Dokotala wanu akakuuzani kuti muli ndi khansa, mumakhala ndi mafunso ambiri m'maganizo mwanu, sichoncho? Tamva za 'chemo' ndi 'radiation', koma dokotala wanu akhoza kukhala akulankhula za gulu latsopano la mankhwala otchedwa 'Angiogenesis Inhibitors'. Kodi mankhwala achilendowa amatchedwa chiyani? Kodi kwenikweni amagwira ntchito yanji? Musadandaule, tiyeni tikambirane mwachidule.
Choyamba, tiyeni tiwone, kodi zoletsa angiogenesis izi ndi ziti?
Mwachidule, uwu ndi mtundu wa mankhwala omwe amaletsa kukula kwa mitsempha yatsopano yamagazi, yomwe ndi mitsempha yamagazi yomwe imapereka zotupa. Mayina ena a izi ndi anti-angiogenics, anti-angiogenic agents, ndi anti-angiogenic therapy.
Taganizirani izi, kuti chilichonse chikule, chimafunika chakudya, zakudya, eti? Maselo a khansa ali choncho. Amafunikanso magazi odzaza ndi michere kuti akule ndikufalikira. Selo la khansa likakhala laling'ono, limapulumuka poyamwa magazi ena kuchokera ku minofu yathanzi yozungulira. Koma selo likakula kufika pa mamilimita 1-2, liyenera kupanga njira yakeyake yatsopano ya mitsempha yamagazi. Kupanda kutero, silingakulire.
Apa ndi pomwe mankhwala otchedwa Angiogenesis Inhibitors amalowa. Mankhwalawa amagwira ntchito poletsa njira yomwe maselo a khansa amapangira mitsempha yatsopano yamagazi. Zili ngati kudula madzi opita ku mtengo. Izi zimachedwetsa kukula kwa khansa, ndipo nthawi zina chotupacho chimatha kuchepa. Chithandizochi sichingachiritse khansa kwathunthu, koma chingathe kulamulira kukula kwa chotupacho ndikukulolani kukhala ndi okondedwa anu kwa nthawi yayitali.
Kodi mankhwalawa amagwira ntchito bwanji m'thupi?
Mankhwalawa amasokoneza njira yotchedwa angiogenesis . Iyi ndi njira yachibadwa m'matupi athu. Tangoganizirani ngati mutadula dzanja lanu, mitsempha yatsopano yamagazi iyenera kukula kuti ichiritse bala ndikubweretsa magazi kudera limenelo. Zimenezo zimatchedwa angiogenesis. Maselo ovulalawo amatumiza chizindikiro, monga "Tithandizeni!" Chizindikirochi chimapangitsa mitsempha yatsopano yamagazi kukula.
Koma vuto ndilakuti, maselo a khansa amagwiritsanso ntchito njira yomweyi kuti apindule. Maselo a khansa amatumizanso zizindikiro zofanana ndi kukulitsa mitsempha yatsopano yamagazi. Mitsempha yamagazi iyi ndi yomwe imapatsa chotupacho michere yomwe chimafunikira, zomwe zimapangitsa kuti chikule ndikufalikira ku ziwalo zina za thupi.
Angiogenesis Inhibitors amagwira ntchito posokoneza njira yolumikizirana iyi kuchokera ku khansa. Mankhwala ambiriwa amagwira ntchito poletsa puloteni yotchedwa vascular endothelial growth factor (VEGF) . Ganizirani za VEGF ngati chizindikiro chachikulu "chothandizira" chomwe chimatulutsidwa ndi maselo a khansa. Chizindikiro cha VEGF ichi chikalumikizana ndi ma receptor a VEGF pamaselo a khansa, mitsempha yatsopano yamagazi imayamba kupanga.
Tsopano tiyeni tiwone momwe mankhwalawa amaletsera chizindikiro ichi.
- Kuletsa chizindikiro cha VEGF kuti chisamamatire ku cholandirira: Mankhwala ena (monga ma antibodies a monoclonal monga Bevacizumab (Avastin®) amapita mwachindunji ku puloteni ya VEGF ndikuyimangirira. Kenako singathe kupita ku cholandiriracho ndikuyimangirira. Zili ngati kuletsa kalata isanafike kwa wolandirayo.
- Kuletsa zizindikiro kuchokera ku ma receptor a VEGF: Mankhwala ena (monga, ma inhibitors a tyrosine kinase monga sorafenib (Nexavar®) ndi sunitinib (Sutent®)) amaletsa receptor kutumiza uthengawo, ngakhale italandira chizindikirocho.
- Kuletsa machitidwe ena olumikizirana: Mankhwala ena (monga, ma immunomodulators monga thalidomide ndi lenalidomide (Revlimid®)) amasokoneza machitidwe ena olumikizirana omwe amagwira ntchito mu njirayi.
Kodi mankhwalawa amagwiritsidwa ntchito pa mitundu iti ya khansa?
Madokotala nthawi zambiri amapereka mankhwala oletsa angiogenesis awa kwa khansa yowonjezereka kapena yobwerezabwereza . Mitundu ina ya khansa yomwe chithandizochi chikulangizidwa ndi iyi:
- Khansa ya muubongo
- Khansa ya m'mawere
- Khansa ya pachibelekero
- Khansa ya m'matumbo
- Khansa ya m'chubu cha fallopian
- Khansa ya impso
- Khansa ya chiwindi
- Khansa ya m'mapapo
- Lymphoma
- Myeloma yambiri
- Khansa ya kapamba
- Khansa ya m'mimba
- Khansa ya m'mimba
- Khansa ya chithokomiro
- Khansa ya m'mimba/endometrial
Kuphatikiza apo, mankhwala awa (VEGF inhibitors) amagwiritsidwanso ntchito pochiza matenda ena a maso omwe mitsempha yamagazi imakula modabwitsa m'diso.
Kodi chimachitika ndi chiyani panthawi ya chithandizo?
Madokotala nthawi zambiri sapereka mankhwalawa okha. Nthawi zambiri amaperekedwa pamodzi ndi mankhwala ena a khansa, monga chithandizo cha immunotherapy ndi chemotherapy .
Taganizirani ngati nkhondo. Mankhwala oletsa angiogenesis amadula chakudya ndi zipolopolo (magazi) zomwe mdani (khansa) amapeza. Mankhwala ena (monga chemotherapy) amapita mwachindunji kwa mdani (maselo a khansa) ndikuwaukira. Njira ziwirizi zikagwira ntchito limodzi, zotsatira zake zimakhala zopambana kwambiri.
Kutengera mtundu wa mankhwala omwe mwapatsidwa, mungafunike kumwa ngati piritsi kamodzi kapena kawiri patsiku, kapena mungafunike kumwa ngati IV (monga saline ) mumtsempha nthawi zonse.
Kodi chithandizochi chimatenga nthawi yayitali bwanji?
Kutalika kwa chithandizo chanu kumadalira zinthu zambiri, kuphatikizapo mtundu wa mankhwala omwe mwapatsidwa komanso mtundu wa khansa yomwe muli nayo. Anthu ambiri amapitiriza kumwa mankhwalawa bola ngati akugwira ntchito. Nthawi zina, chithandizo chingaimitsidwe ngati zotsatira zake zimakhala zovuta kwambiri kuzipirira. Dokotala wanu adzakambirana nanu za ubwino ndi zotsatirapo za chithandizocho ndikupanga chisankho chabwino kwambiri.
Kodi zotsatirapo zake ndi zoopsa zake ndi ziti?
Monga mankhwala ena aliwonse, mankhwala awa akhoza kukhala ndi zotsatirapo zoyipa komanso zoopsa. Zambiri mwa izi ndi mavuto a kutuluka magazi (kutuluka magazi) ndi kutseka magazi. Nthawi zina, zotsatirapo zoyipazi zimatha kukhala zoopsa kwa moyo. Chifukwa chake ndikofunikira kudziwa izi.
Dokotala wanu nthawi zonse amawunika thanzi lanu kuti achepetse zoopsa izi.
| Zotsatirapo/zoopsa zomwe zingatheke | Kufotokozera kosavuta |
|---|---|
| Kuthamanga kwa magazi | Kuthamanga kwa magazi. Izi ziyenera kufufuzidwa ndi kulamulidwa nthawi zonse. |
| Kutuluka magazi mkati | Kutuluka magazi m'thupi. |
| Kuchira pang'onopang'ono kwa bala | Chifukwa chakuti zimasokoneza mapangidwe a mitsempha yatsopano yamagazi, zimatha kuwonjezera nthawi yomwe mabala amachira. |
| Kuboola kwa m'mimba | Kawirikawiri, pamakhala chiopsezo cha kubooka kwa m'mimba kapena matumbo. |
| Kuchepa kwa ntchito ya chithokomiro | Kuchepetsa liwiro la chithokomiro, chomwe chimayang'anira mahomoni a thupi. |
| Kuwonongeka kwa chiwindi | Nthawi zina ntchito ya chiwindi ingakhudzidwe. |
| Magazi amaundana | Pali chiopsezo cha magazi kuundana m'mitsempha yamagazi. Izi zingayambitse matenda monga matenda a mtima kapena sitiroko. |
Chofunika kwambiri chomwe mungachite ndikumvetsetsa zotsatirapo zake ndi zoopsa zake musanayambe kulandira chithandizo. Mukadziwa zomwe mungayembekezere, mutha kudziwa bwino za kusintha kwa thupi lanu. Ngati muwona china chake chachilendo, dziwitsani dokotala wanu nthawi yomweyo. Kenako angakuphunzitseni momwe mungathanirane ndi zotsatirapo zake kapena kusintha mlingo wa mankhwala anu.
Kodi pali zinthu zomwe zingalepheretse izi mwachibadwa?
Funso limene anthu ambiri amafunsa ndi ili. Zakudya zina zimakhala ndi mankhwala omwe amaletsa zizindikiro zina zomwe zimakhudzidwa ndi angiogenesis. Zakudya zambirizi zimapezeka mu zakudya za ku Mediterranean. Mwachitsanzo:
- Katsitsumzukwa
- Muzu wa dandelion
- Tiyi wobiriwira
- Mafuta a azitona
- Mtedza
- Vinyo wofiyira
- Mphesa zofiyira
Ofufuza zamankhwala akuyesera kugwiritsa ntchito mankhwala amenewa popanga mankhwala atsopano, koma kafukufuku ameneyu akadali pachiyambi.
Koma chofunika kwambiri kukumbukira apa ndichakuti zakudya izi sizingalowe m'malo mwa mankhwala a khansa. Mwanjira ina, kudya mphesa zofiira zambiri ndi kumwa tiyi wobiriwira sikungalepheretse khansa kupangika. Limenelo ndi lingaliro lolakwika kotheratu.
Komabe, kudya zakudya zopatsa thanzi n'kofunika kwambiri kuti thupi lanu likhale lamphamvu. Ndikofunikira kupereka zakudya zabwino kwa thupi lanu panthawi ya chithandizo cha khansa komanso pambuyo pake.
Kodi ndi liti pamene muyenera kulankhula ndi dokotala?
Ngati mukukumana ndi zizindikiro zosayembekezereka panthawi ya chithandizo, funsani dokotala nthawi yomweyo.
Makamaka ngati mukuona zizindikiro za matenda omwe angakupheni, monga matenda a mtima kapena sitiroko, pitani ku Dipatimenti Yothandiza Anthu Odwala Mwadzidzidzi (ETU) nthawi yomweyo.
Mankhwala oletsa angiogenesis ndi mankhwala ofunikira kwambiri omwe amalepheretsa maselo a khansa kuti azitha kuchira thupi lathu. Sangachiritse khansa kwathunthu, koma angathandize kuchepetsa kufalikira kwake ndikukupatsani nthawi yochulukirapo yoti mukhale ndi moyo. Ngati dokotala wanu akulangizani mankhwalawa, onetsetsani kuti mwalankhula ndi dokotala wanu za udindo wake pa dongosolo lanu lonse la chithandizo.
Uthenga Wopita Nawo Kunyumba
- Angiogenesis Inhibitors ndi mtundu wa mankhwala omwe amaletsa kupangika kwa mitsempha yatsopano yamagazi yomwe imapatsa maselo a khansa magazi. Izi zimalepheretsa maselo a khansa kupeza michere yomwe amafunikira komanso kuwongolera kukula kwawo.
- Ngakhale izi sizichiritsa khansa yonse, zimatha kuletsa kufalikira kwa matendawa ndikukhalitsa moyo wautali.
- Chithandizochi nthawi zambiri chimaperekedwa pamodzi ndi mankhwala ena, monga chemotherapy.
- Ndikofunikira kudziwa zotsatirapo zake monga kuthamanga kwa magazi, magazi kuundana, komanso kuchedwa kuchira kwa bala, komanso kudziwitsa dokotala wanu ngati mukukumana ndi vuto lililonse.
- Ngakhale zakudya zina zachilengedwe zili ndi zinthu zomwe zimasokoneza njirayi, siziyenera kugwiritsidwa ntchito m'malo mwa chithandizo chamankhwala.
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