Ese amaraso yawe agwa nta mpamvu? Reka tumenye byinshi kuri Factor V Leiden Thrombophilia!

Imibiri yacu yose si imwe, si byo se? Hari igihe dushobora kugira itandukaniro rito mu mibiri yacu tutazi. Uyu munsi tugiye kuvuga kuri imwe muri iyo ndwara twavukanye, ituma amaraso yacu yipfundika cyane, bivuze ko ishobora kwipfundika bitari ngombwa. Ibi byitwa Factor V Leiden Thrombophilia .

None se Factor V Leiden ni iki?

Muri make, iyi ni indwara yo kuvura amaraso . Ni ukuvuga ko uvukana impinduka mu ngirabuzimafatizo zawe. Iyi mpinduka ituma amaraso yawe ashobora kuvura kurusha uko bisanzwe. Ibi bigushyira mu kaga ko kurwara indwara nka:

• Indwara yo mu mitsi miremire (DVT): Ibi bibaho igihe amaraso apfundika mu mitsi miremire y'umubiri wawe, cyane cyane mu maguru cyangwa mu maboko yawe. Ariko, rimwe na rimwe ashobora kwibasira imitsi ahantu nko mu mwijima, mu mpyiko, mu bwonko no mu maso.
• Kuziba kw'amaraso mu mitsi y'ibihaha (PE) : Ibi ni akaga gato. Ikibaho hano ni uko kimwe mu bice by'amaraso byavuzwe haruguru, cyangwa amaraso yacitse ahandi, kivamo, kikanyura mu maraso, maze kigafatana mu bihaha byawe.

Ariko iki kibazo ni uko kuba ufite iyi ndwara bitavuze ko uzagira DVT cyangwa PE . Mu by’ukuri, abantu bagera ku icyenda kuri icumi bafite iyi ndwara ntibazigera bagira ikibazo cyo kubyimba kw’amaraso mu buzima bwabo. Ariko, ni ngombwa kumva ko uri mu kaga gakomeye kurusha abandi.

Ubusanzwe iyi ndwara ya 'Factor V Leiden' ikunze kugaragara mu moko atandukanye. Muri rusange ikunze kugaragara cyane mu bazungu muri Leta Zunze Ubumwe za Amerika no mu Burayi.

• Abantu bagera kuri 5 ku 100 bakomoka mu Burayi.
• Abantu bagera kuri 2 ku 100 bafite inkomoko muri Hisipaniya.
• Hafi umuntu 1 ku bantu 100 b'umwirabura cyangwa Abanyamerika kavukire.
• Mu bantu bakomoka muri Aziya, ni munsi ya 1 mu 100.

Ariko, hafi umuntu umwe kuri batanu bafite amaraso mu mitsi yabo basanze bafite ubwoko bwa gene bwa `Factor V Leiden`. Iyi gene yitwa `Factor V Leiden.' Inyuguti ya V isobanura imibare y'ikiromani isobanura batanu.

Ni ibihe bimenyetso by'iyi ndwara?

Dore ikintu ugomba kuzirikana: Iyi mihindagurikire y’uturemangingo yonyine ntabwo itera ibimenyetso . Ushobora kuyigira ubuzima bwawe bwose utabizi. Ariko, nk'uko byavuzwe mbere, ibimenyetso bigaragara gusa iyo amaraso yavunitse.

Icy'ingenzi: Niba utekereza ko ufite ibimenyetso bya `DVT` cyangwa `PE`, hamagara 911 cyangwa nimero y'ubutabazi bw'ibanze yo mu gace utuyemo ako kanya . Bitabaye ibyo, jya mu biro by'ubutabazi bw'ibanze by'ibitaro biri hafi yawe vuba bishoboka hamwe n'umuntu. Ibi si ibintu byo kwibagirwa.

Ibimenyetso bya thrombosis yo mu mitsi miremire (DVT) bishobora kuba birimo:

• Kubyimba ukuguru cyangwa ukuboko, kumva ushyushye iyo ubikozeho, ndetse n'ibara ry'uruhu rihinduka (wenda rihinduka umutuku cyangwa ubururu).
• Kumva ububabare iyo ukoze kuri ukuguru cyangwa ukuboko, ububabare iyo ukandagiye .
• Imitsi iri munsi y'uruhu minini kuruta ibisanzwe kandi igaragara hejuru .
• Iyo amaraso apfunditse mu mitsi iri mu gifu, ushobora kubabara mu gifu cyangwa kubabara mu ruhande .
• Iyo amaraso apfunditse mu bwonko, bishobora gutera kuribwa umutwe bitunguranye kandi bikomeye cyangwa gukubita ibisebe .

Ibimenyetso bya embolism y'ibihaha (PE) bishobora kuba birimo:

• Guhumeka bigoranye mu buryo butunguranye .
• Kubabara cyane mu gituza iyo uhumeka umwuka mwinshi, ukorora, cyangwa witsamuye.
• Gukorora, rimwe na rimwe amaraso make asohoka hamwe n'amabyi .
• Urusaku rwo guhumeka iyo uhumeka.
• Umutima wihuta cyane (tachycardia) .
• Kumva mfite impungenge kandi nta mutuzo .
• Kumva umeze nk'ugiye guta ubwenge (ni gake cyane ushobora no guta ubwenge) .

Ni iki gitera indwara ya Factor V Leiden?

Impamvu nyamukuru ibi ni ubwoko bwa gene . Hari poroteyine mu mubiri wacu ifasha kubumba amaraso, yitwa `Coagulation factor V` . Mu by'ukuri, ifasha guhagarika kuva amaraso iyo habayeho igikomere. Bityo, umubiri wacu utegetswe gukora iyi poroteyine na gene yitwa `F5` .

Ubusanzwe, twese turagwa kopi ebyiri zisanzwe z'iyi gene ya `F5`. Ariko, iyo uraga kopi imwe cyangwa nyinshi zidasanzwe z'iyi gene, bivugwa ko ufite ubwoko bwa `Factor V Leiden` (rimwe na rimwe bwitwa `mutation`). Izina `Leiden` rikomoka mu mujyi wa Leiden mu Buholandi aho abashakashatsi bavumbuye ubwo bwoko bwa gene.

Iyi gene ya `Factor V Leiden` itera impinduka nto mu miterere ya poroteyine ya `factor V` ikorerwa mu mubiri wacu. Kubera iyi mpinduka, iyi poroteyine ya `factor V` yahindutse irwanya ibikorwa by'izindi poroteyine ebyiri z'ingenzi zigenzura kuvura kw'amaraso , Poroteyine C (`Poroteyine C`) na Poroteyine S (`Poroteyine S`) . Muri make, izo poroteyine zigenzura ntizishobora kuyihagarika. Hanyuma, poroteyine ya `factor V` ikora cyane kurusha uko bikwiye, maze amaraso agatangira kuvura bitari ngombwa, ndetse n'igihe bidakenewe.

Ese iki kintu gihinduka kuva mu muryango ujya mu wundi?

Yego rwose. Ushobora kuragwa iki kibazo na nyoko cyangwa so, cyangwa bombi. Factor V Leiden iragwa mu buryo bw'ihererekanya ry'umubiri (autosomal dominant inheritance pattern).Ibyo bivuze ko nubwo waba warahawe iyi gene idasanzwe n'umwe mu babyeyi bawe gusa, ushobora kuraragwa iyi ndwara.

Abantu benshi (bafite Factor V Leiden) bazungura kopi imwe gusa y’iyi gene idasanzwe. Ibi byitwa heterozygous . Ni gake cyane, ushobora kuzungura kopi ebyiri zidasanzwe z’iyi gene kuri nyoko na so. Ibi byitwa homozygous .

Ni ibihe bintu by'inyongera byongera ibyago byo kubyimba kw'amaraso?

Umuntu urwaye Factor V Leiden ashobora kugira ibyago byinshi byo kuvura amaraso iyo:

• Niba warazwe kopi zombi za gene idasanzwe ya `F5` nk'uko byavuzwe mbere (niba uri `homozygous`) .
• Niba bene wanyu b'amaraso (nka mama, papa, abavandimwe bawe) bafite amateka ya DVT cyangwa PE .
• Niba ufite izindi ndwara zo kuvura amaraso .
• Niba urimo kubagwa (cyane cyane nyuma yo kubagwa bikomeye, kuko uzaba uri ahantu hamwe igihe kirekire).
• Niba utwite (muri iki gihe, impinduka mu misemburo n'umwana bishobora gutera umuvuduko ku mitsi).
• Niba ufata ubwoko bumwe na bumwe bw'ibinini byo kuboneza urubyaro (birimo estrogen) cyangwa ubuvuzi bwo gusimbuza imisemburo (ubuvuzi bwo gusimbuza imisemburo) .

Niba ufite kimwe muri ibi bintu bishobora gutera ibyago, ni ngombwa cyane kuvugana na muganga wawe ukamenya ibyago byo kubyimba kw'amaraso n'uburyo bwo kwirinda.

Ni izihe ngorane zishobora guterwa n'iyi ndwara?

Niba ufite Factor V Leiden Thrombophilia, ushobora guhura n'ibi bikurikira:

• Kugira `DVT` cyangwa `PE` mbere y'imyaka 50 .
• Inshuro zirenze imwe, bivuze ko `DVT` cyangwa `PE` bibaho kenshi .
• Udutsi tw'amaraso twibasira imitsi, ubusanzwe turema udutsi duke tw'amaraso , urugero, mu mitsi y'umwijima, ubwonko n'impyiko.
• DVT cyangwa PE mu gihe cyo gutwita cyangwa nyuma yo kubyara .
• DVT cyangwa PE bishobora kubaho mu gihe gito nyuma yo gutangira imiti yo kuboneza urubyaro .

Ni gute abaganga basuzuma iyi ndwara?

Abaganga bashobora kumenya niba ufite iyi ndwara binyuze mu gupima amaraso . Ibi bishobora no kuba birimo gupima imiterere y'umubiri . Muganga wawe ashobora kukugira inama yo gupima iyi ndwara, cyane cyane:

• Niba warigeze kugira DVT cyangwa PE mbere , cyane cyane niba byarakubayeho ukiri muto kuruta uko byari byitezwe.
• Niba umwe mu bavandimwe bawe b'amaraso afite amateka yo kubyimba kw'amaraso .

Factor V Leiden ivurwa ite?

Factor V Leiden ni indwara y'ubuzima bwose. Ibyo bivuze ko nta buryo bwihariye bwo kuvura iyi gene. Ahubwo, uburyo bwo kuvura bukora kugira ngo amaraso asanzwe apfundikire kandi bugabanye ibyago byo kuvura amaraso mu gihe kizaza . Muganga wawe ashobora kukugira inama yo kuvura nka:

• Imiti igabanya amaraso (izwi kandi nka "blood thinners") : Iyi miti ifasha mu gushonga amaraso asanzwe kandi ikabuza ko habaho udukoko dushya.
• Amasogisi yo gukanda : Aya ni amasogisi yihariye yo kwambarwa ku maguru kugira ngo arusheho gutembera neza kw'amaraso no kugabanya ibyago byo kubyimba kw'amaraso.
• Gushyira Vena cava filter : Iki ni igikoresho gito gishyirwa mu mutsi munini kugira ngo hirindwe ko amaraso yaziba mu bihaha. Si buri wese ugikeneye.
• Kubaga gukuraho amaraso apfutse : Hari igihe biba ngombwa ko ubagwa kugira ngo amaraso apfutse cyane akurweho.

Igihe ugomba gufata imiti igabanya amaraso giterwa n'ibyago byawe byo kurwara andi maraso. Hari abantu bakeneye gufata uyu muti mu gihe cy'amezi make gusa. Abandi bashobora kuwufata igihe kirekire, ndetse n'ubuzima bwabo bwose. Muganga wawe azagusobanurira gahunda yo kuvura ikubereye.

Ni ryari ukwiye kujya kwa muganga?

Niba uzi ko ufite iyi ndwara, ni ngombwa ko uhora ubonana na muganga.

• Jya kwisuzumisha kwa muganga byibuze rimwe mu mwaka .
• Niba ufite DVT cyangwa PE kandi ukaba uri kuvurwa, uzakenera kujya kwa muganga wawe kugira ngo agukurikirane buri gihe kugira ngo arebe uko ubuvuzi bwifashe.
• Niba ufata imiti igabanya amaraso nka Warfarin , ugomba gupimwa amaraso (Prothrombin time test - PT / INR test) buri gihe kugira ngo urebe niba umuti ukora neza kandi niba ingano yawo ari yo.

Nanone, ni ngombwa kuvugana na muganga mu bihe nk'ibi:

• Mbere yo gukoresha uburyo bwo kuboneza urubyaro (cyane cyane ubw'ibikubiyemo estrogen).
• Mbere yo gutangira kuvura indwara yo gusimbuza imisemburo .
• Niba uteganya gutwita, mbere y'ibyo .

Ibi bivuga iki ku byerekeye igihe umuntu ategereje kubaho?

Ku bantu benshi, kugira Factor V Leiden ntacyo bigiraho ingaruka ku buzima bwabo busanzwe . Nubwo wagira ikibazo cyo kubyimba kw'amaraso, iyo uhawe ubuvuzi bwihuse kandi bukwiye, ushobora kwirinda ingaruka zikomeye . Niba ufite impungenge ku mibereho yawe cyangwa ingorane zizaza, vugana na muganga wawe ku byerekeye izo ngaruka.

Ni iki twagombye kwirinda niba dufite Factor V Leiden?

Muganga wawe azaguha inama akurikije uko umerewe, ariko muri rusange, ni byiza kwirinda ibi bintu:

• Kunywa itabi, kunywa inzoga, no gukoresha ibindi bicuruzwa by'itabi .
• Kwicara mu mwanya umwe igihe kirekire (urugero: gukora mu biro, gufata urugendo rurerure muri bisi cyangwa gari ya moshi, cyangwa gutwara indege amasaha menshi). Niba bishoboka, haguruka ugende n'amaguru nibura rimwe mu isaha.
• Irinde kunywa inzoga nyinshi , cyane cyane mu ngendo ndende.
• Ibinini byo kuboneza urubyaro n'imiti isimbura imisemburo irimo estrogen (ugomba kuvugana na muganga mbere yo kubikoresha).

Ese kubura Factor V na Factor V Leiden ni kimwe?

Yego, ntukivange ibyo byombi. Ibi ni indwara ebyiri zitandukanye cyane mu bijyanye n'uturemangingo . Ariko, izi ndwara zombi zifitanye isano n'impinduka muri gene ya `F5`.

Muri Factor V Leiden Thrombophilia, ihinduka ry’uturemangingo rituma amaraso yawe yibumba byoroshye.

Ariko, mu ndwara yitwa 'Factor V deficiency' , ihinduka ry'uturemangingo ribuza amaraso yawe kubumba neza igihe bibaye ngombwa. Ibi bivuze ko uri mu kaga ko kuva amaraso. 'Factor V deficiency' ni indwara idasanzwe (hafi imwe kuri miliyoni) yo kuva amaraso. Ishobora gutera ibintu nko kuva amaraso kenshi mu mazuru, kuva amaraso menshi mu gihe cy'imihango, no kuva amaraso kenshi nyuma yo kubagwa.

Amaherezo, ibintu byo kwibuka

Rero, niba umenye ko wowe cyangwa undi muntu uzi afite indwara ya Factor V Leiden Thrombophilia, ntugahite utinya. Wibuke ko abantu benshi bafite iyi ndwara bashobora kubaho ubuzima bwiza badafata amaraso .

Ariko, iyo ugize ikibazo cyo kuvura amaraso, hari uburyo bwo kuvura butanga umusaruro . Ikintu cy'ingenzi ni ugukurikiza amabwiriza ya muganga witonze, ugahabwa ibizamini n'ubuvuzi ukeneye, kandi ukabaho ubuzima busanzwe kandi bushimishije hamwe n'iki kibazo, ukacyifata neza mbere yuko kiba ikibazo.

Factor V Leiden, Thrombophilia, kuvura amaraso, DVT, PE, indwara y'uturemangingo, kuvura amaraso, indwara y'uturemangingo