Kodi inuyo kapena munthu amene mumamudziwa adapatsidwa mankhwala otchedwa 'Givosiran' ndi dokotala? Mukamva dzina limenelo, mungamve ngati simukudziwa bwino, kutanthauza kuti simukudziwa bwino, ndipo mwina mantha pang'ono. Ndizachibadwa kumva choncho. Chifukwa awa si mitundu ya mankhwala yomwe timamva tsiku lililonse. Chifukwa chake lero, tiyeni tikambirane za mankhwala otchedwa Givosiran, ntchito yake, momwe angagwiritsire ntchito, komanso njira zodzitetezera zomwe muyenera kutsatira, m'njira yosavuta yomwe mungamvetse.
Kodi Givosiran uyu ndi chiyani?
Mwachidule, Givosiran ndi katemera. Amadziwika ndi dzina lodziwika bwino la ``(GIVLAARI)``. Mankhwalawa amagwiritsidwa ntchito makamaka pochiza matenda osowa kwambiri otchedwa ``Acute Hepatic Porphyria``` .
Tsopano mwina mukudabwa kuti 'Acute Hepatic Porphyria' ndi chiyani. Uwu ndi matenda a majini omwe amapezeka m'chiwindi chathu. Thupi lathu limafuna mankhwala otchedwa 'porphyrin' kuti apange hemoglobin m'magazi. Komabe, mwa anthu omwe ali ndi matendawa, chifukwa cha vuto la njirayi, mankhwala otchedwa porphyrin amasonkhana mosafunikira m'thupi. Izi zingayambitse zizindikiro zazikulu monga kupweteka kwambiri m'mimba, kusanza, kufooka kwa minofu, ndi mavuto amisala.
Katemera uyu, wotchedwa Givosiran, ndi wapadera kwambiri. Wapangidwa pogwiritsa ntchito ukadaulo wapamwamba kwambiri wotchedwa 'small interferencing RNA' (siRNA) . Izi zikutanthauza kuti mankhwalawa amalowa mwachindunji m'maselo athu ndikuletsa uthenga wa majini womwe umayambitsa kuchulukana koopsa kwa porphyrin. Zili ngati kuletsa munthu amene akukupatsani upangiri wolakwika.
Izi sizili ngati mankhwala wamba ochepetsa ululu. Ndi mankhwala omwe amagwiritsidwa ntchito kwambiri omwe amapita ku gwero la matendawa ndikuchiza.
Zinthu zomwe muyenera kuuza dokotala wanu musanamwe mankhwala
Musanayambe kugwiritsa ntchito Givosiran, ndikofunikira kwambiri kukambirana momasuka ndi dokotala wanu za mbiri yanu yonse ya thanzi. Onetsetsani kuti mwawauza izi:
- Matenda a impso: Ngati muli ndi vuto lililonse lokhudzana ndi impso.
- Matenda a chiwindi: Ngati muli ndi matenda ena a chiwindi kuwonjezera pa vuto lanu la porphyria.
- Matenda a ziwengo: Uzani dokotala wanu ngati muli ndi vuto la ziwengo ku mankhwala ena aliwonse, chakudya, utoto, kapena zotetezera, osati Givosiran yokha.
- Mimba: Ngati muli ndi pakati kapena mukuyembekezera mwana posachedwa.
- Ngati ndinu mayi woyamwitsa: Ngati mukuyamwitsa mwana wanu.
Kutengera ndi izi, dokotala adzasankha ngati chithandizochi chili choyenera kwa inu kapena ayi komanso momwe mungachitire.
Momwe mungapezere mankhwala ndi zomwe muyenera kusamala nazo
Iyi si mankhwala omwe mungatenge kunyumba ndikugwiritsa ntchito.
- Kupereka: Iyi ndi jakisoni woperekedwa pansi pa khungu .
- Malo: Katemerayu amaperekedwa kokha kuchipatala, monga chipatala kapena chipatala, ndi katswiri wodziwa bwino ntchito zachipatala.
- Kwa ana: Ngati mankhwalawa agwiritsidwa ntchito kwa ana aang'ono, chisamaliro chapadera chikufunika motsogozedwa ndi dokotala wa ana.
- Ngati mwaphonya mlingo: Dokotala wanu adzakupatsani tsiku ndi nthawi yoti mukalandire katemera wanu. Ndikofunikira kwambiri kupeza chithandizo chanu pa nthawi yake. Ngati pazifukwa zina simungathe kupita tsiku limenelo, imbani dokotala wanu kapena chipatala nthawi yomweyo ndikuwadziwitsa.
- Ngati mumwa mopitirira muyeso: Popeza izi zimaperekedwa ndi dokotala, mwayi womwa mopitirira muyeso ndi wochepa kwambiri. Komabe, ngati mukukayikira kuti china chake chachitika, muyenera kuyimbira foni nthawi yomweyo ku National Poisons Information Centre ku Colombo National Hospital , kapena pitani ku Emergency Treatment Unit (ETU) ya chipatala chapafupi.
Zotsatirapo zomwe zingakhalepo chifukwa cha mankhwalawa
Monga mankhwala ena aliwonse, Givosiran ingayambitse zotsatirapo zoyipa mwa anthu ena. Ndikofunikira kudziwa izi. Tiyeni tigawane izi m'magawo awiri.
| Zotsatirapo ndi zizindikiro | Kufotokozera |
|---|---|
| Zotsatirapo zoyipa zomwe zimafuna chithandizo chamankhwala mwachangu | |
| Matenda a ziwengo | Matuza pakhungu, matenda ofanana ndi chikanga, kuyabwa, kutupa kwa nkhope, milomo kapena lilime, komanso kuvutika kupuma. Ngati chilichonse mwa izi chichitika, ndi vuto ladzidzidzi. |
| Zizindikiro za Kuvulala kwa Chiwindi | Mkodzo wakuda wachikasu kapena bulauni, maso kapena khungu kukhala lachikasu (jaundice), kupweteka kumtunda kwa kumanja kwa m'mimba, nseru, kusowa chilakolako cha chakudya, kumva kutopa, ndi malungo. |
| Zizindikiro za Kuvulala kwa Impso | Kuvuta kukodza kapena kusintha kwakukulu kwa kuchuluka kwa mkodzo womwe mumatuluka (kutulutsa mkodzo wochepa kwambiri kapena kusatulutsa mkodzo konse). |
| Zinthu zomwe nthawi zambiri sizili zazikulu, koma ziyenera kufotokozedwa kwa dokotala ngati zikupitirira | |
| Kusanza | Kumva ngati m'mimba mwako mukugwedezeka kapena mukufuna kusanza. |
| Ululu pamalo obayira jakisoni | Kufiira, kutupa pang'ono, kapena kupweteka pamalo omwe jakisoni amaperekedwa. |
| Kutopa | Kumva kutopa kwambiri kuposa masiku onse. |
Kodi pangakhale mavuto ndi mankhwala ena?
Inde, zingathekedi. Timatcha zimenezo kuti 'Kuyanjana kwa Mankhwala'. Katemera wa Givosiran amatha kuyanjana ndi mankhwala ena.
Choncho, uzani dokotala wanu zonse zomwe mumagwiritsa ntchito . Izi zikutanthauza:
- Mankhwala operekedwa ndi madokotala a matenda ena.
- Mankhwala omwe angagulidwe ku pharmacy popanda mankhwala (monga mankhwala ochepetsa ululu, chimfine).
- Mavitamini, mchere kapena zowonjezera zina.
- Zitsamba za Ayurvedic, zakomweko kapena zachikhalidwe.
- Ngati mumasuta kapena kumwa mowa, ndiuzeni.
Makamaka, mankhwala amisala otchedwa thioridazine sayenera kugwiritsidwa ntchito pamodzi ndi katemerayu konse. Komanso, mankhwala okhala ndi caffeine ndi mankhwala a chifuwa monga dextromethorphan angayambitse mavuto ndi izi.
Mndandandawu sunathe, choncho ndi bwino kumuuza dokotala wanu momveka bwino zonse zomwe mukumwa.
Uthenga Wopita Nawo Kunyumba
- Givosiran ndi jakisoni wapadera woperekedwa pansi pa khungu la matenda osowa a chiwindi otchedwa 'Acute Hepatic Porphyria'.
- Mankhwalawa amaperekedwa kuchipatala kapena ku chipatala ndi katswiri wodziwa bwino ntchito zachipatala. Si oyenera kugwiritsidwa ntchito kunyumba.
- Musanayambe chithandizo, ndikofunikira kudziwitsa dokotala wanu za matenda anu onse, ziwengo, ndi mankhwala ena onse ndi zowonjezera zomwe mukumwa.
- Nthawi zonse samalani ndi zotsatirapo zoopsa, monga ziwengo kapena zizindikiro za kuwonongeka kwa chiwindi kapena impso. Ngati muwona chilichonse mwa izi, dziwitsani dokotala wanu nthawi yomweyo.
- Musaphonye mayeso a magazi ndi nthawi yokumana ndi dokotala wanu.
- Ngati muli ndi mafunso kapena nkhawa zokhudzana ndi mankhwalawa, munthu wabwino kwambiri woti mufunse za mankhwalawa ndi dokotala amene akukuthandizani.
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