Mwina munamvapo za " Cortisol " ( Cortisol ), makamaka pokambirana za " stress ." Komabe, cortisol si 'stress hormone' chabe. Ndipotu, ndi hormone yofunika kwambiri yomwe imagwira ntchito yofunika kwambiri m'thupi lanu. Ku Nirogi Lanka, tiyeni tiwone bwino lomwe kuti cortisol ndi chiyani komanso momwe imagwirira ntchito kwa inu.
Kodi Cortisol ndi chiyani? Kodi ndi 'hormone yovutitsa maganizo' chabe?
Mwachidule, cortisol ndi mahomoni opangidwa ndi ma adrenal glands anu ( ma adrenal glands )—ma glands ang'onoang'ono omwe ali pamwamba pa impso zanu zonse. Ndi mtundu wa glucocorticoid , womwe uli m'gulu la mahomoni otchedwa steroid hormones .
Inde, monga momwe mungaganizire, cortisol imagwirizana kwambiri ndi kupsinjika maganizo. Kaya mukukumana ndi kupsinjika mwadzidzidzi, kupsinjika kosatha , kapena kupsinjika maganizo pambuyo pa chochitika choopsa , thupi lanu limatulutsa cortisol. Ichi ndichifukwa chake imadziwika kuti "hormone ya kupsinjika maganizo."
Komabe, kumbukirani: Ntchito ya Cortisol si yokhudza kupsinjika kokha. Homoni iyi imagwira ntchito zina zofunika kwambiri m'thupi lanu.
Kodi cortisol imakhudza bwanji thupi lanu?
Cortisol imakhudza pafupifupi chiwalo chilichonse m'thupi lanu, ndipo imayang'anira ntchito zingapo zofunika. Tiyeni tiwone zomwezo.
Kuwongolera momwe mumayankhira kupsinjika maganizo
Mukayamba kuopsezedwa kapena kuchita mantha, thupi lanu nthawi yomweyo limalowa mu mkhalidwe wa "nkhondo kapena kuthawa". Mahomoni monga adrenaline amatulutsidwa kaye, kenako cortisol kuti mukhale maso. Kuphatikiza apo, cortisol imathandiza chiwindi chanu kutulutsa shuga, zomwe zimakupatsirani mphamvu zomwe mukufuna nthawi yomweyo.
Kagayidwe kachakudya ndi kuchuluka kwa shuga m'magazi
Kagayidwe kachakudya ndi njira yomwe thupi lanu limagwiritsa ntchito popanga mphamvu pa moyo watsiku ndi tsiku. Cortisol imayang'anira izi mwa kuyang'anira momwe thupi lanu limagwiritsira ntchito shuga.
Mwachitsanzo:
- Imalumikizana ndi kapamba wanu kuti ichepetse kupanga insulin ndikuwonjezera kupanga glucagon. Ngakhale kuti insulin imachepetsa shuga m'magazi, glucagon imagwira ntchito yokweza shuga.
- Imawongoleranso momwe shuga imagwiritsidwira ntchito ndi minofu yanu yamafuta, chiwindi, ndi minofu.
Kuletsa kutupa
M'kupita kwa nthawi, cortisol imatha kukulitsa kuchuluka kwa shuga m'magazi anu.chitetezo chamthupi mwa kuchepetsa kutupa (kutupa kapena kufiira). Komabe, ngati kuchuluka kwa cortisol m'thupi lanu kukukwera kwa nthawi yayitali, thupi lanu likhoza kuzolowera, zomwe zingayambitse zotsatira zosiyana: kutupa kwambiri ndi kufooka kwa chitetezo chamthupi .
Kuwongolera kuthamanga kwa magazi
Ngakhale kuti njira yeniyeniyo ndi yovuta, kafukufuku akuwonetsa kuti kuchuluka kwa cortisol kochuluka nthawi zonse kungayambitse kuthamanga kwa magazi, pomwe kuchepa kwambiri kungayambitse kuthamanga kwa magazi.
Kuthandiza kulamulira nthawi yogona ndi kudzuka
Kawirikawiri, kuchuluka kwa cortisol m'thupi lanu kumakhala kotsika kwambiri usiku ndipo kumafika pachimake mukangodzuka. Izi zikusonyeza kuti cortisol imagwira ntchito yofunika kwambiri mu kayendedwe ka thupi lanu la circadian , kapena nthawi yanu yachibadwa yogona ndi kudzuka.
Kodi thupi lanu limalamulira bwanji kuchuluka kwa cortisol?
Thupi lanu lili ndi njira yotsogola yowongolera kuchuluka kwa cortisol, makamaka yolamulidwa ndi hypothalamus ndi pituitary gland muubongo wanu. Zigawo ziwirizi zimawongolera kupanga kwa cortisol ndi adrenal glands yanu.
Umu ndi momwe njirayi imagwirira ntchito:
- Pamene kuchuluka kwa cortisol m'magazi mwanu kumatsika, hypothalamus yanu imatulutsa CRH (corticotropin-releasing hormone) .
- CRH iyi imasonyeza kuti pituitary gland yanu imapanga ACTH (adrenocorticotropic hormone) .
- Kenako ACTH imalimbikitsa ma adrenal glands anu kuti apange cortisol ndikuyitulutsa m'magazi anu.
Kuti mukhale ndi cortisol yokwanira bwino, hypothalamus yanu, pituitary gland, ndi adrenal glands zonse ziyenera kugwira ntchito mogwirizana. Ngati mukukumana ndi zizindikiro zoopsa, chonde funsani ogwira ntchito zadzidzidzi kapena kuchipatala chapafupi nthawi yomweyo.
Kodi chimachitika ndi chiyani ngati kuchuluka kwa cortisol m'magazi anu kuli kokwera kwambiri?
Thupi lanu likamakhala ndi cortisol yambiri kwa nthawi yayitali, limayambitsa matenda otchedwa hypercortisolism . Izi nthawi zambiri zimagwirizanitsidwa ndi matenda otchedwa Cushing's syndrome .
Kodi n’chiyani chimayambitsa kuchuluka kwa cortisol m’thupi?
- Mankhwala a Corticosteroid: Kugwiritsa ntchito mlingo waukulu kwa nthawi yayitali (monga prednisone, prednisolone, dexamethasone).
- Zotupa zomwe zimatulutsa ACTH: Izi nthawi zambiri zimayamba mu pituitary gland.
- Zilonda za adrenal: Zomera zomwe zimapezeka pa adrenal glands zomwe zimapangitsa kuti cortisol ikhale yambiri.
Zizindikiro za cortisol yokwera
Ngati muli ndi cortisol yokwera kapena matenda a Cushing, mungazindikire zizindikiro zotsatirazi:
- Kunenepa: Makamaka kuzungulira nkhope yanu ndi pakati pa msambo.
- Mafuta ochulukirapo: Amakula pakati pa mapewa anu, nthawi zambiri amatchedwa "buffalo hump."
- Kusintha kwa khungu:Madontho otambalala ofiirira pamimba panu.
- Kufooka kwa minofu: Makamaka m'manja ndi m'ntchafu zanu zakumtunda (zomwe zimagwirizanitsidwa ndi kufooka kwa minofu ).
- Shuga wambiri m'magazi: Nthawi zambiri amapita ku matenda a shuga amtundu wachiwiri.
- Kuthamanga kwa magazi: Kuthamanga kwa magazi kwambiri.
- Hirsutism: Kukula kwambiri kwa tsitsi m'thupi mwa akazi.
- Kuchepa kwa mafupa: Matenda a mafupa, omwe amawonjezera kwambiri chiopsezo chanu cha kusweka kwa mafupa.
Kodi chimachitika ndi chiyani ngati kuchuluka kwa cortisol m'magazi anu kuli kochepa kwambiri?
Pamene kuchuluka kwa cortisol m'magazi kumatsika pansi pa mulingo woyenera, madokotala amatcha izi kuti hypocortisolism kapena adrenal insufficiency . Pali mitundu iwiri ikuluikulu.
Kodi n’chiyani chimayambitsa kuchepa kwa cortisol m’thupi?
- Kulephera kwa adrenal cortex koyamba: Nthawi zambiri kumachitika pamene chitetezo cha mthupi chanu chikuukira adrenal glands; izi zimadziwika kuti matenda a Addison .
- Kulephera kwa adrenal kwachiwiri: Kumachitika chifukwa cha kulephera kugwira ntchito kwa pituitary (hypopituitarism) kapena chotupa cha pituitary.
Zizindikiro za cortisol yotsika
Ngati kuchuluka kwa cortisol m'magazi anu kuli kotsika, mutha kukhala ndi zotsatirazi:
- Kutopa kosatha: Kumva kutopa kosatha.
- Kuchepetsa thupi kosamveka bwino.
- Kusowa chilakolako.
- Kuthamanga kwa magazi pang'ono (hypotension).
Kodi mungatani kuti muchepetse kuchuluka kwa cortisol m'magazi anu?
Ngati muli ndi vuto la matenda monga Cushing's syndrome, muyenera kulandira chithandizo chamankhwala, chomwe chingaphatikizepo mankhwala kapena opaleshoni. Komabe, mutha kuthandiza thupi lanu kuti lizitha kuyendetsa bwino cortisol kudzera mu zizolowezi zabwino izi:
- Kugona bwino kumafunika patsogolo: Kusagona mokwanira kapena kusintha nthawi, monga kusinthana usiku, kungawonjezere cortisol.
- Kuchita masewera olimbitsa thupi nthawi zonse: Kuchita masewera olimbitsa thupi nthawi zonse kumathandiza kuti munthu azigona bwino komanso kuchepetsa nkhawa.
- Kuchita masewera olimbitsa thupi popuma mozama: Kupuma mokhazikika kumalimbikitsa dongosolo lanu la mitsempha la parasympathetic — dongosolo la "kupumula ndi kugaya" lomwe limathandiza kukhazika mtima pansi thupi lanu.
- Yang'anani pa chisangalalo ndi kuseka: Kuseka kumatulutsa ma endorphins, omwe amathandiza kuchepetsa kuchuluka kwa cortisol mwachibadwa.
- Pangani ubale wabwino: Kusamvana kosalekeza muubwenzi kungayambitse kupsinjika maganizo kosatha.
Mfundo Yomaliza: Zimene Muyenera Kukumbukira
Ngakhale kuti cortisol nthawi zambiri imaonedwa kuti ndi yoipa, ndi mahomoni ofunikira kwambiri pa ntchito zambiri za thupi. Kuthana ndi kupsinjika maganizo ndi chida champhamvu chosungira cortisol moyenera. Komabe, nthawi zina kuchuluka kwa cortisol m'magazi sikungatheke ndipo kumasonyeza vuto linalake la thanzi.
Ngati mukukumana ndi zizindikiro za cortisol yokwera kapena yotsika, ndikofunikira kuti mufunsane ndi katswiri wa zaumoyo. Kudzera mu mayeso osavuta ozindikira matenda, amatha kudziwa ngati zizindikiro zanu zikugwirizana ndi glands zanu za adrenal kapena pituitary ndikupereka chisamaliro choyenera.
