Ese nawe uhora ufite inyota kandi unyara inshuro zigera kuri makumyabiri ku munsi? Ese iyi ni indwara ya Arginine Vasopressin / Diyabete Insipidus?

Ese nawe ufite inyota idashira? Ese wumva udashobora kunywa amazi ahagije? Ese ugomba no kujya mu bwiherero inshuro nyinshi ku munsi, rimwe na rimwe ndetse rimwe cyangwa kabiri mu isaha? Niba ugomba kubyuka nijoro kugira ngo worohe udasinzira neza, iki si ikintu cyoroshye gufata. Uyu munsi tugiye kuvuga ku ndwara idakunze kugaragara ariko ishobora kuvurwa igaragaza ibimenyetso bisa. Mbere, iyi ndwara yitwaga 'Diabetes Insipidus'.

Indwara ya Arginine Vasopressin ni iki?

Muri make, iyi ndwara iba iyo umubiri wawe ukora inkari nyinshi cyane. Ibi bivuze ko umubiri wawe udashobora kubika amazi ahagije. Impamvu nyamukuru ibitera ni ikibazo cy’umusemburo witwa Arginine Vasopressin (AVP) . Abaganga kandi bita uyu musemburo "AVP" Umusemburo urwanya imiyoboro y’amaraso (ADH) . Uyu musemburo wa "AVP" ugira uruhare runini mu gutuma amazi mu mubiri agumana ubuziranenge mu mpyiko zacu.

Hari ubwoko bubiri bw'ingenzi bw'ibi bihe:

1. Kubura AVP (AVP-D): Ibi bibaho iyo umubiri wawe udakora imisemburo ya AVP ihagije.

2. Ubudahangarwa bwa AVP (AVP-R): Iki ni igihe impyiko zawe zidakira neza imisemburo ya AVP. Ibi bivuze ko nubwo imisemburo ihari, impyiko ntiziyikoresha.

Ni ibihe bimenyetso by'iyi ndwara?

Ibimenyetso by'ingenzi by'ibura rya AVP n'ubudahangarwa bwa AVP ni ibi bikurikira:

• Gukenera kunyara kenshi: Ikimenyetso cy'ingenzi cy'ibi ni ukubyuka kugira ngo unywe, atari ku manywa gusa, ahubwo no nijoro (Nocturia) .
• Gusohora inkari nyinshi z'amabara yoroheje cyangwa zirimo amazi: Ubusanzwe, umuntu asohora inkari hagati ya litiro 1 na 3 ku munsi. Ariko, umuntu ufite iyi ndwara ashobora kwandura inkari zigera kuri litiro 20 ku munsi. Tekereza ukuntu ari ingano!
• Inyota ikabije (Polydipsia): Kumva utarimo kwihagarika inyota nubwo waba unywa amazi angana iki.

Ibi bimenyetso ni ikimenyetso gikomeye cy'uko hari ikintu kitagenda neza mu mubiri wawe. Ni ngombwa cyane gushaka inama kwa muganga vuba bishoboka.

Ni gute ibi bimenyetso bigira ingaruka ku bana bato?

Iyo iki kibazo kibaye ku bana bato, ibimenyetso bishobora kuba bitandukanye gato. Bimwe muri byo birimo:

• Kubura amazi menshi mu mubiri.
• Kwihagarika impatwe.
• Kuruka.
• Guhorana umuriro kenshi.
• Kugaragaza imyitwarire irangwa n'uburakari n'umujinya mwinshi.
• Iterambere riragabanuka / Kunanirwa gutera imbere.

Niba impinja cyangwa abana bato bafite ibi bimenyetso, bagomba kwihutira kubonwa na muganga.

Kuki habaho izi ndwara za arginine vasopressin?

Impamvu ziratandukanye, bitewe n'ubwoko bwavuzwe haruguru.

Impamvu zitera kubura AVP `(AVP-D)`

Iyi ndwara ya diyabete isanzwe yitwaga insipidus , iterwa no kubura kwa arginine vasopressin (AVP). Iyi ni yo ndwara ikunze kugaragara cyane.

Ibi bishobora guterwa na:

• Kwangirika kwa hypothalamus cyangwa pituitary gland (ibi ni ibice by'ingenzi by'ubwonko bigenzura imisemburo). Uku kwangirika gushobora guterwa no kubagwa cyangwa gukomereka mu mutwe.
• Impinduka zimwe na zimwe mu ngirabuzimafatizo (Impinduka mu ngirabuzimafatizo z’umurage)
• Iremwa ry'ibibyimba .
• Kubyimba / Granuloma biterwa n'indwara zimwe na zimwe, nka sarcoidosis cyangwa igituntu.
• Hari igihe impamvu ishobora kutaboneka (idiopathike) . Ibi bivuze ko hafi kimwe cya kabiri cy'abarwayi, impamvu iba itazwi.

Impamvu zitera kudakora neza kwa AVP (AVP-R)

Ubwo bwoko bw’indwara bwahoze bwitwa insipidus ya diyabete ya nephrogenic . Muri iki gihe, agahu k’ubwonko gakora imisemburo ya AVP, ariko impyiko ntiziyitabira neza.

Hari impamvu nyinshi zibitera:

• Impinduka zimwe na zimwe mu miterere y'uturemangingo.
• Udukingirizo tw'inkari twafunzwe .
• Gukoresha imiti imwe n'imwe igihe kirekire, cyane cyane lithiyumu .
• Ubwiyongere bwa kalisiyumu mu maraso (Hypercalcemia) .
• Igipimo cya potasiyumu kiri hasi mu maraso (Hypokalemia) .

Ubwoko bwihariye bubaho mu gihe cyo gutwita

Ibi byitwa Indwara ya Gestational Arginine Vasopressin (gAVP-d) . Ibi ni gake cyane. Mu gihe cyo gutwita, placenta ikora enzyme nyinshi cyane isenya imisemburo ya AVP.

Ufite amahirwe menshi yo kugira iyi ndwara, kubera impamvu runaka :

• Niba utwite impanga cyangwa abana benshi .
• Niba ufite ikibazo kigira ingaruka ku mikorere y'umwijima, nka preeclampsia cyangwa HELLP syndrome .

Inkuru nziza ni uko iyi ndwara ya `gAVP-d` ikunze kurangira nyuma y'ibyumweru bibiri cyangwa bitatu nyuma yo kubyara.

Ni izihe ngorane ziterwa n'iyi ndwara?

Ingorane nyamukuru ya AVP-D na AVP-R ni ukubura amazi mu mubiri , ari byo kubura amazi n'ibinyabutabire bikenewe kugira ngo umubiri ukore neza.

Ubusanzwe ushobora kugenzura ko inkari zawe zisohoka unywa amazi menshi kurusha ayo ukeneye, ariko iyo utabikoze, ushobora kubura amazi vuba cyane.

Kubura amazi mu mubiri bishobora gushyira ubuzima mu kaga. Niba ufite ibimenyetso byo kubura amazi mu mubiri, nko kuzungera, kugira isesemi, cyangwa umunaniro ukabije, jya kwa muganga uhegereye vuba bishoboka.

Abaganga babibona bate?

Kubera ko ibimenyetso byo kugira inyota no kwihagarika kenshi bishobora guterwa n'izindi ndwara zisanzwe, abaganga babanza gukuraho izindi ndwara iyo basuzuma `AVP-D` cyangwa `AVP-R`. Niba ufite ibi bimenyetso, muganga wawe ashobora gutegeka ko hakorwa ibizamini byinshi.

Mu gusuzuma iyi ndwara, ni ngombwa kumenya niba ari `AVP-D` cyangwa `AVP-R` n'impamvu itera.

Ibizamini byo gusuzuma indwara

• Ikizamini cyo kubura amazi: Ubu ni bwo buryo bwizewe bwo gusuzuma AVP-D cyangwa AVP-R. Uzakurikiranwa neza muri iki kizamini, kuko bishobora gutera umwuma. Iki kizamini kigamije kutanywa amazi mu gihe cy'amasaha menshi no kureba uko umubiri wawe witwara. Niba ufite iyi ndwara, uzakomeza kuzana inkari nyinshi z'amazi kandi zifite ibara ryoroheje. Niba udafite iyi ndwara, uzazana inkari nke z'umuhondo wijimye gusa.
• Igipimo cy'amaraso ya Copeptine: Copeptine ni umusaruro w'imisemburo ya AVP.
• Gupima isukari mu maraso: Ibi bikorwa kugira ngo harebwe diyabete, nayo ifite ibimenyetso bisa.
• Isesengura ry'inkari: Ibi bipima osmolality ( ubwinshi bw'inkari) na ketone mu nkari.
• Ibizamini byo gupima nka MRI scans (MRI - Magnetic Resonance Imaging): Ibi bikorwa kugira ngo harebwe niba hari icyangiritse kuri pituitary gland cyangwa hypothalamus.

Ni gute ibi `AVP-D` na `AVP-R` bivurwa?

Uburyo bwo kuvurwa buterwa n'uko ufite `AVP-D` cyangwa `AVP-R`. Uko uburyo bwo kuvurwa bwaba buri kose, ni ngombwa kunywa amazi menshi kugira ngo wirinde umwuma.

Uburyo bwo kuvura indwara ya AVP-D (Ubukene)

Desmopressin ni wo muti w'ingenzi wa AVP-D. Ni umuti ukora kimwe n'umusemburo wa AVP. Ushobora gufatwa mu buryo butandukanye (urugero, nk'umuti wo mu mazuru, nk'ikinini).

Desmopressin rimwe na rimwe ikoreshwa ku ndwara idasanzwe yo gutwita "(gAVP-d)". Ariko, rimwe na rimwe mu gihe cyo gutwita, ishobora kugenzurwa no kunywa amazi menshi.

Uburyo bwo kuvura indwara ya AVP-R (Resistance)

Kuvura `AVP-R` biragoye gato. Hari igihe uburyo bwinshi bugomba gukoreshwa hamwe. Urugero:

• Imiti igabanya ubukana bwa Thiazide(Nubwo iyi ari ubwoko bw'imiti yongera igihe cyo kunyara, ikora mu buryo butandukanye muri iki gihe)
• Imiti igabanya ubushyuhe itari iya steroide (NSAIDs)

Niba indwara ya `AVP-R` iterwa n'umuti urimo gufata, muganga wawe ashobora kuvura iyo ndwara aguhindurira undi muti.

Ni ryari ngomba kujya kwa muganga?

Niba ufite `AVP-D` cyangwa `AVP-R`, ni ngombwa cyane kubonana na muganga wawe buri gihe kugira ngo akugire inama. Muri ubu buryo, muganga wawe ashobora gukora ibizamini kugira ngo akurikirane uko umeze no kwemeza ko ubuvuzi bwawe bukora neza.

Ushobora gusanga ari ingirakamaro kubaza muganga wawe ibi bibazo:

• Ese mfite `AVP-D` cyangwa `AVP-R`?
• Impamvu ni iyihe?
• Ese iyi ni indwara idakira (imara igihe kirekire) cyangwa ni indwara y'igihe gito?
• Ni ubuhe buryo bwo kuvura mfite?
• Ni amazi angahe nkwiye kunywa ku munsi?
• Ni iki kindi nakora kugira ngo menye uko ibintu bimeze?
• Ese umuryango wanjye nawo uri mu kaga ko kurwara indwara ya arginine vasopressin?

Ni iki nakwitega mu gihe mfite `AVP-D` cyangwa `AVP-R`?

Icyerekezo (umusaruro) ku ndwara za `AVP-D` na `AVP-R` muri rusange ni cyiza. Niba ufata ubuvuzi bukwiye kandi ukanywa amazi ahagije, ntugomba kugira ibibazo bikomeye.

Ariko, aba bantu bafite ibyago byinshi byo kugira ingorane:

• Impinja
• Abantu barengeje imyaka 65
• Abantu bafite ubumuga bwo mu mutwe cyangwa ubumuga bwo mu mutwe

Aba bantu bashobora kugorwa no kumenya inyota yabo, cyangwa ntibashobore kuyifataho ingamba.

Kuki ibi bitazwi nka 'Diabetes Insipidus' ubu?

Mu 2022, imiryango myinshi y’ubuvuzi yafashe icyemezo cyo guhindura izina rya `Diabetes Insipidus` ikaba `Arginine Vasopressin Deficiency` na `Arginine Vasopressin Resistance`. Impamvu nyamukuru y’ibi ni urujijo rwatewe n’ijambo `Diabetes` n’ingaruka mbi ku buzima ryateye.

Iyo abantu benshi bavuze gusa "diyabete", baba bashaka kuvuga diyabete mellitus . Iterwa n'isukari nyinshi mu maraso. Ifite kandi ibimenyetso nko kugira inyota no kwihagarika kenshi. Ariko, ikunze kugaragara cyane kurusha indwara za `AVP-D` na `AVP-R` (zahoze zitwa `Diabetes Insipidus`). Nanone, uburyo bwo kuvura diyabete mellitus butandukanye cyane n'uburyo bwo kuvura `AVP-D` na `AVP-R`.

Ijambo "diyabete" rikomoka ku ijambo ry'Ikigereki "diabetesine," risobanura "kunyuramo." Iryo zina rikoreshwa kubera ko, kimwe no muri diyabete, amazi anyura mu mubiri vuba cyane, ari na byo bibaho muri izi ndwara za arginine vasopressin.

Amaherezo, ngomba kukubwira... (Ubutumwa bwo kujyana mu rugo)

Niba ufite `AVP-D` (ubukene bwa arginine vasopressin) cyangwa `AVP-R` (ubudahangarwa bwa arginine vasopressin), ushobora kumva umara igihe kinini cy'ubuzima bwawe mu bwiherero, ntushobora kumara inyota yawe uko wanywa amazi angana kose. Ariko inkuru nziza ni uko izi ndwara zishobora kugenzurwa.

Muganga wawe azategura gahunda yo kuvura ikubereye, kandi azakubwira n'amazi ukeneye kunywa ku munsi kugira ngo ukomeze kugira amazi menshi. Ntugatinye. Shaka ubufasha n'ubuyobozi bya muganga wawe. Wibuke ko iyi atari "diyabete." Niyo mpamvu ari ngombwa kwisuzumisha no kuvurwa neza. Ntabwo uri wenyine, komeza umenye amakuru, kandi ukomere.

Indwara za Arginine Vasopressin, Diyabete Insipidus, AVP, ADH, Inyota nyinshi, Kunyara kenshi, Kubura amazi mu mubiri, Polydipsia, Nocturia, Desmopressin, Impyiko, Imisemburo