Kei te hiahia anō koe ki te mōhio mō te Anomaly Pelger-Huet? Me kōrero tāua!

Kua kōrerotia mai e te tākuta ki a koe mō tētahi panoni iti i roto i ō toto mā i te wā i whakamātauria ai koe? Tērā pea ko te Pelger-Huet Anomaly. Tērā pea he mea nui te ingoa, engari kaua e manukanuka , kāore i te tino kino. Me kōrero tātou mō tēnei me ētahi atu taipitopito, me te ngāwari noa iho.

He aha te Anomaly Pelger-Huet?

Ki te whakarapopoto, ko te Pelger-Huet Anomaly (PHA) he mate ira e pā ana ki ngā neutrophils, he momo toto ma i roto i te tinana. He rite ngā neutrophils ki ngā hōia ririki i roto i te tinana e āwhina ana i te tinana ki te whawhai ki ngā iroriki.

Ko te rerekētanga o tō tātou DNA te take o tēnei āhuatanga, inā koa i roto i tētahi ira e kiia nei ko te Lamin B Receptor (ira LBR). Ko tēnei ira LBR te mea e āwhina ana i ngā pūtau neutrophil ki te whanake me te tipu tika.

Titiro mai, he pokapū whakahaere tō ia pūtau neutrophil, e kiia nei ko te karihi . Kei roto i tēnei karihi ngā mōhiohio DNA katoa e hiahiatia ana e te pūtau hei mahi me te tipu. I te nuinga o te wā, ka wehea te karihi o te neutrophil hauora kia toru, neke atu rānei ngā wāhanga. Heoi, e rua ngā wāhanga o te karihi o te neutrophil i roto i te tangata whai Pelger-Huette. He rite ki te dumbbell, he ngako i ngā taha e rua, he angiangi te waenganui. He tino onge, i roto i ētahi tāngata, ka taea e tēnei karihi neutrophil te āhua porowhita, arā, he rite ki te hua manu.

Engari ko te mea nui i konei, ahakoa i whānau mai koe me te Pelger-Huette anomaly, i te nuinga o te wā ka mahi noa ō pūtau neutrophil. Ko te tikanga o tēnei kāore rātou i tino ngoikore ki te tiaki i a koe mai i te mate. Nō reira, he iti noa iho ngā raruraru hauora nui e puta mai ana.

Tērā tētahi atu mate e kiia nei ko te Pseudo Pelger-Huet Anomaly (PPHA) . Ka pā pea tēnei ki ētahi tāngata i muri mai i te ao. Ka puta pea te PPHA hei pānga taha o ētahi rongoā, hei tohu rānei o tētahi atu mate, pērā i te mate pāwera.

He aha ngā tohu o te Anomaly Pelger-Huette?

I konei me arotahi tātou ki ngā momo e rua i kōrerohia e tātou i mua ake nei.

He mea tuku iho Pelger-Huet Anomaly (HPA)

Mena kei a koe te Pelger-Huette anomaly (HPA), he mea tuku iho, kāore he tohu e pā ana ki a koe. Tērā pea kāore koe e mōhio kei a koe te mate. Ka kitea noa iho i te nuinga o te wā ina mahia he whakamātautau toto mō tētahi atu take.

Pseudo Pelger-Huet Anomaly (PPHA)

Heoi, ki te mea he pseudo-Pelger-Huette anomaly (PPHA) tōu, arā, ka puta ake i muri mai, ka pāngia pea koe e ngā tohu e pā ana ki te mate taketake i puta ai.Hei tauira, mēnā he mate te pūtake o te PPHA, tera pea ka puta ngā tohu pēnei i te kirika me te mamae o te tinana e pā ana ki taua mate.

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He aha te take o te āhuatanga rerekē o Pelger-Huette?

Ka rerekē anō hoki te take mō tēnei i runga i ngā momo e rua i kōrerohia i mua ake nei.

Te Āhuatanga Tuku Iho o Pelger-Huette (HPA)

Nā te whakarerekētanga o te ira Lamin B Receptor (LBR) tēnei i puta ai, e ai ki tā mātou i kōrero ai i mua ake nei. Mā tēnei ira LBR e tohutohu tō tātou tinana ki te hanga i ngā pūmua e hiahiatia ana hei tiaki i ngā pūtau neutrophil me te hoatu i te āhua tika ki a rātou. I roto i te Pelger-Huytt anomaly, ka whakararuraru tēnei whakarerekētanga ira i taua tukanga, ka puta ai te āhua o ngā karihi o ngā neutrophil ki taua āhua dumbbell. He āhuatanga tēnei ka taea te tuku iho mai i ngā mātua ki ngā tamariki.

Te rerekētanga Pseudo Pelger-Huette (PPHA)

Ehara tēnei i te mate ira. He maha ngā āhuatanga ka puta ai tēnei mate:

• Ngā mate wheua wheua: Hei tauira, ko ngā mate leukemia pērā i te myelodysplastic syndrome me te acute myeloid leukemia (AML).
• Ētahi mate urutā: inā koa ngā mate ka kawea e te kutu.
• Ngā rongoā ārai mate: Ko ēnei rongoā, e hoatu ana mō ētahi mate, koinei pea te take.
• Te pānga ki te irahiko: Hei tauira, i te wā e rongoatia ana te mate pukupuku.

Ki te kī atu te tākuta kei a koe te 'PHA' me te 'PPHA' rānei, he mea tino nui kia whakamōhiotia te tākuta mō ngā rongoā katoa e tangohia ana e koe, tae atu ki ngā huaora.

He aha ngā āhuatanga mōrearea mō tēnei mate?

Ko te tino take mō te mate Pelger-Huette (PHA) ko te whai mātua tūturu me tēnei mate. Ko te tikanga, mēnā he PHA tōu whaea, tōu pāpā rānei, e 50% te tūponotanga ka riro mai i a koe. He rite ki te whiu moni, kāore e taea te kī pono, engari ka taea tonu.

Mō te mate 'PPHA', ko te pānga ki ngā mate hauora, ki ngā maimoatanga rānei kua whakahuatia i mua ake nei he āhuatanga mōrearea.

He raruraru kei roto i tēnei mate?

I te nuinga o te wā, kāore te mate Pelger-Huette ira tuku iho (PHA) e puta ai ngā raruraru nui. Nā te mea, ahakoa ka whakarerekē i te āhua o ō pūtau neutrophil, kāore e tino whakarerekē i tā rātou mahi. Ka whawhai tonu rātou ki ngā iroriki.

Heoi, ki te mea he pseudopelgar-huwat anomalous (PPHA) tōu, ka taea e te mate hauora taketake i puta ai (pērā i te leukemia) te whakararuraru i a koe. Nō reira, he mea nui kia kōrero koe ki tō tākuta mō tēnei, kia mōhio ai hoki koe ki ngā mea ka puta.

Me pēhea te tautuhi a ngā tākuta i te mate Pelger-Huette?

Ko te nuinga o ngā tākuta e whakamahi ana i ngā whakamātautau toto hei tātaritanga i tēnei mate.Ka mahia he whakamātautau e kiia nei ko te peripheral blood smear. Ko tēnei whakamātautau he tango i tētahi pata o tō tauira toto, ka horahia kia angiangi ki runga i tētahi kiriata karāhe, kātahi ka tirohia i raro i tētahi karuārai.

Ka tirotirohia tēnei e te tohunga mate, e te tohunga toto rānei.

Mena he Pelger-Huette anomaly tāu, ka kitea mārama i tēnei whakamātautau te āhua rerekē o ngā karihi o ō pūtau neutrophil (pērā i te dumbbell).

He rongoā anō kei te wātea mō te mate Pelger-Huette?

Anei te rongo pai! Ko te mate Pelger-Huette tuku iho (PHA) kāore he tohu e puta mai ana, nō reira kāore e hiahiatia he maimoatanga motuhake. Ahakoa kei a koe tēnei mate, ka taea e koe te noho noa i te ao.

Heoi, mō te PPHA, he mea nui kia rongoātia te mate taketake i puta ai. Kia ora rā anō taua mate, ka memeha haere pea te āhua PPHA.

Āhea ahau me toro atu ki te tākuta?

Ki te kitea e koe he Pelger-Huette anomaly tōu, me whakamōhio atu ki tō tākuta mēnā ka puta he tohu hou (pēnei i te kirika, te ngenge nui, te maha o ngā mate pāwera). Kātahi ka taea e tō tākuta te whakatau mēnā he hononga ngā tohu ki te PHA, ki te PPHA, ki tētahi atu mea rānei.

Ina haere koe ki te tākuta, he mea pai hoki kia pātai koe i ēnei pātai:

• He mate tuku iho ā Pelger-Huette (HPA), he mate rūpahu (PPHA) rānei tōku?
• Tērā pea ka riro i aku tamariki tēnei mate? (Mēnā he HPA)
• Kia pēhea te auau o taku haerenga ki te tākuta?
• He aha ngā tohu e tika ana kia tino mōhio ahau?

He aha taku e tumanako ai mō tēnei āhuatanga?

Kāore te Pelger-Huette anomaly (PHA) e whakararu i a koe, e kore hoki e whai pānga nui ki tō oranga. I te nuinga o te wā, kāore e pā ki ō mahi o ia rā.

Heoi, ki te mea kei a koe tēnei mate (ina koa te momo 'PPHA'), he tohu pea tēnei mō tētahi atu mate hauora e pā ana ki a koe. Koia te take e āwangawanga ai ngā tākuta mō tēnei mate. Ki te whakapae tō tākuta kei a koe te 'PHA', te 'PPHA' rānei, ka mahia e rātou ngā whakamātautau e tika ana hei whakaū, ā, ka mahi hoki i ngā mahi hei whakakore i ētahi atu mate hauora.

Tērā pea kei a koe te Pelger-Huette anomaly (PHA) ā, kāore koe i te mōhio nā te mea kāore he tohu āu. Tērā pea ka whakaaro koe, "Ki te kore e pā ki ahau, he aha ahau i whakaaro ai mōna?" He pono kāore pea koe e māuiui nā tēnei whakarerekētanga pūtau. Engari he mea nui kia mōhio koe ki tō tākuta. Kei reira tō tākuta hei āwhina i a koe kia noho hauora. Ā, he mea āwhina te mōhio ki ēnei mea iti o tō tinana. Nā te mea kei a koe te Pelger-Huette anomaly he mea anō tēnei e hanga ana i a koe hei "koe". Kāore he mea hei manukanuka.

Whakarāpopototanga (Karere hei tango ki te kāinga)

Āe, me whakarāpopoto tātou i ētahi o ngā mea i kōrerohia e tātou:

• Ko te Pelger-Huet Anomaly (PHA) he āhuatanga ira e puta ai te āhua rerekē o te karihi o ngā neutrophils, he momo toto ma.
• Kāore tēnei i te mea morearea, ā, kāore hoki e puta he tohu. He pai te mahi a ngā pūtau neutrophil.
• E rua ngā momo o tēnei: ​​ko te 'HPA', he mea tuku iho, me te 'PPHA', ka puta ake i muri mai i ētahi atu mate, i ētahi atu rongoā rānei.
• Kāore e hiahiatia he rongoā mō te HPA. Mō te PPHA, ka rongoāhia te pūtake.
• Ka tātaritatia tēnei āhuatanga mā te whakamātautau toto (te whakamātautau toto ā-taha).
• Ki te kitea e koe tēnei mate, kaua e manukanuka. Heoi anō, kōrero ki tō tākuta mō tēnei mea, kia whiwhi ai koe i ngā tohutohu e tika ana. Mēnā ka puta mai he tohu hou, whakamōhio atu ki tō tākuta.

Ko tāku tumanako kua whakautua e tēnei tuhinga te nuinga o āu pātai mō te mate urutā Pelger-Huette. Kia maumahara, mō ngā raruraru hauora katoa, he pai ake te kōrero māhorahora ki tō tākuta.