Kodi muli ndi Ankylosing Spondylitis? Tiyeni tikambirane za TNF Inhibitors

Kodi mumayambanso tsiku lanu ndi msana wolimba komanso ululu mukadzuka m'mawa? Kodi mwatopa ndi ululu womwe umabwera chifukwa cha mafupa anu mukamayenda kapena kuyenda? Izi zitha kukhala zizindikiro za ankylosing spondylitis , kapena mwachidule AS. Uwu ndi matenda otupa omwe amachitika kwa nthawi yayitali msana ndi mafupa ena. Chifukwa chake ngati muli ndi vutoli, dokotala wanu mwina adalankhula za mtundu wapadera wa mankhwala otchedwa TNF Inhibitors. Tiyeni tikambirane izi momveka bwino lero.

N’chifukwa chiyani mafupa amapweteka mu AS? Kodi TNF ndi chiyani?

Chabwino, tiyeni tinene mwachidule. Tonsefe tili ndi chitetezo chamthupi m'thupi lathu. Ndicho chimatiteteza polimbana ndi majeremusi omwe amayambitsa matenda. Koma m'mikhalidwe ngati AS, chitetezo chamthupichi chimakhala chogwira ntchito mopitirira muyeso. Chili ngati mlonda amene nthawi zonse amakhala maso.

Izi zikachitika, matupi athu amayamba kupanga puloteni yapadera yotchedwa Tumor Necrosis Factor, kapena TNF . Puloteni iyi ya TNF ndiyo imayambitsa kutupa m'mafupa athu, zomwe zikutanthauza kutupa, kutupa, kufiira, ndi kupweteka. Ichi ndichifukwa chake mafupa monga msana wanu ndi chiuno chanu zimakhala zolimba, zotupa, komanso zopweteka.

Ndiye kodi ma TNF Inhibitors amenewa ndi chiyani?

Mwachidule, mankhwala oletsa TNF ndi mtundu wa mankhwala omwe 'amaletsa' puloteni ya TNF yomwe tidakambirana kale, yomwe imayambitsa kutupa. Izi sizili ngati mankhwala ochepetsa ululu wamba. Mankhwala oletsa ululu amangoletsa ululu kwakanthawi. Koma mankhwala oletsa TNF amagwira ntchito mozama kwambiri kuposa pamenepo.

Madokotala amatchanso mankhwalawa kuti 'TNF blockers', 'biologics', kapena 'anti-TNF drugs'. Pali mitundu ingapo ya TNF inhibitors yomwe imavomerezedwa ndi AS:

• Adalimumab
• Certolizumab pegol
• Etanercept
• Golimumab
• Infliximab

Dokotala wanu nthawi zambiri amaganizira za chithandizochi ngati zizindikiro zanu sizikulamulidwa ndi mankhwala ochepetsa ululu (NSAIDs). Si mankhwala onse oletsa TNF omwe amagwira ntchito kwa aliyense. Mankhwala amodzi angagwire ntchito bwino kwa anthu ena, koma osati kwa ena. Choncho dokotala wanu angayese mankhwala osiyanasiyana mpaka atapeza omwe akukuthandizani.

Kodi mankhwala awa amagwiritsidwa ntchito bwanji?

Pali njira ziwiri zazikulu zoperekera mankhwalawa , zomwe zimasiyana malinga ndi mtundu wa mankhwala omwe mwapatsidwa.

1. Monga jakisoni pansi pa khungu (jakisoni)

Mankhwala ena amabwera ngati jakisoni. Chinthu chabwino kwambiri ndichakuti mutha kuwapereka kunyumba. Dokotala wanu kapena namwino wophunzitsidwa bwino adzakuwonetsani momwe mungaperekere mankhwalawa moyenera. Nthawi zambiri amaperekedwa pakhungu la m'mimba kapena ntchafu yanu. Chofunika ndikusintha malo omwe jakisoniyo amaperekedwa, osati omwewo nthawi zonse.

2. Monga madzi amchere omwe amaperekedwa mumtsempha (Intravenous Infusion)

Mankhwala monga Golimumab ndi Infliximab amaperekedwa ngati madzi amchere m'mitsempha. Izi zimafuna kuti mupite kuchipatala kapena ku malo operekera mankhwala. Chithandizochi chingatenge maola angapo. Dokotala nthawi zambiri amakupatsirani mankhwalawo kwa maola awiri kenako n’kukusungani pansi pa ulonda kwa maola ena awiri kuti aone ngati muli ndi vuto lalikulu la ziwengo. Mungafunike kumwa mankhwalawa milungu iwiri iliyonse poyamba, koma nthawi ino ingachepe pakapita nthawi.

Kodi ubwino wa TNF Inhibitors ndi wotani?

Kafukufuku wasonyeza kuti anthu omwe ali ndi AS amalandira zabwino zambiri kuchokera ku chithandizochi.

• Ululu umachepa kwambiri.
• Kugwira ntchito kwa mafupa ndi kusinthasintha kwawo kumawonjezeka.
• Zizindikiro monga kuuma kwa mafupa m'mawa ndi kutupa zimatha kuchepa.
• Amachepetsa kutupa kuzungulira msana ndi mafupa ena.
• Amachepetsa kuwonongeka kosatha kwa mafupa pakapita nthawi.

Anthu ambiri amayamba kuona kusiyana akangomwa mankhwala awiri kapena atatu okha. Komabe, nthawi zina zimatenga miyezi itatu kuti aone zotsatira zake zonse. Chifukwa chake, ndikofunikira kukhala oleza mtima ndi chithandizocho.

Timadziwanso za zotsatirapo zake.

Monga mankhwala ena aliwonse, mankhwalawa amatha kukhala ndi zotsatirapo zake. Komabe, anthu ambiri amakumana ndi zotsatirapo zazing'ono zokha. Chofunika kwambiri ndikudziwa izi ndikudziwitsa dokotala wanu nthawi yomweyo ngati muli ndi vuto lililonse.

Popeza mankhwala amenewa amaletsa ntchito ya chitetezo chamthupi chathu, mphamvu zathu zolimbana ndi majeremusi zimatha kuchepa pang'ono. Izi zimawonjezera pang'ono chiopsezo cha matenda .

Pali chiopsezo choti chifuwa chachikulu (TB) chibwererenso. Musadandaule, dokotala wanu adzakuyesani TB ndi matenda ena musanayambe kumwa mankhwalawa.

Pansipa pali zotsatirapo zina zomwe zingachitike.

Nthawi zina, mankhwalawa angawonjezere pang'ono chiopsezo chotenga khansa ya pakhungu (khansa ya pakhungu yopanda melanoma), kotero dokotala wanu adzadziwanso zimenezo.

Ndani sayenera kugwiritsa ntchito mankhwalawa?

Mankhwala oletsa TNF si oyenera aliyense. Dokotala wanu sangakulembeni mankhwala ngati muli ndi vuto lililonse mwa awa:

• Ngati ndinu mayi woyamwitsa .
• Pakadali pano muli ndi matenda opatsirana.Ngati pali matenda opatsirana.
• Ngati muli ndi mbiri ya matenda monga lupus kapena multiple sclerosis .
• Ngati muli ndi khansa kapena maselo omwe asanafike khansa (izi zitha kusiyana malinga ndi zomwe dokotala wasankha pa milandu ya khansa yomwe ili ndi zaka zoposa 10 ndipo yachiritsidwa ndi kuchiritsidwa).
• Ngati muli ndi mbiri ya matenda aakulu a mtima .

Kodi izi zingagwiritsidwe ntchito panthawi ya mimba?

Funso ili ndi lofunika kwambiri kwa anthu ambiri. Kafukufuku wasonyeza kuti mankhwala ambiriwa ndi otetezeka kugwiritsa ntchito panthawi ya mimba. Komabe, mankhwala ena, makamaka mu trimester yachiwiri kapena yachitatu ya mimba, amatha kudutsa mu placenta kupita kwa mwana.

Ngati mukuyembekezera mwana, lankhulani ndi dokotala wanu wa nyamakazi za izi. Iye akhoza kukupatsani mankhwala omwe ndi abwino kwa inu, monga Certolizumab, omwe sadutsa m'mimba mwa placenta.