ꯑꯩꯈꯣꯌꯅꯥ ꯀꯦꯟꯁꯔ ꯍꯥꯌꯕꯥ ꯋꯥꯍꯩ ꯑꯁꯤ ꯇꯥꯕꯗꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯃꯔꯛꯇꯥ ꯀꯌꯥ ꯑꯃꯅꯥ ꯋꯥꯈꯜ ꯋꯥꯕꯥ ꯑꯃꯁꯨꯡ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯐꯥꯑꯣꯏ꯫ ꯃꯗꯨ ꯅꯣꯔꯃꯦꯂꯅꯤ꯫ ꯑꯗꯨꯕꯨ ꯃꯦꯗꯤꯀꯦꯜ ꯁꯥꯏꯟꯁꯀꯤ ꯆꯥꯎꯈꯠꯂꯀꯄꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯃꯥꯂꯦꯝ ꯑꯁꯤꯗꯥ ꯑꯅꯧꯕꯥ ꯂꯥꯌꯦꯡꯁꯤꯡ ꯂꯥꯛꯂꯦ ꯃꯗꯨꯅꯥ ꯑꯩꯈꯣꯌꯗꯥ ꯀꯦꯟꯁꯔ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯂꯤ ꯑꯃꯁꯨꯡ ꯍꯦꯟꯅꯥ ꯐꯕꯥ ꯄꯨꯟꯁꯤ ꯃꯍꯤꯡ ꯑꯃꯥ ꯍꯤꯡꯂꯤ꯫ ꯉꯁꯤ ꯑꯩꯈꯣꯌꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯒ꯭ꯔꯣꯊꯇꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯑꯃꯁꯨꯡ ꯊꯤꯡꯂꯤꯕꯥ ꯗ꯭ꯔꯒꯁꯤꯡꯒꯤ ꯌꯥꯝꯅꯥ ꯑꯈꯟꯅꯕꯥ ꯀ꯭ꯂꯥꯁ ꯑꯃꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯋꯥꯔꯤ ꯁꯥꯅꯔꯤ꯫ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤꯕꯨ ꯇꯥꯏꯔꯣꯁꯤꯟ ꯀꯤꯅꯥꯁ ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ, ꯅꯠꯠꯔꯒꯥ ꯊꯣꯏꯗꯣꯛ ꯍꯦꯟꯗꯣꯛꯅꯥ ꯇꯤ.ꯀꯦ.ꯑꯥꯏ.
ꯌꯥꯝꯅꯥ ꯂꯥꯏꯅꯥ ꯍꯥꯌꯔꯕꯗꯥ, ꯇꯥꯏꯔꯣꯁꯤꯟ ꯀꯤꯅꯥꯁ ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ (TKIs) ꯍꯥꯌꯕꯁꯤ ꯀꯔꯤꯅꯣ?
ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ "ꯇꯥꯔꯒꯦꯠ ꯇꯧꯔꯕꯥ ꯊꯦꯔꯥꯄꯤꯁꯤꯡ" ꯀꯧꯕꯥ ꯍꯤꯗꯥꯛ ꯃꯈꯜ ꯑꯃꯅꯤ꯫ ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯑꯁꯤꯒꯨꯝꯅꯥ ꯈꯟꯊꯕꯤꯌꯨ: ꯆꯥꯡ ꯅꯥꯏꯅꯥ ꯀꯦꯟꯁꯔꯒꯤ ꯍꯤꯗꯥꯛ (ꯀꯦꯃꯣꯊꯦꯔꯥꯄꯤ) ꯑꯁꯤ ꯂꯥꯟ ꯑꯃꯗꯥ ꯊꯥꯗꯣꯀꯈꯤꯕꯥ ꯕꯣꯝ ꯑꯃꯒꯥ ꯃꯥꯟꯅꯩ꯫ ꯃꯁꯤꯅꯥ ꯌꯦꯛꯅꯕꯥ ꯂꯥꯟꯃꯤꯁꯤꯡ (ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ)ꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯑꯩꯈꯣꯌꯒꯤ ꯏꯁꯥꯒꯤ ꯃꯔꯥꯜ ꯂꯩꯖꯗ꯭ꯔꯕꯥ ꯃꯤꯑꯣꯏꯁꯤꯡ (ꯍꯀꯆꯥꯡ ꯐꯕꯥ ꯁꯦꯂꯁꯤꯡ) ꯁꯤꯍꯅꯕꯥ ꯉꯝꯃꯤ꯫ ꯑꯗꯨꯕꯨ ꯇꯤ.ꯀꯦ.ꯑꯥꯏ.ꯅꯥ ꯀꯧꯕꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯂꯥꯌꯦꯡ ꯑꯁꯤ ꯁ꯭ꯅꯥꯏꯄꯥꯔ ꯑꯃꯒꯨꯝꯕꯅꯤ꯫ ꯃꯁꯤꯅꯥ ꯄꯥꯟꯗꯝ ꯑꯗꯨ ꯇꯁꯦꯡꯅꯥ ꯌꯦꯡꯏ ꯑꯃꯁꯨꯡ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯈꯛꯇꯗꯥ ꯑꯃꯥꯡ-ꯑꯇꯥ ꯊꯣꯀꯍꯜꯂꯤ꯫ ꯍꯀꯁꯦꯜ ꯐꯕꯥ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯑꯃꯥꯡ-ꯑꯇꯥ ꯊꯣꯀꯄꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯅꯦꯝꯃꯤ꯫
ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯂꯩꯕꯥ ꯑꯦꯅꯖꯥꯏꯃꯁꯤꯡ ꯊꯤꯡꯗꯨꯅꯥ ꯊꯕꯛ ꯇꯧꯏ ꯃꯗꯨꯅꯥ ꯃꯈꯣꯌꯕꯨ ꯌꯥꯡꯅꯥ ꯆꯥꯎꯈꯠꯄꯥ ꯑꯃꯁꯨꯡ ꯈꯥꯌꯗꯣꯀꯄꯥ ꯉꯃꯍꯜꯂꯤ꯫ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯃꯄꯨꯡ ꯐꯥꯅꯥ ꯐꯍꯅꯕꯥ ꯉꯃꯗꯕꯥ ꯌꯥꯏ, ꯑꯗꯨꯕꯨ ꯃꯈꯣꯌꯅꯥ ꯀꯦꯟꯁꯔ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯕꯥ ꯉꯃꯒꯅꯤ ꯑꯃꯁꯨꯡ ꯃꯁꯤꯕꯨ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯔꯤꯃꯤꯁꯅꯗꯥ ꯊꯝꯕꯥ ꯉꯃꯒꯅꯤ , ꯅꯠꯠꯔꯒꯥ ꯃꯈꯣꯌꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯀꯦꯟꯁꯔꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯃꯇꯝ ꯁꯥꯡꯅꯥ ꯑꯃꯁꯨꯡ ꯍꯀꯆꯥꯡ ꯐꯅꯥ ꯍꯤꯡꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯒꯅꯤ꯫
ꯍꯤꯗꯥꯛ ꯑꯁꯤꯅꯥ ꯍꯀꯆꯥꯡꯒꯤ ꯃꯅꯨꯡꯗꯥ ꯀꯔꯝꯅꯥ ꯊꯕꯛ ꯇꯧꯕꯒꯦ?
ꯃꯁꯤ ꯈꯉꯅꯕꯒꯤꯗꯃꯛ ꯑꯩꯈꯣꯌꯒꯤ ꯍꯀꯆꯥꯡꯗꯥ ꯂꯩꯔꯤꯕꯥ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯀꯔꯝꯅꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯌꯦꯡꯁꯤ꯫ ꯑꯩꯈꯣꯌꯒꯤ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤ ꯈꯥꯌꯗꯣꯀꯄꯥ ꯑꯁꯤ ꯃꯩ ꯊꯥꯕꯒꯨꯝꯅꯥ ꯈꯟꯗꯨꯅꯥ ꯌꯦꯡꯕꯤꯌꯨ꯫
1. ꯒ꯭ꯔꯣꯊ ꯐꯦꯛꯇꯔꯁꯤꯡ: ꯃꯁꯤ ꯂꯥꯏꯠ ꯁꯨꯏꯆ ꯑꯗꯨ ꯐ꯭ꯂꯤꯞ ꯇꯧꯕꯥ ꯐꯤꯉ꯭ꯒꯔꯒꯨꯝꯅꯥ ꯑꯣꯏ꯫ ꯃꯈꯣꯌꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯁꯦꯂꯁꯤꯡꯗꯥ "ꯍꯧꯖꯤꯛ ꯈꯥꯌꯗꯣꯀꯄꯥ" ꯍꯥꯌꯕꯒꯤ ꯁꯤꯒꯅꯦꯜ ꯄꯤꯔꯤ꯫
2. ꯇꯥꯏꯔꯣꯁꯤꯟ ꯀꯤꯅꯥꯁꯦꯁ: ꯃꯁꯤ ꯃꯉꯥꯂꯒꯤ ꯁꯨꯏꯆꯁꯤꯡꯅꯤ꯫ ꯅꯍꯥꯛꯅꯥ ꯃꯈꯣꯌꯗꯨ ꯅꯍꯥꯛꯀꯤ ꯈꯨꯠꯁꯥꯅꯥ ꯁꯣꯀꯍꯅꯕꯥ ꯃꯇꯃꯗꯥ, ꯃꯈꯣꯌ ꯑꯗꯨ ‘ꯑꯣꯟ’ ꯑꯣꯏꯔꯀꯏ, ꯑꯃꯁꯨꯡ ꯁꯦꯂꯁꯤꯡ ꯑꯗꯨ ꯈꯥꯌꯗꯣꯀꯄꯥ ꯍꯧꯔꯀꯏ꯫ ꯃꯊꯧ ꯇꯥꯕꯥ ꯑꯗꯨ ꯂꯣꯏꯔꯕꯥ ꯃꯇꯨꯡꯗꯥ ꯃꯈꯣꯌꯅꯥ ꯑꯃꯨꯛ ꯍꯟꯅꯥ ‘ꯑꯣꯐ’ ꯇꯧꯏ꯫
ꯍꯀꯆꯥꯡ ꯐꯕꯥ ꯁꯦꯂꯁꯤꯡꯗꯥ, ꯃꯁꯤꯒꯤ ꯁꯨꯏꯆ ꯑꯁꯤꯅꯥ ꯃꯄꯨꯡ ꯐꯥꯅꯥ ꯊꯕꯛ ꯇꯧꯏ꯫ ꯃꯊꯧ ꯇꯥꯕꯥ ꯃꯇꯃꯗꯥ ‘ꯑꯣꯟ’ ꯇꯧꯏ, ꯑꯃꯁꯨꯡ ꯊꯕꯛ ꯑꯗꯨ ꯂꯣꯏꯔꯕꯥ ꯃꯇꯨꯡꯗꯥ ‘ꯑꯣꯐ’ ꯇꯧꯏ꯫
ꯑꯗꯨꯕꯨ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯈꯔꯗꯥ, ꯃꯔꯨꯑꯣꯏꯅꯥ ꯀ꯭ꯔꯣꯅꯤꯛ ꯃꯥꯏꯂꯣꯏꯗ ꯂꯤꯎꯀꯦꯃꯤꯌꯥ (CML) ꯀꯧꯕꯥ ꯕ꯭ꯂꯗ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯑꯃꯗꯥ, ‘ꯇꯥꯏꯔꯣꯁꯤꯟ ꯀꯤꯅꯥꯁ’ ꯀꯧꯕꯥ ꯁꯨꯏꯆ ꯑꯁꯤ ꯊꯨꯒꯥꯏ꯫ ꯃꯁꯤ ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ ‘ꯑꯣꯟ’ ꯑꯣꯏ꯫ ꯃꯁꯤꯅꯥ ꯇꯥꯀꯄꯗꯤ ꯁꯦꯂꯁꯤꯡꯅꯥ ꯂꯦꯞꯇꯅꯥ "ꯈꯥꯌꯗꯣꯀꯄꯥ, ꯈꯥꯌꯗꯣꯀꯄꯥ, ꯈꯥꯌꯗꯣꯀꯄꯥ" ꯍꯥꯌꯕꯥ ꯁꯤꯒꯅꯦꯜ ꯑꯁꯤ ꯐꯪꯂꯤ꯫ ꯑꯗꯨꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯗꯅꯥ ꯈꯥꯌꯗꯣꯀꯏ, ꯃꯁꯤꯅꯥ ꯕꯣꯟ ꯃꯦꯔꯣ ꯃꯄꯨꯡ ꯐꯥꯍꯜꯂꯤ ꯑꯃꯁꯨꯡ ꯍꯀꯆꯥꯡ ꯐꯕꯥ ꯕ꯭ꯂꯗ ꯁꯦꯂꯁꯤꯡ ꯄꯨꯊꯣꯀꯄꯥ ꯊꯤꯡꯏ꯫
ꯃꯗꯨꯗꯥ ꯇꯤ.ꯀꯦ.ꯑꯥꯏ.ꯒꯤ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤ ꯊꯧꯗꯥꯡ ꯂꯧꯔꯤ꯫ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯇꯧꯔꯤꯕꯥ ꯑꯁꯤ ꯃꯇꯝ ꯄꯨꯝꯅꯃꯛꯇꯥ ꯑꯣꯟꯊꯣꯛꯂꯕꯥ ꯁꯣꯏꯆ ꯑꯗꯨ ꯐꯣꯔꯁ ꯑꯣꯏꯅꯥ ꯑꯣꯐ ꯇꯧꯕꯅꯤ꯫ ꯑꯗꯨꯗꯒꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯅꯥ ꯈꯥꯌꯗꯣꯀꯄꯥ ꯉꯝꯅꯕꯥ ꯁꯤꯒꯅꯦꯜ ꯑꯗꯨ ꯃꯥꯡꯈꯤ, ꯑꯃꯁꯨꯡ ꯃꯈꯣꯌꯒꯤ ꯒ꯭ꯔꯣꯊ ꯑꯗꯨ ꯂꯦꯄꯈꯤ꯫ ꯑꯗꯨꯒꯨꯝꯕꯥ ꯊꯧꯑꯣꯡ ꯑꯗꯨ ꯀꯌꯥꯗꯥ ꯑꯀꯛꯅꯕꯥ ꯑꯣꯏꯕꯒꯦ ꯍꯥꯌꯕꯗꯨ ꯑꯗꯣꯝꯅꯥ ꯈꯉꯕꯤꯔꯤꯕꯔꯥ?
ꯇꯤ.ꯀꯦ.ꯑꯥꯏ.ꯒꯤ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤ ꯀꯔꯤ ꯃꯈꯂꯒꯤ ꯀꯦꯟꯁꯔꯒꯤꯗꯃꯛꯇꯥ ꯁꯤꯖꯤꯟꯅꯕꯒꯦ?
ꯍꯥꯌꯔꯤꯕꯥ ꯍꯤꯗꯥꯀꯁꯤꯡ ꯑꯁꯤ ꯍꯧꯖꯤꯛ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯀꯌꯥꯗꯥ ꯁꯤꯖꯤꯟꯅꯔꯦ꯫ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯥ ꯇꯦꯕꯜ ꯑꯁꯤ ꯌꯦꯡꯕꯤꯌꯨ꯫
| ꯀꯦꯟꯁꯔ ꯃꯈꯜ꯫ | ꯏꯆꯝ ꯆꯝꯕꯥ ꯄꯥꯎꯈꯨꯝ ꯑꯃꯥ꯫ |
|---|---|
| HER2-ꯄꯣꯖꯤꯇꯤꯚ ꯑꯣꯏꯕꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ꯫ | ꯁꯦꯂꯁꯤꯡꯒꯤ ꯃꯊꯛꯇꯥ HER2 ꯀꯧꯕꯥ ꯄ꯭ꯔꯣꯇꯤꯟ ꯑꯃꯥ ꯍꯦꯟꯅꯥ ꯌꯥꯎꯕꯥ ꯕ꯭ꯔꯦꯁ꯭ꯠ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯑꯃꯅꯤ꯫ |
| ꯀ꯭ꯔꯣꯅꯤꯛ ꯂꯤꯝꯐꯣꯁꯥꯏꯇꯤꯛ ꯂꯤꯎꯀꯦꯃꯤꯌꯥ꯫ | ꯋꯥꯏꯠ ꯕ꯭ꯂꯗ ꯁꯦꯜ ꯃꯈꯜ ꯑꯃꯗꯥ ꯁꯣꯀꯍꯜꯂꯤꯕꯥ ꯇꯞꯅꯥ ꯇꯞꯅꯥ ꯍꯦꯅꯒꯠꯂꯛꯂꯤꯕꯥ ꯕ꯭ꯂꯗ ꯀꯦꯟꯁꯔ ꯑꯃꯅꯤ꯫ |
| ꯒꯦꯁ꯭ꯠꯔꯣꯏꯟꯇꯦꯁ꯭ꯇꯥꯏꯅꯦꯜ ꯁ꯭ꯠꯔꯣꯃꯜ ꯇꯤꯎꯃꯔꯁꯤꯡ꯫ | ꯃꯁꯤ ꯗꯥꯏꯖꯦꯁ꯭ꯇꯤꯚ ꯁꯤꯁ꯭ꯇꯦꯃꯒꯤ ꯋꯥꯂꯁꯤꯡꯗꯥ ꯊꯣꯀꯄꯥ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯊꯣꯀꯄꯥ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯑꯃꯅꯤ꯫ |
| ꯀꯤꯗꯅꯤꯒꯤ ꯀꯦꯟꯁꯔ꯫ | ꯀꯤꯗꯅꯤꯒꯤ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯍꯧꯔꯀꯄꯥ ꯀꯦꯟꯁꯔꯁꯤꯡꯒꯤꯗꯃꯛ꯫ |
| ꯂꯪꯁ ꯀꯦꯟꯁꯔ (ꯅꯟ-ꯁ꯭ꯃꯣꯜ ꯁꯦꯜ ꯂꯪꯁ ꯀꯦꯟꯁꯔ) | ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯀꯃꯟ ꯑꯣꯏꯕꯥ ꯃꯈꯂꯒꯤ ꯂꯪꯁ ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡꯅꯕꯥ꯫ |
| ꯁ꯭ꯀꯤꯟ ꯀꯦꯟꯁꯔ (ꯃꯦꯂꯥꯅꯣꯃꯥ) ꯑꯁꯤꯅꯆꯤꯡꯕꯥ꯫ | ꯈꯣꯡꯎꯄꯀꯤ ꯃꯆꯨ ꯄꯤꯔꯤꯕꯥ ꯁꯦꯂꯁꯤꯡꯗꯥ ꯊꯣꯀꯄꯥ ꯑꯀꯅꯕꯥ ꯈꯣꯡꯎꯄꯀꯤ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯑꯃꯅꯤ꯫ |
ꯃꯔꯨꯑꯣꯏꯕꯥ ꯋꯥꯐꯃꯗꯤ ꯇꯤ.ꯀꯦ.ꯑꯥꯏ.ꯒꯤ ꯗ꯭ꯔꯒ ꯄꯨꯝꯅꯃꯛꯅꯥ ꯀꯦꯟꯁꯔ ꯃꯈꯜ ꯈꯨꯗꯤꯡꯃꯛꯀꯤꯗꯃꯛ ꯊꯕꯛ ꯇꯧꯗꯦ꯫ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯀꯦꯟꯁꯔꯒꯤ ꯖꯦꯅꯦꯇꯤꯛ ꯃꯦꯀꯑꯄꯇꯥ ꯌꯨꯝꯐꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯅꯍꯥꯛꯀꯤꯗꯃꯛꯇꯥ ꯑꯆꯨꯝꯕꯥ ꯇꯥꯔꯒꯦꯠ ꯇꯧꯔꯕꯥ ꯗ꯭ꯔꯒ ꯑꯗꯨ ꯈꯅꯒꯅꯤ꯫
ꯍꯤꯗꯥꯀꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯂꯩꯕ꯭ꯔꯥ?
ꯍꯣꯏ. ꯍꯤꯗꯥꯛ ꯑꯃꯍꯦꯛꯇꯒꯨꯝꯅꯥ ꯃꯁꯤꯒꯤ ꯑꯃꯅꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯂꯩꯕꯥ ꯌꯥꯏ꯫ ꯑꯗꯨꯕꯨ ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯑꯃꯁꯨꯡ ꯅꯍꯥꯛꯅꯥ ꯂꯧꯔꯤꯕꯥ ꯍꯤꯗꯥꯛ ꯃꯈꯜ ꯑꯗꯨꯒꯤ ꯃꯇꯨꯡ ꯏꯟꯅꯥ ꯌꯥꯝꯅꯥ ꯈꯦꯠꯅꯩ꯫ ꯃꯤꯑꯣꯏ ꯈꯔꯗꯗꯤ ꯑꯄꯤꯀꯄꯥ ꯑꯁꯣꯛ-ꯑꯄꯟ ꯈꯛꯇꯃꯛ ꯊꯦꯡꯅꯔꯀꯄꯥ ꯌꯥꯏ, ꯑꯗꯨꯒꯥ ꯑꯇꯩ ꯈꯔꯗꯗꯤ ꯍꯦꯟꯅꯥ ꯁꯥꯊꯤꯕꯥ ꯑꯁꯣꯛ-ꯑꯄꯟ ꯊꯣꯀꯄꯥ ꯌꯥꯏ꯫
ꯃꯍꯧꯁꯥꯅꯥ ꯎꯕꯥ ꯐꯪꯂꯤꯕꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇ ꯈꯔꯗꯤ ꯃꯈꯥꯗꯥ ꯄꯤꯔꯤꯕꯁꯤꯡꯁꯤꯅꯤ:
- ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯋꯥꯈꯜ ꯆꯔꯥꯡꯅꯕꯥ: ꯃꯁꯤ ꯌꯥꯝꯅꯥ ꯀꯃꯟ ꯑꯣꯏ꯫
- ꯗꯥꯏꯔꯤꯌꯥ: ꯕꯣꯋꯦꯜ ꯃꯨꯚꯃꯦꯟꯇ꯫
- ꯈꯣꯡꯒꯤ ꯄ꯭ꯔꯣꯕ꯭ꯂꯦꯃꯁꯤꯡ: ꯈꯣꯡ-ꯈꯨꯠ ꯁꯣꯛ-ꯄꯅꯕꯥ, ꯁꯣꯀꯄꯥ, ꯁꯣꯀꯄꯥ, ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯊꯣꯀꯄꯥ ꯀꯦꯁꯁꯤꯡꯗꯥ , ꯁ꯭ꯇꯦꯚꯦꯟꯁ-ꯖꯣꯟꯁꯟ ꯁꯤꯟꯗ꯭ꯔꯣꯃꯒꯨꯝꯕꯥ ꯁꯥꯊꯤꯕꯥ ꯈꯣꯡ-ꯈꯨꯠꯀꯤ ꯀꯟꯗꯤꯁꯅꯁꯤꯡ ꯊꯣꯀꯄꯥ ꯌꯥꯏ꯫
- ꯅꯣꯡꯃꯩ ꯀꯥꯞꯄꯥ ꯑꯃꯁꯨꯡ ꯈꯣꯡ ꯍꯥꯝꯕꯥ꯫
- ꯍꯥꯏ ꯕ꯭ꯂꯗ ꯄ꯭ꯔꯦꯁꯔ (ꯍꯥꯌꯕꯗꯤ ꯍꯥꯏꯄꯔꯇꯦꯟꯁꯟ) .
- ꯄ꯭ꯔꯣꯇꯤꯟ ꯌꯨꯔꯤꯌꯥ꯫
- ꯑꯔꯨꯝꯕꯥ ꯍꯟꯊꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ꯫
ꯃꯔꯨꯑꯣꯏꯕꯥ: ꯅꯍꯥꯛꯅꯥ ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤ ꯍꯧꯗ꯭ꯔꯤꯉꯩꯗꯥ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯛꯅꯥ ꯂꯧꯒꯗꯧꯔꯤꯕꯥ ꯍꯤꯗꯥꯛ ꯑꯗꯨꯒꯤ ꯑꯣꯏꯊꯣꯀꯄꯥ ꯌꯥꯕꯥ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯑꯗꯨ ꯃꯌꯦꯛ ꯁꯦꯡꯅꯥ ꯈꯟꯅꯒꯅꯤ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯇꯃꯗꯥ ꯑꯅꯧꯕꯥ ꯂꯥꯏꯑꯣꯡ ꯑꯃꯥ ꯅꯠꯠꯔꯒꯥ ꯑꯁꯣꯛ-ꯑꯄꯟ ꯑꯃꯥ ꯂꯥꯀꯄꯥ ꯃꯇꯃꯗꯥ ꯈꯨꯗꯛꯇꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯈꯪꯍꯅꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫
ꯂꯥꯏꯌꯦꯡꯕꯗꯥ ꯂꯥꯏꯊꯣꯀꯍꯟꯅꯕꯥ ꯑꯩꯈꯣꯌꯅꯥ ꯀꯔꯤ ꯇꯧꯕꯥ ꯌꯥꯕꯒꯦ?
ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡꯕꯥ ꯑꯁꯤ ꯍꯀꯆꯥꯡ ꯑꯃꯁꯨꯡ ꯋꯥꯈꯜ ꯑꯅꯤꯃꯛꯇꯥ ꯁꯤꯡꯅꯕꯥ ꯈꯣꯉꯆꯠ ꯑꯃꯅꯤ꯫ ꯈꯣꯡꯆꯠ ꯑꯁꯤ ꯈꯔꯥ ꯂꯥꯏꯊꯣꯀꯍꯟꯅꯕꯥ ꯑꯗꯣꯝꯅꯥ ꯇꯧꯕꯥ ꯌꯥꯕꯥ ꯊꯕꯛ ꯈꯔꯥ ꯂꯩꯔꯤ꯫
- ꯋꯥꯈꯜ ꯇꯥꯗꯕꯒꯤ ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯐꯕꯥ ꯋꯥꯐꯃꯗꯤ ꯅꯨꯡꯉꯥꯏꯅꯥ ꯂꯩꯕꯅꯤ: ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ ꯐꯥꯎꯔꯕꯗꯤ, ꯃꯁꯤ ꯅꯣꯔꯃꯦꯂꯅꯤ ꯍꯥꯌꯕꯁꯤ ꯈꯪꯖꯤꯅꯕꯤꯌꯨ꯫ ꯌꯥꯔꯤꯕꯃꯈꯩ ꯅꯨꯡꯉꯥꯏꯅꯥ ꯂꯩꯌꯨ꯫ ꯅꯨꯃꯤꯗꯥꯡꯗꯥ ꯑꯇꯦꯅꯕꯥ ꯃꯇꯃꯒꯤ ꯑꯣꯏꯅꯥ ꯇꯨꯝꯕꯥ ꯑꯁꯤꯁꯨ ꯑꯐꯕꯥ ꯑꯃꯅꯤ꯫
- ꯅꯍꯥꯛꯀꯤ ꯗꯥꯏꯇꯇꯥ ꯆꯦꯀꯁꯤꯅꯒꯗꯕꯅꯤ: ꯃꯤꯑꯣꯏ ꯈꯔꯗꯤ ꯆꯥꯛ ꯆꯥꯕꯥ ꯋꯥꯠꯄꯅꯥ ꯃꯔꯝ ꯑꯣꯏꯗꯨꯅꯥ ꯑꯔꯨꯝꯕꯥ ꯍꯟꯊꯔꯀꯏ꯫ ꯑꯇꯣꯞꯄꯁꯤꯡꯅꯥ ꯑꯔꯨꯝꯕꯥ ꯍꯦꯅꯒꯠꯂꯀꯄꯥ ꯌꯥꯏ꯫ ꯀꯔꯤꯒꯨꯝꯕꯥ ꯅꯍꯥꯛꯅꯥ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯃꯑꯣꯡꯗꯥ ꯐꯥꯑꯣꯔꯕꯗꯤ, ꯅ꯭ꯌꯨꯠꯔꯤꯁꯅꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯒꯤ ꯃꯇꯦꯡ ꯂꯧꯕꯤꯌꯨ . ꯃꯗꯨꯒꯤ ꯃꯇꯨꯡꯗꯥ ꯃꯈꯣꯌꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯐꯤꯚꯃꯒꯥ ꯆꯨꯅꯕꯥ ꯗꯥꯏꯠ ꯄ꯭ꯂꯥꯟ ꯑꯃꯥ ꯁꯦꯝꯕꯥ ꯌꯥꯏ꯫
- ꯅꯍꯥꯛꯀꯤ ꯅꯨꯃꯤꯠ ꯑꯗꯨ ꯄ꯭ꯂꯥꯟ ꯇꯧꯕꯤꯌꯨ: ꯂꯥꯏꯌꯦꯡꯕꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯅꯨꯡꯇꯤꯒꯤ ꯄꯨꯟꯁꯤꯗꯥ ꯌꯥꯝꯅꯥ ꯑꯍꯣꯡꯕꯥ ꯄꯨꯔꯀꯄꯥ ꯉꯝꯃꯤ꯫ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯤ ꯑꯦꯄꯣꯏꯟꯇꯃꯦꯟꯇꯁꯤꯡ ꯑꯃꯁꯨꯡ ꯍꯤꯗꯥꯛ-ꯂꯥꯡꯊꯛꯀꯤ ꯑꯦꯄꯣꯏꯟꯇꯃꯦꯟꯇꯁꯤꯡ ꯑꯗꯨ ꯀꯦꯂꯦꯟꯗꯔ ꯑꯃꯗꯥ ꯃꯥꯔꯛ ꯇꯧꯗꯨꯅꯥ ꯋꯥꯐꯃꯁꯤꯡ ꯑꯗꯨ ꯑꯣꯔꯒꯥꯅꯥꯏꯖ ꯇꯧꯅꯕꯥ ꯍꯣꯠꯅꯧ꯫
- ꯄꯦꯂꯤꯑꯣꯇꯤꯛ ꯀꯦꯌꯔꯒꯤ ꯃꯔꯃꯗꯥ ꯈꯪꯖꯤꯅꯕꯤꯌꯨ: ꯃꯁꯤ ꯃꯤꯑꯣꯏ ꯀꯌꯥꯅꯥ ꯈꯪꯗꯕꯥ ꯋꯥꯐꯝ ꯑꯃꯅꯤ, ꯑꯗꯨꯕꯨ ꯃꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫ ꯄꯦꯂꯤꯑꯣꯇꯤꯛ ꯀꯦꯌꯔ ꯑꯁꯤ ꯑꯈꯟꯅꯕꯥ ꯀꯦꯌꯔ ꯃꯈꯜ ꯑꯃꯅꯤ, ꯃꯁꯤꯅꯥ ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡꯕꯒꯤ ꯃꯊꯛꯇꯥ, ꯑꯅꯥꯕꯥ, ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ, ꯋꯥꯈꯜ ꯅꯨꯡꯉꯥꯏꯇꯕꯥ, ꯑꯃꯁꯨꯡ ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯑꯁꯤꯅꯆꯤꯡꯕꯥ ꯂꯥꯏꯑꯣꯡꯁꯤꯡ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯗꯨꯅꯥ ꯅꯍꯥꯛꯀꯤ ꯑꯅꯥꯕꯥ ꯑꯗꯨꯒꯥ ꯍꯦꯟꯅꯥ ꯅꯨꯡꯉꯥꯏꯅꯥ ꯍꯤꯡꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫ ꯃꯁꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯗꯥ ꯍꯪꯕꯤꯌꯨ꯫
ꯃꯇꯃꯒꯤ ꯃꯇꯨꯡ ꯏꯟꯅꯥ ꯀꯦꯟꯁꯔ ꯁꯦꯜ ꯈꯔꯗꯤ ꯇꯤ.ꯀꯦ.ꯑꯥꯏ.ꯒꯤ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤꯒꯤ ꯔꯦꯁꯤꯁ꯭ꯇꯦꯟꯇ ꯑꯣꯏꯔꯀꯄꯥ ꯌꯥꯏ ꯑꯃꯁꯨꯡ ꯂꯥꯌꯦꯡꯕꯗꯥ ꯔꯦꯁꯄꯣꯟꯁ ꯇꯧꯕꯥ ꯂꯦꯄꯈꯤ꯫ ꯃꯁꯤꯕꯨ ‘ꯗ꯭ꯔꯒ ꯔꯦꯁꯤꯁ꯭ꯇꯦꯟꯁ’ ꯍꯥꯌꯅꯥ ꯀꯧꯏ꯫ ꯑꯁꯤꯒꯨꯝꯕꯥ ꯃꯇꯃꯁꯤꯡ ꯑꯁꯤꯗꯥ, ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯅꯍꯥꯀꯄꯨ ꯇꯣꯉꯥꯅꯕꯥ TKI ꯗ꯭ꯔꯒ ꯑꯃꯗꯥ ꯅꯠꯠꯔꯒꯥ ꯇꯣꯉꯥꯅꯕꯥ ꯂꯥꯏꯌꯦꯡꯒꯤ ꯔꯦꯖꯤꯃꯦꯟꯗꯥ ꯍꯣꯡꯗꯣꯀꯄꯥ ꯌꯥꯏ꯫ ꯃꯔꯝ ꯑꯗꯨꯅꯥ ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯃꯇꯃꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯆꯥꯡ ꯅꯥꯏꯅꯥ ꯀꯟꯇꯦꯛꯇ ꯇꯧꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫
ꯇꯦꯛ-ꯍꯣꯝ ꯃꯦꯁꯦꯖ ꯇꯧꯕꯥ꯫
- ꯇꯥꯏꯔꯣꯁꯤꯟ ꯀꯤꯅꯥꯁ ꯏꯅꯍꯤꯕꯤꯇꯔꯁꯤꯡ (ꯇꯤ.ꯀꯦ.ꯑꯥꯏ.ꯁꯤꯡ) ꯑꯁꯤ ꯀꯦꯟꯁꯔ ꯁꯦꯂꯁꯤꯡꯒꯤ ꯆꯥꯎꯈꯠꯄꯗꯥ ꯌꯥꯑꯣꯔꯤꯕꯥ ꯁꯤꯒꯅꯦꯂꯤꯡ ꯁꯤꯁ꯭ꯇꯦꯃꯗꯥ ꯄꯥꯟꯗꯝ ꯊꯝꯂꯤꯕꯥ ꯑꯃꯁꯨꯡ ꯕ꯭ꯂꯣꯛ ꯇꯧꯕꯥ ꯑꯍꯣꯡꯕꯥ ꯗ꯭ꯔꯒꯁꯤꯡꯒꯤ ꯀ꯭ꯂꯥꯁ ꯑꯃꯅꯤ꯫
- ꯀꯦꯟꯁꯔ ꯃꯄꯨꯡ ꯐꯥꯅꯥ ꯐꯍꯅꯕꯒꯤ ꯃꯍꯨꯠꯇꯥ, ꯍꯥꯌꯔꯤꯕꯁꯤꯡ ꯑꯁꯤꯅꯥ ꯂꯥꯌꯅꯥ ꯑꯁꯤꯕꯨ ꯀꯟꯠꯔꯣꯜ ꯇꯧꯏ ꯑꯃꯁꯨꯡ ꯑꯅꯥꯕꯁꯤꯡꯕꯨ ꯍꯦꯟꯅꯥ ꯁꯥꯡꯕꯥ ꯑꯃꯁꯨꯡ ꯍꯦꯟꯅꯥ ꯐꯕꯥ ꯄꯨꯟꯁꯤ ꯃꯍꯤꯡ ꯑꯃꯥ ꯍꯤꯡꯕꯗꯥ ꯃꯇꯦꯡ ꯄꯥꯡꯏ꯫
- ꯃꯁꯤꯒꯤ ꯂꯥꯏꯌꯦꯡ ꯑꯁꯤ ꯑꯌꯥꯝꯕꯗꯤ ꯅꯨꯃꯤꯠ ꯈꯨꯗꯤꯡꯒꯤ ꯂꯧꯕꯥ ꯍꯤꯗꯥꯛ ꯑꯃꯥ ꯑꯣꯏꯅꯥ ꯄꯤꯕꯅꯤ, ꯑꯃꯁꯨꯡ ꯂꯥꯏꯌꯦꯡꯕꯒꯤ ꯊꯧꯔꯥꯡ ꯑꯁꯤ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯅꯥ ꯂꯦꯄꯊꯣꯀꯏ꯫
- ꯁꯥꯏꯗ ꯏꯐꯦꯛꯇꯁꯤꯡ ꯑꯁꯤ ꯑꯣꯏꯊꯣꯀꯄꯥ ꯌꯥꯏ ꯑꯃꯁꯨꯡ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯒꯤ ꯃꯤꯑꯣꯏ ꯑꯃꯗꯥ ꯈꯦꯠꯅꯩ꯫ ꯑꯁꯣꯛ-ꯑꯄꯟ ꯑꯃꯍꯦꯛꯇꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯅꯍꯥꯛꯀꯤ ꯗꯣꯛꯇꯔꯒꯥ ꯈꯨꯗꯛꯇꯥ ꯈꯟꯅ-ꯅꯩꯅꯕꯥ ꯍꯥꯌꯕꯁꯤ ꯌꯥꯝꯅꯥ ꯃꯔꯨꯑꯣꯏ꯫
- ꯇꯤ.ꯀꯦ.ꯑꯥꯏ.ꯒꯤ ꯗ꯭ꯔꯒꯁꯤꯡ ꯑꯁꯤ ꯀꯦꯟꯁꯔ ꯂꯥꯌꯦꯡꯕꯗꯥ ꯑꯆꯧꯕꯥ ꯑꯍꯣꯡꯕꯥ ꯑꯃꯥ ꯑꯣꯏꯔꯤ, ꯃꯁꯤꯅꯥ ꯑꯅꯥꯕꯥ ꯀꯌꯥꯗꯥ ꯑꯅꯧꯕꯥ ꯑꯥꯁꯥ ꯑꯃꯥ ꯄꯤꯔꯤ꯫
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