ꯅꯍꯥꯛꯀꯤ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯑꯗꯨ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯑꯣꯏꯕ꯭ꯔꯥ? ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯋꯥꯔꯤ ꯁꯥꯁꯤ! (ꯑꯩꯆ.ꯏ.ꯑꯥꯔ.꯲-ꯅꯦꯒꯦꯇꯤꯕ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ)

ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯩ ꯍꯥꯌꯅꯥ ꯍꯥꯌꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯀꯔꯤ ꯐꯥꯑꯣꯔꯤꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯋꯥꯍꯩꯅꯥ ꯐꯣꯡꯗꯣꯀꯄꯥ ꯌꯥꯝꯅꯥ ꯂꯨꯏ ꯍꯥꯌꯕꯥ ꯑꯩ ꯈꯉꯏ꯫ ꯋꯥꯍꯪ ꯀꯌꯥ ꯑꯃꯁꯨꯡ ꯑꯀꯤꯕꯥ ꯀꯌꯥ ꯅꯍꯥꯛꯀꯤ ꯋꯥꯈꯂꯗꯥ ꯂꯥꯀꯄꯥ ꯑꯁꯤ ꯅꯣꯔꯃꯦꯂꯅꯤ꯫ ꯑꯗꯨꯕꯨ ꯑꯔꯨꯕꯥ ꯈꯣꯡꯆꯠ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯗꯣꯃꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯕꯥ ꯌꯥꯕꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯋꯥꯐꯝ ꯑꯃꯗꯤ ꯑꯗꯣꯃꯒꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯑꯀꯛꯅꯕꯥ ꯃꯑꯣꯡ ꯃꯇꯧ ꯑꯗꯨ ꯈꯉꯕꯥ ꯑꯁꯤꯅꯤ꯫ ꯀꯦꯟꯁꯔꯒꯤ ꯁ꯭ꯇꯦꯖ, ꯃꯁꯤꯒꯤ ꯃꯈꯜ, ꯃꯁꯤꯒꯤ ꯁꯥꯏꯖ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯂꯩꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯈꯔꯗꯤ ꯈꯪꯖꯤꯅꯕꯥ ꯑꯁꯤ ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯋꯥꯔꯦꯞ ꯂꯧꯕꯗꯥ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫

ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯍꯥꯌꯕꯁꯤ ꯀꯔꯤꯅꯣ?

ꯃꯁꯤ ꯑꯁꯤꯒꯨꯝꯅꯥ ꯂꯧꯁꯤꯅꯁꯤ꯫ ꯑꯩꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯂꯩꯔꯤꯕꯥ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯑꯄꯤꯀꯄꯥ ꯌꯨꯃꯁꯤꯡꯒꯨꯝꯕꯅꯤ꯫ ꯌꯨꯃꯁꯤꯡ ꯑꯁꯤꯗꯥ ꯃꯄꯥꯟꯊꯣꯡꯗꯒꯤ ꯄꯥꯎꯖꯦꯂꯁꯤꯡ ꯂꯥꯀꯄꯥ ꯑꯈꯟꯅꯕꯥ ‘ꯑꯦꯟꯇꯦꯅꯥ’ ꯂꯩ꯫ ꯃꯦꯗꯤꯁꯤꯅꯗꯥ ꯑꯩꯈꯣꯌꯅꯥ ꯍꯥꯌꯔꯤꯕꯥ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ ꯑꯁꯤ ꯀꯧꯏ꯫ ꯍꯥꯌꯔꯤꯕꯥ ꯑꯦꯟꯇꯦꯅꯥꯁꯤꯡ ꯑꯁꯤꯗꯒꯤ ꯁꯦꯜ ꯑꯃꯅꯥ ‘ꯒ꯭ꯔꯣꯊ’ ꯑꯃꯁꯨꯡ ‘ꯗꯤꯚꯥꯏꯗ’ꯒꯨꯝꯕꯥ ꯄꯥꯎꯖꯦꯂꯁꯤꯡ ꯐꯪꯏ꯫

HER2 (Human Epidermal Growth Factor Receptor 2) ꯑꯁꯤ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯑꯈꯟꯅꯕꯥ ꯑꯦꯟꯇꯦꯅꯥ ꯑꯃꯅꯤ꯫ HER2ꯅꯥ ꯍꯀꯆꯥꯡ ꯐꯕꯥ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯒ꯭ꯔꯣꯊ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯅꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ HER2 ꯑꯦꯟꯇꯦꯅꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯍꯦꯟꯅꯥ ꯁꯦꯝꯃꯤ, ꯃꯁꯤꯅꯥ ꯅꯣꯔꯃꯦꯂꯗꯒꯤ ꯌꯥꯝꯅꯥ ꯍꯦꯟꯅꯥ ꯁꯦꯝꯃꯤ꯫ ꯃꯗꯨꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯀꯦꯟꯁꯔ ꯑꯗꯨꯅꯥ ‘ꯆꯥꯎꯈꯠꯄꯥ’ ꯍꯥꯌꯅꯥ ꯂꯦꯞꯄꯥ ꯂꯩꯇꯅꯥ ꯄꯥꯎꯖꯦꯜ ꯑꯃꯥ ꯐꯪꯏ, ꯑꯃꯁꯨꯡ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯁꯟꯗꯣꯀꯄꯥ ꯍꯧꯏ꯫ ꯑꯩꯈꯣꯌꯅꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯁꯤꯕꯨ HER2-Positive ꯍꯥꯌꯅꯥ ꯀꯧꯏ꯫

ꯃꯔꯝ ꯑꯗꯨꯅꯥ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯑꯗꯨ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯑꯣꯏ ꯍꯥꯌꯔꯕꯗꯤ, ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯑꯍꯦꯅꯕꯥ HER2 ꯑꯦꯟꯇꯦꯅꯥ ꯑꯁꯤ ꯂꯩꯇꯦ ꯍꯥꯌꯕꯅꯤ꯫ ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔ ꯑꯗꯨ ꯌꯥꯡꯅꯥ ꯆꯥꯎꯈꯠꯍꯅꯕꯥ ꯉꯝꯕꯥ ꯑꯆꯧꯕꯥ ꯐꯦꯛꯇꯔ ꯑꯃꯠꯇꯥ ꯂꯩꯇꯦ꯫

ꯃꯁꯤ ꯇꯁꯦꯡꯅꯥ ꯆꯥꯡ ꯈꯔꯗꯥ ꯑꯐꯕꯥ ꯄꯥꯎꯅꯤ, ꯃꯔꯃꯗꯤ HER2-ꯅꯦꯒꯦꯇꯤꯕ ꯀꯦꯟꯁꯔꯁꯤꯡꯅꯥ HER2-ꯄꯣꯖꯤꯇꯤꯕ ꯀꯦꯟꯁꯔꯁꯤꯡꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯑꯦꯒ꯭ꯔꯦꯁꯤꯕ ꯑꯣꯏꯕꯥ ꯊꯦꯡꯅꯩ꯫ ꯃꯥꯂꯦꯃꯗꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯑꯌꯥꯝꯕꯥ ꯁꯔꯨꯀꯁꯤꯡꯗꯤ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯑꯣꯏꯅꯥ ꯀ꯭ꯂꯥꯁꯤꯐꯥꯏ ꯇꯧꯏ꯫

ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔꯒꯤ HER2 ꯁ꯭ꯇꯦꯇꯁ ꯑꯗꯨ ꯀꯔꯝꯅꯥ ꯈꯪꯒꯅꯤ?

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯑꯃꯁꯨꯡ HER2-ꯄꯣꯖꯤꯇꯤꯚ ꯀꯦꯟꯁꯔ ꯑꯅꯤꯃꯛꯀꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯃꯥꯟꯅꯩ꯫ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯌꯦꯡꯁꯤꯅꯕꯤꯕꯈꯛꯇꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯀꯔꯤ ꯃꯈꯂꯒꯤ ꯂꯩꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯈꯪꯍꯅꯕꯥ ꯉꯃꯗꯦ꯫ ꯃꯍꯥꯛꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯇꯤꯎꯃꯔ (ꯕꯥꯏꯑꯣꯞꯁꯤ)ꯒꯤ ꯑꯄꯤꯀꯄꯥ ꯁꯦꯝꯄꯜ ꯑꯃꯥ ꯂꯧꯕꯥ ꯑꯃꯁꯨꯡ ꯃꯗꯨ ꯇꯦꯁ꯭ꯠ ꯇꯧꯕꯥ ꯃꯊꯧ ꯇꯥꯒꯅꯤ꯫ ꯃꯁꯤꯒꯤ ꯇꯦꯁ꯭ꯠ ꯑꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ HER2 ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯂꯩꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯆꯨꯝꯅꯥ ꯈꯉꯗꯣꯛꯀꯅꯤ꯫

ꯑꯩꯈꯣꯌꯅꯥ HER2 ꯈꯛꯇꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯌꯦꯡꯁꯤꯅꯕꯥ ꯃꯊꯧ ꯇꯥꯏ!

HER2 ꯑꯁꯤ ꯀꯦꯟꯁꯔ ꯍꯦꯅꯒꯠꯂꯀꯄꯗꯥ ꯁꯣꯀꯍꯜꯂꯤꯕꯥ ꯐꯦꯛꯇꯔ ꯑꯃꯈꯛꯇꯅꯤ꯫ ꯑꯩꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯍꯣꯔꯃꯣꯅꯁꯤꯡꯗꯥ ꯁꯦꯟꯁꯤꯇꯤꯕ ꯑꯣꯏꯕꯥ ꯑꯇꯣꯞꯄꯥ ꯃꯈꯜ ꯑꯅꯤꯒꯤ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ ( ꯍꯣꯔꯃꯣꯟ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ - HR) ꯂꯩ꯫

• ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ (ꯏ.ꯑꯥꯔ.)
• ꯄ꯭ꯔꯣꯖꯦꯁ꯭ꯇꯦꯔꯣꯟ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ (ꯄꯤ.ꯑꯥꯔ.)

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ ꯑꯁꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯂꯩꯔꯕꯗꯤ, ꯍꯣꯔꯃꯣꯟ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯑꯃꯁꯨꯡ ꯄ꯭ꯔꯣꯖꯦꯁ꯭ꯇꯦꯔꯣꯅꯅꯥ ꯀꯦꯟꯁꯔ ꯍꯦꯅꯒꯠꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ ꯔꯤꯁꯦꯄꯇꯔ ꯄꯨꯝꯅꯃꯛ ꯑꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯄꯨꯟꯅꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯩ꯫ ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯅꯍꯥꯛꯀꯤ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯃꯈꯥ ꯇꯥꯅꯥ ꯃꯈꯜ ꯑꯅꯤꯗꯥ ꯈꯥꯌꯗꯣꯀꯄꯥ ꯌꯥꯏ:

1. HR-Positive / HER2-Negative: ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯀꯦꯟꯁꯔ ꯑꯁꯤ HER2ꯗꯥ ꯁꯦꯟꯁꯤꯇꯤꯚ ꯑꯣꯏꯗꯦ, ꯑꯗꯨꯕꯨ ꯍꯣꯔꯃꯣꯅꯁꯤꯡꯗꯥ ꯁꯦꯟꯁꯤꯇꯤꯚ ꯑꯣꯏ꯫ ꯃꯁꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯃꯈꯜꯅꯤ꯫

2. HR-Negative / HER2-Negative: ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯀꯦꯟꯁꯔ ꯑꯁꯤ HER2 ꯅꯠꯠꯔꯒꯥ ꯍꯣꯔꯃꯣꯟ ꯑꯃꯠꯇꯥꯗꯥ ꯁꯦꯟꯁꯤꯇꯤꯕ ꯑꯣꯏꯗꯦ꯫ ꯍꯥꯌꯔꯤꯕꯥ ꯔꯤꯁꯦꯄꯇꯔ ꯑꯍꯨꯝ ꯑꯁꯤ (HER2, ER, PR) ꯑꯁꯤ ꯌꯥꯑꯣꯗꯕꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯃꯈꯜ ꯑꯁꯤꯕꯨ ꯇ꯭ꯔꯤꯄꯜ ꯅꯦꯒꯦꯇꯤꯕ ꯍꯥꯌꯅꯥꯁꯨ ꯀꯧꯏ꯫

ꯐꯦꯛꯇꯔ ꯄꯨꯝꯅꯃꯛ ꯑꯁꯤ ꯈꯪꯕꯅꯥ ꯅꯍꯥꯛ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯕꯥꯏꯑꯣꯂꯣꯖꯤꯀꯦꯜ ꯕꯤꯍꯦꯕꯤꯌꯔꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯍꯦꯟꯅꯥ ꯃꯌꯦꯛ ꯁꯦꯡꯕꯥ ꯋꯥꯐꯝ ꯑꯃꯥ ꯈꯪꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯒꯅꯤ, ꯃꯗꯨꯅꯥ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯆꯨꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯏꯐꯦꯛꯇꯤꯚ ꯑꯣꯏꯕꯥ ꯂꯥꯏꯌꯦꯡꯒꯤ ꯑꯣꯄꯁꯟ ꯑꯃꯥ ꯈꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯒꯅꯤ꯫

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HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?

ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔ ꯑꯁꯤ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯑꯣꯏꯕꯅꯥ, ꯅꯍꯥꯀꯄꯨ HER2 ꯄ꯭ꯔꯣꯇꯤꯅꯗꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯔꯕꯥ ꯊꯦꯔꯥꯄꯤ ꯄꯤꯔꯣꯏ꯫ ꯃꯔꯃꯗꯤ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯊꯕꯛ ꯇꯧꯅꯕꯒꯤꯗꯃꯛ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ HER2 ꯑꯦꯟꯇꯦꯅꯥ ꯂꯩꯕꯥ ꯃꯊꯧ ꯇꯥꯏ꯫ ꯃꯗꯨꯒꯤ ꯃꯍꯨꯠꯇꯥ, ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯁ꯭ꯇꯦꯖ ꯑꯃꯁꯨꯡ ꯃꯁꯤ ꯍꯣꯔꯃꯣꯅꯁꯤꯡꯗꯥ ꯁꯦꯟꯁꯤꯇꯤꯚ ꯑꯣꯏꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨꯗꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯑꯇꯩ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯈꯅꯒꯅꯤ꯫

• ꯁꯔꯖꯔꯤ ꯑꯃꯁꯨꯡ ꯔꯦꯗꯤꯑꯦꯁꯟ: ꯀꯔꯤꯒꯨꯝꯕꯥ ꯀꯦꯟꯁꯔ ꯑꯗꯨ ꯇꯣꯏꯅꯥ ꯈꯪꯗꯣꯛꯂꯕꯗꯤ ꯁꯔꯖꯔꯤꯅꯥ ꯃꯄꯨꯡꯐꯥꯅꯥ ꯂꯧꯊꯣꯀꯄꯥ ꯉꯃꯒꯅꯤ꯫ ꯁꯔꯖꯔꯤꯒꯤ ꯃꯃꯥꯡ ꯅꯠꯠꯔꯒꯥ ꯃꯇꯨꯡꯗꯥ ꯔꯦꯗꯤꯑꯦꯁꯟ ꯊꯦꯔꯥꯄꯤꯁꯨ ꯔꯦꯀꯃꯦꯟꯗ ꯇꯧꯕꯥ ꯌꯥꯏ꯫

• ꯑꯦꯟꯗꯣꯛꯔꯥꯏꯟ/ ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ: ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔ ꯑꯗꯨ HR-Positive/HER2-Negative ꯑꯣꯏꯔꯕꯗꯤ ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯃꯁꯤꯅꯥ ꯍꯀꯆꯥꯡꯗꯥ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯅꯒꯨꯝꯕꯥ ꯍꯣꯔꯃꯣꯅꯁꯤꯡꯒꯤ ꯆꯥꯡ ꯍꯟꯊꯍꯟꯗꯨꯅꯥ ꯊꯕꯛ ꯇꯧꯏ꯫ ꯍꯣꯔꯃꯣꯅꯁꯤꯡ ꯑꯗꯨ ꯂꯣꯏꯔꯕꯥ ꯃꯇꯨꯡꯗꯥ, ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯅꯥ ꯆꯥꯎꯈꯠꯂꯀꯄꯒꯤ ꯄꯥꯎꯖꯦꯜ ꯑꯗꯨ ꯃꯥꯡꯈꯤ, ꯑꯃꯁꯨꯡ ꯀꯦꯟꯁꯔ ꯑꯗꯨ ꯍꯟꯊꯔꯀꯄꯥ ꯅꯠꯠꯔꯒꯥ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ ꯂꯦꯄꯈꯤꯕꯥ ꯌꯥꯏ꯫

• ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ: ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ ꯑꯁꯤ HR-ꯄꯣꯖꯤꯇꯤꯚ / HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤꯗꯃꯛꯇꯥ ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯄꯤꯕꯥ ꯌꯥꯏ꯫ ꯃꯁꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯁ꯭ꯇꯦꯖ ꯑꯃꯁꯨꯡ ꯒ꯭ꯔꯦꯗ, ꯅꯍꯥꯛꯀꯤ ꯆꯍꯤ, ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯑꯄꯨꯅꯕꯥ ꯍꯀꯁꯦꯂꯒꯨꯝꯕꯥ ꯐꯦꯛꯇꯔꯁꯤꯡꯒꯤ ꯃꯈꯥ ꯄꯣꯜꯂꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤꯒꯤ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯅꯥ ꯀꯥꯟꯅꯕꯁꯤꯡꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯋꯥꯡꯕꯥ ꯌꯥꯏ, ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯐꯕꯥ ꯑꯗꯨ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫

• ꯏꯝꯝꯌꯨꯅꯣꯊꯦꯔꯥꯄꯤ: ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔ ꯑꯗꯨ ꯇ꯭ꯔꯤꯄꯜ ꯅꯦꯒꯦꯇꯤꯚ ꯑꯃꯁꯨꯡ ꯑꯦꯗꯚꯥꯟꯁ ꯑꯣꯏꯔꯕꯗꯤ, ꯑꯃꯁꯨꯡ PD-L1 ꯀꯧꯕꯥ ꯑꯇꯣꯞꯄꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯃꯥ ꯂꯩꯔꯕꯗꯤ, ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤ ꯑꯣꯄꯁꯟ ꯑꯃꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ ꯃꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯂꯥꯀꯁꯤꯟꯅꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯁꯥꯒꯤ ꯏꯝꯝꯌꯨꯟ ꯁꯤꯁ꯭ꯇꯦꯝ ꯑꯗꯨ ꯊꯧꯒꯠꯇꯨꯅꯥ ꯊꯕꯛ ꯇꯧꯏ꯫

ꯑꯥꯎꯇꯂꯨꯛ ꯑꯃꯁꯨꯡ ꯄ꯭ꯔꯣꯒ꯭ꯅꯣꯁꯤꯁ꯫

ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯋꯥꯐꯃꯗꯤ ꯃꯗꯨ ꯍꯀꯆꯥꯡꯒꯤ ꯑꯇꯩ ꯃꯐꯃꯁꯤꯡꯗꯥ ꯁꯟꯗꯣꯔꯛꯠꯔꯤꯉꯩ ꯃꯃꯥꯡꯗꯥ ꯊꯤꯖꯤꯅꯕꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯀꯦꯟꯁꯔ ꯑꯗꯨ ꯕ꯭ꯔꯦꯅꯗꯥ ꯂꯣꯀꯦꯂꯥꯏꯖ ꯑꯣꯏꯔꯕꯗꯤ, ꯆꯍꯤ 5ꯒꯤ ꯔꯤꯂꯦꯇꯤꯚ ꯁꯔꯚꯥꯏꯚꯜ ꯔꯦꯠ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯋꯥꯡꯏ꯫ ꯃꯁꯤ ꯃꯔꯨꯑꯣꯏꯅꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔ ꯑꯗꯨ HR-ꯄꯣꯖꯤꯇꯤꯚ ꯑꯣꯏꯔꯕꯗꯤ ꯑꯆꯨꯝꯕꯅꯤ꯫

ꯇ꯭ꯔꯤꯄꯜ-ꯅꯦꯒꯦꯇꯤꯕ ꯀꯦꯟꯁꯔꯁꯤꯡ ꯑꯁꯤ ꯂꯥꯌꯦꯡꯕꯗꯥ ꯈꯔꯥ ꯍꯦꯟꯅꯥ ꯁꯤꯡꯅꯕꯥ ꯑꯣꯏꯔꯤ ꯃꯔꯃꯗꯤ ꯃꯈꯣꯌꯅꯥ ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ ꯅꯠꯠꯔꯒꯥ ꯍꯦꯔ꯲ꯗꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯊꯦꯔꯥꯄꯤꯁꯤꯡꯗꯥ ꯔꯦꯁ꯭ꯄꯣꯟꯁ ꯇꯧꯗꯦ꯫ ꯃꯈꯣꯌ ꯑꯁꯤ ꯍꯦꯟꯅꯥ ꯑꯦꯒ꯭ꯔꯦꯁꯤꯚ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫

ꯃꯈꯥꯗꯥ ꯀꯦꯟꯁꯔꯒꯤ ꯁ꯭ꯇꯦꯖ ꯑꯗꯨꯗꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯆꯍꯤ 5ꯒꯤ ꯑꯣꯏꯕꯥ ꯔꯤꯂꯦꯇꯤꯚ ꯁꯔꯚꯥꯏꯚꯜ ꯔꯦꯠꯁꯤꯡ ꯄꯤꯔꯤ꯫ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯆꯥꯡꯆꯠꯇꯥ ꯈꯛꯇꯅꯤ, ꯅꯍꯥꯛꯀꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯒꯤ ꯐꯤꯚꯝ ꯑꯁꯤ ꯇꯣꯉꯥꯅꯕꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ ꯍꯥꯌꯕꯁꯤ ꯅꯤꯡꯁꯤꯡꯕꯤꯌꯨ꯫

ꯃꯁꯤꯡꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯋꯥꯈꯜ ꯋꯥꯕꯥ ꯊꯣꯀꯍꯜꯂꯣꯏꯗꯕꯅꯤ꯫ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯃꯤꯑꯣꯏ ꯂꯤꯁꯤꯡ ꯀꯌꯥꯒꯤ ꯑꯦꯚꯥꯔꯦꯖ ꯈꯛꯇꯅꯤ꯫ ꯅꯍꯥꯛꯀꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯒꯤ ꯃꯤꯠꯌꯦꯡ ꯑꯁꯤ ꯐꯦꯛꯇꯔ ꯀꯌꯥꯒꯤ ꯃꯈꯥ ꯄꯣꯜꯂꯤ, ꯃꯗꯨꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡꯅꯥ ꯂꯥꯏꯌꯦꯡꯕꯗꯥ ꯀꯔꯝꯅꯥ ꯔꯦꯁꯄꯣꯟꯁ ꯇꯧꯕꯒꯦ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯑꯄꯨꯅꯕꯥ ꯍꯀꯁꯦꯜ ꯑꯁꯤꯁꯨ ꯌꯥꯎꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ, ꯅꯍꯥꯛꯀꯤ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯅꯥ ꯃꯊꯧ ꯇꯥꯕꯥ ꯑꯍꯦꯅꯕꯥ ꯇꯦꯁ꯭ꯠ ꯑꯃꯍꯦꯛꯇꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯑꯃꯨꯛꯇꯪ ꯋꯥꯔꯤ ꯁꯥꯕꯤꯌꯨ꯫