Kodi pali aliyense m'banja mwanu, mwina amayi anu, abambo anu, kapena agogo anu, amene amaiwala zinthu zazing'ono? Mukalephera kukumbukira ngakhale zinthu zazing'ono, timamva chisoni komanso mantha kwambiri. Chifukwa chachikulu cha izi chikhoza kukhala matenda a Alzheimer's. Ndipotu, palibe mankhwala a matendawa pakadali pano. Komabe, pali mankhwala atsopano omwe angathandize kuwongolera kufalikira kwa matendawa mwachangu ndikuchepetsa kupita patsogolo kwake. Kisunla ndi mankhwala amodzi otere omwe abweretsa chiyembekezo chatsopano. Tiyeni tikambirane za izi momveka bwino komanso momveka bwino lero.
Matenda a Alzheimer ndi momwe Kisunla amagwirira ntchito
Mwachidule, matenda a Alzheimer's ndi matenda a muubongo omwe amakula pang'onopang'ono pakapita nthawi. Mwina munamvapo za matenda amenewa ngati matenda oiwala kukumbukira omwe amapezeka kwambiri pakati pa okalamba. Matendawa akakula, ziwalo za ubongo wathu zomwe zimalamulira zinthu zofunika monga kukumbukira, kumvetsetsa, chilankhulo, chidwi, ndi kuganiza zimawonongeka. Chifukwa chachikulu cha izi ndi kuchulukana kwa puloteni ya poizoni yotchedwa amyloid pakati pa maselo a muubongo.
Monga momwe chitoliro cha madzi m'nyumba mwathu chimatsekeredwa ndi dothi ndikuletsa madzi kuyenda, pamene puloteni ya amyloid iyi ikusonkhana pakati pa maselo a ubongo, maselo a ubongo sangathe kulankhulana ndi kugwira ntchito bwino.
Mwina munamvapo kuti matenda a Alzheimer's ndi mtundu wa matenda a dementia. Matenda a dementia ndi mawu ofala omwe amatanthauza matenda omwe amachititsa kuti munthu azivutika kuganiza bwino mpaka kufika poti sangathe kuchita ntchito za tsiku ndi tsiku.
Madokotala nthawi zambiri amagawa matendawa m'magawo angapo. Poyamba, kuiwala kwakanthawi kochepa ndiye chizindikiro chachikulu. Pamene matendawa akupita patsogolo, ngakhale ntchito za tsiku ndi tsiku monga kukonza chakudya, kupeza njira yanu, ndi kusamalira ndalama zimakhala zovuta. Pamagawo otsiriza, mungasonyezenso zizindikiro zamaganizo monga kusiya kucheza ndi anthu, kutaya chidwi ndi chilichonse, ndi kusokonezeka maganizo.
Ndiye, kodi mankhwala atsopano otchedwa Kisunla amachita chiyani? Ali ndi antibody yapadera yotchedwa donanemab-azbt . Chomwe amachita ndichakuti amalimbana ndi mapuloteni a amyloid omwe ndatchula kale omwe amasonkhana muubongo ndikuchotsa muubongo. Mwanjira imeneyi, Kisunla imathandiza kuchepetsa kuwonongeka kwa ubongo ndikuchepetsa liwiro lomwe matendawa amakulirakulira.
Kodi mungagwiritse ntchito bwanji mankhwala a Kisunla?
Kisunla si piritsi. Imaperekedwa ngati njira yothira m'mitsempha (IV) . Monga momwe timachitira ndi saline, muyenera kulandira chithandizochi kuchipatala kapena kuchipatala, chomwe chimatenga mphindi 30.
Mukayamba kulandira chithandizo, mudzapatsidwa mamiligalamu 700 (700 mg) atatu milungu inayi iliyonse. Pambuyo pake, dokotala wanu adzawonjezera mlingo kufika pa mamiligalamu 1400 (1400 mg) milungu inayi iliyonse.
Musanayambe chithandizochi, dokotala wanu adzayitanitsa kujambulidwa kwapadera kwa ubongo kotchedwa tau positron emission tomography (PET) . Izi zimayang'ana kuchuluka kwa amyloid yomwe yaikidwa mu ubongo wanu. Ngati kujambulidwako kukuwonetsa kuti kuchuluka kwa amyloid mu ubongo wanu kwatsika kwambiri, dokotala wanu angasankhe kusiya chithandizocho.
Mfundo zapadera zoti muzisamala nazo komanso zotsatira zake zoyipa
Pali zotsatirapo zoyipa zomwe tiyenera kusamala nazo makamaka pochiza Kisunla. Zimatchedwa ARIA (matenda osagwirizana ndi amyloid) . Mwachidule, mankhwalawa amachititsa kusintha kosazolowereka kuti kuwonekere pa MRI scan ya ubongo. Izi sizimayambitsa zizindikiro nthawi zonse.
Komabe, nthawi zina, anthu ena amatha kuona zizindikiro monga izi:
- Mutu
- Chisokonezo
- Kusanza
- Kusintha kwa masomphenya
- Kutaya mphamvu poyenda
Nthawi zina zizindikiro za ARIA zimatha kufanana kwambiri ndi za sitiroko. Chifukwa chake, ndikofunikira kwambiri kuuza dokotala wanu za mankhwala onse omwe mukumwa kuti athe kudziwa ngati akuchokera ku ARIA kapena china chake.
Ndani ali pachiwopsezo chachikulu cha ARIA?
Anthu ena ali pachiwopsezo chachikulu chotenga matenda a ARIA kutengera kapangidwe ka majini awo. Anthu omwe ali ndi makope awiri a jini yotchedwa apolipoprotein E e4 (ApoE e4) ali pachiwopsezo chachikulu chotenga zotsatirapo zoyipa monga kutupa kwa ubongo kapena kutuluka magazi muubongo. Chifukwa chake, dokotala wanu mwina angakupatseni mayeso a majini kuti muwone ngati muli ndi chiopsezo cha matenda a ARIA musanayambe kulandira chithandizo ndi Kisunla. Muyeneranso kuyesedwa pafupipafupi ndi MRI kuti muwone vutoli panthawi ya chithandizo.
Kodi kupambana kwa mankhwala a Kisunla kunaphunziridwa bwanji?
Kafukufuku wamkulu wa zachipatala wachitika kuti awone momwe mankhwalawa alili othandiza. Odwala ambiri omwe ali ndi matenda a Alzheimer's omwe ali mu gawo loyambirira la matendawa adachita nawo izi.
Ofufuzawa adagawa anthuwa m'magulu awiri.
1. Gulu limodzi linaperekedwa: mankhwala a Kisunla.
2. Gulu lina: linapatsidwa chinthu chomwe chinkaoneka ngati mankhwalawo, koma chinalibe chogwiritsira ntchito (timati ichi ndi placebo ).
Zotsatira zake n'zolimbikitsa kwambiri. Tiyeni timvetse zotsatirazo kuchokera patebulo ili m'munsimu.
| Phindu | Zimene kafukufukuyu adapeza |
|---|---|
| Kuchepetsa kufalikira kwa matendawa | Kuchuluka kwa matenda mwa anthu omwe adalandira Kisunla kunali kocheperako ndi 20% poyerekeza ndi omwe adalandira placebo. |
| Zizindikiro sizikuipiraipira | Anthu 47 pa 100 alionse omwe adalandira Kisunla sanadwale matenda awo mkati mwa chaka chimodzi, poyerekeza ndi 29% yokha ya omwe anali m'gulu la placebo. |
| Kuchepa kwa amyloid muubongo | Kumapeto kwa kafukufukuyu, 76% ya omwe adalandira Kisunla anali ndi kuchuluka kochepa kwambiri kwa amyloid muubongo wawo. |
Zotsatirazi zikusonyeza kuti Kisunla imatha kuchepetsa kwambiri kufalikira kwa matenda a Alzheimer's.
Kodi zimatenga nthawi yayitali bwanji kuti mankhwalawa agwire ntchito ndipo kodi pali kuyanjana kulikonse ndi mankhwala ena?
Mukangolandira mlingo wanu woyamba wa Kisunla, umayamba kugwira ntchito polimbana ndi amyloid muubongo. Komabe, zingatenge miyezi ingapo kuti inu, osamalira anu, ndi dokotala wanu muzindikire kuti zizindikiro zanu zikuchepa ndipo matenda akuchepa.
Kuyanjana ndi mankhwala ena
Chifukwa cha chiopsezo cha kutuluka magazi muubongo ndi ARIA, chisamaliro chapadera chiyenera kutengedwa mukamagwiritsa ntchito Kisunla yokhala ndi mankhwala ochepetsa magazi . Ngakhale kuti palibe umboni womveka bwino, ngati mukumwa mankhwala ochepetsa magazi, muyenera kukambirana izi ndi dokotala wanu musanayambe chithandizo cha Kisunla.
Chofunika kwambiri ndi kudziwitsa dokotala wanu za mankhwala onse omwe mukumwa - kaya dokotala wanu wakupatsani mankhwala, mankhwala ogulitsidwa kunja kwa chipatala, mavitamini, mankhwala a Ayurvedic kapena a Sinhala.
Ngati mukumva zizindikiro zilizonse monga mutu pamene mukumwa mankhwala, musanyalanyaze. Zingakhale chizindikiro cha ARIA, choncho uzani dokotala wanu nthawi yomweyo .
Uthenga Wopita Nawo Kunyumba
- Kisunla ndi mankhwala atsopano omwe amagwiritsidwa ntchito pochiza matenda a Alzheimer's kumayambiriro .
- Izi zimagwira ntchito pochotsa puloteni ya poizoni yotchedwa amyloid yomwe imasonkhana muubongo ndikuchepetsa liwiro lomwe matendawa amakulirakulira.
- Uwu ndi mankhwala olowetsedwa m'mitsempha (IV) ndipo ayenera kulandiridwa kuchipatala kapena ku chipatala.
- Ndikofunikira kwambiri kudziwa za zotsatira zoyipa zomwe zimatchedwa ARIA. Izi zimafuna kuyesedwa pafupipafupi kwa MRI musanayambe komanso panthawi ya chithandizo.
- Ndikofunikira kulankhula momasuka ndi dokotala wanu za mankhwala onse omwe mukumwa (kuphatikizapo mankhwala ochepetsa magazi) ndi zizindikiro zilizonse zatsopano zomwe mukukumana nazo.
- Ngakhale kuti izi si mankhwala, zimachedwetsa kwambiri kupita patsogolo kwa matendawa ndipo zimapatsa chiyembekezo chatsopano odwala ndi mabanja awo.
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