)`: Ko te `(Helicobacter pylori)` he huakita ka noho ki roto i te puku. Ko tēnei mate anō hoki tētahi o ngā take o te `(Hypergastrinemia).`
• Te ngoikore o te whatukuhu: Ka puta pea tēnei āhuatanga ina kore e mahi tika ngā whatukuhu.
• Te Whakamahinga o ngā Ārai Papu Porotene (PPI):Ko te whakamahinga roa o ngā rongoā PPI (pērā i te omeprazole) mō te gastritis, te reflux waikawa, te koretake o te kai, te mate pukupuku peptic rānei tētahi atu tino take.
• Vagotomy: Ko te tango i tētahi wāhanga o te io vagus tēnei. Ka rere tēnei io mai i te roro ki te puku, ā, ka kawe i ngā tohu ki te ngākau me te pūnaha nakunaku. Ka puta pea te hypergastrinemia i muri i tēnei pokanga.

Ngā take o te pikinga o te waikawa o te puku

Nā, me titiro tātou ki ngā take e piki ake ai te hanga waikawa o te puku (Hypergastrinemia):

• Te hyperplasia pūtau-G Antral (pseudo-Zollinger-Ellison syndrome / Ps-ZES): He āhuatanga onge tēnei. He rite ki te mate Zollinger-Ellison, engari kāore he pukupuku e whakaputa ana i te gastrin i roto i te pancreas, i te wāhanga tuatahi rānei o te whekau iti (duodenum).
• Te aukati i te putanga o te puku: Ka puta pea tēnei āhuatanga ina aukatia te ara mai i te puku ki te whekau iti. Whakaarohia he rite ki te paipa wai kua aukatia.
• Te maha o ngā neoplasia endocrine momo-1 (MEN-1): Ka puta ngā pukupuku neuroendocrine i roto i ngā repe adrenal, ngā repe thyroid, ngā repe parathyroid rānei nā tēnei āhuatanga.
• Te mate antrum e puritia ana: Ka puta pea tēnei āhuatanga mēnā ka mahue tetahi wāhanga iti o te pito o raro o te puku (te antrum) i muri i te pokanga hei tango i ngā pukupuku, hei rongoā rānei i ngā mate puku.
• Te mate Zollinger-Ellison (ZES): He āhuatanga tēnei e nui rawa ai te hanga o te homoni gastrin e ngā pukupuku. Ka taea e tēnei āhuatanga (ZES) te whakararu i te puku.

He aha ngā tohu o te mate `(Hypergastrinemia)`?

Mena kei a koe te `(Hypergastrinemia)`, ka pāngia pea koe e ngā tohu penei:

• Mamae puku: Tērā pea ka pāngia koe e te mamae puku i ngā wā katoa.
• Korere pūmau: Korere e roa ana mō ētahi rā.
• Ngā pukupuku repeure: He pukupuku matepukupuku, he pukupuku pai rānei ēnei.
• Ngā mate puku: He mate pāwera e puta mai ana i te mumura o te puku.
• Te esophagitis kino: Te mumura nui me te mamae i roto i te esophagus.

Me pēhea te tautuhi a ngā tākuta i tēnei mate?

Hei tātaritanga tika i te hypergastrinemia, me whakatau e ngā tākuta te nui o te waikawa e whakaputaina ana e tō puku. Ka inehia hoki e rātou te taumata o te gastrin i roto i ō toto.

• I mua i tēnei whakamātautau, ka kī atu tō tākuta kia nohopuku koe (kaua e kai) mō tētahi wā kua whakaritea .
• Waihoki, ki te mea he kaiwhakamahi ``(PPI)`` koe,Me mutu te tango i taua rongoā i te wiki i mua i te whakamātautau.
• Kātahi ka tangohia he tauira o ō toto, ka tirohia ō taumata Gastrin. I ētahi wā, ka tangohia pea ēnei tauira toto i ētahi wā i te rā, mō ētahi rā, kia kite ai mēnā kei te rerekē ō taumata Gastrin.

Mena kei te whakapae tō tākuta kei te hypergastrinemia koe, ka tono pea rātou i ētahi atu whakamātautau hei whakakore i ētahi atu mate. Kei roto i ēnei ko:

• Whakamātautau whakaohooho secretin: Ko te tikanga o tēnei he werohanga o tētahi homoni e kiia nei ko te secretin, e whakaputaina ana e te wāhanga tuatahi o tō whekau iti (duodenum). Mēnā ka piki ohorere ō taumata gastrin, he tohu pea tēnei nō te mate Zollinger-Ellison.
• Whakamātautau pH o te puku: Mā tēnei ka tirohia ngā taumata waikawa i roto i tō puku. Mena he iti iho i te 2 te pH, he tohu pea tēnei mō te mate Zollinger-Ellison.

Me pēhea te rongoā i te Hypergastrinemia?

Ko te maimoatanga mō te hypergastrinemia ka whakawhirinaki ki te take.

• Te mate pukupuku koroni, te aukati i te korokoro, te mate tākihi, me ngā āhuatanga pēnei i te `(MEN-1)` me te `(ZES)`: Ina rongoatia ēnei āhuatanga (mā te pokanga i te nuinga o te wā), ka memeha haere hoki ngā tohu o te `(Hypergastrinemia)`.
• Te mate pukupuku atrophic (ACG) me te mate H. pylori: Ka taea te rongoā i ēnei āhuatanga ki ngā paturopi.
• Ngā aukati papu-porotini (PPI): Mena kei te tango koe i te PPI, ka memeha te hypergastrinemia i roto i ngā rā e rima ki te whitu i muri i te whakamutu i te rongoā.
• Te mate antrum e mau tonu ana: Mā te tango i te toenga o te kiko antral i te pito o raro o te puku ka taea te whakaiti i te nui o te waikawa puku taapiri e whakaputaina ana.

Ko te mea nui ko te kōrero ki tō tākuta mō te maimoatanga pai rawa atu mō tō āhua.

Ka taea e au te whakaiti i te mōrearea o te `(Hypergastrinemia)`?

Mena he roa koe e whakamahi ana i ngā rongoā ārai mate waikawa, i ngā rongoā PPI rānei, tera pea ka pāngia koe e te hypergastrinemia. Nō reira, he mea nui kia kōrero koe ki tō tākuta mō te whakahaere i tēnei mōrearea.

Mena kei a au te `(Hypergastrinemia)`, he aha taku e tumanako atu ai? He aha ngā mea ka puta mena kāore e rongoatia?

Ki te kore e rongoatia tika te hypergastrinemia, ka noho teitei tonu ngā taumata gastrin o te tinana. E whakapae ana ngā kairangahau tera pea ka whai wāhi tēnei ki te tipu o ngā pūtau matepukupuku. Hei tauira:

• Ngā mate pukupuku toto: pērā i te leukemia, te lymphoma, me te myeloma maha.
• Matepukupuku korokoro
• Matepukupuku repeure

Waihoki, mā te `(Hypergastrinemia)` roa ka arahi pea ki ngā pukupuku puku `(gastric carcinoids`, `gastric adenocarcinoma` rānei). E rua ngā momo `(gastric carcinoids)`:

• Momo I ngā carcinoids puku: E pā ana ēnei ki te mate gastritis atrophic mau tonu.
• Ko te nuinga o te wā ka puta i roto i ngā wāhine.
• Ka kitea i roto i ngā wāhi maha o te puku.
• He iti te tūponotanga o te whakawhanake i te mate pukupuku.
• Ngā carcinoids puku momo II: E pā ana ēnei ki ngā mate ZES me MEN-1.
• Ka taea te puta i roto i ngā tāne me ngā wāhine.
• Ka kitea i roto i ngā wāhi maha o te puku.
• I ētahi wā ka huri hei matepukupuku (i waenga i te 7% me te 12%).

He aha te tirohanga mō te tangata e pāngia ana e te `(Hypergastrinemia)`?

Ko te āhua hauora ā muri ake nei o te tangata e pāngia ana e te "Hypergastrinemia" e whakawhirinaki ana ki ētahi āhuatanga:

• Te pūtake o te mate.
• Ngā ira.
• Hītori hauora.
• Te āhua noho.

Heoi, mā te maimoatanga tika, ka taea e te hunga whai "Hypergastrinemia" te ora i ngā oranga hihiri me te noa.

Kei a au te `(Hypergastrinemia)`, me pēhea taku tiaki i a au anō?

Mena kei te tango koe i ngā rongoā aukati waikawa, i ngā rongoā PPI rānei mō te wā roa, he mea nui kia tirotirohia koe e te rata i ia wā. Me toro atu ki tō tākuta mō ētahi tohutohu.

Āhea ahau me toro atu ki te tākuta?

Ki te pāngia koe e tētahi o ēnei tohu hou, ki te whakaaro rānei koe kei te kino haere ō tohu o nāianei, me toro atu koe ki te tākuta, me te tirotiro i tō hauora katoa.

Ngā mea hei maumahara hei whakarāpopototanga

Āe, kia maumahara noa tātou ki tā tātou i kōrero ai:

• Ko te Hypergastrinemia he pikinga o te homoni gastrin i roto i te tinana.
• Ka pā tēnei homoni (Gastrin) ki ngā taumata waikawa i roto i te puku (ka piki, ka heke rānei te waikawa).
• He maha ngā take – te whakamahi tonu i ngā PPI/antacids, te mate H. pylori, te gastritis, te mate Zollinger-Ellison, me ētahi atu.
• Ka tātaritatia tēnei e ngā tākuta mā te whakamātautau i te taumata o te "Gastrin".
• Ka whakawhirinaki te maimoatanga ki te take matua.
• Kaua e warewarehia ngā tohu, nā te mea ki te kore e rongoatia, ka taea e rātou te huri hei pukupuku me te matepukupuku! Rapua he tohutohu hauora tonu.

Ko tāku tumanako ka whai hua ēnei kōrero ki a koe. Kia ora tonu!

` Hypergastrinemia, Gastrin, Waikawa puku, Nakunaku, Zollinger-Ellison syndrome, H. pylori, PPI, Gastritis, Mumura puku