Kodi maso anu ali ndi vuto la matenda a shuga? Tiyeni tikambirane za chithandizo cha Vabysmo (Faricimab)

Ngati muli ndi matenda a shuga, mwina mukudziwa kuti pakapita nthawi, zingakhudze maso anu. Kusawona bwino, kuyandama, ndi khungu losawona bwino ndi zizindikiro zodziwika bwino za matendawa. Mwina munamvapo za jakisoni wa maso ngati chithandizo cha vutoli. Jakisoniyu amatha kusintha masomphenya ndikuletsa kuwonongeka kwina kwa maso anu. Lero, tikambirana za mankhwala atsopano otere, omwe angakuthandizeni kwambiri.

Kodi mankhwala a Vabysmo awa amagwira ntchito bwanji m'maso?

Mwachidule, munthu wodwala matenda a shuga akakhala ndi shuga wambiri m'magazi kwa nthawi yayitali, mitsempha yamagazi yofewa mkati mwa diso imayamba kuwonongeka. Kuwonongeka kumeneku kumachitika mu retina, gawo la diso lomwe limayang'anira zithunzi. Timatcha vutoli diabetesic retinopathy .

Mitsempha yamagazi yoonongekayi imatuluka madzi pang'onopang'ono ndi magazi kulowa mu retina. Pamene vutoli likuipiraipira, diso limayesetsa kupanga mitsempha yatsopano yamagazi kuti ilowe m'malo mwa yoonongekayo. Koma mitsempha yatsopanoyi ndi yofooka kwambiri, ndipo imatuluka madzi ambiri.

Ndiye kodi edema ya macular ndi chiyani?

Pali malo apadera mu retina otchedwa macula . Ichi ndi chomwe chimatithandiza kuona zinthu pamaso pathu, kutanthauza kuti, maso athu owongoka, momveka bwino. Monga tanenera kale, madzi akatuluka m'mitsempha yamagazi, macula iyi imayamba kutupa. Timatcha izi kuti diabetic macular edema .

Apa ndi pamene masomphenya amakhala osawoneka bwino, maso awiri amaoneka ngati awiri, madontho akuda amaoneka ngati osawoneka bwino, ndipo mitundu imaoneka ngati yosawoneka bwino. Anthu ena amatha kutaya masomphenya awo kwathunthu.

Kodi chapadera ndi chiyani pa Vabysmo?

Cholinga chachikulu chochiza vutoli ndikuletsa kuwonongeka kwa retina. Pali mitundu ingapo ya mankhwala omwe amabayidwa m'diso chifukwa cha izi. Mankhwala ambiriwa amagwira ntchito poletsa puloteni yotchedwa VEGF . Mwachidule, VEGF ndi chinthu chofunikira chomwe chimathandiza mitsempha yatsopano yamagazi yosafunikira komanso yofooka kupanga. Chifukwa chake VEGF ikatsekedwa, kupangika kwa mitsempha yatsopano kumawongoleredwa.

Chosakaniza chogwira ntchito mu Vabysmo ndi Faricimab . Mankhwalawa, monga mankhwala ena, amaletsa VEGF. Koma kuwonjezera pa zimenezo, mankhwalawa amachita china chake. Ndiko kuti, amaletsa puloteni ina yotchedwa Ang-2 (angiopoietin-2) . Puloteni iyi ya Ang-2 ikachuluka m'diso, mitsempha yamagazi imakhala yosakhazikika ndipo imatuluka madzi ambiri.

Kodi kafukufuku wokhudza mankhwala amenewa wavumbula chiyani?

Mayeso awiri akuluakulu azachipatala achitika kuti adziwe chitetezo ndi kugwira ntchito kwa Vabysmo, zomwe zakhudza anthu ambiri omwe ali ndi matenda a shuga komanso matenda a maso ochokera m'maiko ndi mafuko osiyanasiyana padziko lonse lapansi.

Mu mayeso awa, Vabysmo adayerekezeredwa ndi mankhwala omwe analipo kale otchedwa Aflibercept (Eylea) , omwe amaletsa VEGF yokha. Omwe adatenga nawo mbali mu mayesowa sanadziwe mankhwala omwe amalandira. Aliyense adalandira jakisoni kangapo, koma ena adalandira jakisoni wochepa kuposa ena.

Kodi zotsatira za kafukufukuyu ndi ziti?

Zotsatira zake n’zolimbikitsa kwambiri.

Kuwongolera masomphenya

Pambuyo pa chaka chimodzi cha chithandizo, masomphenya a omwe adatenga Vabysmo ndi Aflibercept adakula kwambiri kuposa pamene kafukufukuyu adayamba. Izi zikutanthauza kuti mankhwala onsewa anali othandiza mofanana pakukweza masomphenya .

Chiwerengero cha jakisoni chomwe chikufunika (ichi ndiye chinthu chofunikira kwambiri!)

Apa ndi pomwe kusiyana kwakukulu kunaonekera.

M'miyezi yoyambirira ya kafukufukuyu, aliyense ankalandira katemera kamodzi pamwezi, koma kenako nthawi yoperekera katemera inasinthidwa.

• Anthu omwe adalandira Aflibercept adapitiliza kulandira katemerayu milungu 8 iliyonse (ndiye kuti, miyezi iwiri iliyonse) pambuyo pa miyezi 5 yoyambirira.
• Anthu omwe adalandira Vabysmo adalandira chithandizo motsatira "ndondomeko ya mlingo wa munthu aliyense," zomwe zikutanthauza kuti vuto la maso la munthu aliyense linayesedwa ndipo katemerayo anaperekedwa milungu inayi, 8, 12, kapena 16 iliyonse, monga momwe zinalili.

Zotsatira zake zinasonyeza kuti anthu oposa 70% omwe adalandira Vabysmo ankafunika jakisoni milungu 12-16 iliyonse (ndiko kuti, miyezi 3-4 iliyonse) . Komanso, panalibe kusiyana pakati pa kusintha kwa masomphenya pakati pa omwe adalandira mankhwala miyezi 3-4 iliyonse ndi omwe adalandira mankhwala miyezi iwiri iliyonse.

Kodi mankhwalawo apitiliza kugwira ntchito chaka choyamba chitatha?

Inde. Kafukufukuyu adachitika kwa zaka ziwiri. Chomwe adapeza chinali chakuti patatha zaka ziwiri, pafupifupi 78% ya anthu omwe adamwa Vabysmo amafunikira mankhwalawo miyezi itatu kapena inayi iliyonse . Ndipo maso awo adakhalabe abwino monga momwe analili chaka choyamba.

Popeza kuwonongeka kwa maso chifukwa cha matenda a shuga kumapitirira pakapita nthawi, zotsatirazi zikusonyeza kuti Vabysmo ndi Aflibercept zonse zingathandize kupewa kuwonongeka kwa maso kwa nthawi yayitali. Vabysmo ingathandizenso kupeza zotsatira izi ngati mankhwala ochepa apezeka.

Kodi mungapeze bwanji chithandizochi?

Vabysmo ndi madzi. Ndi jakisoni wa m'thupi womwe umaperekedwa mwachindunji m'diso ndi dokotala wodziwa bwino ntchito . Simungachite izi kunyumba.

Mukayamba kulandira chithandizo, mudzalandira jakisoni 4 milungu inayi iliyonse . Dokotala wanu adzayang'ana maso anu ndikusankha ngati mupitirize kulandira jakisoni pakatha milungu 4, 8, 12, kapena 16, kutengera momwe maso anu alili. Anthu ambiri amafunika jakisoni miyezi itatu kapena inayi iliyonse.

Pa nthawi yopereka jakisoni, dokotala adzagwiritsa ntchito kachipangizo kakang'ono kuti atsegule diso lanu. Kenako, adzaika madontho m'diso lanu kuti lichite dzanzi ndikupewa matenda. Kenako, jakisoniyo amaperekedwa ndi singano yopyapyala kwambiri. Simudzamva kupweteka kulikonse panthawiyi.

Zotsatirapo zake ndi momwe mungathanirane nazo?

Monga mankhwala ena aliwonse, mankhwalawa akhoza kukhala ndi zotsatirapo zochepa.

• Zotsatira zoyipa zofala: Kuona kwanu kungakhale kosawoneka bwino kwa kanthawi kochepa mutatha kubayidwa jakisoni. Izi ndi zachilendo. Pewani kuyendetsa galimoto kapena kugwiritsa ntchito makina panthawiyi. Kuona kwanu kudzabwerera mwakale pakapita nthawi yochepa.

• Zizindikiro zazikulu zoti muzisamala nazo: Nthawi zambiri zizindikiro za matenda ena akuluakulu zimatha kuchitika. Muyenera kudziwa izi.
• Madontho akuda kapena mizere ikuwoneka ngati ikuyandama pamaso pa maso.
• Kuwala kowala ngati mphezi .
• Kumva ngati kuti nsalu ikukokedwa pamaso pa maso.
• Kupweteka kwambiri kwa maso .

Kodi pali mavuto aliwonse ndi mankhwala ena?

Pakadali pano palibe kuyanjana kodziwika pakati pa Vabysmo ndi mankhwala ena.

Koma, izi ndizofunikira kwambiri: Onetsetsani kuti mwauza dokotala wanu za mankhwala ena aliwonse omwe mukumwa, kuphatikizapo mankhwala olembedwa ndi dokotala, mavitamini, mankhwala azitsamba, ndi mankhwala achikhalidwe.