E mōhio ana koe ki te mate pukupuku onge e kiia nei ko te Sarcomatoid Carcinoma? Me kōrero taipitopito tāua!

He paku whakamataku te mate pukupuku i a tātou katoa, tika? Engari ehara i te mea he rite katoa ngā mate pukupuku. I tēnei rā ka kōrero tātou mō tētahi momo mate pukupuku onge, uaua hoki. Ko te ingoa ko te Sarcomatoid Carcinoma. Tērā pea he rerekē te ingoa ki a koe, engari me whakamārama noa iho. E kīia ana tēnei e ngā tākuta he momo mate pukupuku tino tere te tipu, he momo mate pukupuku kaha .

He aha te Sarcomatoid Carcinoma?

He whakarāpopototanga noa iho, ko te Sarcomatoid Carcinoma he huinga o ngā momo matepukupuku e rua. Arā, he āhuatanga ōna o te carcinoma me te sarcoma. Nā, kia titiro tātou he aha te carcinoma me te sarcoma.

• Carcinoma: Koinei te momo mate pukupuku tino noa. Ka tīmata i roto i ngā kiko e kapi ana i te mata o ō tātou whekau, o te kiri rānei. Ka karangatia ēnei kiko he kiko epithelial nā te mea he mea hanga mai i ngā pūtau epithelial.
• Sarcoma: He iti ake te kitea o tēnei i te carcinoma. Ka tīmata ngā sarcoma i ngā wāhi pērā i te wheua, te kiko honohono (hei tauira, te kiriuhi, ngā uaua), me te kiko ngohengohe (hei tauira, te uaua, te ngako, ngā io). He momo pūtau e kiia nei ko ngā pūtau mesenchymal.

Nō reira, mō te mate pukupuku sarcomatoid, ka puta he pukupuku kei roto ngā pūtau me ngā kiko e pā ana ki te mate pukupuku me te sarcoma. Ka tere te tipu o ēnei pukupuku, ā, ka horapa (metastasize) ki ngā wāhanga rerekē o te tinana. Ina horapa tēnei, ka pakaru ngā kiko hauora o te tinana.

Kei hea o te tinana tēnei e tino kitea ai?

Ina rongo koe i te ingoa sarcomatoid carcinoma, tera pea ka hono atu koe ki ō pūkahukahu . Heoi, ko tēnei momo mate pukupuku, he rite ki te carcinoma me te sarcoma, ka puta pea i ētahi atu wāhanga o te tinana. Hei tauira:

• Kiri
• Wheua
• Waha
• Repe tairoiti
• Ngā ū
• Puku
• Puku iti
• Ate
• Pancreas
• kōpū
• Repeure
• tōngāmimi
• Ngā whatukuhu
• Ko te wāhi i waenganui o te uma (e kiia ana tēnei ko te "Mediastinum". Kei konei ngā mea pēnei i te ngākau, te trachea, me te repe thymus)

E kiia ana ka horapa tere te mate pukupuku sarcomatoid, e tīmata ana i roto i ngā pukahukahu. Mā tēnei, ka horapa ki ētahi wāhi i te wā kotahi, pērā i ngā repe adrenal, te roro, ngā wheua, te ate, ngā whatukuhu, te peritoneum, te pancreas, te kiri, me te ngākau.

He momo rerekē anō hoki tēnei?

Āe, i whakarōpūhia e te World Health Organization (WHO) te sarcomatoid carcinoma ki ngā momo matua e rima i te tau 2015. Ko ia o ēnei momo e kiia ana ko te "poorly differentiated non-small lung carcinoma." Ko te tikanga o te "poorly differentiated" he tino rerekē ngā pūtau, ā, he uaua ki te kī tika ko tēhea momo. Ko te mate pukupuku pūkahukahu non-small lung he momo mate pukupuku pūkahukahu noa e tere tipu ana, e tere horapa ana hoki.

Ko ēnei momo e rima:

• Ngā mate pukupuku pleomorphic: He maha ngā āhuatanga o ēnei mate pukupuku. Heoi, neke atu i te 10% o ēnei he āhuatanga sarcoma. Koinei te momo mate pukupuku sarcomatoid e tino kitea ana.
• Matepukupuku pūtau-porowhita: I ahu mai te ingoa o tēnei momo matepukupuku i te āhua o ōna pūtau i raro i te karuārai. He roa, he angiangi, ā, he rite ki ngā porowhita o te wira hurihuri.
• Te mate pukupuku pūtau nunui: He nui ngā pūtau o tēnei mate pukupuku e rite ana ki te tauira o ngā sarcomas. I te nuinga o te wā ka puta ēnei i te wāhanga o runga o ngā pukahukahu.
• Carcinosarcoma: Kei roto i tēnei ko te kiko mai i ētahi momo carcinoma, pērā i te adenocarcinoma me te squamous cell carcinoma. Kei roto hoki ko te kiko sarcoma rerekē, kāore i te tino whanake.
• Pūkahukahu blastoma: He momo adenocarcinoma tēnei e rite ana ki te kiko pūkahukahu o te kukune. Ka kitea anō hoki ngā pūtau mesenchymal (pērā i ngā sarcomas).

Ko wai te mea ka nui ake te tūponotanga ka pāngia e tēnei?

Ko te Sarcomatoid Cancer te mea tino noa i roto i ngā tāne . He mea tino noa i roto i te hunga e whakamahi ana i ngā hua tupeka i tēnei wā, i mua rānei . Ko te tau toharite mō te tātaritanga he 65 tau te pakeke.

He pēhea te noa o tēnei?

He momo mate pukupuku tino onge tēnei. He iti noa te ōrau o ngā mate pukupuku pūkahukahu katoa e kiia ana ko te Sarcomatoid Carcinoma, i waenga i te 0.1% me te 0.4%.

He aha ngā tohu o tēnei?

Ko ngā tohu e pā ana ki a koe ka whakawhirinaki ki te wāhi i horapa ai te mate pukupuku i roto i tō tinana. Mena he mate pukupuku sarcomatoid tōu, ka pā pea ki a koe ngā tohu pēnei i:

• Maremare (mau tonu)
• Te uaua ki te manawa (dyspnea)
• Mamae o te uma
• Te toto me te hūpē
• Te ngaronga taumaha me te kore he take

He aha i puta ai tēnei mea?

E whakapono ana ngā tākuta ko tētahi o ngā tino take o te mate pukupuku sarcomatoid ko te tukanga e kiia nei ko te "Epithelial-Mesenchymal Transition (EMT)." I roto i ngā kupu māmā noa iho, koinei te wā e huri ai ngā pūtau epithelial mate pukupuku i roto i te mate pukupuku pūkahukahu ehara i te pūtau iti, ā, ko ētahi o rātou ka huri hei pūtau mesenchymal. Ka horapa tere ngā pūtau mate pukupuku kua huri pēnei puta noa i te tinana.

Ko ēnei huringa pūtau me te tipu tere e hono pinepine ana ki ngā whakarerekētanga ira i roto i ngā pūtau . Kei te mōhio koe, ko ō tātou ira ngā tohutohu e kī ana ki ngā pūtau me pēhea te whanonga. Ko te whakarerekētanga ira he huringa, he hapa rānei i roto i aua tohutohu. Kua kitea e ngā kaipūtaiao he maha ngā whakarerekētanga ira e pā ana ki te sarcomatoid carcinoma.

He aha ngā āhuatanga mōrearea e pā ana ki tēnei?

Ko te take mōrearea he mea e whakanui ake ai te tūponotanga o te whakawhanaketanga o tētahi mate. Mō te mate pukupuku sarcomatoid, ko te kai paipa te take mōrearea matua, me te mea e tino mōhiotia ana. He mea nui kia mōhiotia ko te 80% me te 90% o te hunga e pāngia ana e tēnei mate pukupuku pūkahukahu he kaipaipa o nāianei, o mua rānei.

Kaua e wareware mā te whakamutu i te kai paipa koe e tiaki i a koe mai i ngā mate pūkahukahu maha, tae atu ki te mate pukupuku pēnei i tēnei.

Me pēhea te mōhio o te tākuta ki tēnei?

Ka tirohia koe e tō tākuta i te tuatahi, ā, ki te tika, ka mahia ētahi tikanga whakaahua. Heoi, kia tino mōhio ai koe he sarcomatoid carcinoma tēnei, me whai koiora hei tirotiro i ngā pūtau matepukupuku.

• Whakaahua: Tērā pea ka whakahaerehia e te tākuta he matawai CT hei tirotiro i te wāhi kei reira te matepukupuku. Hei tiro mārama ake i roto i te tinana, ka taea te whakahaere i tētahi matawai CT/PET, i tētahi matawai F-fluorodeoxyglucose (FDG)-PET rānei. Ka whakakotahihia e te matawai CT/PET ngā whakamātautau e rua (CT me PET) i te wā kotahi. Ko te Fluorodeoxyglucose he matū ka werohia ki roto i te tinana i te wā o te matawai PET. Ka kohia ki te taha o ngā pūtau matepukupuku, ka kitea ake i te matawai.

• Te Histopathology: Ko te histopathology te tirotiro mariko o tētahi tauira kiko matepukupuku i tangohia mai i tētahi koiora. Mā te āhua o ngā pūtau ka āwhina i te tākuta ki te whakatau mēnā he carcinoma sarcomatoid, ā, mēnā koinā, he aha te momo (hei tauira, te carcinoma pleomorphic, te carcinoma spindle cell).

• Te matū ārai mate:Ka rapua e tēnei whakamātautau ngā matū e kiia nei ko ngā antigens e pā ana ki ētahi momo pūtau. Ka taea e ētahi antigens te tautuhi i tētahi pūtau he rerekē, he kino rānei.

Me pēhea te rongoā?

Ko te rongoā tino whai hua mō tēnei mate pukupuku ko te pokanga hei tango i te pukupuku katoa. Ka taea e te chemotherapy te āwhina ki te patu i ngā pūtau mate pukupuku e toe ana i muri i te pokanga. Heoi, i te nuinga o te wā, kua horapa te mate pukupuku i te wā e kitea ai, nō reira kāore pea e taea te pokanga. Mena he raruraru pēnei i te mamae, te toto, te uaua rānei ki te manawa, ka taea hoki te hoatu te radiation therapy.

Mō te mate pukupuku sarcomatoid, ko te whakamātautau haumanu pea te whiringa maimoatanga pai rawa atu. Ko te whakamātautau haumanu he rangahau e whakamātautau ana i te haumaru me te whai huatanga o ngā maimoatanga hou. Kei te rangahauhia e ngā kaipūtaiao ngā maimoatanga hei āwhina i te whakaroa i te wā e taea ai e koe te ora me tēnei mate pukupuku. Ko ētahi o ēnei ko:

• Whakaora arotahi: Kei roto i tēnei ko te arotahi ki ngā āhuatanga motuhake e meinga ai ngā pūtau matepukupuku kia nui haere me te kore e taea te whakahaere.
• Ārai Mate: Ka whakaoho tēnei i tō pūnaha ārai mate, ka āwhina i a ia ki te kimi me te whakangaro i ngā pūtau matepukupuku.

He aha tā tātou e taea ai te whakaiti i te mōrearea?

Mā te kōwhiri kia kaua e whakamahi i ngā hua tupeka, ka taea e koe te whakaiti i tō tupono ki te whakawhanake i te sarcomatoid carcinoma, me te maha atu o ngā mate pukupuku pūkahukahu. Koinei te taahiraa tino nui ka taea e koe te mahi.

Ka taea te whakaora katoa i tēnei?

Ina hoki, ko te sarcomatoid carcinoma he momo mate pukupuku e uaua ana ki te whakaora katoa. Heoi, i te mea ka nui ake te ako a ngā kaipūtaiao mō ngā āhuatanga pūtau o ēnei pukupuku, pērā i ngā whakarerekētanga ira, ka taea e rātou te whakawhanake i ngā maimoatanga hou e aro ana ki a rātou. Mena ka kitea koe kei a koe tēnei mate, tera pea ka āhei koe ki te whai wāhi ki tētahi whakamātautau haumanu e whakamātautau ana i ngā maimoatanga hou. Pātai atu ki tō tākuta mō tēnei.

Kia pēhea te roa e ora ai koe me tēnei mate?

He uaua ki te kī kia pēhea te roa o tō oranga i tēnei āhuatanga, engari he mea nui kia mōhio koe. I te toharite, ko te ōrau oranga toharite he 10 marama. Ko te ōrau oranga rima tau he 15%. Heoi, kāore ēnei tatauranga e pā ki te katoa. He maha ngā āhuatanga ka pā ki tō āhuatanga:

• Te momo pūtau motuhake i roto i te mate pukupuku.
• He aha ngā whakarerekētanga ira kua puta?
• Te roa o te wā mai i te tīmatanga o ngā tohu tae noa ki te tautuhia o te mate.
• Te tawhiti kua horapa te mate pukupuku, kua whakangaromia hoki ngā kiko hauora.
• Te whānui o te horapa o te mate pukupuku.
• Mehemea ka taea e te tākuta te tango katoa i te pukupuku matepukupuku.

Nō reira, he mea tino nui kia kōrero mārama koe mō ēnei mea katoa ki tō tākuta kia mārama ake ai koe ki tō āhua.

He aha ngā pātai nui hei pātai atu ki te tākuta?

Ina kitea e koe he mate pukupuku sarcomatoid tōu, tera pea ka tino manukanuka koe, ka pōhēhē hoki nā te mea he kanorau, he uaua hoki ēnei mate pukupuku. He mea nui kia kōrero noa koe ki tō tākuta mō ō whiringa maimoatanga me te ahunga whakamua o te mate. Ka taea e tō tākuta te whakamārama ki a koe he aha ngā mea hei tumanakohia i runga i ngā āhuatanga o ō pūtau mate pukupuku me te wāhi kei reira te mate pukupuku i roto i tō tinana.

Anei ētahi pātai ka taea e koe te pātai atu ki tō tākuta:

• Kua horapa taku mate pukupuku?
• Kia pēhea te kaha o taku mate pukupuku?
• He aha te momo maimoatanga e taunaki ana koe?
• He aha ngā pānga taha e tika ana kia tumanakohia mai i te maimoatanga?
• Ki tō whakaaro he mea pai kia rapua e au tētahi atu whakaaro hauora?
• Me mahi tahi ahau me ngā tohunga tiaki mamae?
• E āhei ana ahau ki te whai wāhi atu ki tētahi whakamātautau haumanu?

Ka taea e tō tākuta te whakarato i ngā mōhiotanga e hiahiatia ana e koe, te tuku i a koe ki ngā whakamātautau haumanu mēnā e tika ana, me te āwhina i a koe ki te whiwhi tiaki mamae.

Ngā mea me maumahara tātou

Āe, mai i ngā kōrero kua kōrerotia e tātou mō te Sarcomatoid Carcinoma, anei ngā mea matua hei maumahara māu:

• He momo mate pukupuku tino onge tēnei, he kaha te horapa, ā, ka tere rawa te horapa.
• E whakaatu ana tēnei i ngā āhuatanga o te carcinoma me te sarcoma.
• Ko te kai paipa te tino take mō tēnei.
• Kei te wāhi kei reira te matepukupuku ngā tohu. I roto i ngā pukahukahu, ko te maremare me te uaua ki te manawa pea ngā tohu.
• Me whakamahi ngā whakamātautau motuhake (te koiora, te whakaahua) hei tautuhi i te mate.
• He uaua ngā kōwhiringa maimoatanga. Haunga te pokanga, te chemotherapy, me te radiation therapy, kei te whakaarohia hoki ngā maimoatanga hou (ngā whakaora kua arotahihia, te immunotherapy).
• Ahakoa he iti te tūponotanga o te ora katoa, kei te whakaatuhia e ngā rangahau hou he tumanako.
• He mea tino nui kia kōrero noa koe ki tō tākuta mō tō āhua, kia mārama hoki ngā mea katoa.

Ko tāku tumanako ka whai hua ēnei mōhiohio ki a koe. Mēnā he pātai anō āu mō tēnei, tēnā whakapā atu ki te tākuta.