Kia ako tātou mō ngā Rongoā Irirangi i roto i tētahi huarahi māmā noa iho. He mea tino nui tēnei māu!

Tērā pea ka mataku koe ina rongo koe i te kupu "radiopharmaceuticals", tika? Mā te kupu "radioactive" ka puta ake he whakaaro mōrearea, engari ki te whakamahia tika i roto i te rongoā, ka tino āwhina. Nō reira, i tēnei rā, me kōrero tātou mō te aha rātou, me pēhea te mahi, me te haumaru hoki mōu.

He aha ēnei rongoā irirangi? Kia mārama tātou!

He kupu ngāwari noa iho, he momo rongoā motuhake anō hoki ēnei '(Ngā Rongoā Irirangi)'. Engari he iti noa te matū irahiko kei roto, arā, he irahiko. Kaua e manukanuka, he irahiko haumaru, he mea whakahaeretia tēnei. Ka whakamahia e ā mātou tākuta, arā, ngā tākuta me ngā kaiwhakarato hauora e pā ana, ēnei rongoā mō ngā whakamātautau whakaahua i roto i te rongoā karihi, me te rongoā i ētahi mate, inā koa ko ngā pukupuku matepukupuku .

Whakaarohia, ina hiahia rātou ki te tirotiro mēnā he hē kei roto i tō tinana, i ētahi wā ka hoatu e ngā tākuta he rongoā iti hei inu, he werohanga rānei i mua i te matawai? He rite tonu tēnei ki tēnā. Ka hangaia, ka tukuna hoki ēnei rongoā motuhake e ngā tāngata kua whakangungua motuhaketia e kiia nei ko ngā kaiwhakaora matū karihi . Kātahi ka whakamahia e ngā tohunga hihi-X me ngā tohunga hangarau hihi-X (RT) hei mahi i ngā whakamātautau whakaahua tātaritanga. I ētahi wā, ka hoatu hoki e ngā tohunga mate pukupuku hihi-X ēnei rongoā hei maimoatanga.

He aha te whakamahinga o ēnei rongoā irirangi?

E rua ngā wāhanga matua e whakamahia ana mō ēnei rongoā. Kia tirohia tātou he aha ēnei.

1. Ngā Rongoā Rongoā Ārai Matepukupuku

He maha ngā wā ka whakamahia ngā rongoā irirangi i roto i ngā whakamātautau whakaahua rongoā karihi . Ka karangatia ēnei e mātou ko ngā "rongoā irirangi tātaritanga". I te Hononga o Amerika anake, e kiia ana e miriona o ēnei whakamātautau rongoā karihi e mahia ana i ia tau. Nō reira, ka taea e koe te whakaaro ki te whānui o te whakamahinga.

Mā ēnei whakamātautau ka taea te tirotiro mēnā kei te mahi tika ngā okana me ngā kiko i roto i tō tinana . Ka mahia tēnei penei:

Ka hoatu he iti noa iho o tēnei rongoā irahiko hei inu, hei manawa, hei werohanga rānei māu. I ētahi wā ka kiia ēnei he radiotracers . Kāore te nui o te rongoā irahiko ka hoatu ki a koe e pā kino ki a koe. He iti noa iho. Ka haere tēnei rongoā ki te wāhi kei reira he raruraru i roto i tō tinana, ka kohia. Kātahi ka kitea e tētahi kāmera tino tairongo, pērā i te kāmera gamma, te irahiko i roto i tō tinana, ā, ka hangaia he whakaahua ka taea e te tākuta te kite.

Whakaarohia, he rite tēnei rongoā ki tētahi kaitirotiro e tomo ana ki roto i te tinana, e kimi ana i ngā wāhi raruraru, ā, e whakaatu mai ana, "Koinei te wāhi kei reira te raruraru."

Anei ētahi tauira o te whakamahinga o ngā rongoā irirangi mō te tātaritanga:

• Pūhauora-18: He taputapu irahiko tēnei e whakamahia whānuitia ana i roto i ngā matawai PET (Positron Emission Tomography scans).
• Technetium 99m: Koinei te huānga irahiko e whakamahia whānuitia ana i roto i te rongoā karihi. E whakamahia ana hei tirotiro i ngā wheua, te mahi a te ate, me te mahi a te tākihi.
• Xenon-133: He rongoā irahiko tēnei ka hongihia e koe. Ka hoatu hei tirotiro i te mahi a ngā pukahukahu (whakamātautau mahi a ngā pukahukahu).
• Rubidium-82: He rongoā tēnei e hoatu ana ki a koe mā roto i te uaua (IV). Ka whakamahia hei tirotiro i te āhua o te uaua o te ngākau (whakaahua myocardial).

2. Ngā Rongoā Rongoā Rongoā

Nā, me kōrero tātou mō te whakamahinga o ēnei rongoā mō te maimoatanga. He rerekē paku ēnei i ērā e whakamahia ana mō te tātaritanga mate. Ka tukuna e ngā rongoā irirangi e whakamahia ana mō te maimoatanga he tino kaha te hihi, ā, ka whakamate i ngā pūtau . Ka mahia tēnei hei patu i ngā pūtau hauora kore, inā koa ngā pūtau matepukupuku .

He rite ēnei rongoā ki ngā "kaiwhai utu." Arā, ka kitea e rātou ngā pūtau matepukupuku ka tukuna tika te rongoā irahiko ki aua pūtau . He rerekē tēnei i te rongoā irahiko hihi o waho , e whakamahi ana i te mīhini hei tuku i ngā hihi irahiko mai i waho o tō tinana. Engari ka mahi tika ēnei rongoā irahiko mā te aro ki te ūnga.

He mea hou tēnei mara, arā, te whakamahinga o ngā rongoā irahiko mō te maimoatanga. Kei te tūhura tonu ngā kairangahau i ngā whakamahinga hou mō ēnei rongoā. E whakapono ana rātou ka whai wāhi nui ngā rongoā irahiko hei rongoā mō te mate pukupuku ā muri ake nei.

He aha ngā rongoā radiopharmaceutical e whakamahia ana hei rongoā i te mate pukupuku?

He maha ngā momo "rongoā irirangi" e whakamahia ana e ngā tākuta hei rongoā i te mate pukupuku. Hei tauira:

• PLUVICTO® (lutetium Lu 177 vipivotide tetraxetan): He rongoā tēnei kua whakaaetia e te US Food and Drug Administration (FDA). E whakamahia ana hei rongoā i te mate pukupuku repeure (PSMA-positive metastatic castration-resistant prostate cancer - PSMA-positive mCRPC).
• Lutathera™ `(Lutathera™ - Lutetium Lu 177 dotatate)`:He rongoā tēnei kua whakaaetia e te FDA. E whakamahia ana hei rongoā i ētahi pukupuku neuroendocrine (ngā pukupuku neuroendocrine gastroenteropancreatic receptor-positive somatostatin) e puta ana i roto i te puku, ngā whekau, me te pancreas.
• Iodine-131: Koinei te momo matua o te rongoā iodine radioactive. Ka taea te rongoā i ētahi mate pukupuku tairoi me ētahi mate o Graves, e mōhiotia ana ko te hyperthyroidism.
• Radium-223: He tino whai hua tēnei mō te rongoā i ngā pukupuku wheua e puta mai ana ina horapa (metastasizes) te mate pukupuku prostate ki ngā wheua. Kua whakaaetia e te US FDA te Radium-223 dichloride (Xofigo™) mō tēnei kaupapa.

Hei tāpiritanga, kei roto i ngā whakamātautau haumanu ētahi atu momo maimoatanga radiopharmaceutical mō ētahi atu momo mate pukupuku i tēnei wā.

He aha ngā rongoā irirangi e whakamahia whānuitia ana?

E ai ki tā mātou i kōrero ai i mua ake nei, ko te Technetium-99m he rongoā irirangi e whakamahia ana e ngā tākuta. E whakamahia ana mō ngā whakamātautau whakaahua tātaritanga. He āwhina ki te "kite" i ngā mea e whai ake nei:

• Te rere o te toto i roto i ō pukahukahu.
• Te rere o te toto i roto i tō pūnaha toto (Te rere o te toto i roto i te toto).
• Ngā wheua.
• Te kiko o te uaua ngākau.
• Ngā repe waikura.
• Te repe tairoiti.

Ko ētahi atu rongoā irirangi e whakamahia whānuitia ana ko:

• ¹⁸F Pūhaumāotaota `(¹⁸F Pūhaumāotaota - FDG)`
• Kariuma-68 TŌTATATE
• Kariuma-68 PSMA `(Kariuma-68 PSMA)`
• ¹⁸F PSMA `(¹⁸F PSMA)`
• Iodine 123 `(Iodine 123)`

Nō reira, he tino haumaru ēnei rongoā irirangi?

He pātai tēnei e pā ana ki te tini tāngata. Ina whakamahia tika, ā, ina whakahaerea, he haumaru ngā rongoā irahiko. Ka mahi tahi tō tākuta irahiko, tō tākuta matepukupuku rānei, me tētahi kaiwhakaora rongoā karihi kia tika ai, kia haumaru ai hoki te nui o te rongoā irahiko ka hoatu ki a koe . Nō reira, kāore he mea hei manukanuka.

Pērā i ngā rongoā katoa, ka pā mai ētahi pānga taha i te rongoā irahiko. Heoi, he nui ake ngā painga o te rongoā i ngā mōrearea. Mā tō tākuta koe e whakamārama i ēnei pānga taha pea i mua i te tīmatanga o te maimoatanga.

Ahakoa kua roa ngā tekau tau e whakamahia ana ngā rongoā irirangi i roto i te whakaahua rongoā karihi, nō nā tata nei tonu i tīmata ai te whakamahi hei rongoā i te mate pukupuku. Kei te rangahau tonu ngā kairangahau i te huarahi e aro atu ai ēnei rongoā irirangi me te patu i ngā pūtau mate pukupuku. Mena kei te hiahia koe ki te ako mō ngā whakamātautau haumanu o ngā rongoā irirangi hei rongoā i te mate pukupuku, kōrero ki tō tākuta. E harikoa ana rātou ki te āwhina i a koe.

Hei whakamutunga, ko ngā mea tino nui me maumahara koe

Āe, mai i ngā mea kua kōrerotia e tātou, koinei ngā mea matua hei maumahara māu:

• He momo rongoā motuhake ngā rongoā irirangi he kaha te irahiko kua whakahaeretia .
• Ka whakamahia whānuitia ēnei mō ngā whakamātautau whakaahua tātaritanga (hei tauira, ngā matawai PET, ngā matawai wheua) me te rongoā i ētahi mate, inā koa te mate pukupuku .
• I roto i ngā mahi tātaritanga, ka mahi ēnei hei "Irahiko tirotiro", e "tohu" ana i ngā wāhi o te tinana kei reira ngā raruraru.
• I roto i ngā maimoatanga, ka āwhina ēnei ki te arotahi me te whakangaro i ngā pūtau matepukupuku .
• He haumaru ēnei rongoā ina hoatu i raro i te tirotiro tika a te taote . Pērā i ngā rongoā katoa, tera pea he iti noa ngā pānga taha, engari he nui ake ngā painga i ērā.
• Kei te whanake tonu tēnei mara, inā koa ko te rongoā mate pukupuku, ā, he maha atu anō ngā whanaketanga ka tumanakohia ā muri ake nei.

Nō reira, ā tērā wā ka rongo anō koe mō te "(Radiopharmaceutical)", kua mārama ake koe ki tōna āhua me tōna whakamahinga, tika? Mēnā he pātai anō āu, kaua e mangere ki te pātai atu ki tō tākuta.

Rongoā Irirangi, Rongoā Karihi, Maimoatanga Matepukupuku, Matawai, Whakaora Irirangi, Tātaritanga