Kodi mukufunanso kudziwa za Pelger-Huet Anomaly? Tiyeni tikambirane za izi!

Kodi dokotala adakuuzanipo za kusintha pang'ono kwa maselo oyera amagazi anu mutayesedwa magazi? Kungakhale Pelger-Huet Anomaly. Dzinalo lingamveke ngati nkhani yaikulu, koma musadandaule , nthawi zambiri silikhala lofunika kwambiri. Tiyeni tikambirane za izi mwatsatanetsatane, m'njira yosavuta.

Kodi Pelger-Huet Anomaly ndi chiyani?

Mwachidule, Pelger-Huet Anomaly (PHA) ndi matenda a majini omwe amakhudza ma neutrophils, mtundu wa maselo oyera m'magazi mwathu. Ma neutrophils ali ngati asilikali ang'onoang'ono m'thupi mwathu omwe amathandiza thupi lathu kulimbana ndi majeremusi.

Vutoli limayamba chifukwa cha kusiyana kwa DNA yathu, makamaka mu jini yotchedwa Lamin B Receptor (jini la LBR). Jini iyi ya LBR ndiyo imathandiza maselo a neutrophil kukula ndikukula bwino.

Tsopano onani, selo lililonse la neutrophil lili ndi malo owongolera, omwe timawatcha kuti nucleus . Fukoli lili ndi chidziwitso chonse cha DNA chomwe selo limafuna kuti ligwire ntchito ndikukula. Kawirikawiri, fuko la neutrophil wathanzi limagawidwa m'magawo atatu kapena kuposerapo. Komabe, fuko la neutrophil mwa munthu amene ali ndi Pelger-Huette lili ndi magawo awiri. Lili ngati dumbbell, lokhala ndi mafuta mbali zonse ziwiri ndi pakati woonda. Nthawi zambiri, mwa anthu ena, fuko la neutrophil ili limatha kukhala lozungulira, kutanthauza kuti, lofanana ndi dzira.

Koma chofunika apa ndichakuti ngakhale mutabadwa ndi Pelger-Huette anomaly, nthawi zambiri maselo anu a neutrophil amagwira ntchito bwino. Izi zikutanthauza kuti sakulephera kwambiri kukutetezani ku matenda. Chifukwa chake, nthawi zambiri zimayambitsa mavuto ochepa azaumoyo.

Palinso vuto lina lotchedwa Pseudo Pelger-Huet Anomaly (PPHA) . Izi zitha kuchitika mwa anthu ena akakula. PPHA ikhoza kuchitika ngati zotsatira zoyipa za mankhwala ena kapena ngati chizindikiro cha vuto lina, monga matenda.

Kodi zizindikiro za Pelger-Huette anomaly ndi ziti?

Apa tifunika kuyang'ana kwambiri pa mitundu iwiri yomwe tidakambirana kale.

Hereditary Pelger-Huet Anomaly (HPA)

Ngati muli ndi Pelger-Huette anomaly (HPA), yomwe imabadwa nayo, nthawi zambiri simukhala ndi zizindikiro zilizonse. Mwina simungadziwe kuti muli ndi vutoli. Nthawi zambiri limapezeka mwangozi pamene kuyezetsa magazi kumachitika pazifukwa zina.

Pseudo Pelger-Huet Anomaly (PPHA)

Komabe, ngati muli ndi vuto la pseudo-Pelger-Huette (PPHA), zomwe zikutanthauza kuti linayamba pambuyo pake, mutha kukumana ndi zizindikiro zokhudzana ndi vuto lomwe linayambitsa.Mwachitsanzo, ngati PPHA yayamba chifukwa cha matenda, pakhoza kukhala zizindikiro monga malungo ndi kupweteka kwa thupi komwe kumakhudzana ndi matendawa.

Kodi n’chiyani chimayambitsa vuto la Pelger-Huette?

Chifukwa cha izi chimasiyananso malinga ndi mitundu iwiri yomwe takambirana kale.

Matenda a Pelger-Huette (HPA) a Hereditary Pelger-Huette

Izi zimachitika chifukwa cha kusintha kwa majini a Lamin B Receptor (LBR), monga tanenera kale. Jini iyi ya LBR imalangiza thupi lathu kupanga mapuloteni ofunikira kuti ateteze maselo a neutrophil ndikuwapatsa mawonekedwe oyenera. Mu Pelger-Huytt anomaly, kusintha kwa majini kumeneku kumasokoneza njira imeneyi, zomwe zimapangitsa kuti ma nuclei a neutrophils atenge mawonekedwe a dumbbell. Uwu ndi mkhalidwe womwe ungalandire kuchokera kwa makolo kupita kwa ana.

Pseudo Pelger-Huette anomaly (PPHA)

Iyi si matenda a majini. Pali zinthu zingapo zomwe zingayambitse vutoli:

• Matenda a m'mafupa: Zitsanzo zake ndi matenda a leukemia monga myelodysplastic syndrome ndi acute myeloid leukemia (AML).
• Matenda ena: makamaka matenda ofalitsidwa ndi nkhupakupa.
• Mankhwala Oletsa Kutupa kwa Thupi: Mankhwala awa, omwe amaperekedwa pa matenda ena, angakhalenso chifukwa chake.
• Kukhudzidwa ndi kuwala kwa dzuwa: Mwachitsanzo, panthawi ya chithandizo cha khansa.

Ngati dokotala wakuuzani kuti muli ndi `PHA` kapena `PPHA`, ndikofunikira kwambiri kudziwitsa dokotala za mankhwala onse omwe mukumwa, ngakhale mavitamini.

Kodi ndi zinthu ziti zomwe zimayambitsa vutoli?

Vuto lalikulu la Pelger-Huette anomaly (PHA) ndi kukhala ndi kholo lanu lenileni lomwe lili ndi vutoli. Izi zikutanthauza kuti ngati amayi anu kapena abambo anu ali ndi PHA, muli ndi mwayi wokwana 50% wolandira. Zili ngati kuponya ndalama, simungatsimikize, koma zitha kuchitika.

Pa vuto la `PPHA`, kukhudzidwa ndi matenda kapena chithandizo chomwe chatchulidwa kale ndi zinthu zomwe zingawopseze.

Kodi pali zovuta zilizonse zokhudzana ndi vutoli?

Kawirikawiri, cholowa cha Pelger-Huette anomaly (PHA) sichimayambitsa mavuto akulu. Chifukwa, ngakhale chimasintha mawonekedwe a maselo anu a neutrophil, sichimasintha kwambiri momwe amagwirira ntchito. Amapitirizabe kulimbana ndi majeremusi.

Komabe, ngati muli ndi pseudopelgar-huwat anomalous (PPHA), vuto lachipatala lomwe linayambitsa (monga leukemia) lingayambitse mavuto. Chifukwa chake, ndikofunikira kulankhula ndi dokotala wanu za izi ndikudziwa zomwe mungayembekezere.

Kodi madokotala amazindikira bwanji Pelger-Huette anomaly?

Madokotala amagwiritsa ntchito mayeso a magazi makamaka kuti adziwe vutoli. Makamaka,Kuyezetsa magazi kotchedwa peripheral blood smear kumachitika. Kuyezetsa kumeneku kumaphatikizapo kutenga dontho la magazi anu, kuwafalitsa pang'ono pa galasi, ndikuyang'ana pansi pa maikulosikopu.

Izi zimafufuzidwa ndi katswiri wa matenda a m'magazi kapena katswiri wa matenda a m'magazi.

Ngati muli ndi vuto la Pelger-Huette, mayesowa adzawonetsa bwino mawonekedwe osazolowereka a ma nuclei a maselo anu a neutrophil (monga dumbbell).

Kodi pali chithandizo cha Pelger-Huette anomaly?

Nkhani yabwino ndi iyi! Matenda a Hereditary Pelger-Huette anomaly (PHA) nthawi zambiri samayambitsa zizindikiro zilizonse, kotero safuna chithandizo chapadera. Ngakhale mutakhala ndi vutoli, mutha kukhala moyo wabwinobwino.

Komabe, pankhani ya `PPHA`, ndikofunikira kuchiza matenda omwe adayambitsa matendawa. Matendawa akachira, vuto la `PPHA` limathanso kutha.

Kodi ndiyenera kupita kwa dokotala liti?

Ngati mwapeza kuti muli ndi vuto la Pelger-Huette, onetsetsani kuti mwadziwitsa dokotala wanu ngati mwayamba zizindikiro zatsopano (monga malungo, kutopa kwambiri, matenda opatsirana pafupipafupi). Dokotala wanu amatha kudziwa ngati zizindikirozo zikugwirizana ndi `PHA`, `PPHA`, kapena china chake.

Mukapita kukaonana ndi dokotala, ndi bwino kufunsa mafunso awa:

• Kodi ndili ndi vuto la cholowa la `(HPA)` kapena pseudo `(PPHA)` Pelger-Huette?
• Kodi n'zotheka kuti ana anga adzalandira vutoli? (Ngati HPA)
• Kodi ndiyenera kupita kwa dokotala kangati?
• Ndi zizindikiro ziti zomwe ndiyenera kuzidziwa bwino?

Kodi ndiyenera kuyembekezera chiyani ndi vutoli?

Pelger-Huette anomaly (PHA) yokha siikupwetekani kapena kupangitsa kusiyana kwakukulu m'moyo wanu. Nthawi zambiri sizimakhudza zochita zanu za tsiku ndi tsiku.

Komabe, ngati muli ndi vutoli (makamaka mtundu wa `PPHA`), likhoza kukhala chizindikiro cha vuto lina la thanzi. Ndicho chifukwa chake madokotala amadandaula nalo. Ngati dokotala wanu akukayikira kuti muli ndi `PHA` kapena `PPHA`, adzakuyesani mayeso ofunikira kuti atsimikizire, komanso adzachitapo kanthu kuti athetse matenda ena.

Mwina muli ndi Pelger-Huette anomaly (PHA) koma simukudziwa chifukwa mulibe zizindikiro zilizonse. Mungaganize kuti, "Ngati sizikundivutitsa, bwanji ndikuganizira za izi?" N'zoona kuti simungamve kudwala chifukwa cha kusintha kwa maselo kumeneku. Koma ndikofunikira kuuza dokotala wanu za izi. Dokotala wanu alipo kuti akuthandizeni kukhala ndi thanzi labwino. Ndipo zimathandiza kudziwa za zinthu zazing'ono izi m'thupi lanu. Kungoti muli ndi Pelger-Huette anomaly ndi chinthu china chomwe chimakupangitsani kukhala "inu." Palibe chodetsa nkhawa nacho.

Chidule (Uthenga Wopita Nawo Kunyumba)

Chabwino, tiyeni tikambirane mwachidule zina mwa zinthu zomwe tinakambirana:

• Pelger-Huet Anomaly (PHA) ndi matenda a majini omwe amayambitsa mawonekedwe osazolowereka a nucleus ya neutrophils, mtundu wa maselo oyera amagazi.
• Izi nthawi zambiri sizili zoopsa ndipo sizimayambitsa zizindikiro. Maselo a neutrophil amagwira ntchito bwino.
• Pali mitundu iwiri ya izi: `HPA`, yomwe ndi yobadwa nayo, ndi `PPHA`, yomwe imayamba chifukwa cha matenda ena kapena mankhwala ena.
• Nthawi zambiri HPA siifuna chithandizo. Pankhani ya PPHA, chomwe chimayambitsa matendawa chimachiritsidwa.
• Vutoli limapezedwa kudzera mu mayeso a magazi (peripheral blood smear).
• Ngati mwapeza kuti muli ndi vutoli, musadandaule. Komabe, lankhulani ndi dokotala wanu za vutoli ndipo funsani upangiri wofunikira. Dziwitsani dokotala wanu ngati zizindikiro zatsopano zikuwonekera.

Ndikukhulupirira kuti nkhaniyi yayankha mafunso ambiri okhudza Pelger-Huette anomaly. Kumbukirani, ngati muli ndi vuto lililonse la thanzi, ndi bwino kulankhula momasuka ndi dokotala wanu.

Pelger -Huet Anomaly, Ma Neutrophils, Maselo Oyera a Magazi, Matenda a Majini, Kuyesa Magazi, PPHA, HPA