Tiyeni tikambirane za mankhwala a Verzenio (abemaciclib) a khansa ya m'mawere yomwe imayamba msanga.

Pamene inu kapena munthu amene muli naye pafupi apezeka ndi khansa ya m'mawere, n'zachibadwa kumva kutopa komanso kusokonezeka pokambirana za njira zochiritsira. Zimakhala zovuta kwambiri kukumbukira mayina a mankhwala atsopano pamene madokotala akulankhula za mankhwalawo. Lero, tikambirana za mankhwala ena otere, abemaciclib. Tiyeni tikambirane momveka bwino za mankhwala awa, momwe amagwirira ntchito, komanso zomwe muyenera kudziwa mukamamwa.

Kodi Verzenio ndi mankhwala amtundu wanji ndipo amagwira ntchito bwanji?

Mwachidule, Verzenio ndi mtundu wa mankhwala omwe amaletsa kukula kwa maselo a khansa. M'mawu azachipatala, ndi m'gulu la mankhwala otchedwa ``kinase inhibitors''.

Tsopano taganizirani kuti mkati mwa maselo a thupi lathu muli amithenga ang'onoang'ono omwe amatumizirana mauthenga. Kusinthana kwa mauthenga kumeneku ndiko komwe kumatsimikiza ngati selo liyenera kugawikana kapena kukula. Timatcha ma enzyme a amithenga awa. Mu khansa, ena mwa amithengawa amakhala otanganidwa kwambiri ndipo amatumiza uthenga wolakwika ku maselo a khansa, kuwauza kuti "agawikane mwachangu, akule mwachangu."

Verzenio imayang'ana kwambiri ma messenger awiri apadera otchedwa `cyclin-dependent kinases 4 ndi 6`, kapena mwachidule CDK4 ndi CDK6 . Awiriwa ndi awiri omwe amathandiza kwambiri maselo a khansa kukula ndikugawa. Verzenio amachita izi mwa "kuletsa" ntchito ya ma messenger awiriwa. Zimaletsa uthengawo kupita ku selo ya khansa. Kenako maselo a khansa amataya chizindikiro kuti akule ndikugawa. Izi zimapangitsa kuti maselo a khansa asiye kukula kapena kukula kwa chotupacho kuchepa.

Kodi Verzenio imaperekedwa chifukwa cha mtundu wanji wa khansa ya m'mawere?

Verzenio si mankhwala a khansa yonse ya m'mawere. Imagwiritsidwa ntchito makamaka pa khansa yokhala ndi mawonekedwe akeake.

Ali:

• Cholandirira Mahomoni (HR): Izi zikutanthauza kuti maselo a khansa awa amagwiritsa ntchito mahomoni, monga estrogen, kuti akule. Izi zikutanthauza kuti mahomoni ndi "chakudya" cha khansa izi.
• HER2-negative: Komanso, khansa yamtunduwu siipanga puloteni yotchedwa `HER2` pamwamba pake.

Verzenio nthawi zambiri imaperekedwa kwa anthu omwe ali ndi zizindikiro zonsezi, omwe ali ndi khansa ya m'mawere yoyambirira , komanso omwe ali pachiwopsezo chachikulu chobwereranso khansa atalandira chithandizo. "Gawo loyambirira" limatanthauza kuti khansayo sinafalikire kupitirira bere kapena ma lymph nodes apafupi.

Kodi ndiyenera kugwiritsa ntchito bwanji mankhwalawa?

Verzenio ndi piritsi lomwe mumameza. Samalani ndi zinthu izi mukamaigwiritsa ntchito.

• Mlingo: Kawirikawiri amalembedwa kuti amwedwe kawiri patsiku.
• Nthawi ya tsiku: Yesetsani kumwa mankhwala anu nthawi yomweyo tsiku lililonse, makamaka m'mawa ndi madzulo. Izi zidzakuthandizani kuti thupi lanu likhale ndi mankhwala okwanira nthawi zonse.
• Kumwa ndi chakudya: Piritsi ili likhoza kumwedwa ndi chakudya kapena ayi. Palibe vuto pa izi.
• Momwe mungamezere: Izi ndizofunikira kwambiri! Piritsi liyenera kumezedwa lonse . Musamaphwanye, kutafuna, kapena kuswa piritsi. Ngati muli ndi mapiritsi osweka kapena odulidwa, musawagwiritse ntchito ndipo uzani dokotala wanu.
• Ngati mukusanza: Ngati mukusanza mutangomwa mankhwala, dumphani mlingo umenewo . Musamwe piritsi lina. Imwani mlingo wanu wotsatira panthawi yomwe mwakonza.

Chithandizo cha Verzenio cha khansa ya m'mawere yoyambirira nthawi zambiri chimaperekedwa kwa zaka ziwiri. Izi zikutanthauza kuti chithandizo chimayimitsidwa ngati khansayo yabwerera, ngati muli ndi zotsatirapo zoyipa kwambiri, kapena ngati zaka ziwiri zatha. Ngati muli ndi zotsatirapo zina, dokotala wanu angachepetse mlingo wanu kapena kusiya kumwa mankhwalawo kwakanthawi kenako n’kuyambanso.

Kodi Verzenio ndi yothandiza bwanji?

Kupambana kwa Verzenio kwatsimikiziridwa kudzera mu mayeso akuluakulu azachipatala. Chofunika kwambiri mwa izi ndi mayeso azachipatala otchedwa `monarchE`.

Mu kafukufukuyu, odwala 5,637 omwe ali ndi mitundu ya khansa ya m'mawere yomwe yatchulidwa pamwambapa adagwiritsidwa ntchito. Anagawidwa m'magulu awiri.

1. Gulu limodzi linapatsidwa chithandizo cha mahomoni ndi Verzenio .

2. Gulu lina linapatsidwa chithandizo cha mahomoni okha .

Kenako anatsatira anthuwa kwa zaka zinayi. Anayang'ana kuchuluka kwa anthu omwe anapulumuka popanda khansa kubwerera, khansa yatsopano, kapena kufa. Muyeso uwu umatchedwa invasive disease-free survival (IDFS).

Zotsatira pambuyo pa zaka 4 ndi izi:

• IDFS ya omwe adalandira chithandizo cha mahomoni ndi Verzenio inali 85.5% .
• IDFS ya omwe adalandira chithandizo cha mahomoni okha inali 78.6% .

Kodi mudzayang'aniridwa bwanji panthawi ya chithandizo?

Verzenio imayamba kugwira ntchito m'thupi lanu kuyambira tsiku lomwe mwayamba kumwa. Dokotala wanu adzachita zinthu zosiyanasiyana kuti ayang'anire momwe chithandizo chanu chikuyendera.

• Kujambula: Nthawi zambiri, patatha milungu 6 mutayamba kulandira chithandizo, mudzayesedwa kuti muwone momwe khansa ikukhudzira chithandizocho. Komabe, nthawi ino dokotala wanu angasinthe malinga ndi vuto lanu.
• Kuyesa Magazi: Izi ndizofunikira kwambiri. Nthawi zina Verzenio ingayambitse kuchepa kwa maselo oyera m'thupi. Matendawa amatchedwa ``neutropenia.'' Maselo oyera m'magazi ali ngati asilikali m'thupi mwathu, omwe amatiteteza ku matenda. Ngati ali ochepa, matenda oopsa amatha kuchitika. Chifukwa chake, dokotala wanu azichita mayeso amagazi nthawi zonse kuti ayang'ane kuchuluka kwa maselo oyera m'magazi, ma neutrophils, ndi ma platelet. Izi zidzaonetsetsa kuti kupitiriza kumwa mankhwalawa ndikotetezeka.

Kodi mungatani kuti muthane ndi zotsatirapo zake?

Ndizachibadwa kukhala ndi zotsatirapo zoyipa mukalandira chithandizo cha khansa. Chofunika kwambiri ndichakuti musachite mantha ndikufotokozera dokotala wanu zotsatirapo zilizonse zoyipa mwachangu momwe mungathere . Angadziwe ngati zili zoopsa ndikukupatsani upangiri wofunikira.

Nazi zotsatirapo zoyipa zomwe zimafala kwambiri komanso momwe mungathanirane nazo.

Kuphatikiza apo, dokotala wanu adzakuphunzitsaninso za zizindikiro za zotsatirapo zoyipa, monga mavuto a m'mapapo (chifuwa, kupuma movutikira) kapena magazi kuundana (kutupa, kupweteka m'miyendo). Ngati mukukumana ndi chilichonse mwa izi, ndikofunikira kufunafuna upangiri wa dokotala nthawi yomweyo.

Kodi ndiyenera kupewa chiyani ndikamamwa Verzenio?

Mukamamwa Verzenio, kuyanjana ndi zakudya zina ndi mankhwala ena kungachitike. Izi zitha kusintha momwe mankhwalawa amagwirira ntchito kapena kuwonjezera zotsatirapo zake.