Mwina mwamvapo za mahomoni otchedwa "Estrogen," sichoncho? Ndi mahomoni ofunikira omwe amagwira ntchito yofunika kwambiri m'thupi la mkazi. Koma kodi mukudziwa kuti nthawi zina, estrogen, yomwe ndi yothandiza kwambiri m'thupi lathu, imatha kugwira ntchito ngati "feteleza" pa maselo ena a khansa, kuwathandiza kukula mwachangu? Musadandaule. Iyi ndi nkhani yovuta pang'ono, koma tiyeni tikambirane za iyo m'njira yosavuta yomwe mungamvetse.
Mwachidule, kodi khansa imeneyi yodalira estrogen ndi chiyani?
Choyamba, tiyenera kufotokoza bwino izi. Homoni ya estrogen siimayambitsa khansa. Izi zikutanthauza kuti, estrogen si khansa. Komabe, ngati selo la khansa likukula m'thupi pazifukwa zina, ena mwa maselo a khansa amapeza mphamvu ndi chilimbikitso chomwe amafunikira kuti akule, agawikane, ndikufalikira kuchokera ku homoni ya estrogen m'thupi lathu. Monga momwe feteleza amagwiritsidwira ntchito kumera chomera, maselo a khansa awa amagwiritsa ntchito "feteleza" yotchedwa estrogen kuti ikule mwachangu.
Taganizirani motere. Selo ya khansa ili ngati chitseko. Pali malo pomwe kiyi imayikidwa pachitseko chimenecho (timachitcha kuti cholandirira). Homoni ya estrogen ili ngati kiyi imeneyo. Homoni ya estrogen ikabwera ndi kumangirira ku cholandirira pa selo ya khansa, zimakhala ngati kuyika kiyi ndikutsegula chitseko, ndipo selo ya khansa imalandira uthenga wakuti, "Tsopano gawani, chulukitsani, ndikufalikira." Khansa zomwe zimadalira mahomoni a estrogen ndipo zimadyetsedwa ndi iwo ndi zomwe timatcha khansa yodalira estrogen .
Vutoli limapezeka makamaka m'mitundu ingapo ya khansa yomwe imakhudza akazi.
- Khansa ya m'mawere
- Khansa ya m'chiberekero
- Khansa ya m'mimba/endometrial
Pochiza mitundu iyi ya khansa, madokotala a khansa amagwiritsa ntchito mankhwala (mankhwala a mahomoni) omwe amaletsa mahomoni a estrogen kufika m'maselo a khansa.
Kodi ndi khansa iti yomwe matendawa amapezeka kwambiri?
Komabe, izi nthawi zambiri zimakambidwa pankhani ya khansa ya m'mawere . Si khansa zonse za m'mawere zomwe zimadalira estrogen. Koma pali mitundu ina yomwe ili ngati estrogen. Mwina mwawonapo mawu awa m'malipoti anu a khansa ya m'mawere.
- Khansa ya m'mawere ya ER-positive (ER+): Izi zikutanthauza kuti maselo a khansa ali ndi ma estrogen receptors.
- Khansa ya m'mawere yokhala ndi HR-positive (HR+): Izi zikutanthauza kuti maselo a khansa ali ndi ma hormone receptors. Izi zikutanthauza kuti amayankha ku mahomoni amodzi kapena onse awiri a estrogen kapena progesterone.
- Khansa ya m'mawere ya Luminal A
- Khansa ya m'mawere ya Luminal B
- Khansa ya m'mawere yokhala ndi katatu
Izi n'zovuta pang'ono, koma tanthauzo lake ndilakuti mahomoni amathandiza khansa kukula. Kudziwa izi ndikofunikira kwambiri pokonzekera chithandizo.
N’chifukwa chiyani izi zimachitika? Ndi zinthu ziti zomwe zimawonjezera chiopsezo?
Monga tafotokozera kale, izi zimachitika chifukwa cha mapuloteni apadera omwe ali pa maselo a khansa (ma hormone receptors). Maselo athanzi alinso ndi ma receptor awa. Pamene estrogen ibwera ndi kumangirirana nawo, maselo amenewo amagwira ntchito bwino. Koma maselo a khansa "amalanda" njirayi ndikugwiritsa ntchito kugawa ndikukula m'njira zomwe akufuna.
Kumbukirani, estrogen si chinthu choyatsa moto. Zili ngati kuwonjezera palafini pa moto womwe ukuyaka kale. Zimawonjezera motowo.
Pali zinthu zingapo zomwe zimawonjezera chiopsezo chotenga khansa yamtunduwu. Chachikulu ndi kuchuluka kwa nthawi yomwe thupi la mkazi limakumana ndi mahomoni otchedwa estrogen pa moyo wake wonse.
Mutha kupeza lingaliro lomveka bwino la zinthu zoopsa izi kuchokera patebulo lomwe lili pansipa.
| Zoopsa | Kufotokozera kosavuta |
|---|---|
| Kutha msinkhu usanafike zaka 12 | Kuyamba msambo wanu msanga kumatanthauza kuti thupi limakhala ndi hormone ya estrogen kwa nthawi yayitali. |
| Kusamba kumachitika munthu akakwanitsa zaka 55. | Kusamba mochedwa kumatanthauza kuti nthawi ya msambo imakhala yayitali, zomwe zimawonjezera nthawi yokumana ndi estrogen. |
| Kutenga mankhwala obwezeretsa mahomoni (HRT) pa nthawi ya kusamba | Mahomoni amaperekedwa kunja kwa thupi kuti athetse kusasangalala kwa nthawi yopuma (monga kutentha thupi). Izi zimawonjezeranso kuchuluka kwa estrogen. |
| Kulamulira kwa estrogen | Kugwirizana pakati pa mahomoni a estrogen ndi progesterone m'thupi kumasokonekera, zomwe zimapangitsa kuti milingo ya estrogen ikwere pang'ono. |
| Kunenepa kwambiri | Maselo amafuta m'thupi amapanga hormone ya estrogen, kotero kulemera kwa thupi kukakwera, milingo ya estrogen nayonso imatha kukwera. |
| Matenda a ovary a Polycystic (PCOS) | PCOS ingayambitsenso kusalingana kwa mahomoni, zomwe zingayambitse kusintha kwa milingo ya estrogen. |
Chinachake chapadera chokhudza mankhwala a Tamoxifen
Pali nkhani yapadera apa. Tamoxifen ndi mankhwala othandiza kwambiri pa khansa ya m'mawere yomwe imadalira mahomoni. Imagwira ntchito poletsa estrogen kufika m'maselo a m'mawere. Komabe, m'chiberekero cha mkazi amene wasiya kusamba, mankhwalawa amayamba kugwira ntchito mosiyana kwambiri, monga estrogen. Chifukwa chake, nthawi zambiri, pamakhala chiopsezo chokhala ndi khansa ya m'chiberekero yomwe imadalira estrogen mukamagwiritsa ntchito mankhwalawa. Ngakhale izi sizichitika kawirikawiri, dokotala wanu adzakuuzani za izi ndipo adzachita mayeso ofunikira panthawi yoyenera.
Kodi madokotala amapeza bwanji izi?
Ngati mukuganiza kuti muli ndi khansa, chinthu choyamba chomwe dokotala wanu angachite ndikutenga chitsanzo cha maselo a khansa n’kuwatumiza ku labu. Izi zimatchedwa biopsy .
Mu labotale, chitsanzo cha selo ichi chimatengedwa ndikuyesedwa kuti chione ngati chili ndi ma receptors omwe amatha kumamatira ku mahomoni a estrogen ndi progesterone.
- Ngati lipoti la mayeso likunena kuti HR+ (Hormone Receptor-Positive) , zikutanthauza kuti estrogen, progesterone, kapena mahomoni onse awiri akuthandiza khansa yanu kukula.
- Ngati lipoti la mayeso likunena kuti HR- (Hormone Receptor-Negative) , zikutanthauza kuti mahomoni awa sakhudza kukula kwa khansa yanu.
Chidziwitsochi n'chofunikira kwambiri pokonzekera chithandizo.
Kodi mankhwala ake ndi otani?
Khansa ikatsimikizika kuti imadalira mahomoni (HR+), madokotala adzalangiza chithandizo chotchedwa hormone therapy . Izi zimaphatikizapo kuletsa hormone estrogen kukhala "chakudya" cha maselo a khansa. Izi zitha kuchitika m'njira zingapo.
- Kuletsa estrogen kufika ku maselo a khansa: Monga kuyika chinthu mu bowo la chitseko ndikuchitseka, mankhwala osokoneza bongo amaletsa ma estrogen receptors. Kenako estrogen sangathe kubwera ndi kumangirirana nawo.
- Kuletsa kupanga kwa estrogen m'thupi: Mankhwala amaperekedwa omwe amachepetsa kapena kuletsa kupanga kwa estrogen.
- Kusintha estrogen ndi chinthu china: Nthawi zina, hormone "yabodza" yopangidwa mu labu yomwe imaoneka ngati estrogen koma maselo a khansa sangagwiritsidwe ntchito imaperekedwa ku thupi. Kenako maselo a khansa amatenga hormone yabodzayo ndipo amanyengedwa kuti akule, koma sangathe kutero.
Chithandizo cha mahomoni nthawi zambiri sichiperekedwa chokha. Chimaperekedwa pamodzi ndi mankhwala ena, monga opaleshoni , chemotherapy, kapena radiation therapy, kutengera mtundu ndi kukula kwa khansa.
Kodi ma phytoestrogens ochokera ku chakudya ndi zakumwa ali ndi mphamvu iliyonse?
Izi ndi vuto kwa anthu ambiri. Zakudya zina za zomera zimakhala ndi mankhwala omwe amagwira ntchito ngati estrogen m'matupi athu. Timatcha izi kuti phytoestrogens . Zitsanzo za izi ndi zinthu monga soya, mkaka, ndi tirigu wonse.
Ofufuza sakugwirizanabe ngati ma phytoestrogens awa amakhudza chiopsezo cha khansa yodalira estrogen. Kafukufuku wina akusonyeza kuti angakhale othandiza kwa anthu omwe ali ndi estrogen yochepa m'thupi. Koma sizikudziwika bwino momwe amakhudzira anthu omwe ali kale ndi estrogen yambiri m'thupi. Chifukwa chake, ngati muli ndi khansa yamtunduwu kapena muli pachiwopsezo, ndi bwino kulankhula ndi dokotala wanu kapena katswiri wa zakudya za zakudya zanu.
Estrogen ndi mahomoni ofunikira kwambiri kuti thupi la mkazi likhale lolimba. Amathandiza pa chilichonse kuyambira pa njira yathu yoberekera mpaka kulimba kwa mafupa. Koma mahomoni ofunikira omwewa amatha kuyambitsa mitundu ina ya khansa. Ngati muli ndi khansa ya m'mawere, chiberekero, kapena mazira, dokotala wanu adzafuna kudziwa ngati imadalira estrogen. Chidziwitso chimenecho chidzawathandiza kusankha chithandizo choyenera komanso chothandiza kwambiri kwa inu.
Uthenga Wopita Nawo Kunyumba
- Homoni ya estrogen si yoyambitsa khansa. Izi zikutanthauza kuti estrogen siyambitsa khansa.
- Komabe, mitundu ina ya khansa (makamaka khansa ya m'mawere, uterine, ndi mazira) imagwiritsa ntchito hormone ya estrogen ngati "mafuta" pakukula kwawo.
- Kuyeza magazi m'thupi (biopsy) kungathandize kudziwa ngati khansa yanu imadalira mahomoni (HR+) kapena ayi.
- Ngati khansa ndi HR+, imatha kuthetsedwa bwino kwambiri ndi mankhwala a mahomoni.
- Ngati muli ndi mafunso okhudza zinthu zomwe zimayambitsa matenda anu, zakudya, kapena chithandizo, munthu woyenera komanso woyenera kulankhula naye ndi dokotala wanu.
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