Kodi thupi lanu limatuluka madzi ngati amenewa? Tiyeni tikambirane za Capillary Leak Syndrome!

Kodi mudamvapo za Capillary Leak Syndrome? Dzinali lingamveke ngati lovuta pang'ono. Koma mwachidule, ndi vuto lomwe gawo lamadzimadzi la magazi, lotchedwa plasma, limatuluka m'mitsempha yaying'ono yamagazi m'matupi athu, lotchedwa capillaries. Madzi awa amatuluka m'minofu yathu, minofu, ziwalo, ndi m'mabowo a thupi. Imeneyi ikhoza kukhala vuto lalikulu, choncho ndikofunikira kudziwa za vutoli.

Kodi vuto lotchedwa capillary leak syndrome ndi chiyani?

Chabwino, tiyeni tifotokoze pang'ono. Tangoganizani kuti thupi lanu lili ndi njira ya mapaipi amadzi. Mapaipi awa ndi mitsempha yathu yamagazi. Mapaipi ang'onoang'ono komanso abwino kwambiri omwe ali mu izi amatchedwa ma capillaries. Awa ndi machubu omwe mpweya ndi michere zimadutsamo kupita ku ziwalo zonse za thupi lathu. Chifukwa chake, mu `(Capillary Leak Syndrome)`, gawo lamadzimadzi la magazi, ndiko kuti , plasma , limatuluka kudzera m'mapaipi ang'onoang'ono awa. Zili ngati madzi akutuluka mupaipi yamadzi.

Kutuluka kwa madzi kumeneku kumapangitsa kuti madzi azisonkhana m'malo osiyanasiyana a thupi. Mwachitsanzo, madzi amenewa amatha kulowa m'minofu, m'minofu, m'ziwalo zosiyanasiyana, kapena m'malo (m'mabowo a thupi) kumene ziwalo zimakhala.

Zochitika za `(Capillary Leak Syndrome)` izi zitha kuchitika kangapo pachaka, kapena kamodzi kokha m'moyo. Komabe, ngati sizichiritsidwa mwachangu, kuthamanga kwa magazi kumatha kutsika mwadzidzidzi, zomwe zimapangitsa kuti ziwalo zilephere kugwira ntchito komanso nthawi zina imfa. Choncho ichi si chinthu chopepuka.

Palibe mankhwala ochiritsira matendawa pakadali pano. Komabe, ndikofunikira kupeza chithandizo chamankhwala mwachangu kuti muchepetse zizindikiro. Nthawi zina, n'zotheka kupewa matenda ena mtsogolo mwa kupitiriza kugwiritsa ntchito mankhwala kapena kulandira mankhwala amchere.

Kodi pali mitundu ina ya izi? Kodi zimasiyana bwanji?

Inde, pali mitundu iwiri ikuluikulu ya `(Capillary Leak Syndrome)`. Tiyeni tiwone zomwe zili.

• Matenda Oyambitsa Kutuluka kwa Magazi a Capillary: Amatchedwanso ``Primary Capillary Leak Syndrome'' kapena ``Clarkson's disease'', uwu ndi mkhalidwe womwe kuukira kumachitika mobwerezabwereza , ngakhale mwa munthu wathanzi.
• Matenda a Secondary Capillary Leak Syndrome: Apa ndi pamene kuukira kumachitika kamodzi chifukwa cha matenda ena, vuto lina, kapena mankhwala.

Mwachidule, chimodzi ndi chinthu chomwe chingachitike mosalekeza, ndipo china ndi chinthu chomwe chimachitika kwakanthawi pazifukwa zina.

Ndani amene ali ndi mwayi waukulu wopeza vutoli?

"Systemic Capillary Leak Syndrome" ndi matenda osowa kwambiri.Anthu osakwana 500 padziko lonse lapansi akuti ali ndi vutoli. Limapezeka kwambiri mwa anthu azaka zapakati. Silipezeka kawirikawiri mwa ana aang'ono. Komabe, chifukwa anthu omwe ali ndi vutoli nthawi zina amadziwidwa molakwika kuti ali ndi vuto lina, chiwerengero chenicheni cha anthu omwe ali ndi vutoli chikhoza kukhala chokwera kwambiri.

Komabe, Secondary Capillary Leak Syndrome imatha kuchitika pa msinkhu uliwonse. Matenda ena, matenda, ndi mankhwala angayambitse vutoli.

Kodi chimachitika ndi chiyani m'thupi pamene izi zachitika? (Magawo atatu)

Zomwe zimachitika m'thupi lathu panthawi ya kuukira kwa `(Capillary Leak Syndrome)` zitha kugawidwa m'magawo atatu. Tiyeni tiwone zomwe zili.

Gawo loyamba: Zizindikiro zisanawonekere (gawo la Prodromal)

Iyi ndi nthawi yomwe munthu amadwala tsiku limodzi kapena awiri asanamwalire. Panthawiyi, mungayambe kuona zizindikiro zina.

• Kumva kutopa
• Ludzu lochuluka la madzi
• Zinthu monga kunenepa mwadzidzidzi zimatha kuchitika.

Gawo lachiwiri: Gawo lotulutsa madzi kapena kubwezeretsanso mphamvu ya thupi

Apa ndi pamene kuukira kumachitikadi. Chomwe chimachitika ndichakuti madzi ndi albumin (mtundu wa mapuloteni m'magazi) zimatuluka m'mitsempha yanu yamagazi kupita m'malo omwe ali pakati pa minofu yanu. Izi zimachepetsa kuchuluka kwa magazi omwe amanyamula mpweya. Kuthamanga kwa magazi kumatsika, ndipo maselo ofiira amagazi amasonkhana pamodzi, zomwe zimapangitsa magazi anu kukhala okhuthala. Kutuluka kwa madzi kumeneku kumapangitsa kuti magazi azichepa, komwe kumatchedwa hypovolemia .

Gawo lachitatu: Pambuyo pa kuukira `(Gawo lotuluka kapena gawo lolemba anthu ntchito)`

Iyi ndi nthawi yomwe kuukirako kutha. Chomwe chimachitika ndichakuti mitsempha yanu yamagazi imayamba kuyamwa madzi ndi albumin kuchokera m'maselo kachiwiri. Komabe, panthawiyi, thupi lanu limatha kusonkhanitsa madzi ambiri (madzi ochulukirapo) . Zotsatira zake, thupi lanu limatha kupanga mkodzo wochuluka (polyuria) ndipo mapapu anu amatha kudzaza ndi madzi (pulmonary edema).

Taganizirani izi, zili ngati siponji yomwe imayamwa madzi. Choyamba, madziwo amatuluka m'thupi, kenako akayamwanso mofulumira kwambiri, amayamwa madzi ambiri kuposa momwe ayenera kukhalira.

Kodi n’chiyani chimayambitsa izi?

Tiyeni tsopano tiwone zomwe zingayambitse `(Capillary Leak Syndrome)`.

Zifukwa za `(Systemic Capillary Leak Syndrome)`

Kunena zoona, chomwe chimayambitsa matenda a Systemic Capillary Leak Syndrome sichikudziwikabe. Ofufuza amakhulupirira kuti mwina izi zimachitika chifukwa cha momwe chitetezo cha mthupi lathu chimayankhira matenda enaake kapena matenda enaake.

Zifukwa za `(Secondary Capillary Leak Syndrome)`

Pali zifukwa zingapo zomwe zimayambitsa izi. Choyambitsa chofala kwambiri ndi matenda otchedwa sepsis . Izi zikutanthauza kuti, vuto lomwe lingayambitse imfa chifukwa cha matenda. Kuphatikiza apo, palinso zifukwa zina:

• Matenda a autoimmune:Chomwe chimachitika pamenepa ndichakuti chitetezo chathu cha mthupi chimaukira maselo athu athanzi.
• Matenda a kusiyana kwa maselo a khansa: Vuto lomwe lingachitike panthawi ya chithandizo cha mitundu ina ya khansa ya m'magazi (acute promyelocytic leukemia kapena acute myeloid leukemia).
• Matenda a Engraftment: Vuto lomwe lingachitike mutasintha mafupa.
• Hemophagocytic lymphohistiocytosis: Matenda omwe angawononge moyo chifukwa cha chitetezo chamthupi chomwe chimagwira ntchito mopitirira muyeso.
• Matenda a ovarian hyperstimulation: Vuto lomwe lingachitike panthawi ya chithandizo cha kubereka.
• Kupha poizoni wa ricin.
• Kulumidwa ndi njoka.
• Matenda opatsirana chifukwa cha kutuluka magazi m'thupi: Gulu la matenda opatsirana omwe amayamba chifukwa cha mavairasi.

Mankhwala ena, monga mankhwala oletsa khansa otchedwa gemcitabine (gemcitabine - Gemzar®) ndi tagraxofusp (tagraxofusp - Elzonris®) , angayambitsenso izi (Secondary Capillary Leak Syndrome).

Kodi zizindikiro zomwe matendawa amayamba ndi ziti?

Kawirikawiri, tsiku limodzi kapena awiri musanayambe kuukira kwa ``Capillary Leak Syndrome'', kutanthauza kuti, panthawi ya ``prodromal phase'', mutha kuwona zizindikiro monga:

• Kupweteka m'mimba kapena kupweteka kwa minofu (myalgia).
• Kutopa kwambiri kapena kufooka.
• Mutu .
• Kuwonjezeka kwa ludzu la madzi.
• Kukwiya msanga, kukwiya msanga.
• Kusanza.
• Kulemera kwadzidzidzi.
• Zizindikiro za matenda opatsirana ndi mavairasi kapena matenda opatsirana m'njira ya kupuma.

Ngati mukuona zizindikiro ngati izi, musatenge mopepuka, ponena kuti, "O, mwina ndi chimfine chabe," makamaka ngati munakumanapo ndi zomwezi kale.

Ndi zizindikiro ziti zomwe zimachitika mukakhala ndi matenda?

Pa nthawi ya kuukira kwa `(Capillary Leak Syndrome)`, kutanthauza kuti, panthawi ya `(kutuluka kapena kutsitsimutsa thupi)`, zizindikiro zimatha kusiyana pakati pa munthu ndi munthu. Komabe, zotsatirazi ndi zizindikiro zodziwika bwino zomwe zingawonekere:

• Kutupa, makamaka m'miyendo (peripheral edema).
• Kutsegula m'mimba.
• Kuthamanga kwa magazi pang'ono (hypotension).
• Kuundana kwa magazi (hypercoagulability) - Izi zitha kuchitika chifukwa cha kuchuluka kwa maselo ofiira a magazi (hematocrit) kapena kuchuluka kwa maselo oyera a magazi (leukocytosis).

Kodi madokotala amazindikira bwanji izi?

Dokotala adzazindikira matenda a Capillary Leak Syndrome mwa kufunsa za mbiri yanu yachipatala ndikukupimani thupi. Adzafufuza ngati kuthamanga kwa magazi anu kuli kotsika.

Komanso, asanatsimikizire kuti iyi ndi Capillary Leak Syndrome, matenda ena ayenera kuchotsedwa. Angayese magazi angapo kuti achite izi:

• Yang'anani kuchuluka kwa maselo ofiira m'magazi ( hematocrit ).
• Yesani kuona ngati hemoglobin ili ndi kuchuluka kwa magazi (puloteni yomwe imapezeka m'maselo ofiira a magazi).
• Yang'anani ngati mapuloteni ali otsika m'magazi (hypoalbuminemia).

Kuphatikiza apo, kuyezetsa magazi kungachitike kuti aone ngati pali puloteni yosadziwika bwino ya chitetezo chamthupi yotchedwa ``monoclonal gammopathy, kapena puloteni ya M'' m'magazi. Anthu omwe ali ndi ``Capillary Leak Syndrome'' akhoza kukhala ndi ``puloteni ya M'' yosadziwika bwino m'magazi mwawo.

Kodi chimachiritsidwa bwanji? Kodi chingachiritsidwe?

Mwatsoka, palibe mankhwala ochiritsira matenda a Capillary Leak Syndrome. Madokotala amayesetsa kuwongolera zizindikiro ndikuletsa mavuto.

Pa nthawi ya matenda a ``Capillary Leak Syndrome'', madokotala amayesetsa kulamulira kuthamanga kwa magazi ndikusunga magazi oyenda bwino m'ziwalo. Amayesetsanso kupewa kutupa kwambiri ndi madzimadzi ochulukirapo. Angagwiritse ntchito:

• Glucocorticoids: Izi ndi mtundu wa steroid womwe umathandiza kuchepetsa kutuluka kwa madzi kuchokera m'mitsempha yamagazi.
• Madzi olowetsedwa m'mitsempha: Zinthu monga saline zimaperekedwa kuti ziwonjezere kuyenda kwa magazi kupita ku ziwalo monga impso.

Nthawi zambiri mumafunika kugonekedwa kuchipatala mutadwala. Pa nthawi ya chithandizo, dokotala wanu apitiliza kuyang'anira kuthamanga kwa magazi ndi kuthamanga kwa magazi kuti atsimikizire kuti mulibe madzi ambiri m'thupi lanu, zomwe zingayambitse mavuto ena, monga kutupa kwa mapapo ndi kulephera kwa mtima mwadzidzidzi.

Pambuyo pa kuukira kwa Capillary Leak Syndrome, yomwe imadziwika kuti post-leak phase kapena recruitment phase, dokotala angakulembereni mankhwala ochepetsa mphamvu ya mkodzo (mankhwala omwe amakupangitsani kupanga mkodzo wambiri) kuti muchepetse kuchuluka kwa madzi owonjezera m'thupi lanu.

Kodi Systemic Capillary Leak Syndrome (SCLS) ingalepheretsedwe kubwereranso?

Simungathe kuletsa Systemic Capillary Leak Syndrome kuti isachitike poyamba. Koma, mukangokumana ndi vuto, mumadziwa kuti muli ndi vutoli.

Komabe, kumwa mankhwala nthawi zonse kapena kulandira mankhwala amchere kungathandize kupewa matenda ena mtsogolo ndikuchepetsa kuopsa kwake. Mankhwalawa angaphatikizepo:

• Kulandira jekeseni ya immunoglobulin (IVIG) pamwezi .
• Mankhwala omwa a mphumu, monga theophylline (theophylline - Elixophyllin®), terbutaline (terbutaline - Brethine®), ndi montelukast (montelukast - Singulair®) .
• Chepetsani kutupaMa steroid.

Kodi tsogolo la anthu omwe ali ndi vutoli ndi lotani? `(Outlook)`

Matenda a Capillary Leak Syndrome nthawi zambiri amatha kuthandizidwa ndi mankhwala oletsa kufalikira kwa matendawa. Chithandizo chimakhala chothandiza kwambiri ngati matendawa apezeka msanga ndipo mavuto ake ndi ochepa. Mavuto ena akuluakulu omwe angachitike ndi matenda a Capillary Leak Syndrome ndi awa:

• Matenda a chipinda: Kupanikizika kwambiri mkati mwa minofu ndi kuchepa kwa magazi.
• Kuchulukana kwa madzi m'thupi mozungulira mtima ndi mapapo (mtima tamponade, pericardial effusion, ndi pleural effusion).
• Kulephera kwa mtima.
• Kulephera kwa impso.
• Matenda a mitsempha.
• Kutupa kwa mapapo.
• Rhabdomyolysis: Kulephera kwa impso chifukwa cha kuwonongeka kwa minofu.
• Stroke.

Izi zitha kumveka zoopsa, koma monga tanenera kale, chithandizo chachangu komanso chisamaliro choyenera ndizofunikira kwambiri.

Kodi ndiyenera kupita kwa dokotala liti?

Ngati mukuganiza kuti muli ndi vuto la Capillary Leak Syndrome, pitani kwa dokotala nthawi yomweyo. Angakuthandizeni kuthana ndi zizindikiro zanu ndikukupatsani mpumulo.

Kumbukirani, ngakhale kuti vutoli ndi losowa, ndikofunikira kudziwa zizindikiro zake ndikupempha upangiri wa dokotala mwachangu ngati mukukayikira.

Uthenga Wopita Nawo Kunyumba

Chabwino, tiyeni tikambirane mfundo zofunika kwambiri zokhudza `(Capillary Leak Syndrome)` zomwe tinakambirana:

• Apa ndi pamene gawo lamadzimadzi la magazi (plasma) limatuluka m'mitsempha yaying'ono yamagazi (ma capillaries) m'thupi lathu.
• Izi zitha kuchitika kamodzi kapena mobwerezabwereza.
• Ngati sichinachiritsidwe, mavuto aakulu angachitike, choncho chithandizo chamankhwala mwachangu n'chofunika.
• Ngakhale kuti palibe mankhwala ochiritsira matenda, pali mankhwala oletsa zizindikiro ndi kupewa matenda ena mtsogolo.
• Ngati mukukayikira zizindikiro zilizonsezi, pitani kwa dokotala nthawi yomweyo. Mukazindikira matendawa mwachangu ndikuyamba kulandira chithandizo, mwayi wanu wochira umakhala wabwino.

Kotero, ndikukhulupirira kuti izi zikuthandizani. Khalani ndi thanzi labwino!

Matenda a Capillary Leak, Kutuluka kwa Plasma, Kuthamanga kwa Magazi Kochepa, Matenda a Clarkson, Edema, Kutuluka kwa Madzi M'thupi