ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡꯕꯗꯥ ꯑꯅꯧꯕꯥ ꯑꯥꯁꯥ ꯑꯃꯥ: ꯇ꯭ꯔꯨꯀꯥꯞ (ꯀꯦꯄꯤꯚꯥꯁꯦꯔꯇꯤꯕ)ꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯏꯆꯝ ꯆꯝꯕꯥ ꯋꯥꯍꯟꯊꯣꯛ ꯑꯃꯗꯥ ꯈꯉꯂꯁꯤ꯫

ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯊꯦꯡꯅꯕꯗꯥ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯁꯤꯡꯅꯕꯥ ꯑꯃꯥ ꯑꯣꯏꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯑꯩꯈꯣꯌꯅꯥ ꯈꯉꯏ꯫ ꯑꯗꯨꯕꯨ ꯃꯦꯗꯤꯀꯦꯜ ꯁꯥꯏꯟꯁꯀꯤ ꯆꯥꯎꯈꯠꯂꯀꯄꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯑꯅꯧꯕꯥ ꯑꯥꯁꯥꯁꯤꯡ ꯍꯥꯄꯆꯤꯜꯂꯤ꯫ ꯉꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯑꯅꯧꯕꯥ ꯑꯥꯁꯥ ꯑꯃꯥ ꯄꯨꯔꯀꯄꯥ ꯗ꯭ꯔꯒ ꯑꯃꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯔꯤ, ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯑꯀꯛꯅꯅꯥ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯕꯥ ꯑꯃꯁꯨꯡ ꯂꯥꯌꯦꯡꯕꯥ ꯗ꯭ꯔꯒ ꯑꯃꯥ꯫ ꯗ꯭ꯔꯒ ꯑꯁꯤꯒꯤ ꯃꯃꯤꯡ ꯇ꯭ꯔꯨꯀꯥꯞ ꯍꯥꯌꯅꯥ ꯀꯧꯏ꯫

ꯇ꯭ꯔꯨꯀꯞ ꯍꯥꯌꯕꯁꯤ ꯀꯔꯤꯅꯣ? ꯆꯥꯡ ꯅꯥꯏꯅꯥ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛ ꯄꯤꯕꯒꯥ ꯈꯦꯠꯅꯕꯔꯥ?

ꯇ꯭ꯔꯨꯀꯥꯞ (capivasertib) ꯑꯁꯤ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯊꯦꯔꯥꯄꯤ ꯑꯃꯅꯤ꯫ ꯍꯧꯖꯤꯛ ꯑꯗꯣꯝꯅꯥ ꯈꯅꯕꯤꯔꯃꯒꯅꯤ, "ꯃꯁꯤ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯔꯕꯥ ꯊꯦꯔꯥꯄꯤ ꯑꯁꯤ ꯀꯔꯤꯅꯣ?"

ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯃꯔꯨ-ꯃꯔꯥꯡ ꯌꯥꯝꯅꯥ ꯂꯩꯕꯥ ꯕꯥꯒꯥꯟ ꯑꯃꯥ ꯈꯅꯕꯤꯌꯨ꯫ ꯆꯥꯡ ꯅꯥꯏꯅꯥ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ ꯇꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯕꯥꯒꯥꯟ ꯄꯨꯝꯕꯥ ꯍꯥꯔꯕꯤꯁꯥꯏꯗꯅꯥ ꯁꯦꯡꯗꯣꯀꯄꯒꯥ ꯃꯥꯟꯅꯩ꯫ ꯃꯁꯤꯅꯥ ꯃꯍꯤꯛ-ꯃꯇꯥꯏꯁꯤꯡꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯍꯀꯁꯦꯜ ꯐꯕꯥ ꯄꯥꯝꯕꯤꯁꯤꯡꯁꯨ ꯍꯥꯠꯄꯥ ꯉꯝꯃꯤ꯫ ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯕꯨ ꯍꯥꯠꯂꯕꯁꯨ, ꯃꯁꯤꯅꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯂꯩꯔꯤꯕꯥ ꯍꯀꯆꯥꯡ ꯐꯕꯥ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯑꯀꯥꯌꯕꯥ ꯄꯤꯕꯁꯨ ꯌꯥꯏ꯫

ꯑꯗꯨꯕꯨ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯔꯕꯥ ꯊꯦꯔꯥꯄꯤ ꯑꯁꯤ ꯃꯔꯨꯝ ꯑꯃꯥ ꯊꯤꯕꯥ ꯑꯃꯁꯨꯡ ꯃꯗꯨ ꯈꯛꯇꯃꯛ ꯁ꯭ꯞꯔꯦ ꯇꯧꯕꯒꯥ ꯃꯥꯟꯅꯩ꯫ ꯃꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯕꯨ ꯊꯨꯅꯥ ꯆꯥꯎꯈꯠꯍꯅꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯂꯤꯕꯥ ꯑꯀꯛꯅꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯅꯁꯤꯡ ꯈꯉꯗꯣꯀꯏ, ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌꯕꯨ ꯊꯤꯡꯏ꯫ ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯍꯀꯆꯥꯡ ꯐꯕꯥ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯑꯃꯥꯡ-ꯑꯇꯥ ꯊꯣꯀꯄꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯍꯟꯊꯩ꯫

ꯇ꯭ꯔꯨꯀꯞ ꯑꯁꯤ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯊꯦꯔꯥꯄꯤ ꯑꯃꯅꯤ꯫ ꯌꯨ.ꯑꯦꯁ.ꯀꯤ ꯑꯦꯐ.ꯗꯤ.ꯑꯦ.ꯅꯥ ꯲꯰꯲꯳ꯗꯥ ꯗ꯭ꯔꯒ ꯑꯁꯤ ꯑꯌꯥꯕꯥ ꯄꯤꯈꯤ, ꯃꯁꯤ ꯑꯈꯟꯅꯅꯥ ꯍꯣꯔꯃꯣꯟ-ꯄꯣꯖꯤꯇꯤꯕ (ꯑꯩꯆ.ꯑꯥꯔ.-ꯄꯣꯖꯤꯇꯤꯕ) ꯑꯃꯁꯨꯡ ꯑꯀꯛꯅꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯑꯣꯏꯕꯥ ꯑꯍꯣꯡꯕꯥ ꯂꯩꯕꯥ ꯑꯦꯗꯚꯥꯟꯁ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔꯒꯤꯗꯃꯛꯇꯅꯤ꯫ ꯗ꯭ꯔꯒ ꯑꯁꯤ ꯃꯍꯧꯁꯥꯅꯥ ꯐꯨꯂꯚꯦꯁ꯭ꯠꯔꯦꯟꯇ ꯀꯧꯕꯥ ꯑꯇꯣꯞꯄꯥ ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ ꯑꯃꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯄꯤꯖꯩ꯫

ꯇ꯭ꯔꯨꯀꯄꯅꯥ ꯍꯀꯆꯥꯡꯗꯥ ꯀꯔꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯕꯒꯦ?

ꯍꯣꯔꯃꯣꯟ-ꯗꯤꯄꯦꯟꯗꯦꯟꯇ (HR-ꯄꯣꯖꯤꯇꯤꯚ) ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯂꯩꯕꯥ ꯄꯦꯁꯦꯟꯇ ꯈꯔꯗꯤ PIK3CA, AKT1, ꯅꯠꯠꯔꯒꯥ PTEN ꯀꯧꯕꯥ ꯖꯤꯅꯁꯤꯡꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯂꯩ꯫ ꯃꯔꯨꯑꯣꯏꯅꯥ ꯑꯦ.ꯀꯦ.ꯇꯤ.꯱ ꯖꯤꯅꯗꯥ ꯃ꯭ꯌꯨꯇꯦꯁꯟ ꯇꯧꯕꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯕꯨ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯆꯥꯎꯈꯠꯄꯥ ꯑꯃꯁꯨꯡ ꯈꯥꯌꯗꯣꯀꯄꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫

ꯇ꯭ꯔꯨꯀꯄꯅꯥ ꯇꯧꯔꯤꯕꯥ ꯑꯁꯤ ꯑꯦ.ꯀꯦ.ꯇꯤ . ꯃꯁꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯆꯥꯎꯈꯠꯄꯥ ꯈꯣꯡꯖꯦꯜ ꯌꯥꯡꯁꯤꯂꯍꯜꯂꯤꯕꯥ ꯁꯨꯏꯆ ꯑꯃꯥ ꯑꯣꯐ ꯇꯧꯕꯒꯥ ꯃꯥꯟꯅꯩ꯫

ꯃꯁꯤ ꯈꯛꯇꯥ ꯅꯠꯇꯦ꯫ ꯍꯣꯔꯃꯣꯅꯗꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯕꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯍꯦꯅꯒꯠꯂꯀꯄꯗꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯏꯗꯥ ꯂꯩꯔꯤꯕꯥ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯅꯒꯨꯝꯕꯥ ꯍꯣꯔꯃꯣꯅꯁꯤꯡꯗꯥ ꯃꯈꯥ ꯄꯣꯜꯂꯤ꯫ ꯃꯔꯝ ꯑꯁꯤꯅꯥ ꯇ꯭ꯔꯨꯀꯞ ꯑꯁꯤ ꯐꯨꯂꯚꯦꯁ꯭ꯠꯔꯦꯟꯇ ꯀꯧꯕꯥ ꯍꯣꯔꯃꯣꯅꯒꯤ ꯂꯥꯌꯦꯡ ꯑꯃꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯄꯤꯔꯤ꯫

• ꯇ꯭ꯔꯨꯀꯞ: ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯒ꯭ꯔꯣꯊ ꯔꯦꯠ ꯍꯦꯅꯒꯠꯍꯜꯂꯤꯕꯥ ꯑꯦ.ꯀꯦ.ꯇꯤ.
• ꯐꯨꯂꯚꯦꯁ꯭ꯠꯔꯦꯟꯇ: ꯍꯣꯔꯃꯣꯟ ꯏꯁ꯭ꯠꯔꯣꯖꯦꯟ ꯑꯁꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯌꯧꯕꯥ ꯉꯃꯍꯟꯗꯦ꯫

ꯃꯥꯌꯀꯩ ꯑꯅꯤꯃꯛꯇꯒꯤ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯑꯦꯇꯦꯛ ꯇꯧꯕꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯒ꯭ꯔꯣꯊ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯗꯥ ꯌꯥꯝꯅꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫

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ꯃꯁꯤꯒꯤ ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤ ꯑꯩꯒꯤꯗꯃꯛꯇꯗꯤ ꯆꯨꯝꯃꯤ ꯍꯥꯌꯕꯁꯤ ꯑꯩꯅꯥ ꯀꯔꯝꯅꯥ ꯈꯪꯒꯅꯤ?

ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯀꯦꯁꯁꯤꯡ ꯑꯁꯤꯗꯥ ꯇ꯭ꯔꯨꯀꯦꯞ ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯆꯨꯅꯕꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ:

• ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔ ꯑꯗꯨ꯫ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯁꯤ ꯑꯦꯗꯚꯥꯟꯁ ꯑꯣꯏꯔꯕꯗꯤ, ꯅꯠꯠꯔꯒꯥ ꯍꯀꯆꯥꯡꯒꯤ ꯑꯇꯩ ꯃꯐꯃꯁꯤꯡꯗꯥ ꯁꯟꯗꯣꯀꯈ꯭ꯔꯕꯗꯤ (ꯃꯦꯇꯥꯁ꯭ꯇꯦꯇꯤꯛ) .
• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯑꯀꯛꯅꯕꯥ ꯇꯦꯁ꯭ꯇꯁꯤꯡꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯃꯃꯥꯡꯗꯥ ꯄꯅꯈ꯭ꯔꯤꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯑꯣꯏꯕꯥ ꯑꯍꯣꯡꯕꯁꯤꯡ (PIK3CA, AKT1, PTEN) ꯂꯩꯔꯦ ꯍꯥꯌꯕꯥ ꯀꯅꯐꯥꯔꯝ ꯇꯧꯔꯕꯗꯤ .
• ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯍꯥꯟꯅꯅꯥ ꯍꯣꯔꯃꯣꯟ ꯊꯦꯔꯥꯄꯤ ꯂꯧꯈ꯭ꯔꯕꯗꯤ, ꯑꯃꯁꯨꯡ ꯂꯥꯏꯌꯦꯡ ꯑꯗꯨꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯅꯠꯠꯔꯒꯥ ꯃꯇꯨꯡꯗꯥ ꯀꯦꯟꯁꯔ ꯑꯗꯨ ꯑꯃꯨꯛ ꯍꯟꯅꯥ ꯂꯥꯛꯂꯕꯗꯤ꯫

ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯗꯤ, ꯅꯍꯥꯛꯀꯤ ꯑꯣꯟꯀꯣꯂꯣꯖꯤꯁ꯭ꯠ ꯑꯗꯨꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯆꯨꯝꯃꯤ ꯍꯥꯌꯕꯗꯨ ꯂꯦꯄꯀꯅꯤ꯫ ꯃꯍꯥꯛꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔꯗꯥ ꯂꯩꯔꯤꯕꯥ ꯖꯦꯅꯦꯇꯤꯛ ꯑꯣꯏꯕꯥ ꯑꯍꯣꯡꯕꯁꯤꯡ ꯑꯗꯨ ꯌꯦꯡꯁꯤꯅꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯑꯔꯣꯏꯕꯥ ꯋꯥꯔꯦꯞ ꯂꯧꯅꯕꯒꯤꯗꯃꯛ ꯅꯍꯥꯛꯀꯤ ꯃꯄꯨꯡꯐꯥꯕꯥ ꯃꯦꯗꯤꯀꯦꯜ ꯍꯤꯁ꯭ꯇꯔꯤ ꯑꯗꯨ ꯌꯦꯡꯁꯤꯅꯒꯅꯤ꯫

ꯇ꯭ꯔꯨꯀꯥꯄꯀꯤ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯑꯗꯨ ꯀꯔꯤꯅꯣ? ꯃꯈꯣꯌꯁꯤꯡ ꯑꯁꯤ ꯀꯔꯝꯅꯥ ꯃꯦꯅꯦꯖ ꯇꯧꯒꯅꯤ?

ꯍꯤꯗꯥꯛ ꯑꯃꯍꯦꯛꯇꯒꯨꯝꯅꯥ, ꯇ꯭ꯔꯨꯀꯄꯅꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯊꯣꯀꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯃꯈꯣꯌ ꯈꯔꯗꯤ ꯌꯥꯝꯅꯥ ꯁꯥꯊꯤꯕꯥ ꯑꯣꯏꯕꯥ ꯌꯥꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯈꯉꯕꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫

ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯃꯈꯣꯌ ꯊꯣꯛꯂꯕꯗꯤ ꯅꯍꯥꯛꯅꯥ ꯀꯔꯤ ꯇꯧꯒꯗꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯌꯥꯎꯔꯤ꯫

ꯃꯁꯤꯒꯤ ꯃꯊꯛꯇꯥ, ꯅꯍꯥꯛꯅꯥ ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ, ꯈꯣꯡ ꯍꯥꯝꯕꯥ, ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ, ꯃꯤꯠ ꯎꯗꯕꯥ, ꯑꯃꯁꯨꯡ ꯏꯒꯤ ꯇꯦꯁ꯭ꯠ ꯔꯤꯖꯜꯇ ꯈꯔꯗꯥ ꯑꯍꯣꯡꯕꯥ ꯂꯥꯀꯄꯁꯨ ꯌꯥꯏ꯫

ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯃꯔꯨꯑꯣꯏꯕꯗꯤ: ꯅꯍꯥꯛꯀꯤ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯑꯗꯨ ꯀꯩꯗꯧꯉꯩꯗꯥ ꯂꯦꯄꯀꯅꯨ ꯅꯠꯠꯔꯒꯥ ꯗꯣꯛꯇꯔꯒꯤ ꯄꯥꯎꯇꯥꯛ ꯌꯥꯎꯗꯅꯥ ꯗꯣꯖ ꯑꯗꯨ ꯍꯣꯡꯗꯣꯛ-ꯍꯣꯡꯖꯤꯟ ꯇꯧꯔꯣꯏꯗꯕꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯋꯥꯈꯜ ꯇꯥꯗꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯂꯩꯔꯕꯗꯤ ꯃꯈꯣꯌꯒꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯕꯤꯌꯨ꯫

ꯇ꯭ꯔꯨꯀꯦꯞ ꯑꯁꯤ ꯑꯇꯩ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ ꯅꯠꯠꯔꯒꯥ ꯆꯤꯟꯖꯥꯀꯁꯤꯡꯒꯥ ꯏꯟꯇꯔꯦꯛꯇ ꯇꯧꯕꯔꯥ?

ꯍꯣꯌ, ꯃꯁꯤꯁꯨ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏꯕꯥ ꯋꯥꯐꯝ ꯑꯃꯅꯤ꯫ ꯇ꯭ꯔꯨꯀꯦꯞ ꯑꯁꯤ ꯑꯇꯩ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛ ꯑꯃꯁꯨꯡ ꯆꯤꯟꯖꯥꯛ ꯈꯔꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯏꯟꯇꯔꯦꯛꯇ ꯇꯧꯕꯥ ꯌꯥꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯅꯍꯥꯛꯅꯥ ꯂꯧꯔꯤꯕꯥ ꯍꯤꯗꯥꯛ ꯄꯨꯝꯅꯃꯛ (ꯑꯇꯣꯞꯄꯥ ꯀꯟꯗꯤꯁꯅꯁꯤꯡꯒꯤ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯀꯁꯤꯡ, ꯚꯤꯇꯥꯃꯤꯅꯁꯤꯡ, ꯑꯃꯁꯨꯡ ꯍꯔꯕꯦꯜ ꯄ꯭ꯔꯗꯛꯇꯁꯤꯡ ꯐꯥꯎꯕꯥ ꯌꯥꯎꯅꯥ) ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯈꯪꯍꯅꯒꯗꯕꯅꯤ꯫

ꯃꯁꯤꯒꯤ ꯃꯔꯃꯗꯤ ꯑꯩꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯅꯥ ꯁꯤ.ꯋꯥꯏ.ꯄꯤ.꯳ꯑꯦ ꯀꯧꯕꯥ ꯑꯦꯅꯖꯥꯏꯝ ꯑꯃꯥ ꯁꯤꯖꯤꯟꯅꯗꯨꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯁꯤꯕꯨ ꯁꯣꯀꯍꯟꯗꯨꯅꯥ ꯍꯀꯆꯥꯡꯗꯒꯤ ꯂꯧꯊꯣꯀꯏ꯫ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛ ꯑꯃꯁꯨꯡ ꯆꯤꯟꯖꯥꯛ ꯈꯔꯅꯥ ꯁꯤ.ꯋꯥꯏ.ꯄꯤ.꯳ꯑꯦ.ꯒꯤ ꯑꯦꯅꯖꯥꯏꯝ ꯑꯁꯤꯅꯥ ꯊꯕꯛ ꯇꯧꯕꯒꯤ ꯃꯑꯣꯡ ꯑꯁꯤ ꯍꯣꯡꯗꯣꯀꯄꯥ ꯌꯥꯏ꯫

• CYP3A ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ: ꯃꯁꯤꯅꯥ CYP3A ꯑꯦꯅꯖꯥꯏꯃꯒꯤ ꯑꯦꯛꯁꯟ ꯑꯗꯨ ꯊꯤꯡꯏ꯫ ꯃꯁꯤꯅꯥ ꯇ꯭ꯔꯨꯀꯦꯞ ꯑꯁꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯂꯩꯍꯅꯕꯥ ꯌꯥꯏ ꯑꯃꯁꯨꯡ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯀꯤ ꯔꯤꯁ꯭ꯛ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯌꯥꯏ꯫ ꯑꯦꯟꯇꯤꯕꯥꯏꯑꯣꯇꯤꯛ ꯑꯃꯁꯨꯡ ꯑꯦꯟꯇꯤꯐꯉ꯭ꯒꯦꯜ ꯈꯔꯗꯤ ꯀꯦꯇꯦꯒꯣꯔꯤ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡ ꯆꯜꯂꯤ꯫ ꯃꯔꯨꯑꯣꯏꯅꯥ, ꯅꯍꯥꯛꯅꯥ ꯇ꯭ꯔꯨꯀꯦꯞ ꯂꯧꯕꯥ ꯃꯇꯃꯗꯥ ꯒ꯭ꯔꯦꯄꯐ꯭ꯔꯨꯠ ꯅꯠꯠꯔꯒꯥ ꯒ꯭ꯔꯦꯄꯐ꯭ꯔꯨꯇꯀꯤ ꯖꯨꯁ ꯊꯀꯄꯥ ꯌꯥꯔꯣꯏꯗꯕꯅꯤ꯫
• ꯁꯤ.ꯋꯥꯏ.ꯄꯤ.꯳ꯑꯦ.ꯒꯤ ꯏꯟꯗ꯭ꯌꯨꯁꯔꯁꯤꯡ: ꯃꯁꯤꯅꯥ ꯁꯤ.ꯋꯥꯏ.ꯄꯤ.꯳ꯑꯦ.ꯒꯤ ꯑꯦꯅꯖꯥꯏꯃꯒꯤ ꯑꯦꯛꯇꯤꯚꯤꯇꯤ ꯍꯦꯅꯒꯠꯍꯟꯗꯨꯅꯥ ꯊꯕꯛ ꯇꯧꯏ꯫ ꯃꯁꯤꯅꯥ ꯇ꯭ꯔꯨꯀꯞ ꯑꯁꯤ ꯍꯀꯆꯥꯡꯗꯒꯤ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯂꯧꯊꯣꯀꯄꯥ ꯉꯃꯍꯜꯂꯤ, ꯃꯁꯤꯅꯥ ꯃꯁꯤꯒꯤ ꯏꯐꯦꯛꯇꯤꯕꯅꯦꯁ ꯍꯟꯊꯍꯅꯕꯥ ꯉꯃꯒꯅꯤ . ꯑꯦꯟꯇꯤꯕꯥꯏꯑꯣꯇꯤꯛ ꯈꯔꯗꯤ (ꯔꯤꯐꯥꯝꯄꯤꯁꯤꯅꯒꯨꯝꯕꯥ) ꯑꯃꯁꯨꯡ HIVꯒꯤ ꯍꯤꯗꯥꯛ ꯈꯔꯗꯤ ꯀꯦꯇꯦꯒꯣꯔꯤ ꯑꯁꯤꯒꯤ ꯃꯅꯨꯡ ꯆꯜꯂꯤ꯫

ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯑꯅꯧꯕꯥ ꯍꯤꯗꯥꯛ ꯑꯃꯥ ꯍꯦꯛꯇꯥ ꯍꯧꯗ꯭ꯔꯤꯉꯩꯗꯥ, ꯅꯍꯥꯛꯀꯤ ꯑꯣꯟꯀꯣꯂꯣꯖꯤꯁ꯭ꯠ ꯑꯗꯨꯒꯥ ꯃꯗꯨꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯁꯣꯌꯗꯅꯥ ꯋꯥꯔꯤ ꯁꯥꯕꯤꯌꯨ꯫

ꯍꯤꯗꯥꯛ ꯑꯗꯨꯅꯥ ꯊꯕꯛ ꯇꯧꯔꯤꯕ꯭ꯔꯥ ꯍꯥꯌꯕꯗꯨ ꯀꯔꯝꯅꯥ ꯈꯪꯒꯅꯤ?

ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯟꯗꯤꯁꯟ ꯑꯗꯨ ꯆꯥꯡ ꯅꯥꯏꯅꯥ ꯌꯦꯡꯁꯤꯅꯒꯅꯤ꯫ ꯃꯍꯥꯛꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯁꯤ ꯀꯌꯥ ꯌꯥꯝꯅꯥ ꯐꯖꯅꯥ ꯊꯕꯛ ꯇꯧꯔꯤꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯁꯤꯟꯅꯕꯥ ꯕ꯭ꯂꯗ ꯇꯦꯁ꯭ꯠ, ꯁꯤ.ꯇꯤ.ꯁ꯭ꯀꯦꯟ, ꯑꯃꯁꯨꯡ ꯑꯦꯝ.ꯑꯥꯔ.ꯑꯥꯏ. ꯅꯍꯥꯛꯅꯥ ꯇꯧꯒꯗꯕꯥ ꯊꯕꯛ ꯑꯗꯨꯗꯤ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯍꯥꯌꯔꯀꯄꯒꯨꯝꯅꯥ ꯍꯤꯗꯥꯛ ꯑꯗꯨ ꯂꯧꯕꯈꯛꯇꯅꯤ꯫