Kei te hiahia anō koe ki te mōhio mō te Anomaly Pelger-Huet? Me kōrero tāua!

Kua kōrerotia mai e te tākuta ki a koe mō tētahi panoni iti i roto i ō toto mā i te wā i whakamātauria ai koe? Tērā pea ko te Pelger-Huet Anomaly. Tērā pea he mea nui te ingoa, engari kaua e manukanuka , kāore i te tino kino. Me kōrero tātou mō tēnei me ētahi atu taipitopito, me te ngāwari noa iho.

He aha te Anomaly Pelger-Huet?

Ki te whakarapopoto, ko te Pelger-Huet Anomaly (PHA) he mate ira e pā ana ki ngā neutrophils, he momo toto ma i roto i te tinana. He rite ngā neutrophils ki ngā hōia ririki i roto i te tinana e āwhina ana i te tinana ki te whawhai ki ngā iroriki.

Ko te rerekētanga o tō tātou DNA te take o tēnei āhuatanga, inā koa i roto i tētahi ira e kiia nei ko te Lamin B Receptor (ira LBR). Ko tēnei ira LBR te mea e āwhina ana i ngā pūtau neutrophil ki te whanake me te tipu tika.

Titiro mai, he pokapū whakahaere tō ia pūtau neutrophil, e kiia nei ko te karihi . Kei roto i tēnei karihi ngā mōhiohio DNA katoa e hiahiatia ana e te pūtau hei mahi me te tipu. I te nuinga o te wā, ka wehea te karihi o te neutrophil hauora kia toru, neke atu rānei ngā wāhanga. Heoi, e rua ngā wāhanga o te karihi o te neutrophil i roto i te tangata whai Pelger-Huette. He rite ki te dumbbell, he ngako i ngā taha e rua, he angiangi te waenganui. He tino onge, i roto i ētahi tāngata, ka taea e tēnei karihi neutrophil te āhua porowhita, arā, he rite ki te hua manu.

Engari ko te mea nui i konei, ahakoa i whānau mai koe me te Pelger-Huette anomaly, i te nuinga o te wā ka mahi noa ō pūtau neutrophil. Ko te tikanga o tēnei kāore rātou i tino ngoikore ki te tiaki i a koe mai i te mate. Nō reira, he iti noa iho ngā raruraru hauora nui e puta mai ana.

Tērā tētahi atu mate e kiia nei ko te Pseudo Pelger-Huet Anomaly (PPHA) . Ka pā pea tēnei ki ētahi tāngata i muri mai i te ao. Ka puta pea te PPHA hei pānga taha o ētahi rongoā, hei tohu rānei o tētahi atu mate, pērā i te mate pāwera.

He aha ngā tohu o te Anomaly Pelger-Huette?

I konei me arotahi tātou ki ngā momo e rua i kōrerohia e tātou i mua ake nei.

He mea tuku iho Pelger-Huet Anomaly (HPA)

Mena kei a koe te Pelger-Huette anomaly (HPA), he mea tuku iho, kāore he tohu e pā ana ki a koe. Tērā pea kāore koe e mōhio kei a koe te mate. Ka kitea noa iho i te nuinga o te wā ina mahia he whakamātautau toto mō tētahi atu take.

Pseudo Pelger-Huet Anomaly (PPHA)

Heoi, ki te mea he pseudo-Pelger-Huette anomaly (PPHA) tōu, arā, ka puta ake i muri mai, ka pāngia pea koe e ngā tohu e pā ana ki te mate taketake i puta ai.Hei tauira, mēnā he mate te pūtake o te PPHA, tera pea ka puta ngā tohu pēnei i te kirika me te mamae o te tinana e pā ana ki taua mate.

He aha te take o te āhuatanga rerekē o Pelger-Huette?

Ka rerekē anō hoki te take mō tēnei i runga i ngā momo e rua i kōrerohia i mua ake nei.

Te Āhuatanga Tuku Iho o Pelger-Huette (HPA)

Nā te whakarerekētanga o te ira Lamin B Receptor (LBR) tēnei i puta ai, e ai ki tā mātou i kōrero ai i mua ake nei. Mā tēnei ira LBR e tohutohu tō tātou tinana ki te hanga i ngā pūmua e hiahiatia ana hei tiaki i ngā pūtau neutrophil me te hoatu i te āhua tika ki a rātou. I roto i te Pelger-Huytt anomaly, ka whakararuraru tēnei whakarerekētanga ira i taua tukanga, ka puta ai te āhua o ngā karihi o ngā neutrophil ki taua āhua dumbbell. He āhuatanga tēnei ka taea te tuku iho mai i ngā mātua ki ngā tamariki.

Te rerekētanga Pseudo Pelger-Huette (PPHA)

Ehara tēnei i te mate ira. He maha ngā āhuatanga ka puta ai tēnei mate:

• Ngā mate wheua wheua: Hei tauira, ko ngā mate leukemia pērā i te myelodysplastic syndrome me te acute myeloid leukemia (AML).
• Ētahi mate urutā: inā koa ngā mate ka kawea e te kutu.
• Ngā rongoā ārai mate: Ko ēnei rongoā, e hoatu ana mō ētahi mate, koinei pea te take.
• Te pānga ki te irahiko: Hei tauira, i te wā e rongoatia ana te mate pukupuku.

Ki te kī atu te tākuta kei a koe te 'PHA' me te 'PPHA' rānei, he mea tino nui kia whakamōhiotia te tākuta mō ngā rongoā katoa e tangohia ana e koe, tae atu ki ngā huaora.

He aha ngā āhuatanga mōrearea mō tēnei mate?

Ko te tino take mō te mate Pelger-Huette (PHA) ko te whai mātua tūturu me tēnei mate. Ko te tikanga, mēnā he PHA tōu whaea, tōu pāpā rānei, e 50% te tūponotanga ka riro mai i a koe. He rite ki te whiu moni, kāore e taea te kī pono, engari ka taea tonu.

Mō te mate 'PPHA', ko te pānga ki ngā mate hauora, ki ngā maimoatanga rānei kua whakahuatia i mua ake nei he āhuatanga mōrearea.

He raruraru kei roto i tēnei mate?

I te nuinga o te wā, kāore te mate Pelger-Huette ira tuku iho (PHA) e puta ai ngā raruraru nui. Nā te mea, ahakoa ka whakarerekē i te āhua o ō pūtau neutrophil, kāore e tino whakarerekē i tā rātou mahi. Ka whawhai tonu rātou ki ngā iroriki.

Heoi, ki te mea he pseudopelgar-huwat anomalous (PPHA) tōu, ka taea e te mate hauora taketake i puta ai (pērā i te leukemia) te whakararuraru i a koe. Nō reira, he mea nui kia kōrero koe ki tō tākuta mō tēnei, kia mōhio ai hoki koe ki ngā mea ka puta.

Me pēhea te tautuhi a ngā tākuta i te mate Pelger-Huette?

Ko te nuinga o ngā tākuta e whakamahi ana i ngā whakamātautau toto hei tātaritanga i tēnei mate.Ka mahia he whakamātautau e kiia nei ko te peripheral blood smear. Ko tēnei whakamātautau he tango i tētahi pata o tō tauira toto, ka horahia kia angiangi ki runga i tētahi kiriata karāhe, kātahi ka tirohia i raro i tētahi karuārai.

Ka tirotirohia tēnei e te tohunga mate, e te tohunga toto rānei.

Mena he Pelger-Huette anomaly tāu, ka kitea mārama i tēnei whakamātautau te āhua rerekē o ngā karihi o ō pūtau neutrophil (pērā i te dumbbell).

He rongoā anō kei te wātea mō te mate Pelger-Huette?

Anei te rongo pai! Ko te mate Pelger-Huette tuku iho (PHA) kāore he tohu e puta mai ana, nō reira kāore e hiahiatia he maimoatanga motuhake. Ahakoa kei a koe tēnei mate, ka taea e koe te noho noa i te ao.

Heoi, mō te `PPHA`, he mea nui kia rongoātia te mate taketake i puta ai. Kia ora rā anō taua mate, ka memeha haere pea te āhua `PPHA`.

Āhea ahau me toro atu ki te tākuta?

Ki te kitea e koe he Pelger-Huette anomaly tōu, me whakamōhio atu ki tō tākuta mēnā ka puta he tohu hou (pēnei i te kirika, te ngenge nui, te maha o ngā mate pāwera). Kātahi ka taea e tō tākuta te whakatau mēnā he hononga ngā tohu ki te `PHA`, ki te `PPHA`, ki tētahi atu mea rānei.

Ina haere koe ki te tākuta, he mea pai hoki kia pātai koe i ēnei pātai:

• He mate tuku iho ā Pelger-Huette `(HPA)`, he mate rūpahu `(PPHA)` rānei tōku?
• Tērā pea ka riro i aku tamariki tēnei mate? (Mēnā he HPA)
• Kia pēhea te auau o taku haerenga ki te tākuta?
• He aha ngā tohu e tika ana kia tino mōhio ahau?

He aha taku e tumanako ai mō tēnei āhuatanga?

Kāore te Pelger-Huette anomaly (PHA) e whakararu i a koe, e kore hoki e whai pānga nui ki tō oranga. I te nuinga o te wā, kāore e pā ki ō mahi o ia rā.

Heoi, ki te mea kei a koe tēnei mate (ina koa te momo 'PPHA'), he tohu pea tēnei mō tētahi atu mate hauora e pā ana ki a koe. Koia te take e āwangawanga ai ngā tākuta mō tēnei mate. Ki te whakapae tō tākuta kei a koe te 'PHA', te 'PPHA' rānei, ka mahia e rātou ngā whakamātautau e tika ana hei whakaū, ā, ka mahi hoki i ngā mahi hei whakakore i ētahi atu mate hauora.

Tērā pea kei a koe te Pelger-Huette anomaly (PHA) ā, kāore koe i te mōhio nā te mea kāore he tohu āu. Tērā pea ka whakaaro koe, "Ki te kore e pā ki ahau, he aha ahau i whakaaro ai mōna?" He pono kāore pea koe e māuiui nā tēnei whakarerekētanga pūtau. Engari he mea nui kia mōhio koe ki tō tākuta. Kei reira tō tākuta hei āwhina i a koe kia noho hauora. Ā, he mea āwhina te mōhio ki ēnei mea iti o tō tinana. Nā te mea kei a koe te Pelger-Huette anomaly he mea anō tēnei e hanga ana i a koe hei "koe". Kāore he mea hei manukanuka.

Whakarāpopototanga (Karere hei tango ki te kāinga)

Āe, me whakarāpopoto tātou i ētahi o ngā mea i kōrerohia e tātou:

• Ko te Pelger-Huet Anomaly (PHA) he āhuatanga ira e puta ai te āhua rerekē o te karihi o ngā neutrophils, he momo toto ma.
• Kāore tēnei i te mea morearea, ā, kāore hoki e puta he tohu. He pai te mahi a ngā pūtau neutrophil.
• E rua ngā momo o tēnei: ​​ko te 'HPA', he mea tuku iho, me te 'PPHA', ka puta ake i muri mai i ētahi atu mate, i ētahi atu rongoā rānei.
• Kāore e hiahiatia he rongoā mō te HPA. Mō te PPHA, ka rongoāhia te pūtake.
• Ka tātaritatia tēnei āhuatanga mā te whakamātautau toto (te whakamātautau toto ā-taha).
• Ki te kitea e koe tēnei mate, kaua e manukanuka. Heoi anō, kōrero ki tō tākuta mō tēnei mea, kia whiwhi ai koe i ngā tohutohu e tika ana. Mēnā ka puta mai he tohu hou, whakamōhio atu ki tō tākuta.

Ko tāku tumanako kua whakautua e tēnei tuhinga te nuinga o āu pātai mō te mate urutā Pelger-Huette. Kia maumahara, mō ngā raruraru hauora katoa, he pai ake te kōrero māhorahora ki tō tākuta.

` Te Āhuatanga Pelger-Huet, Ngā Neutrophil, Ngā Pūtau Toto Mā, Ngā Mate Ira, Ngā Whakamātautau Toto, PPHA, HPA