Injection ya Inotersen ya Matenda a Mitsempha: Tiyeni Tidziwe Bwino Zake

Kodi inuyo kapena wina m'banja mwanu muli ndi matenda osowa kwambiri otchedwa hATTR? Kodi dokotala wanu wakupatsani katemera wotchedwa Inotersen ngati chithandizo cha mavuto a mitsempha omwe amabwera chifukwa cha mankhwalawa? Lero tikambirana momveka bwino za mankhwalawa, momwe tingagwiritsire ntchito, ndi zinthu zomwe tiyenera kusamala nazo. Popeza mankhwalawa ndi ovuta pang'ono, ndikofunikira kumvetsetsa bwino.

Kodi mankhwala awa otchedwa Inotersen ndi chiyani?

Mwachidule, Inotersen ndi mankhwala omwe amagwiritsidwa ntchito pochiza kuwonongeka kwa mitsempha mwa odwala omwe ali ndi vuto linalake la majini lotchedwa hereditary transthyretin-mediated amyloidosis (hATTR) . Nthawi zambiri amagulitsidwa pansi pa dzina la Tegsedi.

Tsopano tiyeni tiwone chomwe vutoli limatchedwa hATTR. Ili ndi matenda osowa omwe amapatsiridwa kuchokera ku mibadwomibadwo kudzera m'majini. Chifukwa cha kusintha kosazolowereka kwa puloteni yotchedwa transthyretin, yomwe imapangidwa m'chiwindi cha thupi lathu, puloteni iyi imasonkhana ndikusungidwa m'malo osiyanasiyana a thupi, makamaka m'mitsempha. Ma depositi awa (ma depositi amyloid) amawononga mitsempha ndipo angayambitse dzanzi m'miyendo, kupweteka, kufooka, kuvutika kuyenda, komanso kungakhudze mtima ndi impso.

Choncho chimene katemera wa Inotersen amachita ndikuwongolera kupanga mapuloteni osazolowereka ndi kuchepetsa kuwonongeka kwina kwa mitsempha. Iyi si njira yochizira matendawa, koma imathandiza kwambiri kuwongolera kupitirira kwa matendawa, kutanthauza kuipiraipira kwa matendawa.

Zinthu zomwe muyenera kuuza dokotala wanu musanamwe mankhwalawa

Musanayambe kulandira chithandizo ndi Inotersen, ndikofunikira kuuza dokotala wanu za mbiri yanu yonse ya thanzi. Onetsetsani kuti mwawauza za:

• Matenda a impso: Ngati muli ndi matenda a impso kapena munadwalapo matenda aliwonse a impso.
• Mavuto a magazi: Ngati muli ndi vuto lomwe limachepetsa kuchuluka kwa maselo ofiira, maselo oyera, kapena ma platelet m'magazi anu. Izi ndizofunikira kwambiri chifukwa mankhwalawa amatha kukhudza kuchuluka kwa ma platelet m'magazi anu.
• Matenda a ziwengo: Ngati mwakhalapo ndi vuto la ziwengo chifukwa cha Inotersen, mankhwala ena aliwonse, chakudya, kapena utoto.
• Mimba: Ngati muli ndi pakati, kapena mukuyembekeza kutenga pakati posachedwa.
• Kuyamwitsa: Ngati ndinu mayi amene akuyamwitsa mwana wanu.

Kutengera ndi izi, dokotala wanu adzasankha ngati mankhwalawa ndi oyenera kwa inu komanso njira zina zodzitetezera zomwe muyenera kutsatira mukalandira chithandizo.

Kodi ndiyenera kugwiritsa ntchito bwanji mankhwalawa?

Iyi ndi jakisoni pansi pa khungu. Nthawi zambiri imaperekedwa kamodzi pa sabata.

• Maphunziro: Dokotala wanu kapena namwino wophunzitsidwa bwino adzakuwonetsani momveka bwino momwe mungakonzekerere katemerayu komanso momwe mungadzibayire nokha kunyumba. Musadandaule, zimakhala zosavuta mukangozolowera.
• Tsatirani malangizo awa: Imwani mankhwala monga momwe mwalangizidwira, panthawi yoyenera, ndipo musamwe mankhwala opitirira muyeso womwe mwalangizidwa.
• Kutaya singano: Musataye singano ndi ma syringe ogwiritsidwa ntchito kale m'zinyalala. Ziyenera kuyikidwa mu chidebe chapadera cha sharping. Ngati mulibe, mutha kupeza imodzi kwa dokotala wanu kapena kuchipatala.
• Kumwa mankhwala ochulukirapo: Ngati mukuganiza kuti mwamwa mankhwala ochulukirapo, musachite mantha ndipo nthawi yomweyo imbani National Poisons Information Centre ku Colombo National Hospital, kapena pitani ku Emergency Treatment Unit (ETU) ya chipatala chapafupi.
• Ngati mwaphonya mlingo: Ngati mwaphonya mlingo, imwani mwamsanga mukakumbukira. Koma ngati patsala masiku osakwana awiri kuti mutenge mlingo wotsatira, thawani mlingo womwe mwaphonya. Ingomwani mlingo wotsatira panthawi yomwe mwakonza. Musamwe mlingo wowirikiza kawiri.

Zotsatirapo zomwe zingakhalepo mukatenga mankhwala

Monga mankhwala ena aliwonse, Inotersen ingayambitse zotsatira zina zoyipa. Zina mwa izi zitha kukhala zoopsa, choncho ndikofunikira kuzidziwa.

Zinthu zina zomwe zingagwirizane ndi mankhwalawa

Mankhwala ena omwe mumamwa angagwirizane ndi Inotersen, zomwe zingakhudze mphamvu yake kapena zotsatira zake zoyipa. Chifukwa chake, uzani dokotala wanu za mankhwala onse omwe mumamwa. Samalani kwambiri ndi mankhwala otsatirawa:

• Mankhwala ochepetsa magazi: Mankhwala monga warfarin, apixaban, clopidogrel, ndi aspirin. Kumwa izi pamodzi ndi Inotersen kungapangitse kuti magazi azituluka kwambiri.
• Mankhwala ochepetsa ululu (NSAIDs): Mankhwala monga ibuprofen ndi naproxen. Mankhwalawa angakhudzenso impso ndikuwonjezera chiopsezo cha kutuluka magazi.
• Mankhwala ena omwe angakhudze impso ndi awa: maantibayotiki ena ndi okodzetsa (mankhwala omwe amawonjezera kutulutsa mkodzo).
• Vitamini A: Mlingo wa vitamini A m'thupi lanu ukhoza kuchepa mukamamwa mankhwalawa. Chifukwa chake, ndikofunikira kwambiri kupeza vitamini A wokwanira.Lankhulani ndi dokotala wanu za zakudya ndi mavitamini omwe mumadya, ndipo tengani vitamini A yowonjezera ngati pakufunika kutero.