Icyizere gishya ku bafite Hemophilia A: Menya ibya Altuviiio!

Ese wowe cyangwa umuntu wo mu muryango wawe ufite Hemophilia A? Niba ari uko bimeze, ushobora kuba uzi neza ingorane zo guhagarika kuva amaraso nubwo waba wakomeretse gato, ndetse no gukenera guterwa inshinge kenshi. Iki ni ikibazo gihindura ubuzima. Ariko ubu hari umuti mushya ushobora gukoreshwa mu kuvura iki kibazo, kandi ushobora gukoreshwa rimwe mu cyumweru. Uyu munsi, turimo kuvuga kuri uwo muti witwa Altuviiio.

Hemophilia A ni iki? Ni gute Altuviiio yafasha?

Muri make, hemofiliya A ni indwara iterwa n’uturemangingo iva ku mubyeyi ijya ku mwana. Umuntu ufite iyi ndwara aba afite urugero ruto cyane rwa Factor VIII, poroteyine y’ingenzi ifasha amaraso kubumba.

Tekereza amaraso yacu nk'urukuta rufatanye. Iyo habayeho igikomere, uru rukuta rugomba gufatana kugira ngo rufungwe. Igipimo cya VIII ni nk'isima ifatanya uru rukuta. Kubera ko umuntu urwaye hemophilia A adafite iyi 'simenti' (Igipimo cya VIII), bifata igihe kirekire kugira ngo amaraso ahagarike kuva mu gikomere.

Iyi ndwara ishobora kuba yoroheje, iri hagati, cyangwa ikomeye, bitewe n'urwego rwa factor VIII. Kubera ko iyi ndwara ikomoka ku murage (X-linked), ikunze kugaragara ku bagabo, kandi abarwayi bayo bakomeye cyane ni bo bayirwara. Abagore nabo bashobora kuyirwara, ariko ibimenyetso akenshi biba byoroshye.

Umuntu urwaye hemophilia ikomeye ashobora kuva amaraso mu ngingo, mu mitsi, cyangwa mu ngingo z'imbere nta mpamvu igaragara, atari ukuva amaraso make gusa. Ibyo tubyita "kuva amaraso mu buryo bwihuse." Iyo bidavuwe neza, bishobora kwangiza igihe kirekire ndetse bikaba byanashyira ubuzima mu kaga.

Uburyo busanzwe bwo kuvura ni ugutera poroteyine ya recombinant factor VIII, ikorerwa muri laboratwari. Ibi bikoreshwa mu buryo bubiri:

1. Kuvura "igihe cyose bikenewe": Gutera urushinge gusa iyo amaraso atangiye kuva kugira ngo bihagarare.

2. Uburyo bwo kwirinda: Kugira ngo hirindwe kuva amaraso ku barwayi bafite indwara zikomeye, inshinge zihoraho zitangwa ku gihe cyagenwe (urugero, kabiri cyangwa gatatu mu cyumweru).

Aha niho Altuviiio igaragara. Nubwo imiti myinshi isanzweho ya factor VIII isaba doze ebyiri cyangwa eshatu mu cyumweru, Altuviiio ni doze imwe mu cyumweru. Ibi biterwa nuko imiterere yayo yihariye ya poroteyine (`Fc-VWF-XTEN`) ituma factor VIII iguma ihamye kandi ikora mu mubiri igihe kirekire.

Ukoresha uyu muti ute?

Altuviiio ni umuti w'amazi ushyirwa mu mitsi. Ni ukuvuga guterwa mu mitsi (mu mitsi). Ubusanzwe uyu muti utangwa n'inzobere mu by'ubuzima mu bitaro cyangwa mu ivuriro.

Agasanduku k'imiti karimo agacupa k'ifu, seringi irimo amazi, n'ibindi bikoresho bikenewe. Ubwa mbere, ugomba kuvanga ifu n'amazi kugira ngo wongere umuti. Kugira ngo ubigereho, ugomba gukoresha adaptateri yihariye kugira ngo ushyire buhoro buhoro amazi ava muri seringi mu gacupa. Hanyuma, ugomba kuzunguza agacupa buhoro buhoro kugira ngo ifu ishonge burundu. Hanyuma, ugomba kongera gukuramo amazi muri seringi.

Icy'ingenzi: Reba neza mbere yo gukoresha umuti. Amazi yateguwe agomba kuba afite ibara ridafite ibara cyangwa umuhondo woroshye . Ntuyakoreshe niba afite inenge cyangwa uduce duto. Umuti wateguwe ugomba gukoreshwa mu masaha 3.

Ushobora gukenera ibinini birenga kimwe ku gipimo cyagenwe. Niba ari uko bimeze, uzakenera guhuza imiti iva mu binini byinshi ukayishyira mu cyuma kinini muganga azaguha.

Iyo ingano imaze gutegurwa, umuyoboro wihariye uhambirwa kuri syringe, uhuzwa n'urushinge rwinjijwe mu mitsi. Hanyuma syringe irakanda buhoro buhoro kugira ngo itere umuti mu mubiri. Ibi bishobora gufata iminota hagati ya 1 na 10.

Ni izihe ngaruka zihariye z'uyu muti?

Hari igihe umubiri wacu ukora ikintu kimeze nk' 'abarwanya' iyi poroteyine ya Factor VIII itangwa hanze. Mu buvuzi, izi zitwa inzitizi cyangwa antibodies. Iyo izi nzitizi zikozwe, zisenya Factor VIII, bigatuma umuti udakora neza cyane.

Ntibiramenyekana neza ukuntu ibi bikunze kugaragara mu bantu bakoresha Altuviiio. Ariko ntugahangayike, muganga wawe azasuzuma amaraso yawe buri gihe kugira ngo arebe niba ibyo bipimo byaramaze kugaragara.

• Iyo imiti igabanya ubukana iri ku rugero rwo hasi, muganga ashobora kongera urugero rw'umuti.
• Niba urugero rw'imiti igabanya ubukana bw'imiti yawe rubaye rwinshi cyane, ushobora kutazongera gukoresha Altuviiio. Ibi nibibaho, muganga wawe azagusobanurira ubundi buryo bwo kuvura bwagenewe abantu bafite imiti igabanya ubukana bw'imiti.

Ni iki ubushakashatsi bwagaragaje?

Ubushakashatsi bwakozwe kugira ngo harebwe akamaro ka Altuviiio bwatanze umusaruro mwiza cyane. Reka tubirebe mu mbonerahamwe yoroshye.

Ibi bisubizo bigaragaza ko Altuviiio ari umuti mwiza cyane wo gukumira kuva amaraso no kugabanya kuva amaraso iyo bibaye.

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• Umuti ukora vuba gute?

Altuviiio yongera urugero rwa factor VIII yawe ako kanya nyuma yo guterwa urushinge. Ibi bigabanya ibyago byo kuva amaraso vuba. Ariko, ntuhagarike gufata umuti utabanje kugirwa inama na muganga . Kugira ngo urugero rwa factor VIII rwawe rukomeze kuba hejuru, ugomba gufata umuti uko byateganyijwe buri cyumweru.

• Ese irakora ku yindi miti?

Uko tubizi, Altuviiio ntabwo byatangajwe ko ikora ku yindi miti. Ariko, ni ngombwa kubwira muganga wawe imiti yose ufata, ndetse na vitamine.

• Uyu ni umuti wihariye?

Yego. Altuviiio ni umuti 'wihariye'. Ibi bivuze ko ushobora kutaboneka muri farumasi isanzwe, kandi ushobora gukenerwa kuboneka muri farumasi y’ibitaro cyangwa binyuze muri sisitemu ya leta. Muganga wawe azagufasha muri ibi.