Tamoxifen - Zomwe muyenera kudziwa zokhudza mankhwala a khansa ya m'mawere awa

Dokotala akakuuzani inu kapena wokondedwa wanu kuti muli ndi "khansa ya m'mawere ," sizachilendo kumva ngati dziko lanu lonse lagwa. Pamodzi ndi mantha ndi nkhawa zomwe zimabwera m'maganizo mwanu, mumakhalanso ndi mafunso ambiri okhudza chithandizo ndi mankhwala omwe dokotalayo akukupatsani. "Kodi mankhwalawa ndi abwino kwa thupi?", "Kodi angayambitse zotsatirapo zoyipa ?", "Kodi izi zigwiradi ntchito?" Zinthu ngati zimenezo mwina zikukuzungulirani. Umu ndi momwe tikambirane za Tamoxifen, mankhwala ofunikira kwambiri omwe amagwiritsidwa ntchito kwambiri pochiza khansa ya m'mawere, m'njira yosavuta komanso yochezeka masiku ano.

Mwachidule, kodi Tamoxifen ndi chiyani?

Tamoxifen ndi mankhwala omwe amagwiritsidwa ntchito pochiza khansa ya m'mawere yokhala ndi mahomoni . Amabwera ngati piritsi (Nolvadex®) kapena madzi (Soltamox®).

Tsopano mwina mukuganiza kuti, "Kodi khansa iyi yodalira mahomoni ndi chiyani?" Ndi yosavuta kwambiri. Maselo ena a khansa m'thupi lathu ali ngati chomera chaching'ono. Monga momwe chomera chimafunikira madzi ndi zakudya kuti chikule ndikukula, maselo a khansa awa amafunikira mahomoni otchedwa estrogen kapena progesterone kuti akule ndi kufalikira. Ndicho chimene timachitcha 'khansa yodalira mahomoni.'

Chomwe mankhwala a tamoxifen amachita ndikuletsa ntchito ya hormone ya estrogen yomwe maselo a khansa amafunikira. Zili ngati kutseka pompo ya madzi ya chomera. Kenako maselo a khansa salandira uthenga womwe akufunikira kuti akule.

Komanso, madokotala nthawi zina amalimbikitsa mankhwalawa kuti ateteze khansa kwa anthu omwe ali pachiwopsezo chachikulu chotenga khansa ya m'mawere (mwachitsanzo, ngati wina m'banjamo adadwalapo khansa ).

Kodi mankhwalawa akulangizidwa kwa ndani?

Tamoxifen siperekedwa kwa odwala onse a khansa ya m'mawere. Dokotala wanu adzaganizira zinthu zambiri, kuphatikizapo mbiri yanu yachipatala ndi mtundu wa khansa, kuti adziwe ngati mankhwalawa ndi oyenera kwa inu. Amagwiritsidwa ntchito makamaka pazochitika zotsatirazi:

• Anthu omwe ali ndi mbiri ya banja lawo ya khansa kapena kusintha kwa majini a BRCAPofuna kupewa khansa kwa anthu omwe ali pachiwopsezo chachikulu chotenga khansa ya m'mawere chifukwa cha zinthu monga:
• Pewani kubwereranso kwa khansa kwa munthu amene kale anali ndi khansa ya m'mawere ndipo walandira chithandizo monga opaleshoni , chemotherapy , kapena radiation therapy .
• Pewani khansa m'bere lina lathanzi kwa munthu amene ali ndi khansa m'bere limodzi.
• Kwa munthu amene ali ndi khansa yoyambirira kwambiri, monga DCIS (ductal carcinoma in situ) , lekani kufalikira kwambiri ndikukhala khansa yoopsa kwambiri.

Kodi ubwino waukulu wa Tamoxifen ndi uti?

Tamoxifen ndi mankhwala omwe athandiza kupulumutsa miyoyo ya akazi mamiliyoni ambiri padziko lonse lapansi kwa zaka zambiri. Ubwino wake ndi wofunika kwambiri.

• Amachepetsa kubwereranso kwa khansa: Mankhwalawa amatha kuchepetsa chiopsezo cha khansa kubwereranso pambuyo pa chithandizo ndi 30% mpaka 50% .
• Zimateteza bere lina: Kwa munthu amene wakhala ndi khansa m'bere limodzi, chiopsezo chotenga khansa m'bere lina chimachepa ndi pafupifupi 50% .
• Amaletsa khansa: Kwa munthu amene ali pachiwopsezo chachikulu, chiopsezo chotenga khansa chingachepe ndi pafupifupi 40% .
• Amalimbitsa mafupa: Mankhwalawa amathandiza kupewa matenda otupa mafupa , matenda ochepetsa mafupa omwe amapezeka makamaka munthu akasiya kusamba.
• Amachepetsa cholesterol: Tamoxifen ilinso ndi mphamvu yochepetsera kuchuluka kwa cholesterol yoyipa m'thupi.

Kodi zotsatirapo zake zingakhale zotani mukatenga Tamoxifen?

Monga mankhwala ena aliwonse, Tamoxifen ingayambitse zotsatira zina zoyipa. Koma izi sizikutanthauza kuti mudzakumana nazo zonse. Anthu ena sangamve chilichonse. Ena angakumane ndi chimodzi kapena ziwiri. Kudziwa zinthu izi pasadakhale kudzakuthandizani kuthana nazo.

Tiyeni tigawane zotsatirapo izi m'magawo awiri.

Kodi ndi liti pamene muyenera kuyimbira dokotala mwachangu?

Ngati mukumwa Tamoxifen ndipo mukukumana ndi zizindikiro zotsatirazi, muyenera kudziwitsa dokotala wanu nthawi yomweyo kapena kupita ku Dipatimenti Yodzidzimutsa (ETU) ya chipatala chapafupi nanu.

• Ngati mukumva kupweteka pachifuwa kapena kupuma movutikira .
• Ngati mukumva malungo .
• Ngati muli ndi zizindikiro za sitiroko - mwachitsanzo, kulankhula movutikira, kusawona bwino, kapena dzanzi ladzidzidzi mbali imodzi ya thupi (mkono, mwendo, kapena nkhope).
• Ngati miyendo yanu, akakolo, kapena mapazi anu atupa mwadzidzidzi (makamaka mwendo umodzi wokha).
• Ngati simungathe kusiya kusanza .
• Ngati muli ndi magazi osadziwika bwino m'mimba mwanu .

Mafunso ena ofala okhudza Tamoxifen

Kodi Tamoxifen ndi mankhwala a chemotherapy?

Ayi. Apa ndi pomwe anthu ambiri amasokonezeka. Tamoxifen ndi mankhwala a mahomoni . Ndi a gulu la mankhwala otchedwa Selective Estrogen Receptor Modulators (SERMs) . Chemotherapy ndi mankhwala omwe amapha maselo omwe amagawanitsa mofulumira (maselo a khansa komanso maselo athanzi). Koma Tamoxifen imagwira ntchito mosiyana, pamlingo wa mahomoni.

Kodi n'zotheka kutenga Tamoxifen panthawi ya mimba?

Ayi ndithu. Kutenga mimba mukumwa tamoxifen kungayambitse mavuto aakulu obereka . Chifukwa chake ngati mukumwa mankhwalawa, muyenera kupewa kutenga mimba . Kuletsa kubereka pogwiritsa ntchito mahomoni (monga mapiritsi oletsa kubereka) sikoyenera panthawiyi, choncho lankhulani ndi dokotala wanu za kugwiritsa ntchito njira yoletsa kubereka yopanda mahomoni (monga makondomu kapena ma IUD). Ndikofunikira kugwiritsa ntchito njira yoletsa kubereka kwa miyezi iwiri mutasiya kumwa mankhwalawa.

Ndi zakudya ndi zakumwa ziti zomwe muyenera kupewa mukamagwiritsa ntchito Tamoxifen?

Inde. Zakudya ndi zakumwa zina zimatha kuchepetsa mphamvu ya Tamoxifen. Chifukwa chake, ndi bwino kupewa izi:

• Chipatso champhesa
• Ma tangerines
• Mowa wamtundu uliwonse

Kodi zotsatirapo zake zimachitika nthawi yomweyo mutayamba kumwa mankhwalawo?

Izi zimasiyana malinga ndi munthu. Anthu ena angayambe kuona kusintha pang'ono kuyambira tsiku lomwe amwa piritsi loyamba. Ena sangazindikire chilichonse kwa miyezi ingapo.

Kodi mankhwalawa amakhala nthawi yayitali bwanji m'thupi akasiya kumwa?

Tamoxifen imakhalabe m'thupi kwa milungu iwiri mutamwa piritsi lomaliza, koma zingatenge miyezi itatu kuti ituluke kwathunthu m'thupi lanu.