Calcitonine ni iki? Reka tuyige mu buryo bworoshye!

Ese wigeze wumva ijambo calcitonin? Wenda waryumvise kwa muganga, cyangwa se wararisomye ahantu runaka. Mu by'ukuri iyi ni hormone yihariye mu mubiri wacu. Ariko nanone bishobora kuvugwa ko ari hormone idasobanutse neza. Reka turebe icyo iyi calcitonin ari cyo n'icyo ikora ku mubiri wacu mu buryo bworoshye.

Calcitonine ni iki? Ituruka he?

Muri make, calcitonine ni imisemburo ikorwa n’ingirabuzimafatizo yacu ya tiroyide. Uzi ko ingirabuzimafatizo ya tiroyide ari agahu gato kameze nk’ikinyugunyugu gaherereye imbere mu ijosi ryacu, munsi y’uruhu. Ubwoko bwihariye bw’uturemangingo muri iyo ngirabuzimafatizo, kitwa C-cells cyangwa parafollicular cells, gakora iyi hormone ya calcitonine ikayisohora mu maraso yacu.

Ariko igitangaje ni uko abahanga mu bya siyansi batarasobanukirwa neza imikorere nyayo y'iyi misemburo, calcitonine. Ni ukuvuga ko tuzi icyo ikora, ariko ntabwo tuzi impamvu tuyifite. Nubwo haba hari ibintu bidasanzwe mu rugero rwa calcitonine, ntabwo bikunze guteza ibimenyetso bikomeye, cyangwa rimwe na rimwe ntibigire na kimwe.

Mu bihe byashize, abaganga bakoreshaga ubwoko bwa calcitonine mu kuvura indwara zimwe na zimwe. Urugero, kugira ngo bavure indwara nka Paget's disease of the flesh, cyangwa hypercalcemia, indwara aho calcium mu maraso iba nyinshi cyane. Ariko ubu, hamwe n'imiti mishya, cyane cyane bisphosphonates, calcitonin ntikunze gukoreshwa mu kuvura.

Ni iki calcitonin ikora ku mubiri wacu?

Akamaro k'ingenzi k'umusemburo wa calcitonine ni ukugabanya urugero rwa calcium mu maraso yacu. Wibuke ko ibi bireba calcium mu maraso, ntabwo ari calcium mu magufwa. Ibi bibikora mu buryo bubiri bw'ingenzi:

1. Ihagarika imikorere y'uturemangingo duhindura amagufwa: Hari ubwoko bw'uturemangingo twitwa osteoclasts mu magufwa yacu. Utu turemangingo dusenya amagufwa yacu twongeramo kalisiyumu mu maraso. Umusemburo wa calcitonine uhagarika by'agateganyo imikorere y'utu turemangingo. Ibi bigabanya ingano ya kalisiyumu yongerwa mu maraso.

2. Bigabanya kongera kwinjiza kalisiyumu mu mpyiko mu maraso: Kalisiyumu isohoka inkari ziyunguruwe n'impyiko zacu. Ariko, kalisiyumu imwe yongera kwinjiza mu maraso n'impyiko. Umusemburo wa calcitonine ugabanya kongera kwinjiza kalisiyumu mu mpyiko mu maraso muri ubu buryo. Kubera iyo mpamvu, urugero rwa kalisiyumu mu maraso ruragabanuka.

Tekereza kuri ubu buryo: urugero rwa kalisiyumu mu maraso yacu ni nk'urugero rw'amazi mu kigega cy'amazi. Kalisitonine ni nk'umuntu ufasha kugabanya urugero rw'amazi iyo azamutse.

Kuki tiroyide yacu ikora calcitonine?

Ingirabuzimafatizo yacu ikora calcitonine ishingiye ku rugero rwa calcium mu maraso yacu. Iyo urugero rwa calcium mu maraso rwiyongereye, ingirabuzimafatizo ikora calcitonine nyinshi. Mu buryo nk'ubwo, iyo urugero rwa calcium mu maraso rugabanutse, ingano ya calcitonine ikorwa na thyroid nayo iragabanuka. Ibi ni nk'uburyo bwo kugenzura bukora.

Ni gute wasuzuma urugero rwa calcitonine? Kuki iki kizamini gikorwa?

Muganga wawe ashobora gupima amaraso kugira ngo arebe urugero rwa calcitonine yawe.

Ariko, kubera ko urugero rudasanzwe rwa calcitonine rudakunze gutera ibimenyetso bikomeye, abaganga bakunze gutanga iki kizamini kubera impamvu zimwe na zimwe. Zimwe muri zo zirimo:

• Kugira ngo bifashe mu gusuzuma indwara nka Medullary Thyroid Cancer (MTC) cyangwa C-cell hyperplasia .
• Kugenzura intsinzi y'ubuvuzi bwa kanseri ya tiroyide yo mu bwoko bwa medullary (MTC).
• Niba hari umuntu wo mu muryango wawe ufite indwara yitwa Multiple Endocrine Neoplasia (MEN type 2) .

Igipimo gisanzwe cya calcitonine ni iki?

Muri rusange, agaciro gasanzwe ka calcitonine ni aka gakurikira:

• Ku bagabo: Munsi ya picograms 25 kuri mililitiro (Munsi ya 25 pg/mL)
• Ku bagore: Munsi ya picograms 20 kuri mililitiro (Munsi ya 20 pg/mL)

Ariko ikintu kimwe ugomba kuzirikana ni uko izi ndangagaciro zisanzwe zishobora gutandukana gato bitewe na laboratwari. Kubwibyo, ugomba guhora ureba agaciro gasanzwe ka laboratwari ku maraso yawe.

Niba wakorewe ikizamini cya calcitonine, muganga wawe azagusobanurira ibisubizo kandi akubwire niba ukeneye ibindi bipimo.

Bigenda bite iyo urugero rwa calcitonine rwiyongereye?

Kugira calcitonine nyinshi bisa nkaho nta ngaruka mbi bigira ku mibiri yacu. Kandi nta bimenyetso bikomeye bitera. Ariko, calcitonine nyinshi ishobora kuba ikimenyetso cy'indwara ebyiri zidasanzwe. Ni izihe?

1. Kanseri ya Thyroid yo mu bwoko bwa Medullary (MTC): Iyi ni kanseri idakunze kugaragara igaragara mu gasabo ka tiroyide. Itangira mu turemangingo twa C dukora calcitonine. Iyi kanseri ituma utu turemangingo dukora calcitonine nyinshi cyane.

2. Kurwara cyane kwa selile C:Iyi si kanseri (itari kanseri). Ariko ikibaho muri ibi ni uko uturemangingo twa C dukura mu buryo budasanzwe. Iyi ngingo yagutse ishobora gukora calcitonine nyinshi. Hari igihe iyi ndwara, yitwa C-cell hyperplasia, ishobora guhinduka kanseri ya tiroyide ikabije (MTC).

Niba ufite ibimenyetso bya kimwe muri ibi, muganga wawe ashobora kukugira inama yo gupima calcitonin.

Bigenda bite iyo urugero rwa calcitonine rugabanutse?

Ingano nke ya calcitonine isa nkaho ntacyo ikora cyane ku mibiri yacu. Ndetse n'abantu bakuweho tiroyide burundu, bityo bakaba bafite ingero zitagaragara za calcitonine, ntibagira ibimenyetso bifitanye isano n'urugero rwa calcium mu maraso yabo. Iki ni ikintu gitangaje kuri iyi hormone.

Ni irihe tandukaniro riri hagati ya Hormone Parathyroid na Calcitonin?

Hormone Parathyroid (PTH) na Calcitonin byombi bifasha mu kugenzura urugero rwa kalisiyumu mu maraso yacu. Ariko, itandukaniro riri mu buryo bikora n'uburyo bigira ingaruka ku rugero rwa kalisiyumu mu maraso yacu.

• Imisemburo ya parathyroid (PTH) yongera urugero rwa kalisiyumu mu maraso yacu. PTH inafasha mu kugenzura urugero rwa fosifore mu maraso no mu magufwa yacu. Inakora Vitamine D.
• Calcitonine igabanya urugero rwa kalisiyumu mu maraso yacu.

Ariko, abahanga mu bya siyansi bemeza ko imisemburo ya parathyroid (PTH) igira uruhare runini kurusha calcitonine mu kugenzura urugero rwa kalisiyumu mu maraso yacu. Ibi biterwa ahanini n'uko urugero rudasanzwe rwa PTH rushobora gutera indwara zikomeye nka hypercalcemia (calcium nyinshi mu maraso) cyangwa hypocalcemia (calcium nke mu maraso). Ariko, urugero rudasanzwe rwa kalisiyumu nta ngaruka rugira ku mubiri.

Ese calcitonine na calcitriol ni kimwe?

Oya, calcitonine na calcitriol ni ibintu bibiri bitandukanye. Nubwo imisemburo yombi igira ingaruka ku rugero rwa calcium, ifite imirimo itandukanye.

• Calcitriol ni irindi zina rya vitamine D ikora. Yongera urugero rwa kalisiyumu mu maraso. Ibikora ite? Yongera ingano ya kalisiyumu ishobora kwinjira mu mara yacu iturutse ku biribwa turya. Iyo kalisiyumu yinjira mu maraso. Calcitriol kandi ibuza impyiko gutakaza kalisiyumu. Imisemburo ya parathyroid (PTH) itera imbaraga enzyme ihindura vitamine D muri kalisiyumu.
• Calcitonin ikora mu kugabanya urugero rwa kalisiyumu mu maraso.

Rero, amaherezo, ibintu tugomba kwibuka (Ubutumwa bwo kujyana mu rugo)

Calcitonine ni imisemburo idasanzwe kandi y’amayobera.

• Urugero rwaba ruri hasi cyangwa ruri hejuru, ntabwo rushobora guteza ingaruka mbi cyangwa ibimenyetso bikomeye.
• Ariko, urugero rwa calcitonine ruri hejuru rushobora kuba ikimenyetso cy'indwara nka kanseri ya tiroyide ifata imitsi (MTC) cyangwa selile ya C-cell hyperplasia.
• Niba ufite ibimenyetso by'izi ndwara, cyangwa niba ufite ibibazo ku byago byawe byo kurwara, menya neza ko uvugana na muganga wawe. Barahari kugira ngo bagufashe. Ntugatinye, icy'ingenzi ni ukumenya neza buri kimwe.

Urabyumva? Ndizera ko aya makuru azagufasha.

Kalisitonine , Kalisitonine, Tiroyide, Imisemburo, Kalisiyumu, Kalisiyumu mu maraso, Kanseri ya Tiroyide yo mu bwoko bwa Medullary