ꯅꯍꯥꯛꯅꯥ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯈꯪꯂꯕ꯭ꯔꯥ? ꯋꯥꯔꯤ ꯁꯥꯟꯅꯔꯁꯤ!

ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯗꯣꯝꯅꯥ ꯌꯥꯝꯅꯥ ꯇꯥꯕꯤꯔꯝꯂꯒꯅꯤ꯫ ꯑꯗꯨꯕꯨ ꯃꯁꯤꯒꯤ ꯃꯈꯜ ꯑꯁꯤꯒꯤ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ‘HER2-ꯅꯦꯒꯦꯇꯤꯕ’ ꯍꯥꯌꯕꯁꯤ ꯀꯔꯤꯅꯣ ꯍꯥꯌꯕꯁꯤ ꯑꯗꯣꯝꯅꯥ ꯇꯁꯦꯡꯅꯥ ꯈꯉꯕꯤꯔꯤꯕꯔꯥ? ꯃꯁꯤꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯈꯔꯗꯒꯤ ꯈꯔꯥ ꯈꯦꯠꯅꯩ, ꯑꯃꯁꯨꯡ ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤꯁꯨ ꯇꯣꯉꯥꯅꯕꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ ꯋꯥꯈꯜ ꯋꯥꯕꯥ ꯂꯩꯔꯣꯏ, ꯉꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ `HER2-Negative Breast Cancer` ꯑꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯗꯣꯝꯅꯥ ꯈꯉꯕꯤꯕꯥ ꯌꯥꯕꯥ ꯏꯆꯝ ꯆꯝꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯒꯅꯤ, ꯑꯣꯀꯦ?

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯍꯥꯌꯕꯁꯤ ꯀꯔꯤꯅꯣ?

ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, `HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ` ꯍꯥꯌꯕꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯕ꯭ꯔꯦꯁ꯭ꯇꯇꯥ ꯂꯩꯕꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ `ꯍꯤꯎꯃꯦꯟ ꯑꯦꯄꯤꯗꯥꯔꯃꯦꯜ ꯒ꯭ꯔꯣꯊ ꯐꯦꯛꯇꯔ 2 (HER2) ꯀꯧꯕꯥ ꯑꯈꯟꯅꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯃꯥ ꯌꯥꯝꯅꯥ ꯅꯠꯠꯔꯒꯥ ꯌꯥꯝꯅꯥ ꯅꯦꯝꯅꯥ ꯂꯩꯇꯦ ꯍꯥꯌꯕꯁꯤꯅꯤ꯫ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯃꯍꯧꯁꯥꯅꯥ ꯍꯣꯔꯃꯣꯅꯁꯤꯡ (ꯃꯔꯨꯑꯣꯏꯅꯥ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯑꯃꯁꯨꯡ ꯄ꯭ꯔꯣꯖꯦꯁ꯭ꯇꯦꯔꯣꯟ) ꯅꯠꯠꯔꯒꯥ `HER2` ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯊꯣꯀꯏ ꯍꯥꯌꯕꯁꯤ ꯅꯍꯥꯛꯅꯥ ꯈꯪꯂꯕ꯭ꯔꯥ? ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, `HER2-ꯄꯣꯖꯤꯇꯤꯕ` ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯗꯥ, `HER2` ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯃꯊꯛꯇꯥ ꯂꯩ, ꯃꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯈꯥꯌꯗꯣꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯇꯤꯎꯃꯔꯁꯤꯡ ꯁꯦꯝꯃꯤ꯫

ꯑꯗꯨꯕꯨ `HER2-ꯅꯦꯒꯦꯇꯤꯚ` ꯀꯦꯁꯁꯤꯡꯗꯥ, `HER2` ꯄ꯭ꯔꯣꯇꯤꯟ ꯌꯥꯝꯅꯥ ꯂꯩꯕꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯀꯦꯟꯁꯔ ꯂꯥꯀꯄꯥ ꯉꯃꯗꯦ꯫ ꯍꯥꯌꯕꯗꯤ ꯑꯇꯣꯞꯄꯥ ꯐꯦꯛꯇꯔꯁꯤꯡꯁꯨ ꯌꯥꯑꯣꯏ꯫

ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯅꯥ ꯅꯥꯔꯦ ꯍꯥꯌꯅꯥ ꯈꯪꯗꯣꯀꯄꯥ ꯃꯇꯃꯗꯥ, ꯃꯈꯣꯌꯅꯥ ꯅꯍꯥꯛꯀꯤ `HER2` ꯁ꯭ꯇꯦꯇꯁ (i.e., ꯄꯣꯖꯤꯇꯤꯚ ꯅꯠꯠꯔꯒꯥ ꯅꯦꯒꯦꯇꯤꯚ) ꯁꯣꯌꯗꯅꯥ ꯌꯦꯡꯒꯅꯤ꯫ ꯍꯥꯌꯔꯤꯕꯥ ꯑꯁꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯑꯈꯟꯅꯕꯥ ꯃꯒꯨꯅꯁꯤꯡꯅꯤ, ꯃꯈꯣꯌꯁꯤꯡ ꯑꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ `ꯕꯥꯏꯑꯣꯃꯥꯔꯀꯔ` ꯍꯥꯌꯅꯥ ꯀꯧꯏ, ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌꯁꯤꯡ ꯑꯁꯤ ꯃꯌꯦꯛ ꯁꯦꯡꯅꯥ ꯈꯉꯂꯕꯥ ꯃꯇꯃꯗꯥ, ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ ꯑꯗꯣꯃꯒꯤꯗꯃꯛꯇꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯆꯨꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯏꯐꯦꯛꯇꯤꯕ ꯑꯣꯏꯕꯥ ꯂꯥꯌꯦꯡ ꯑꯗꯨ ꯂꯦꯄꯊꯣꯀꯄꯥ ꯉꯃꯒꯅꯤ꯫ ꯈꯪꯂꯦ?

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯃꯈꯂꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?

ꯍꯧꯖꯤꯛ ꯈꯪꯗꯣꯛꯂꯤꯕꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯑꯌꯥꯝꯕꯗꯤ `HER2-ꯅꯦꯒꯦꯇꯤꯚ` ꯃꯈꯂꯒꯤ ꯑꯣꯏ꯫ ꯃꯁꯤꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯃꯈꯜ ꯑꯅꯤ ꯂꯩ, ꯃꯈꯣꯌꯁꯤꯡ ꯑꯁꯤ ꯀꯔꯤꯅꯣ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯁꯤ:

1. ꯍꯣꯔꯃꯣꯟ ꯔꯤꯁꯦꯄꯇꯔ-ꯄꯣꯖꯤꯇꯤꯕ ꯑꯃꯁꯨꯡ HER2-ꯅꯦꯒꯦꯇꯤꯕ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ (HR+/HER2-) :

ꯃꯁꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯃꯈꯂꯅꯤ, ꯃꯁꯤꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯄꯨꯝꯅꯃꯛꯀꯤ ꯆꯥꯎꯔꯥꯛꯅꯥ ꯆꯥꯗꯥ 70 (70%) ꯑꯣꯏꯔꯤ꯫ ꯃꯁꯤꯒꯤ ꯀꯦꯁ ꯑꯁꯤꯗꯥ, ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯍꯣꯔꯃꯣꯟ (ER+), ꯄ꯭ꯔꯣꯖꯦꯁ꯭ꯇꯦꯔꯣꯟ ꯍꯣꯔꯃꯣꯟ (PR+) ꯅꯠꯠꯔꯒꯥ ꯑꯅꯤꯃꯛꯇꯥ ꯁꯦꯟꯁꯤꯇꯤꯚ ꯑꯣꯏꯕꯥ ꯔꯤꯁꯦꯞꯇꯔꯁꯤꯡ ꯂꯩ꯫ ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯍꯣꯔꯃꯣꯅꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ ꯑꯁꯤꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯆꯦꯅꯕꯥ ꯃꯇꯃꯗꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ ꯍꯧꯏ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯀꯦꯟꯁꯔ ꯃꯈꯂꯁꯤꯡ ꯑꯁꯤꯅꯥ HER2 ꯄ꯭ꯔꯣꯇꯤꯅꯒꯤ ꯆꯥꯡ ꯋꯥꯡꯅꯥ ꯌꯥꯎꯗꯦ꯫ ꯃꯔꯝ ꯑꯁꯤꯅꯥ ꯃꯈꯣꯌꯕꯨ HR+/HER2- ꯍꯥꯌꯅꯥ ꯀꯧꯏ꯫

2. ꯍꯣꯔꯃꯣꯟ ꯔꯤꯁꯦꯄꯇꯔ-ꯅꯦꯒꯦꯇꯤꯕ ꯑꯃꯁꯨꯡ HER2-ꯅꯦꯒꯦꯇꯤꯕ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ (HR-/HER2-) :

ꯃꯁꯤꯒꯤ ꯃꯈꯜ ꯑꯁꯤꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯄꯨꯝꯅꯃꯛꯀꯤ ꯆꯥꯎꯔꯥꯛꯅꯥ ꯆꯥꯗꯥ 11 (11%) ꯑꯣꯏ꯫ ꯍꯥꯌꯔꯤꯕꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯅꯠꯠꯔꯒꯥ ꯄ꯭ꯔꯣꯖꯦꯁ꯭ꯇꯦꯔꯣꯟ ꯑꯃꯠꯇꯥ ꯔꯤꯁꯦꯄꯇꯔ ꯂꯩꯇꯦ꯫ ꯃꯁꯤꯗꯁꯨ ꯅꯠꯇꯅꯥ, ꯃꯃꯥꯡꯗꯥ ꯍꯥꯌꯈꯤꯕꯒꯨꯝꯅꯥ, `HER2` ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯋꯥꯡꯗꯦ꯫ ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯍꯣꯔꯃꯣꯟ ꯅꯠꯔꯒꯥ `HER2` ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯃꯠꯇꯥꯅꯥ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯍꯦꯅꯒꯠꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯗꯦ . ꯃꯁꯤꯒꯤ ꯑꯇꯣꯞꯄꯥ ꯃꯃꯤꯡ ꯑꯃꯗꯤ `ꯇ꯭ꯔꯤꯄꯜ-ꯅꯦꯒꯦꯇꯤꯕ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ` ꯍꯥꯌꯕꯅꯤ꯫ ꯃꯁꯤꯒꯤ ꯃꯔꯃꯗꯤ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯔꯤꯁꯦꯄꯇꯔ, ꯄ꯭ꯔꯣꯖꯦꯁ꯭ꯇꯦꯔꯣꯟ ꯔꯤꯁꯦꯄꯇꯔ, ꯑꯃꯁꯨꯡ `HER2` ꯄ꯭ꯔꯣꯇꯤꯟ ꯄꯨꯝꯅꯃꯛ ꯑꯁꯤ ꯀꯦꯁ ꯑꯁꯤꯗꯥ `ꯅꯦꯒꯦꯇꯤꯚ` ꯑꯣꯏ꯫

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?

ꯇꯁꯦꯡꯕꯗꯤ, HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯑꯇꯩ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯑꯃꯍꯦꯛꯇꯒꯥ ꯌꯥꯝꯅꯥ ꯃꯥꯟꯅꯩ꯫ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯑꯁꯤ ꯅꯍꯥꯛꯅꯥ ꯈꯪꯖꯤꯅꯒꯗꯕꯅꯤ:

• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯎꯅꯁꯥ ꯑꯃꯒꯤ ꯅꯠꯠꯔꯒꯥ ꯑꯅꯤꯃꯛꯀꯤ ꯁꯥꯏꯖ ꯅꯠꯠꯔꯒꯥ ꯃꯑꯣꯡ ꯑꯗꯨꯗꯥ ꯑꯆꯝꯕꯥ ꯑꯍꯣꯡꯕꯥ ꯑꯃꯥ ꯎꯔꯕꯗꯤ꯫
• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯅꯠꯠꯔꯒꯥ ꯑꯥꯔꯝꯄꯤꯇꯇꯥ ꯑꯅꯧꯕꯥ ꯂꯪꯁ, ꯂꯪꯁ ꯅꯠꯠꯔꯒꯥ ꯐꯔꯅꯤꯆꯔ ꯑꯃꯥ ꯎꯕꯥ ꯐꯪꯂꯕꯗꯤ, ꯃꯔꯨꯑꯣꯏꯅꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯂꯝ ꯑꯗꯨ ꯅꯍꯥꯛꯀꯤ ꯊꯥꯒꯤ ꯑꯣꯏꯕꯥ ꯊꯥꯒꯤ ꯈꯣꯡꯀꯥꯞ ꯑꯗꯨꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯍꯣꯡꯂꯛꯠꯔꯕꯗꯤ꯫
• ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯅꯠꯠꯔꯒꯥ ꯅꯤꯄꯥꯂꯒꯤ ꯈꯣꯡꯗꯥ ꯑꯍꯣꯡꯕꯥ ꯂꯥꯀꯄꯥ꯫ ꯈꯨꯗꯝ ꯑꯣꯏꯅ:
• ꯑꯣꯔꯦꯟꯖ ꯄꯤꯂꯒꯨꯝꯅꯥ ꯈꯣꯡꯗꯥ ꯗꯤꯝꯄꯜ ꯇꯧꯕꯥ꯫
• ꯈꯣꯡ ꯍꯥꯝꯕꯥ, ꯈꯣꯡ ꯍꯥꯝꯕꯥ꯫
• ꯁ꯭ꯀꯦꯂꯤ ꯁ꯭ꯀꯤꯟ꯫
• ꯂꯦꯞꯇꯅꯥ ꯁꯣꯀꯄꯥ ꯑꯃꯥ꯫
• ꯈꯣꯡꯒꯤ ꯃꯆꯨ ꯍꯣꯡꯂꯀꯄꯥ (ꯂꯥꯂꯍꯧ, ꯃꯆꯨ, ꯑꯉꯧꯕꯥ, ꯅꯠꯠꯔꯒꯥ ꯑꯆꯝꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯑꯉꯧꯕꯥ)꯫
• ꯅꯤꯄꯜ ꯗꯤꯁꯆꯥꯔꯖ ꯇꯧꯕꯥ . ꯃꯁꯤ ꯏꯒꯨꯝꯅꯥ ꯂꯥꯂꯍꯧꯕꯥ, ꯃꯌꯦꯛ ꯁꯦꯡꯕꯥ ꯂꯤꯛꯌꯨꯏꯗ ꯑꯃꯥ ꯅꯠꯠꯔꯒꯥ ꯁꯉ꯭ꯒꯣꯃꯒꯤ ꯑꯉꯧꯕꯥ ꯃꯆꯨ (ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯃꯤꯔꯣꯜꯂꯤꯉꯩ ꯅꯠꯠꯔꯒꯥ ꯈꯣꯝꯂꯥꯡ ꯄꯤꯊꯀꯄꯥ ꯑꯣꯏꯔꯕꯗꯤ) ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫
• ꯅꯤꯄꯜ ꯏꯅꯚꯥꯔꯁꯟ (ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯃꯥꯡꯗꯥ ꯂꯩꯔꯃꯗ꯭ꯔꯕꯗꯤ)꯫

ꯃꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏꯅꯥ ꯈꯉꯖꯤꯅꯕꯥ ꯌꯥꯏ ꯃꯗꯨꯗꯤ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯅꯥ ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯅꯍꯥꯛꯀꯤ ꯃꯤꯠꯌꯦꯡꯗꯥ ꯃꯌꯦꯛ ꯁꯦꯡꯅꯥ ꯑꯍꯣꯡꯕꯥ ꯄꯨꯔꯀꯄꯥ ꯉꯃꯗꯦ . ꯃꯁꯤꯗꯁꯨ ꯅꯠꯇꯅꯥ, ꯑꯍꯣꯡꯕꯥ ꯀꯌꯥ ꯑꯁꯤ ꯕꯦꯅꯤꯐꯤꯁꯔꯤ, ꯅꯣꯔꯃꯦꯜ ꯀꯟꯗꯤꯁꯅꯁꯤꯡꯗꯁꯨ ꯎꯕꯥ ꯐꯪꯏ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯁꯤꯁ꯭ꯇꯦꯝ, ꯐꯥꯏꯕ꯭ꯔꯣꯑꯦꯗꯦꯅꯣꯃꯥ)꯫ ꯃꯔꯝ ꯑꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯎꯅꯁꯥ ꯑꯗꯨ ꯆꯥꯡ ꯅꯥꯏꯅꯥ ꯌꯦꯡꯁꯤꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯆꯍꯤꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯁ꯭ꯛꯔꯤꯅꯤꯡ ꯇꯧꯕꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ . ꯀꯔꯤꯒꯨꯝꯕꯥ ꯑꯍꯣꯡꯕꯥ ꯑꯃꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯋꯥꯈꯜ ꯋꯥꯕꯥ ꯂꯩꯔꯕꯗꯤ, ꯃꯁꯤ ꯀꯦꯟꯁꯔ ꯅꯠꯠꯔꯒꯥ ꯑꯇꯣꯞꯄꯥ ꯀꯟꯗꯤꯁꯟ ꯑꯃꯒꯤ ꯈꯨꯗꯝ ꯑꯃꯥ ꯑꯣꯏꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯈꯪꯗꯣꯛꯅꯕꯥ ꯗꯣꯛꯇꯔ ꯑꯃꯗꯥ ꯁꯣꯌꯗꯅꯥ ꯇꯥꯀꯄꯤꯌꯨ꯫

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯀꯔꯤꯅꯥ ꯊꯣꯀꯍꯅꯕꯒꯦ?

ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, HER2-ꯅꯦꯒꯦꯇꯤꯕ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯂꯩꯕꯥ ꯖꯤꯅꯁꯤꯡ ꯅꯠꯠꯔꯒꯥ DNAꯗꯥ ꯑꯍꯣꯡꯕꯥ ꯂꯥꯀꯄꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯍꯥꯌꯅꯥ ꯀꯧꯏ, ꯃꯗꯨꯅꯥ ꯁꯦꯂꯁꯤꯡ ꯑꯗꯨꯕꯨ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯑꯣꯏꯍꯜꯂꯤ꯫ ꯃꯗꯨꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯗꯅꯥ ꯌꯥꯡꯅꯥ ꯈꯥꯌꯗꯣꯀꯏ ꯑꯃꯁꯨꯡ ꯃꯁꯤꯡ ꯌꯥꯝꯅꯥ ꯍꯦꯅꯒꯠꯂꯀꯏ, ꯃꯗꯨꯅꯥ ꯇꯤꯎꯃꯔꯁꯤꯡ ꯁꯦꯝꯃꯤ꯫

ꯔꯤꯁ꯭ꯛ ꯐꯦꯛꯇꯔꯁꯤꯡ꯫

HER2-ꯅꯦꯒꯦꯇꯤꯕ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯁꯤꯡꯗꯥ ꯖꯤꯅꯦꯇꯤꯛ ꯃ꯭ꯌꯨꯇꯦꯁꯅꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯑꯆꯨꯝꯕꯥ ꯃꯔꯝ ꯀꯔꯤꯅꯣ ꯍꯥꯌꯕꯁꯤ ꯍꯧꯖꯤꯛ ꯐꯥꯑꯣꯕꯥ ꯑꯦꯛꯁꯄꯔꯇꯁꯤꯡꯅꯥ ꯁꯣꯏꯗꯅꯥ ꯈꯉꯕꯥ ꯉꯃꯗ꯭ꯔꯤ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯃꯈꯣꯌꯅꯥ ꯃꯍꯧꯁꯥꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯥꯀꯄꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯌꯥꯕꯥ ꯐꯦꯛꯇꯔ ꯀꯌꯥ ꯈꯪꯗꯣꯀꯈ꯭ꯔꯦ꯫ ꯃꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯌꯥꯑꯣꯔꯤ:

• ꯏꯅꯍꯦꯔꯤꯇꯦꯗ ꯖꯦꯅꯦꯇꯤꯛ ꯃ꯭ꯌꯨꯇꯦꯁꯟ : HER2ꯒꯥ ꯃꯔꯤ ꯂꯩꯅꯕꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯥ ꯃꯔꯤ ꯂꯩꯅꯕꯥ ꯑꯀꯛꯅꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯃꯠꯇꯥ ꯂꯩꯇꯦ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯀꯅꯥꯒꯨꯝꯕꯥ ꯑꯃꯅꯥ BRCA1 ꯅꯠꯠꯔꯒꯥ BRCA2ꯒꯨꯝꯕꯥ ꯖꯤꯅꯁꯤꯡꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯑꯃꯥ ꯏꯅꯍꯦꯔꯤ ꯇꯧꯔꯕꯗꯤ, ꯃꯈꯣꯌꯅꯥ ꯃꯍꯧꯁꯥꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ (ꯑꯃꯁꯨꯡ ꯑꯇꯩ ꯀꯦꯟꯁꯔ ꯈꯔꯗꯤ) ꯂꯥꯀꯄꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯟꯅꯥ ꯂꯩ꯫
• ꯅꯍꯥꯛ ꯅꯠꯠꯔꯒꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯃꯨꯡꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯅꯥ ꯃꯃꯥꯡꯗꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯩꯈ꯭ꯔꯦ꯫: ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯃꯃꯥꯡꯗꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯩꯔꯕꯗꯤ, ꯅꯍꯥꯛꯅꯥ ꯃꯗꯨ ꯑꯃꯨꯛ ꯍꯟꯅꯥ ꯂꯥꯀꯄꯒꯤ ꯑꯀꯛꯅꯕꯥ ꯔꯤꯁ꯭ꯛ ꯂꯩ꯫ ꯃꯁꯤꯗꯁꯨ ꯅꯠꯇꯅꯥ, ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯏꯒꯤ ꯃꯔꯤ-ꯃꯇꯥꯁꯤꯡ (ꯃꯔꯨꯑꯣꯏꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯃꯃꯥ, ꯃꯄꯥ, ꯃꯆꯤꯟ-ꯃꯅꯥꯑꯣ, ꯑꯉꯥꯡꯁꯤꯡ)ꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯩꯔꯕꯗꯤ ꯅꯍꯥꯀꯁꯨ ꯈꯔꯥ ꯍꯦꯟꯅꯥ ꯔꯤꯁ꯭ꯛ ꯂꯩ꯫
• ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯅꯠꯠꯔꯒꯥ ꯄ꯭ꯔꯣꯖꯦꯁ꯭ꯇꯦꯔꯣꯟ ꯍꯣꯔꯃꯣꯅꯁꯤꯡꯗꯥ ꯑꯦꯛꯁꯄꯣꯖ ꯇꯧꯕꯥ : ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯍꯥꯅꯕꯥ ꯄꯤꯔꯤꯌꯗ ꯑꯗꯨ ꯅꯍꯥ ꯑꯣꯏꯔꯤꯉꯩꯗꯥ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯆꯍꯤ 12ꯒꯤ ꯃꯃꯥꯡꯗꯥ) ꯍꯧꯔꯀꯄꯥ ꯇꯥꯔꯕꯗꯤ, ꯅꯠꯠꯔꯒꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯂꯦꯃꯍꯧꯔꯤꯕꯥ ꯃꯦꯅꯣꯄꯣꯖ (e.g., ꯆꯍꯤ 55ꯒꯤ ꯃꯇꯨꯡꯗꯥ) ꯑꯣꯏꯔꯕꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡ ꯑꯁꯤ ꯁꯦꯛꯁ ꯍꯣꯔꯃꯣꯅꯁꯤꯡ ꯑꯁꯤ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯁꯣꯀꯍꯜꯂꯦ꯫ ꯃꯁꯤ ꯔꯤꯁ꯭ꯛ ꯐꯦꯛꯇꯔ ꯑꯃꯁꯨ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ ꯍꯣꯔꯃꯣꯟ ꯔꯤꯞꯂꯦꯁꯃꯦꯟꯇ ꯊꯦꯔꯥꯄꯤ ꯈꯔꯅꯁꯨ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯂꯧꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯌꯥꯏ꯫
• ꯌꯨ ꯊꯀꯄꯥ : ꯔꯤꯁꯔꯆꯅꯥ ꯇꯥꯛꯂꯤ ꯃꯗꯨꯗꯤ ꯅꯣꯡꯃꯗꯥ ꯁ꯭ꯇꯦꯟꯗꯔꯗ ꯗ꯭ꯔꯤꯉ꯭ꯛ ꯑꯃꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯊꯀꯄꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯔꯤꯁ꯭ꯀꯁꯨ ꯍꯦꯅꯒꯠꯍꯜꯂꯤ꯫

ꯃꯁꯤꯒꯤ ꯃꯊꯛꯇꯥ, ꯆꯍꯤ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ, ꯑꯣꯕꯦꯁꯤꯇꯤ, ꯑꯃꯁꯨꯡ ꯑꯦꯛꯁꯔꯁꯥꯏꯖ ꯇꯧꯗꯕꯅꯆꯤꯡꯕꯥ ꯐꯦꯛꯇꯔꯁꯤꯡꯅꯁꯨ ꯃꯍꯧꯁꯥꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯌꯥꯏ꯫

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯀꯔꯝꯅꯥ ꯈꯪꯗꯣꯀꯄꯒꯦ?

ꯃꯍꯧꯁꯥꯅꯥ ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯕꯥꯏꯑꯣꯞꯁꯤꯒꯤ ꯈꯨꯠꯊꯥꯡꯗꯥ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯈꯪꯗꯣꯀꯏ . ꯃꯁꯤꯗꯥ ꯆꯤꯡꯅꯕꯥ ꯂꯩꯕꯥ ꯂꯝ ꯅꯠꯠꯔꯒꯥ ꯃꯐꯝ ꯑꯃꯗꯒꯤ ꯇꯤꯁ꯭ꯌꯨꯒꯤ ꯑꯄꯤꯀꯄꯥ ꯁꯦꯝꯄꯜ (ꯄꯤꯁ) ꯑꯃꯥ ꯂꯧꯗꯨꯅꯥ ꯂꯦꯕꯇꯥ ꯊꯥꯕꯥ ꯌꯥꯑꯣꯏ꯫ ꯃꯐꯝ ꯑꯗꯨꯗꯥ ꯄꯦꯊꯣꯂꯣꯖꯤꯁ꯭ꯠ ꯑꯃꯅꯥ ꯁꯦꯝꯄꯜ ꯑꯗꯨ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯄꯀꯤ ꯃꯈꯥꯗꯥ ꯌꯦꯡꯁꯤꯜꯂꯤ ꯑꯃꯁꯨꯡ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯂꯩꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯏ꯫

ꯀꯔꯤꯒꯨꯝꯕꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯀꯅꯐꯔꯝ ꯇꯧꯔꯕꯗꯤ, ꯃꯗꯨꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯑꯈꯟꯅꯕꯥ ꯇꯦꯁ꯭ꯇꯁꯤꯡ ꯇꯧꯗꯨꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯗꯨꯒꯤ ꯃꯊꯛꯇꯥ `HER2` ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯂꯩꯕꯒꯦ, ꯅꯠꯠꯔꯒꯥ `HER2` ꯖꯤꯅꯒꯤ ꯀꯣꯄꯤ ꯀꯌꯥ ꯂꯩꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯁꯤꯜꯂꯤ꯫

• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ `HER2` ꯄ꯭ꯔꯣꯇꯤꯟ ꯅꯠꯠꯔꯒꯥ ꯖꯤꯅꯒꯤ ꯅꯣꯔꯃꯦꯜ (ꯂꯣ) ꯃꯁꯤꯡ ꯂꯩꯔꯕꯗꯤ, ꯅꯍꯥꯛꯅꯥ `HER2-ꯅꯦꯒꯦꯇꯤꯚ` ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯩ꯫

ꯃꯁꯤꯒꯤꯗꯃꯛꯇꯥ ꯄꯥꯡꯊꯣꯀꯄꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯂꯦꯕꯣꯔꯦꯇꯔꯤ ꯇꯦꯁ꯭ꯠ ꯑꯅꯤꯗꯤ:

꯱.ꯏꯝꯝꯌꯨꯅꯣꯍꯤꯁ꯭ꯇꯣꯀꯦꯃꯤꯁ꯭ꯠꯔꯤ (ꯑꯥꯏ.ꯑꯩꯆ.ꯁꯤ.) : ꯇꯦꯁ꯭ꯠ ꯑꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯃꯊꯛꯇꯥ ꯂꯩꯕꯥ ꯍꯦꯔ꯲ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯁꯤ ꯈꯉꯗꯣꯛꯅꯕꯥ ꯑꯀꯛꯅꯕꯥ ꯑꯦꯟꯇꯤꯕꯣꯗꯤꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯗꯥꯏꯁꯤꯡ ꯁꯤꯖꯤꯟꯅꯩ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ IHC ꯔꯤꯖꯜꯇ ꯑꯗꯨ 0 ꯅꯠꯠꯔꯒꯥ 1+ ꯑꯣꯏꯔꯕꯗꯤ, ꯀꯦꯟꯁꯔ ꯑꯗꯨ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯑꯣꯏꯅꯥ ꯂꯧꯏ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯔꯤꯖꯜꯇ ꯑꯗꯨ 2+ ꯑꯣꯏꯔꯕꯗꯤ (ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯗꯥ "ꯏꯛꯌꯨꯏꯚꯣꯀꯦꯜ" ꯅꯠꯠꯔꯒꯥ "ꯕꯣꯔꯗꯔꯂꯥꯏꯟ" ꯍꯥꯌꯅꯥ ꯀꯧꯏ), HER2 ꯁ꯭ꯇꯦꯇꯁ ꯑꯗꯨ ꯀꯅꯐꯥꯔꯝ ꯇꯧꯅꯕꯥ FISH ꯀꯧꯕꯥ ꯇꯦꯁ꯭ꯠ ꯑꯃꯁꯨ ꯄꯥꯡꯊꯣꯀꯏ꯫

2. ꯐ꯭ꯂꯨꯑꯣꯔꯁꯦꯟꯁ ꯏꯟ ꯁꯤꯇꯨ ꯍꯥꯏꯕ꯭ꯔꯤꯗ (FISH) : ꯇꯦꯁ꯭ꯠ ꯑꯁꯤꯅꯥ HER2 ꯄ꯭ꯔꯣꯇꯤꯟ ꯁꯦꯝꯂꯤꯕꯥ HER2 ꯖꯤꯅꯒꯤ ꯀꯣꯄꯤ ꯀꯌꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯂꯩꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯁꯤꯜꯂꯤ꯫ ꯃꯁꯤꯗꯥ ꯑꯈꯟꯅꯕꯥ ꯃꯥꯏꯛꯔꯣꯁ꯭ꯀꯣꯞ ꯑꯃꯗꯤ ꯐ꯭ꯂꯨꯑꯣꯔꯁꯦꯟꯇ (ꯂꯥꯏꯠ-ꯏꯃꯤꯇꯤꯡ) ꯃꯥꯔꯀꯔꯁꯤꯡ ꯁꯤꯖꯤꯟꯅꯩ꯫ ꯑꯥꯏ.ꯑꯩꯆ.ꯁꯤ.ꯒꯤ ꯇꯦꯁ꯭ꯇꯀꯤ ꯔꯤꯖꯜꯇ ꯑꯁꯤ ꯋꯥꯔꯦꯞ ꯂꯧꯕꯥ ꯉꯃꯗꯕꯥ ꯀꯦꯁꯁꯤꯡꯗꯥ, ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ ꯲+, FISH ꯇꯦꯁ꯭ꯇꯅꯥ HER2 ꯁ꯭ꯇꯦꯇꯁ (ꯅꯦꯒꯦꯇꯤꯕ ꯅꯠꯠꯔꯒꯥ ꯄꯣꯖꯤꯇꯤꯕ) ꯑꯁꯤ ꯁꯣꯏꯗꯅꯥ ꯀꯅꯐꯔꯝ ꯇꯧꯕꯥ ꯉꯃꯒꯅꯤ꯫

`HER2` ꯇꯦꯁ꯭ꯇꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯊꯛꯇꯥ, ꯄꯦꯊꯣꯂꯣꯖꯤꯁ꯭ꯠ ꯑꯁꯤꯅꯥ ꯕꯥꯏꯑꯣꯞꯁꯤ ꯁꯦꯝꯄꯜ ꯑꯗꯨꯁꯨ ꯌꯦꯡꯁꯤꯅꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯀꯦꯟꯁꯔꯗꯥ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ (ꯏ.ꯇꯤ.ꯌꯨ.) ꯑꯃꯁꯨꯡ ꯄ꯭ꯔꯣꯖꯦꯁ꯭ꯇꯦꯔꯣꯟ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ (ꯄꯤ.ꯑꯥꯔ.) ꯂꯩꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨꯁꯨ ꯌꯦꯡꯒꯅꯤ꯫

ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯁ꯭ꯇꯦꯖ ꯑꯗꯨ ꯈꯪꯗꯣꯛꯅꯕꯥ (ꯃꯁꯤꯅꯥ ꯇꯤꯎꯃꯔ ꯑꯗꯨ ꯀꯌꯥꯝ ꯆꯥꯎꯕꯒꯦ ꯑꯃꯁꯨꯡ ꯂꯤꯝꯐ ꯅꯣꯗꯁꯤꯡ ꯅꯠꯠꯔꯒꯥ ꯍꯀꯆꯥꯡꯒꯤ ꯑꯇꯩ ꯂꯥꯞꯅꯥ ꯂꯩꯕꯥ ꯃꯐꯃꯁꯤꯡꯗꯥ ꯁꯟꯗꯣꯀꯈꯤꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯅꯕꯒꯤꯗꯃꯛ) ꯅꯍꯥꯛꯅꯥ ꯃꯦꯃꯣꯒ꯭ꯔꯥꯐ, ꯑꯂꯠꯔꯥꯁꯥꯎꯟꯗ, ꯁꯤ.ꯇꯤ.ꯁ꯭ꯀꯦꯟ, ꯅꯠꯠꯔꯒꯥ ꯑꯦꯝ.ꯑꯥꯔ.ꯑꯥꯏ.

ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯏꯅꯐꯣꯔꯃꯦꯁꯟ ꯄꯨꯝꯅꯃꯛ (HER2 ꯁ꯭ꯇꯦꯇꯁ, HR ꯁ꯭ꯇꯦꯇꯁ, ꯀꯦꯟꯁꯔꯒꯤ ꯁ꯭ꯇꯦꯖ, ꯑꯃꯁꯨꯡ ꯀꯦꯟꯁꯔꯒꯤ ꯃꯑꯣꯡ-ꯃꯇꯧ) ꯑꯁꯤ ꯄꯨꯟꯁꯤꯟꯗꯨꯅꯥ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯆꯨꯅꯕꯥ ꯂꯥꯏꯌꯦꯡꯒꯤ ꯄ꯭ꯂꯥꯟ ꯑꯃꯥ ꯁꯦꯃꯒꯅꯤ꯫

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯐꯕꯥ ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯈꯦꯠꯅꯕꯥ ꯌꯥꯏ꯫ ꯃꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯁ꯭ꯇꯦꯖ, ꯍꯣꯔꯃꯣꯟ ꯔꯤꯁꯦꯞꯇꯔ-ꯄꯣꯖꯤꯇꯤꯚ ꯅꯠꯠꯔꯒꯥ ꯅꯦꯒꯦꯇꯤꯚ (HR+/HER2- ꯅꯠꯠꯔꯒꯥ HR-/HER2-) ꯑꯣꯏꯔꯕꯁꯨ, ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯑꯄꯨꯅꯕꯥ ꯍꯀꯁꯦꯂꯒꯤ ꯃꯈꯥ ꯄꯣꯜꯂꯤ꯫

ꯃꯍꯧꯁꯥꯅꯥ, ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯁꯤꯡꯁꯤ ꯌꯥꯎꯕꯥ ꯌꯥꯏ:

• ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯁꯔꯖꯔꯤ : ꯀꯦꯟꯁꯔꯒꯤ ꯇꯤꯎꯃꯔ ꯑꯃꯁꯨꯡ ꯑꯣꯏꯊꯣꯀꯄꯥ ꯌꯥꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯃꯗꯨꯒꯤ ꯑꯀꯣꯌꯕꯗꯥ ꯂꯩꯕꯥ ꯍꯀꯁꯦꯜ ꯐꯕꯥ ꯇꯤꯁꯨ ꯈꯔꯗꯤ ꯂꯧꯊꯣꯀꯄꯥ꯫ ꯃꯁꯤ ꯂꯝꯄꯦꯛꯇꯣꯃꯤ (lumpectomy) ꯑꯣꯏꯕꯥ ꯌꯥꯏ, ꯃꯗꯨꯅꯥ ꯕ꯭ꯔꯦꯁ꯭ꯇꯀꯤ ꯁꯔꯨꯛ ꯑꯃꯥ ꯂꯧꯊꯣꯀꯄꯥ ꯅꯠꯠꯔꯒꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯄꯨꯝꯅꯃꯛ ꯂꯧꯊꯣꯀꯄꯥ ꯉꯝꯕꯥ ꯃꯦꯁ꯭ꯇꯦꯛꯇꯣꯃꯤ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫
• ꯔꯦꯗꯤꯑꯦꯁꯟ ꯊꯦꯔꯥꯄꯤ : ꯍꯥꯏ-ꯑꯦꯅꯔꯖꯤ ꯔꯦ ꯑꯁꯤ ꯁꯔꯖꯔꯤꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯂꯦꯡꯗꯅꯥ ꯂꯩꯕꯥ ꯌꯥꯕꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯑꯃꯍꯦꯛꯇꯕꯨ ꯃꯥꯡꯍꯅꯕꯥ, ꯅꯠꯠꯔꯒꯥ ꯁꯔꯖꯔꯤꯒꯤ ꯃꯃꯥꯡꯗꯥ ꯇꯤꯎꯃꯔ ꯑꯗꯨ ꯁꯣꯟꯊꯍꯟꯅꯕꯥ ꯁꯤꯖꯤꯟꯅꯩ꯫

ꯕꯦꯁꯤꯛ ꯇ꯭ꯔꯤꯠꯃꯦꯟꯇꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯃꯊꯛꯇꯥ, ꯀꯦꯟꯁꯔ ꯃꯈꯂꯒꯤ ꯃꯇꯨꯡ ꯏꯟꯅꯥ ꯑꯇꯣꯞꯄꯥ ꯑꯀꯛꯅꯕꯥ ꯂꯥꯏꯌꯦꯡꯁꯤꯡꯁꯨ ꯂꯩꯔꯤ:

HR+/HER2- (ꯍꯣꯔꯃꯣꯟ ꯔꯤꯁꯦꯄꯇꯔ-ꯄꯣꯖꯤꯇꯤꯚ, HER2-ꯅꯦꯒꯦꯇꯤꯚ) ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯌꯦꯡ꯫

ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯑꯁꯤ ꯍꯣꯔꯃꯣꯅꯗꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯕꯅꯥ, ꯁꯔꯖꯔꯤ ꯑꯃꯁꯨꯡ/ꯅꯠꯠꯔꯒꯥ ꯔꯦꯗꯤꯑꯦꯁꯟ ꯊꯦꯔꯥꯄꯤꯒꯤ ꯃꯊꯛꯇꯥ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯑꯁꯤꯁꯨ ꯃꯔꯨꯑꯣꯏ:

• ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ : ꯂꯥꯌꯦꯡꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯍꯦꯅꯒꯠꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯂꯤꯕꯥ ꯍꯣꯔꯃꯣꯟ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯅꯠꯠꯔꯒꯥ ꯄ꯭ꯔꯣꯖꯦꯁ꯭ꯇꯦꯔꯣꯅꯒꯤ ꯆꯥꯡ ꯍꯟꯊꯍꯟꯗꯨꯅꯥ ꯅꯠꯠꯔꯒꯥ ꯍꯣꯔꯃꯣꯅꯁꯤꯡ ꯑꯗꯨ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯆꯦꯅꯕꯥ ꯊꯤꯡꯗꯨꯅꯥ ꯊꯕꯛ ꯇꯧꯏ꯫ ꯈꯨꯗꯝ ꯑꯣꯏꯅ:
• ꯑꯦꯔꯣꯃꯦꯇꯦꯖ ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯑꯦꯅꯥꯁ꯭ꯠꯔꯣꯖꯣꯜ, ꯂꯦꯠꯔꯣꯖꯣꯜ, ꯑꯦꯛꯁꯦꯃꯦꯁ꯭ꯇꯦꯟ)
• ꯒꯣꯅꯥꯗꯣꯠꯔꯣꯄꯤꯟ-ꯔꯤꯂꯤꯖꯤꯡ ꯍꯣꯔꯃꯣꯟ (GnRH) ꯑꯦꯒꯣꯅꯤꯁ꯭ꯇꯁꯤꯡ (ꯑꯣꯚꯔꯑꯣꯂꯗꯒꯤ ꯍꯣꯔꯃꯣꯅꯁꯤꯡ ꯄꯨꯊꯣꯀꯄꯥ ꯊꯤꯡꯕꯥ)
• `ꯁꯦꯂꯦꯛꯇꯤꯕ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯔꯤꯁꯦꯄꯇꯔ ꯃꯣꯗ꯭ꯌꯨꯂꯦꯇꯔꯁꯤꯡ (SERMs)` (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯇꯥꯃꯣꯛꯁꯤꯐꯦꯟ, ꯔꯥꯂꯣꯛꯁꯤꯐꯦꯟ)

ꯀꯦꯁ ꯈꯔꯗꯗꯤ, ꯅꯍꯥꯛꯅꯥ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯄꯨꯊꯣꯀꯄꯥ ꯉꯝꯕꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯣꯚꯔꯑꯣꯂꯁꯤꯡ ꯂꯧꯊꯣꯛꯅꯕꯥ ꯁꯔꯖꯔꯤ (oophorectomy) ꯇꯧꯕꯥ ꯃꯊꯧ ꯇꯥꯕꯥ ꯌꯥꯏ꯫ ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ ꯑꯁꯤ ꯃꯁꯥ ꯃꯊꯟꯇꯥ ꯅꯠꯠꯔꯒꯥ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯔꯕꯥ ꯊꯦꯔꯥꯄꯤꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯆꯍꯤ ꯀꯌꯥꯒꯤ ꯑꯣꯏꯅꯥ ꯄꯤꯕꯥ ꯌꯥꯏ꯫

• ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯊꯦꯔꯥꯄꯤ : ꯂꯥꯌꯦꯡꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯑꯀꯛꯅꯕꯥ ꯑꯋꯥꯠꯄꯥ ꯂꯩꯕꯁꯤꯡꯗꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤ ꯑꯃꯁꯨꯡ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯆꯥꯎꯈꯠꯄꯥ ꯑꯃꯁꯨꯡ ꯁꯟꯗꯣꯀꯄꯥ ꯊꯤꯡꯅꯕꯥ ꯃꯈꯣꯌꯗꯥ ꯑꯦꯇꯦꯛ ꯇꯧꯏ꯫ HR+/HER2- ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤ ꯑꯣꯏꯅꯗꯤ, CDK4/6 ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯄꯥꯂꯕꯣꯁꯤꯛꯂꯤꯕ, ꯔꯥꯏꯕꯣꯁꯤꯛꯂꯤꯕ, ꯑꯦꯕꯦꯃꯥꯁꯤꯛꯂꯤꯕ) ꯀꯧꯕꯥ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤ ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯁꯤꯖꯤꯟꯅꯩ꯫ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯈꯥꯌꯗꯣꯀꯄꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯔꯤꯕꯥ ꯑꯦꯅꯖꯥꯏꯝ ꯑꯃꯥ ꯕ꯭ꯂꯣꯛ ꯇꯧꯏ꯫
• ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ: HR+/HER2- ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯈꯔꯒꯤ ꯑꯣꯏꯅꯗꯤ, ꯃꯔꯨꯑꯣꯏꯅꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯀꯦꯟꯁꯔ ꯑꯗꯨ ꯁꯟꯗꯣꯀꯈ꯭ꯔꯕꯗꯤ ꯅꯠꯠꯔꯒꯥ ꯑꯦꯒ꯭ꯔꯦꯁꯤꯚ ꯑꯣꯏꯔꯕꯗꯤ, ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ ꯑꯃꯁꯨꯡ/ꯅꯠꯠꯔꯒꯥ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯔꯕꯥ ꯊꯦꯔꯥꯄꯤꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ ꯔꯤꯀꯃꯦꯟꯗ ꯇꯧꯕꯥ ꯌꯥꯏ꯫

HR-/HER2- (ꯇ꯭ꯔꯤꯄꯜ-ꯅꯦꯒꯦꯇꯤꯚ) ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯌꯦꯡ꯫

ꯇ꯭ꯔꯤꯄꯜ-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯍꯣꯔꯃꯣꯅꯗꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯗꯕꯥ ꯃꯔꯝꯅꯥ, ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ ꯑꯁꯤ ꯏꯐꯦꯛꯇꯤꯚ ꯑꯣꯏꯗꯦ꯫ ꯁꯔꯖꯔꯤ ꯑꯃꯁꯨꯡ/ꯅꯠꯠꯔꯒꯥ ꯔꯦꯗꯤꯑꯦꯁꯟ ꯊꯦꯔꯥꯄꯤꯒꯤ ꯃꯊꯛꯇꯥ, ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯑꯁꯤ ꯃꯔꯨꯑꯣꯏꯅꯥ ꯁꯤꯖꯤꯟꯅꯩ:

• ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ : ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ ꯑꯁꯤ ꯇ꯭ꯔꯤꯄꯜ-ꯅꯦꯒꯦꯇꯤꯕ ꯀꯦꯟꯁꯔꯒꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯂꯥꯌꯦꯡ ꯑꯃꯅꯤ꯫ ꯗꯣꯛꯇꯔꯁꯤꯡꯅꯥ ꯇꯣꯉꯥꯟ-ꯇꯣꯉꯥꯅꯕꯥ ꯃꯈꯂꯒꯤ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ ꯗ꯭ꯔꯒꯁꯤꯡ ꯁꯤꯖꯤꯟꯅꯩ꯫ ꯃꯈꯣꯌꯅꯥ ꯗ꯭ꯔꯒ ꯑꯃꯥ ꯅꯠꯠꯔꯒꯥ ꯗ꯭ꯔꯒ ꯀꯌꯥꯒꯤ ꯀꯝꯕꯤꯅꯦꯁꯟ ꯑꯃꯥ ꯄꯤꯕꯥ ꯌꯥꯏ꯫
• ꯏꯝꯝꯌꯨꯅꯣꯊꯦꯔꯥꯄꯤ : ꯃꯁꯤ ꯌꯥꯝꯅꯥ ꯑꯅꯧꯕꯥ ꯂꯥꯏꯌꯦꯡ ꯑꯃꯅꯤ꯫ ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡꯒꯤ ꯃꯁꯥꯒꯤ ꯏꯝꯝꯌꯨꯟ ꯁꯤꯁ꯭ꯇꯦꯃꯕꯨ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯈꯉꯗꯣꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯃꯥꯡꯍꯟ ꯇꯥꯀꯍꯅꯕꯥ ꯉꯃꯍꯟꯗꯨꯅꯥ ꯊꯕꯛ ꯇꯧꯏ꯫ ꯄꯦꯝꯕ꯭ꯔꯣꯂꯤꯖꯨꯃꯕ (ꯀꯦꯌꯠꯔꯨꯗꯥ®) ꯑꯁꯤ ꯐꯨꯗ ꯑꯃꯁꯨꯡ ꯗ꯭ꯔꯒ ꯑꯦꯗꯃꯤꯅꯤꯁ꯭ꯠꯔꯦꯁꯟ (ꯑꯦꯐ.ꯗꯤ.ꯑꯦ.)ꯅꯥ ꯑꯌꯥꯕꯥ ꯄꯤꯔꯕꯥ ꯏꯝꯝꯌꯨꯅꯣꯊꯦꯔꯥꯄꯤ ꯗ꯭ꯔꯒ ꯑꯃꯅꯤ ꯑꯃꯁꯨꯡ ꯃꯁꯤ ꯇ꯭ꯔꯤꯄꯜ-ꯅꯦꯒꯦꯇꯤꯕ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯈꯔꯒꯤꯗꯃꯛ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯄꯤꯔꯤ꯫
• ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯊꯦꯔꯥꯄꯤ : ꯕꯤ.ꯑꯥꯔ.ꯁꯤ.ꯑꯦ.ꯒꯤ ꯖꯤꯟ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯂꯩꯕꯥ ꯇ꯭ꯔꯤꯄꯜ-ꯅꯦꯒꯦꯇꯤꯕ ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤꯗꯃꯛꯇꯥ, ꯄꯤ.ꯑꯦ.ꯑꯥꯔ.ꯄꯤ.ꯒꯤ ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯑꯣꯂꯥꯄꯥꯔꯤꯕ, ꯇꯥꯂꯥꯖꯣꯄꯥꯔꯤꯕ) ꯀꯧꯕꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯗ꯭ꯔꯒꯁꯤꯡ ꯁꯤꯖꯤꯟꯅꯩ꯫ ꯃꯁꯤꯗꯁꯨ ꯅꯠꯇꯅꯥ, ꯃꯦꯇꯥꯁ꯭ꯇꯦꯇꯤꯛ ꯂꯥꯌꯅꯥꯒꯤ ꯑꯣꯏꯅꯗꯤ, ꯑꯅꯧꯕꯥ ꯃꯈꯂꯒꯤ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯊꯦꯔꯥꯄꯤꯁꯤꯡ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯑꯦꯟꯇꯤꯕꯣꯗꯤ-ꯗ꯭ꯔꯒ ꯀꯟꯖꯨꯒꯦꯠꯁꯤꯡ) ꯍꯧꯖꯤꯛ ꯐꯪꯂꯦ꯫

ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯀꯔꯤꯅꯣ?

ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡꯕꯅꯥ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯏꯐꯦꯛꯇꯤꯕ ꯑꯣꯏꯅꯥ ꯊꯦꯡꯅꯕꯥ ꯉꯝꯂꯕꯁꯨ, ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ, ꯔꯦꯗꯤꯑꯦꯁꯟ ꯊꯦꯔꯥꯄꯤ, ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ, ꯇꯥꯔꯒꯦꯠ ꯇꯧꯔꯕꯥ ꯊꯦꯔꯥꯄꯤ, ꯑꯃꯁꯨꯡ ꯏꯝꯝꯌꯨꯅꯣꯊꯦꯔꯥꯄꯤ ꯌꯥꯑꯣꯅꯥ ꯂꯥꯌꯦꯡ ꯄꯨꯝꯅꯃꯛꯅꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯈꯔꯥ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯃꯇꯝ ꯈꯔꯒꯤ ꯑꯣꯏꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯆꯠꯄꯥ ꯌꯥꯏ꯫ ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ, ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ, ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ, ꯈꯣꯡ ꯍꯥꯝꯕꯥ, ꯆꯥꯛ ꯆꯥꯕꯥ ꯋꯥꯠꯄꯥ, ꯃꯤꯠ ꯁꯣꯟꯊꯕꯥ, ꯈꯣꯡꯗꯥ ꯑꯍꯣꯡꯕꯥ ꯂꯥꯀꯄꯥ, ꯗꯥꯏꯔꯤꯌꯥ ꯅꯠꯠꯔꯒꯥ ꯈꯣꯡ ꯍꯥꯝꯕꯥ, ꯑꯃꯁꯨꯡ ꯕ꯭ꯂꯗ ꯁꯦꯜ ꯃꯁꯤꯡ ꯅꯦꯝꯕꯥ ꯑꯁꯤꯅꯆꯤꯡꯕꯥ꯫

ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯑꯁꯤ ꯀꯔꯤꯅꯣ, ꯃꯈꯣꯌ ꯑꯁꯤ ꯀꯌꯥꯝ ꯁꯥꯡꯅꯥ ꯂꯩꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌꯕꯨ ꯀꯔꯝꯅꯥ ꯃꯦꯅꯦꯖ ꯇꯧꯒꯗꯒꯦ ꯍꯥꯌꯕꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯁꯣꯌꯗꯅꯥ ꯋꯥꯔꯤ ꯁꯥꯕꯤꯌꯨ꯫ ꯃꯈꯣꯌꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯄꯦꯂꯤꯑꯣꯇꯤꯛ ꯀꯦꯌꯔ ꯁ꯭ꯄꯦꯁꯤꯑꯦꯂꯤꯁ꯭ꯇꯁꯤꯡꯗꯁꯨ ꯔꯤꯐꯔ ꯇꯧꯕꯥ ꯌꯥꯏ꯫ ꯄꯦꯂꯤꯑꯣꯇꯤꯛ ꯀꯦꯌꯔ ꯑꯁꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯑꯔꯣꯏꯕꯥ ꯇꯥꯉ꯭ꯀꯀꯁꯤꯡꯒꯤꯗꯃꯛꯇꯗꯤ ꯈꯛꯇꯥ ꯅꯠꯇꯅꯥ ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯃꯦꯅꯦꯖ ꯇꯧꯗꯨꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯄꯨꯟꯁꯤꯒꯤ ꯃꯒꯨꯟ ꯑꯗꯨ ꯉꯥꯛꯇꯨꯅꯥ ꯊꯝꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯆꯥꯡ ꯑꯁꯤ ꯀꯌꯥꯅꯣ?

HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯄꯨꯝꯅꯃꯛꯇꯥ, ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯕ꯭ꯔꯦꯁ꯭ꯇꯇꯥ ꯁꯣꯀꯍꯜꯂꯕꯥ ꯑꯃꯁꯨꯡ ꯁꯟꯗꯣꯀꯄꯥ ꯉꯃꯗꯕꯥ ꯃꯇꯃꯗꯥ (ꯂꯣꯀꯦꯜ ꯁ꯭ꯇꯦꯖ) ꯍꯤꯡꯕꯒꯤ ꯆꯥꯡ ꯑꯁꯤ ꯀꯦꯟꯁꯔ ꯑꯗꯨꯅꯥ ꯍꯀꯆꯥꯡꯒꯤ ꯂꯥꯞꯅꯥ ꯂꯩꯕꯥ ꯑꯣꯔꯒꯥꯅꯁꯤꯡꯗꯥ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯂꯤꯚꯔ, ꯂꯪꯁ, ꯕ꯭ꯔꯦꯟ, ꯁꯔꯨ) (ꯃꯦꯇꯥꯁ꯭ꯇꯦꯇꯤꯛ ꯀꯦꯟꯁꯔ ꯅꯠꯠꯔꯒꯥ ꯂꯥꯞꯅꯥ ꯂꯩꯕꯥ ꯁ꯭ꯇꯦꯖ)ꯗꯥ ꯁꯟꯗꯣꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯌꯥꯝꯅꯥ ꯋꯥꯡꯏ꯫ꯃꯅꯥꯛ ꯅꯀꯄꯥ ꯂꯤꯝꯐ ꯅꯣꯗꯁꯤꯡ ꯈꯛꯇꯗꯥ ꯁꯟꯗꯣꯔꯀꯄꯥ ꯑꯗꯨꯕꯨ ꯂꯥꯞꯅꯥ ꯂꯩꯕꯥ ꯑꯣꯔꯒꯥꯅꯁꯤꯡꯗꯥ (ꯔꯤꯖꯅꯦꯜ ꯁ꯭ꯇꯦꯖ) ꯁꯟꯗꯣꯀꯄꯥ ꯉꯃꯗꯕꯥ ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤ ꯍꯤꯡꯕꯒꯤ ꯆꯥꯡ ꯑꯁꯤ ꯃꯔꯛꯇꯥ ꯂꯩꯕꯥ ꯃꯐꯝ ꯑꯃꯗꯥ ꯂꯩ꯫

ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯅꯍꯥꯛꯀꯤ ꯔꯤꯀꯣꯚꯔꯤꯒꯤ ꯆꯥꯡ, ꯅꯠꯠꯔꯒꯥ ꯄ꯭ꯔꯣꯒ꯭ꯅꯣꯁꯤꯁ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯗꯥꯏꯑꯦꯒ꯭ꯅꯣꯁꯤꯁꯀꯤ ꯑꯀꯛꯅꯕꯥ ꯐꯦꯛꯇꯔꯁꯤꯡꯒꯤ ꯃꯈꯥ ꯄꯣꯜꯂꯤ ꯍꯥꯌꯕꯁꯤ ꯅꯤꯡꯁꯤꯡꯕꯥ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯃꯁꯤꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯂꯥꯞꯅꯥ ꯁꯟꯗꯣꯀꯈꯤꯕꯒꯦ (ꯁ꯭ꯇꯦꯖ), ꯀꯦꯟꯁꯔ ꯑꯗꯨꯅꯥ ꯍꯣꯔꯃꯣꯟ ꯔꯤꯁꯦꯄꯇꯔ ꯁ꯭ꯇꯦꯇꯁ (HR+/HER2- ꯅꯠꯠꯔꯒꯥ HR-/HER2-) ꯂꯩꯕ꯭ꯔꯥ, ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯑꯦꯒ꯭ꯔꯦꯁꯤꯚ ꯑꯣꯏꯕꯒꯦ (ꯒ꯭ꯔꯦꯗ), ꯅꯍꯥꯛꯀꯤ ꯆꯍꯤ, ꯑꯄꯨꯅꯕꯥ ꯍꯀꯁꯦꯜ, ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯅꯥ ꯂꯥꯏꯌꯦꯡꯕꯗꯥ ꯀꯔꯝꯅꯥ ꯔꯦꯁꯄꯣꯟꯁ ꯇꯧꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯌꯥꯎꯏ꯫ ꯍꯥꯌꯔꯤꯕꯥ ꯋꯥꯐꯃꯁꯤꯡ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯀꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯀꯄꯨ ꯀꯔꯤ ꯊꯣꯛꯀꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯈꯪꯍꯅꯕꯥ ꯌꯥꯕꯥ ꯋꯥꯐꯃꯁꯤꯡꯅꯤ꯫ ꯁ꯭ꯇꯦꯇꯤꯁ꯭ꯇꯤꯛꯁ ꯑꯁꯤ ꯑꯦꯚꯥꯔꯦꯖ ꯈꯛꯇꯅꯤ, ꯑꯃꯁꯨꯡ ꯃꯁꯤ ꯃꯤꯄꯨꯝ ꯈꯨꯗꯤꯡꯃꯛꯀꯤ ꯑꯣꯏꯅꯥ ꯑꯃꯒꯥ ꯑꯃꯒꯥ ꯃꯥꯟꯅꯔꯣꯏ꯫

ꯑꯩꯅꯥ ꯃꯇꯧ ꯀꯔꯝꯅꯥ ꯏꯁꯥꯕꯨ ꯌꯦꯡꯁꯤꯅꯕꯤꯒꯅꯤ? (ꯁꯦꯜꯐ-ꯀꯦꯌꯔ) ꯑꯃꯁꯨꯡ ꯑꯦꯟ.

ꯅꯍꯥꯛ ꯑꯁꯤ ꯑꯍꯥꯅꯕꯥ ꯇꯥꯉ꯭ꯀꯛꯀꯤ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯩꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯥ ꯑꯣꯏꯔꯕꯁꯨ ꯅꯠꯠꯔꯒꯥ ꯑꯦꯗꯚꯥꯟꯁ ꯀꯦꯟꯁꯔꯅꯥ ꯅꯥꯕꯥ ꯃꯤꯑꯣꯏ ꯑꯃꯥ ꯑꯣꯏꯔꯕꯁꯨ, ꯃꯁꯥ-ꯃꯔꯣꯃꯗꯣꯝ ꯂꯦꯄꯆꯕꯥ ꯉꯝꯅꯕꯥ ꯃꯇꯝ ꯂꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡ ꯑꯃꯁꯨꯡ ꯋꯥꯈꯜ ꯑꯅꯤꯃꯛꯇꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯒꯅꯤ꯫ ꯃꯈꯥꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯇꯧꯕꯥ ꯌꯥꯕꯥ ꯊꯕꯛ ꯈꯔꯥ ꯄꯤꯔꯤ:

• ꯃꯊꯧ ꯇꯥꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯅꯨꯡꯉꯥꯏꯅꯥ ꯂꯩꯌꯨ : ꯀꯦꯟꯁꯔ ꯑꯃꯁꯨꯡ ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡꯕꯗꯒꯤ ꯋꯥꯈꯜ ꯋꯥꯕꯥ ꯑꯃꯁꯨꯡ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯐꯥꯎꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯅꯣꯔꯃꯦꯂꯅꯤ꯫ ꯅꯍꯥꯛꯅꯥ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯐꯥꯎꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ, ꯕ꯭ꯔꯦꯛ ꯑꯃꯥ ꯂꯧ ꯑꯃꯁꯨꯡ ꯅꯨꯡꯉꯥꯏꯅꯥ ꯂꯩꯌꯨ꯫ ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡ ꯑꯗꯨ ꯇꯥꯕꯤꯌꯨ꯫
• ꯍꯀꯁꯦꯜ ꯐꯕꯥ, ꯃꯆꯤ ꯑꯣꯏꯕꯥ ꯆꯤꯟꯖꯥꯛ ꯆꯥꯕꯥ : ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯌꯦꯡ ꯈꯔꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯆꯥꯅꯕꯥ ꯆꯤꯟꯖꯥꯛ ꯑꯃꯁꯨꯡ ꯅꯨꯡꯉꯥꯏꯕꯒꯤ ꯋꯥꯈꯜꯂꯣꯅꯗꯥ ꯑꯀꯥꯌꯕꯥ ꯄꯤꯕꯥ ꯌꯥꯏ꯫ ꯑꯗꯨꯕꯨ ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡꯅꯥ ꯃꯊꯧ ꯇꯥꯔꯤꯕꯥ ꯅ꯭ꯌꯨꯠꯔꯤꯑꯦꯟꯇꯁꯤꯡ ꯑꯗꯨ ꯐꯪꯅꯕꯒꯤꯗꯃꯛ ꯕꯦꯂꯦꯟꯁ ꯗꯥꯏꯠ ꯑꯃꯥ ꯆꯥꯅꯕꯥ ꯍꯣꯠꯅꯧ꯫ ꯃꯅꯥ-ꯃꯁꯤꯡ, ꯎꯍꯩ-ꯋꯥꯍꯩꯁꯤꯡ, ꯐꯤꯕꯔ ꯑꯃꯁꯨꯡ ꯄ꯭ꯔꯣꯇꯤꯟ ꯌꯥꯎꯕꯥ ꯆꯤꯟꯖꯥꯀꯁꯤꯡ ꯌꯥꯎꯍꯅꯒꯗꯕꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯀꯔꯤ ꯆꯤꯟꯖꯥꯀꯁꯤꯡ ꯆꯥꯒꯗꯒꯦ ꯅꯠꯠꯔꯒꯥ ꯀꯔꯤ ꯆꯥꯔꯣꯏꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯁꯣꯌꯗꯅꯥ ꯈꯪꯂꯕꯗꯤ, ꯄꯥꯎꯇꯥꯛ ꯂꯧꯅꯕꯒꯤꯗꯃꯛ ꯗꯥꯏꯑꯦꯇꯤꯁꯤꯌꯟ ꯑꯃꯒꯥ ꯇꯥꯟꯅꯧ꯫
• ꯑꯦꯛꯁꯔꯁꯥꯏꯖ ꯇꯧꯕꯥ (ꯑꯗꯨꯕꯨ ꯍꯦꯟꯅꯥ ꯋꯥꯡꯈꯠꯍꯅꯒꯅꯨ) : ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯔꯤꯀꯃꯦꯟꯗ ꯇꯧꯔꯀꯄꯒꯤ ꯃꯇꯨꯡꯏꯟꯅꯥ, ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯆꯨꯅꯕꯥ ꯊꯥꯛ ꯑꯃꯗꯥ ꯆꯥꯡ ꯅꯥꯏꯅꯥ ꯑꯦꯛꯁꯔꯁꯥꯏꯖ ꯇꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯂꯥꯏꯠ ꯋꯥꯀꯤꯡ ꯅꯠꯠꯔꯒꯥ ꯌꯣꯒ ꯐꯥꯑꯣꯕꯥ ꯑꯐꯕꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ ꯃꯁꯤꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯦꯅꯔꯖꯤ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯉꯝꯃꯤ, ꯅꯍꯥꯛꯀꯤ ꯋꯥꯈꯜ ꯐꯒꯠꯍꯅꯕꯥ ꯉꯝꯃꯤ ꯑꯃꯁꯨꯡ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯍꯟꯊꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ, ꯅꯍꯥꯛꯀꯤ ꯗꯥꯏꯑꯦꯒ꯭ꯅꯣꯁꯤꯁ ꯑꯃꯁꯨꯡ ꯂꯥꯏꯌꯦꯡꯗꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯗꯨꯅꯥ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯀꯔꯤ ꯃꯈꯂꯒꯤ ꯑꯦꯛꯁꯔꯁꯥꯏꯖ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯆꯨꯝꯃꯤ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯅꯥ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯇꯧꯒꯗꯒꯦ ꯍꯥꯌꯅꯥ ꯍꯪꯕꯤꯌꯨ꯫
• ꯁ꯭ꯠꯔꯦꯁ ꯃꯦꯅꯦꯖ ꯇꯧꯕꯥ : ꯑꯁꯤꯒꯨꯝꯕꯥ ꯑꯅꯥꯕꯥ ꯑꯃꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯁ꯭ꯠꯔꯦꯁ ꯂꯩꯕꯥ, ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯑꯃꯁꯨꯡ ꯑꯀꯤꯕꯥ ꯐꯥꯎꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯅꯣꯔꯃꯦꯂꯅꯤ꯫ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯊꯕꯛ ꯇꯧꯕꯥ ꯉꯝꯕꯥ ꯃꯁꯤꯕꯨ ꯃꯦꯅꯦꯖ ꯇꯧꯅꯕꯒꯤ ꯄꯥꯝꯕꯩꯁꯤꯡ ꯊꯤꯕꯤꯌꯨ꯫ ꯃꯦꯗꯤꯇꯦꯁꯟ ꯑꯃꯁꯨꯡ ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯒꯤ ꯑꯦꯛꯁꯔꯁꯥꯏꯖꯁꯤꯡꯅꯥ ꯈꯔꯗꯗꯤ ꯊꯕꯛ ꯑꯣꯏꯅꯥ ꯄꯥꯡꯊꯣꯛꯂꯕꯁꯨ, ꯑꯇꯩ ꯈꯔꯅꯥ ꯂꯥꯏꯔꯤꯛ ꯑꯃꯥ ꯄꯥꯕꯥ, ꯃ꯭ꯌꯨꯖꯤꯛ ꯇꯥꯕꯥ, ꯗ꯭ꯔꯣꯏꯪ ꯇꯧꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯒꯥꯔꯗꯦꯅꯤꯡꯒꯨꯝꯕꯥ ꯀ꯭ꯔꯤꯌꯦꯇꯤꯚ ꯑꯣꯏꯕꯥ ꯊꯕꯛ ꯊꯧꯔꯃꯁꯤꯡꯗꯥ ꯁꯔꯨꯛ ꯌꯥꯕꯥ ꯄꯥꯝꯂꯕꯁꯨ ꯌꯥꯏ꯫ ꯅꯍꯥꯀꯄꯨ ꯅꯤꯡꯊꯤꯅꯥ ꯑꯃꯁꯨꯡ ꯅꯨꯡꯉꯥꯏꯅꯥ ꯂꯩꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯂꯤꯕꯥ ꯑꯦꯛꯇꯤꯚꯤꯇꯤ ꯑꯃꯍꯦꯛꯇꯒꯤꯗꯃꯛ ꯅꯨꯃꯤꯠ ꯈꯨꯗꯤꯡꯒꯤ ꯃꯇꯝ ꯈꯔꯥ ꯊꯃꯖꯤꯜꯂꯨ꯫
• ꯁꯥꯏꯀꯣꯂꯣꯖꯤꯀꯦꯜ ꯁꯄꯣꯔꯠ ꯂꯧꯕꯥ꯫: ꯏꯃꯨꯡ ꯃꯅꯨꯡ ꯑꯃꯁꯨꯡ ꯅꯛꯅꯕꯥ ꯃꯔꯨꯄꯁꯤꯡꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯐꯤꯚꯃꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯕꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯀꯦꯟꯁꯔ ꯗꯥꯏꯒ꯭ꯅꯣꯁꯤꯁ ꯑꯃꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯊꯦꯡꯅꯔꯤꯕꯥ ꯑꯇꯣꯞꯄꯁꯤꯡꯒꯥ ꯁꯝꯅꯍꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌꯒꯤ ꯑꯦꯛꯁꯄꯔꯤꯌꯦꯟꯁꯁꯤꯡ ꯁꯦꯌꯔ ꯇꯧꯕꯗꯁꯨ ꯌꯥꯝꯅꯥ ꯁꯛꯇꯤ ꯄꯤꯕꯥ ꯌꯥꯏ꯫ ꯁꯄꯣꯔꯠ ꯒ꯭ꯔꯨꯄꯁꯤꯡ ꯅꯠꯠꯔꯒꯥ ꯀꯦꯟꯁꯔ ꯁꯔꯚꯥꯏꯕꯔꯁꯤꯞ ꯄ꯭ꯔꯣꯒ꯭ꯔꯥꯃꯁꯤꯡꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯍꯪꯕꯤꯌꯨ꯫

ꯑꯩꯅꯥ ꯀꯗꯥꯌꯗꯥ ꯗꯣꯛꯇꯔꯒꯥ ꯎꯅꯒꯗꯒꯦ?

ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯑꯃꯁꯨꯡ ꯃꯇꯨꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯂꯦꯞꯇꯅꯥ ꯀꯟꯇꯦꯛꯇ ꯇꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫

• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯅꯧꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ (ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯂꯦꯡ-ꯑꯣꯠꯄꯗꯥ ꯋꯥꯕꯥ, ꯑꯅꯧꯕꯥ ꯂꯪꯁ ꯑꯃꯥ, ꯁ꯭ꯕꯔ ꯍꯣꯅꯕꯗꯥ ꯋꯥꯕꯥ, ꯃꯔꯝ ꯆꯥꯗꯅꯥ ꯑꯔꯨꯝꯕꯥ ꯍꯟꯊꯔꯀꯄꯥ), ꯅꯠꯠꯔꯒꯥ ꯅꯍꯥꯛꯀꯤ ꯍꯧꯖꯤꯛ ꯂꯩꯔꯤꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯑꯁꯤ ꯍꯦꯟꯅꯥ ꯐꯒꯠꯂꯛꯂꯤꯕꯥ ꯑꯣꯏꯔꯕꯗꯤ , ꯈꯨꯗꯛꯇꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯇꯥꯀꯄꯤꯌꯨ ꯅꯠꯠꯔꯒꯥ ꯈꯪꯍꯅꯕꯤꯌꯨ꯫
• ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯇꯨꯡꯗꯥ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯆꯥꯡ ꯅꯥꯏꯅꯥ ꯐꯣꯂꯣ-ꯑꯞ ꯑꯦꯄꯣꯏꯟꯇꯃꯦꯟꯇꯁꯤꯡ ꯄꯤꯒꯅꯤ . ꯑꯦꯄꯣꯏꯟꯇꯃꯦꯟꯇꯁꯤꯡ ꯑꯁꯤ ꯁꯣꯌꯗꯅꯥ ꯊꯝꯃꯨ꯫ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯔꯤꯀꯣꯚꯔꯤ ꯂꯩꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯁꯤꯅꯕꯥ, ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯊꯣꯀꯄꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯃꯦꯅꯦꯖ ꯇꯧꯕꯥ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯀꯤ ꯑꯄꯨꯅꯕꯥ ꯌꯥꯏꯐ-ꯊꯧꯔꯥꯡ ꯑꯗꯨ ꯌꯦꯡꯁꯤꯅꯕꯅꯤ꯫ ꯍꯥꯌꯔꯤꯕꯥ ꯐꯣꯂꯣ-ꯑꯞ ꯑꯦꯄꯣꯏꯟꯇꯃꯦꯟꯇꯁꯤꯡ ꯑꯁꯤ ꯂꯥꯌꯦꯡꯕꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯑꯍꯥꯅꯕꯥ ꯆꯍꯤ ꯃꯉꯥꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯃꯔꯨꯑꯣꯏꯅꯥ ꯃꯔꯨꯑꯣꯏ . ꯃꯁꯤ ꯑꯌꯥꯝꯕꯥ ꯃꯇꯃꯗꯥ ꯀꯦꯟꯁꯔ ꯑꯃꯨꯛ ꯍꯟꯅꯥ ꯂꯥꯀꯄꯥ ꯃꯇꯃꯅꯤ꯫

ꯑꯩꯒꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯀꯔꯤ ꯋꯥꯍꯪ ꯍꯪꯒꯗꯒꯦ?

ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯔꯀꯄꯥ ꯃꯇꯃꯗꯥ, ꯅꯍꯥꯛꯅꯥ ꯍꯪꯂꯤꯕꯥ ꯋꯥꯍꯪꯁꯤꯡ ꯑꯗꯨ ꯀꯌꯥꯝ ꯑꯄꯤꯀꯄꯥ ꯑꯣꯏꯔꯕꯁꯨ ꯍꯪꯕꯗꯥ ꯋꯥꯈꯜ ꯋꯥꯕꯥ ꯂꯩꯔꯣꯏꯗꯕꯅꯤ꯫ ꯃꯈꯥꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯅꯕꯥ ꯍꯪꯂꯀꯄꯥ ꯌꯥꯕꯥ ꯋꯥꯍꯪ ꯈꯔꯗꯤ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤ:

• ꯑꯩꯒꯤ ꯀꯦꯟꯁꯔ ꯍꯣꯔꯃꯣꯟ ꯔꯤꯁꯦꯞꯇꯔ-ꯄꯣꯖꯤꯇꯤꯚ ꯅꯠꯠꯔꯒꯥ ꯅꯦꯒꯦꯇꯤꯚ ꯑꯣꯏꯕ꯭ꯔꯥ?
• ꯑꯩꯒꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯑꯀꯛꯅꯕꯥ ꯁꯕ-ꯇꯥꯏꯞ ꯑꯃꯁꯨꯡ ꯁ꯭ꯇꯦꯖ ꯑꯗꯨ ꯀꯔꯤꯅꯣ?
• ꯑꯩꯉꯣꯟꯗꯥ ꯀꯔꯤ ꯂꯥꯌꯦꯡꯕꯒꯤ ꯔꯤꯀꯃꯦꯟꯗ ꯇꯧꯔꯤꯕꯒꯦ? ꯀꯔꯤꯒꯤꯅꯣ?
• ꯂꯥꯏꯌꯦꯡꯁꯤꯡ ꯑꯁꯤꯗꯒꯤ ꯑꯇꯦꯅꯕꯥ ꯃꯇꯃꯒꯤ ꯑꯃꯁꯨꯡ ꯑꯇꯦꯅꯕꯥ ꯃꯇꯃꯒꯤ ꯑꯣꯏꯕꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯀꯔꯤ ꯀꯔꯤꯅꯣ? ꯃꯈꯣꯌꯕꯨ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯅꯦꯝꯕꯥ ꯑꯣꯏꯍꯟꯅꯕꯥ ꯀꯔꯤ ꯇꯧꯕꯥ ꯌꯥꯕꯒꯦ?
• ꯂꯥꯏꯌꯦꯡꯕꯗꯥ ꯃꯇꯝ ꯀꯌꯥ ꯆꯪꯕꯒꯦ?
• ꯑꯩꯒꯤ ꯄ꯭ꯔꯣꯒ꯭ꯅꯣꯁꯤꯁꯀꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯩꯉꯣꯟꯗꯥ ꯀꯔꯤ ꯍꯥꯌꯕꯤꯔꯀꯄꯥ ꯌꯥꯕꯒꯦ?
• ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯇꯃꯗꯥ ꯑꯩꯒꯤ ꯅꯨꯡꯇꯤꯒꯤ ꯑꯣꯏꯕꯥ ꯊꯕꯛ-ꯊꯧꯔꯃꯁꯤꯡ (ꯈꯨꯗꯣꯡꯆꯥꯕꯥ, ꯌꯨꯃꯒꯤ ꯊꯕꯛ) ꯃꯈꯥ ꯆꯠꯊꯕꯥ ꯌꯥꯕ꯭ꯔꯥ?
• ꯑꯩꯒꯤ ꯗꯥꯏꯠ ꯑꯃꯁꯨꯡ ꯑꯦꯛꯁꯔꯁꯥꯏꯖꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯩꯅꯥ ꯄꯨꯛꯅꯤꯡ ꯆꯪꯒꯗꯕꯥ ꯑꯈꯟꯅꯕꯥ ꯋꯥꯐꯝ ꯑꯃꯥ ꯂꯩꯕ꯭ꯔꯥ?
• ꯀꯦꯟꯁꯔ ꯑꯃꯨꯛ ꯍꯟꯅꯥ ꯂꯥꯀꯄꯒꯤ ꯔꯤꯁ꯭ꯛ ꯍꯟꯊꯍꯟꯅꯕꯥ ꯑꯩꯅꯥ ꯀꯔꯤ ꯇꯧꯕꯥ ꯌꯥꯕꯒꯦ?
• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯑꯩꯅꯥ ꯁꯄꯣꯔꯠ ꯁꯔꯚꯤꯁꯁꯤꯡ ꯅꯠꯠꯔꯒꯥ ꯀꯥꯎꯟꯁꯦꯂꯤꯡꯒꯤ ꯃꯊꯧ ꯇꯥꯔꯕꯗꯤ, ꯃꯗꯨꯒꯤꯗꯃꯛꯇꯥ ꯑꯩꯅꯥ ꯔꯤꯐꯔꯦꯜ ꯑꯃꯥ ꯂꯧꯕꯥ ꯌꯥꯕ꯭ꯔꯥ?

ꯋꯥꯍꯪꯁꯤꯡ ꯑꯁꯤ ꯏꯗꯨꯅꯥ ꯍꯪꯂꯀꯄꯥ ꯑꯁꯤ ꯑꯐꯕꯥ ꯋꯥꯈꯜꯂꯣꯟ ꯑꯃꯅꯤ, ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯑꯗꯣꯝꯅꯥ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯑꯃꯠꯇꯥ ꯀꯥꯑꯣꯔꯣꯏ꯫

HER2-ꯄꯣꯖꯤꯇꯤꯚ ꯑꯣꯏꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯅꯦꯒꯦꯇꯤꯚ ꯑꯣꯏꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯍꯦꯟꯅꯥ ꯐꯕꯔꯥ?

ꯃꯁꯤ ꯃꯤꯑꯣꯏ ꯀꯌꯥꯅꯥ ꯍꯪꯂꯀꯄꯥ ꯋꯥꯍꯪ ꯑꯃꯅꯤ꯫ ꯑꯗꯨꯕꯨ ꯃꯁꯤꯒꯤ ꯏꯆꯝ ꯆꯝꯕꯥ ꯄꯥꯎꯈꯨꯝ ꯑꯃꯥ ꯄꯤꯕꯥ ꯑꯁꯤ ꯑꯔꯨꯕꯥ ꯑꯃꯅꯤ, ꯃꯔꯃꯗꯤ ꯑꯆꯨꯝꯕꯥ ꯑꯗꯨꯗꯤ ꯃꯁꯤ ‘ꯗꯤꯄꯦꯟꯗꯦꯟꯇ’ꯅꯤ .

ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, HER2-ꯄꯣꯖꯤꯇꯤꯚ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯁꯤꯡ ꯑꯁꯤ HER2-ꯅꯦꯒꯦꯇꯤꯚ ꯀꯦꯟꯁꯔꯁꯤꯡꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯌꯥꯡꯅꯥ ꯆꯥꯎꯈꯠꯂꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯍꯦꯟꯅꯥ ꯑꯦꯒ꯭ꯔꯦꯁꯤꯚ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ ꯑꯗꯨꯝ ꯑꯣꯏꯅꯃꯛ ꯃꯁꯤꯒꯤ ꯀꯥꯟꯅꯕꯥ ꯑꯃꯁꯨ ꯂꯩꯔꯤ꯫ HER2 ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡꯗꯥ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯕꯥ ꯌꯥꯕꯥ ꯑꯀꯛꯅꯕꯥ ꯊꯦꯔꯥꯄꯤꯁꯤꯡ ꯂꯩ, ꯈꯨꯗꯝ ꯑꯣꯏꯅꯥ, ꯍꯔꯁꯦꯞꯇꯤꯟ, ꯄꯦꯔꯖꯦꯇꯥ, ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌ ꯑꯁꯤ HER2-ꯄꯣꯖꯤꯇꯤꯕ ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤꯗꯃꯛꯇꯥ ꯌꯥꯝꯅꯥ ꯏꯐꯦꯛꯇꯤꯕ ꯑꯣꯏ꯫ ꯍꯥꯌꯔꯤꯕꯥ ꯂꯥꯌꯦꯡꯁꯤꯡ ꯑꯁꯤꯅꯥ HER2-ꯅꯦꯒꯦꯇꯤꯕ ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤꯗꯃꯛꯇꯥ ꯊꯕꯛ ꯇꯧꯗꯦ, ꯃꯔꯃꯗꯤ ꯀꯦꯟꯁꯔꯁꯤꯡ ꯑꯗꯨꯗꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ HER2 ꯄ꯭ꯔꯣꯇꯤꯟ ꯌꯥꯝꯅꯥ ꯂꯩꯇꯦ꯫

ꯑꯃꯔꯣꯃꯗꯥ, ꯀꯔꯤꯒꯨꯝꯕꯥ `HER2-ꯅꯦꯒꯦꯇꯤꯕ` ꯀꯦꯟꯁꯔ ꯑꯃꯅꯥ `HR+` (ꯍꯣꯔꯃꯣꯟ ꯔꯤꯁꯦꯄꯇꯔ-ꯄꯣꯖꯤꯇꯤꯕ) ꯑꯣꯏꯔꯕꯗꯤ, ꯍꯥꯌꯕꯗꯤ `HR+/HER2-` ꯃꯈꯂꯒꯤ ꯑꯣꯏꯔꯕꯗꯤ, ꯌꯥꯝꯅꯥ ꯏꯐꯦꯛꯇꯤꯕ ꯑꯣꯏꯕꯥ ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤꯁꯤꯡ ꯑꯃꯁꯨꯡ `CDK4/6 ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ`ꯒꯨꯝꯕꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯊꯦꯔꯥꯄꯤꯁꯤꯡ ꯂꯩ꯫ ꯇꯁꯦꯡꯕꯗꯤ, `HR+/HER2-` ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯑꯁꯤ ꯍꯧꯖꯤꯛ ꯂꯩꯔꯤꯕꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯁꯕꯇꯥꯏꯄꯁꯤꯡꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯐꯕꯥ ꯄ꯭ꯔꯣꯒ꯭ꯅꯣꯁꯤꯁ ꯂꯩ ꯍꯥꯌꯅꯥ ꯂꯧꯅꯩ꯫

ꯑꯗꯨꯕꯨ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯀꯦꯟꯁꯔ ꯑꯗꯨ `HER2-ꯅꯦꯒꯦꯇꯤꯚ` (HR-) (ꯍꯣꯔꯃꯣꯟ ꯔꯤꯁꯦꯞꯇꯔ-ꯅꯦꯒꯦꯇꯤꯚ) ꯑꯣꯏꯔꯕꯗꯤ, ꯍꯥꯌꯕꯗꯤ ꯇ꯭ꯔꯤꯄꯜ-ꯅꯦꯒꯦꯇꯤꯚ ꯑꯣꯏꯔꯕꯗꯤ, ꯃꯍꯧꯁꯥꯅꯥ ꯑꯇꯩ ꯃꯈꯂꯁꯤꯡꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯑꯦꯒ꯭ꯔꯦꯁꯤꯚ ꯑꯣꯏꯕꯥ ꯌꯥꯏ, ꯑꯃꯁꯨꯡ ꯂꯥꯏꯌꯦꯡꯕꯗꯥ ꯈꯔꯥ ꯍꯦꯟꯅꯥ ꯁꯤꯡꯅꯕꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ ꯑꯗꯨꯕꯨ ꯍꯧꯖꯤꯛꯇꯤ ꯃꯗꯨꯒꯤꯗꯃꯛꯇꯁꯨ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ, ꯏꯝꯝꯌꯨꯅꯣꯊꯦꯔꯥꯄꯤ, ꯑꯃꯁꯨꯡ ꯑꯅꯧꯕꯥ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯔꯕꯥ ꯊꯦꯔꯥꯄꯤꯁꯤꯡ ꯂꯩꯔꯦ꯫

ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯑꯃꯅꯥ ꯑꯃꯗꯒꯤ "ꯍꯦꯟꯅꯥ ꯐꯕꯥ" ꯅꯠꯔꯒꯥ "ꯐꯠꯇꯕꯥ" ꯍꯥꯌꯕꯁꯤ ꯑꯣꯏꯊꯣꯀꯄꯥ ꯉꯃꯗꯦ꯫ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯋꯥꯐꯃꯗꯤ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯑꯀꯛꯅꯕꯥ ꯁꯕ-ꯇꯥꯏꯞ ꯑꯗꯨ ꯑꯆꯨꯝꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯈꯪꯗꯣꯀꯄꯥ ꯑꯃꯁꯨꯡ ꯃꯁꯤꯒꯤꯗꯃꯛꯇꯥ ꯆꯨꯅꯕꯥ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯏꯐꯦꯛꯇꯤꯚ ꯑꯣꯏꯕꯥ ꯂꯥꯏꯌꯦꯡ ꯑꯗꯨ ꯐꯪꯕꯅꯤ꯫

ꯑꯔꯣꯏꯕꯗꯥ ꯑꯩꯅꯥ ꯅꯈꯣꯌꯗꯥ ꯍꯥꯌꯖꯅꯤꯡꯕꯗꯤ... (ꯇꯦꯛ-ꯍꯣꯝ ꯃꯦꯁꯦꯖ)

ꯅꯍꯥꯛꯅꯥ `HER2-ꯅꯦꯒꯦꯇꯤꯚ` ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯩꯔꯦ ꯍꯥꯌꯅꯥ ꯈꯪꯂꯕꯥ ꯃꯇꯃꯗꯥ, ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯑꯃꯁꯨꯡ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯐꯥꯎꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯅꯣꯔꯃꯦꯂꯅꯤ꯫ ꯑꯗꯨꯕꯨ ꯅꯤꯡꯁꯤꯡꯕꯤꯌꯨ, ꯃꯁꯤ ꯃꯥꯂꯦꯝ ꯑꯁꯤꯒꯤ ꯑꯔꯣꯏꯕꯥ ꯅꯠꯇꯦ꯫ ꯁꯥꯏꯟꯁ ꯑꯃꯁꯨꯡ ꯃꯦꯗꯤꯀꯦꯜ ꯇꯦꯛꯅꯣꯂꯣꯖꯤ ꯑꯁꯤ ꯉꯁꯤꯗꯤ ꯌꯥꯝꯅꯥ ꯆꯥꯎꯈꯠꯂꯦ, ꯑꯃꯁꯨꯡ ꯃꯁꯤꯒꯤ ꯃꯈꯜ ꯑꯁꯤꯒꯤ ꯀꯦꯟꯁꯔ ꯑꯁꯤꯒꯤꯗꯃꯛꯇꯥ ꯏꯐꯦꯛꯇꯤꯕ ꯑꯣꯏꯕꯥ ꯂꯥꯌꯦꯡ ꯀꯌꯥ ꯑꯃꯥ ꯂꯩꯔꯤ꯫

ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯋꯥꯐꯃꯗꯤ:

• ꯐꯤꯚꯝ ꯑꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯃꯇꯤꯛ ꯆꯥꯅꯥ ꯈꯉꯍꯅꯕꯥ꯫
• ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯅꯍꯥꯛꯀꯤ ꯍꯀꯆꯥꯡꯗꯥ, ꯃꯔꯨꯑꯣꯏꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯎꯅꯁꯥꯗꯥ ꯑꯍꯣꯡꯕꯥ ꯂꯥꯀꯄꯁꯤꯡ ꯑꯗꯨ ꯈꯪꯖꯤꯅꯒꯗꯕꯅꯤ꯫
• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯆꯤꯡꯅꯕꯥ ꯂꯩꯔꯕꯗꯤ ꯃꯇꯝ ꯆꯥꯅꯥ ꯗꯣꯛꯇꯔ ꯑꯃꯒꯥ ꯇꯥꯟꯅꯧ ꯑꯃꯁꯨꯡ ꯆꯦꯛ ꯇꯧ꯫
• ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯑꯃꯨꯛꯇꯪ ꯑꯃꯁꯨꯡ ꯄꯨꯀꯆꯦꯜ ꯁꯦꯡꯅꯥ ꯋꯥꯔꯤ ꯁꯥꯕꯤꯌꯨ, ꯅꯍꯥꯛꯀꯤ ꯋꯥꯍꯪ ꯄꯨꯝꯅꯃꯛ ꯍꯪꯕꯤꯌꯨ ꯑꯃꯁꯨꯡ ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯑꯣꯄꯁꯅꯁꯤꯡꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯐꯕꯥ ꯂꯧꯁꯤꯡ ꯑꯃꯥ ꯂꯧꯕꯤꯌꯨ꯫

ꯅꯤꯡꯁꯤꯡꯕꯤꯌꯨ, ꯈꯣꯡꯆꯠ ꯑꯁꯤꯗꯥ ꯑꯗꯣꯝ ꯈꯛꯇꯒꯤ ꯅꯠꯇꯦ꯫ ꯑꯗꯣꯃꯕꯨ ꯃꯇꯦꯡ ꯄꯥꯡꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯃꯇꯦꯡ ꯄꯥꯡꯅꯕꯥ ꯍꯩꯊꯣꯏ-ꯁꯤꯡꯊꯣꯏꯔꯕꯥ ꯗꯣꯛꯇꯔꯁꯤꯡ, ꯅꯔꯁꯁꯤꯡ, ꯑꯗꯣꯃꯒꯤ ꯏꯃꯨꯡ ꯃꯅꯨꯡ ꯑꯃꯁꯨꯡ ꯑꯗꯣꯃꯒꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯅꯛꯅꯕꯥ ꯃꯔꯨꯄꯁꯤꯡ ꯂꯩꯔꯤ꯫ ꯄꯣꯖꯤꯇꯤꯕ ꯑꯣꯏꯕꯥ ꯋꯥꯈꯜꯂꯣꯟ ꯑꯃꯥ ꯊꯝꯃꯨ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯁꯤꯡꯒꯤ ꯏꯅꯁ꯭ꯠꯔꯛꯁꯅꯁꯤꯡ ꯑꯗꯨ ꯆꯨꯝꯅꯥ ꯏꯅꯒꯗꯕꯅꯤ, ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯅꯥ ꯃꯊꯧ ꯇꯥꯕꯥ ꯁꯄꯣꯔꯠ ꯑꯗꯨ ꯐꯪꯕꯤꯌꯨ, ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯅꯥ ꯁꯣꯌꯗꯅꯥ ꯐꯤꯚꯝ ꯑꯁꯤ ꯃꯥꯌ ꯄꯥꯛꯅꯥ ꯊꯦꯡꯅꯕꯥ ꯉꯃꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯐꯒꯠꯂꯀꯄꯥ ꯉꯃꯒꯅꯤ꯫ ꯑꯗꯣꯝ ꯃꯄꯥꯉ꯭ꯒꯜ ꯀꯅꯕꯥ ꯑꯣꯏꯔꯁꯅꯨ!

` ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ, HER2-ꯅꯦꯒꯦꯇꯤꯕ, ꯀꯦꯟꯁꯔꯒꯤ ꯂꯥꯏꯑꯣꯡ, ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡ, ꯅꯨꯄꯤꯒꯤ ꯍꯀꯁꯦꯜ, ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ, ꯇ꯭ꯔꯤꯄꯜ-ꯅꯦꯒꯦꯇꯤꯕ꯫