Ese umwana wawe akura vuba cyane? Reka twige ku byerekeye ubugiganti!

Hari igihe abana bacu bakura vuba cyane, si byo se? Ariko si ibisanzwe ko bakura cyane mu buryo butunguranye kurusha abandi bana, bafite amaguru manini. Impamvu y'ibi ishobora kuba indwara idakunze kugaragara. Uyu munsi tugiye kuvuga kuri iyo ndwara, ni ukuvuga 'Gigantism'.

'Gigantism' ni iki?

Mu magambo make, gigantism ni indwara idakunze kubaho aho umwana cyangwa umuntu muto akora imisemburo myinshi cyane yo gukura (GH) . Niyo mpamvu aba bana bakura cyane kurusha abandi. Ubusanzwe, iyi misemburo yo gukura (GH) ikorwa n'agace gato kangana n'amashaza gaherereye mu nsi y'ubwonko bwacu. Kitwa imisemburo ya pituitary. Ariko, iyo ikibyimba gito kigaragaye muri iyi misemburo ya pituitary, gishobora gukora imisemburo myinshi yo gukura (GH) kuruta iyo ikenewe. Ni bwo gigantism ibaho.

Ingirabuzimafatizo ya pituitary ni akaremangingo gato kari mu gice cyo hasi cy'ubwonko, munsi ya Hypothalamus. Mu by'ukuri gasohora imisemburo 8. Imisemburo yo gukura (GH) ni imwe muri zo.

Imisemburo yo gukura, izwi kandi nka Human Growth Hormone (hGH), ni ingenzi mu mikurire y'abana. Igira ingaruka ku bice byinshi by'umubiri kandi igafasha umwana gukura neza. Ariko, hari ubwoko bumwe na bumwe bw'imiyoboro y'igufwa ryacu yitwa Epiphyses / Growth Plates, kandi iyo imaze gufunga burundu (ni ukuvuga nyuma y'ubugimbi), imisemburo yo gukura (GH) ntiyongera uburebure. Icyo ikora ni ukubungabunga imiterere n'imikorere y'amagufwa, cartilage, n'izindi ngingo. Iyi misemburo yo gukura (GH) ifitanye isano rya hafi n'imisemburo yitwa Insulin-like Growth Factor 1 (IGF1), ikorwa n'umwijima wacu. Iyi misemburo yombi ifasha mu mikurire no mu mikorere y'igufwa.

Gigantism ni indwara aho umubiri ukora imisemburo myinshi cyane (GH), bigatuma imitsi, amagufwa, n'ingingo zihuza umubiri bikura vuba. Ibi bitera uburebure budasanzwe n'impinduka nyinshi mu ngingo zoroshye z'umubiri. Iyo bitavuwe, bamwe mu bantu bafite gigantism bashobora gukura bakagera ku burebure bwa metero zirenga ebyiri.

Kubwibyo, ni ngombwa cyane gusuzuma indwara no gutangira kuvurwa vuba bishoboka mu gihe cy’indwara ikomeye.

Ni irihe tandukaniro riri hagati ya 'Gigantism' na 'Acromegaly'?

Gigantism na acromegaly byombi ni indwara ziterwa n’imisemburo ikabije yo gukura (GH). Itandukaniro riri ku bayirwara. Acromegaly ikwirakwira mu bantu bakuru. Gigantism ikwirakwira mu bana n’abakiri bato bagikura, ni ukuvuga bataragera mu bugimbi.

Muri make, gigantism ibaho iyo urugero rw'imisemburo ikura (GH) rwiyongera mbere y'uko ibice by'igufwa ry'abana bifunga (ni ukuvuga mbere y'uko ubwangavu burangira).

Iyo urugero rw'imisemburo (GH) yawe yiyongereye nyuma y'uko imirongo y'ibyiciro by ...

Gigantism ni indwara idakunze kugaragara cyane kurusha acromegaly.

Ni nde ufatwa n'ubugizi bwa nabi? Ni iki gikunze kugaragara?

Nubwo iki ari ikibazo kidasanzwe, gigantism ishobora kugaragara ku mwana uwo ari we wese ufite ibipimo by'imikurire bitarafunga (ni ukuvuga ko atararangiza ubwangavu). Bikunze kugaragara ku bahungu kurusha ku bakobwa.

Uburwayi bwa Gigantism mu by'ukuri ni indwara idakunze kugaragara cyane. Urugero, abantu bagera ku 100 gusa ni bo bamaze kugaragara muri Leta Zunze Ubumwe za Amerika kugeza ubu. Bityo rero ushobora kwiyumvisha ukuntu ari imbonekarimwe.

Gukura gusanzwe bibaho gute mu bana? Ni irihe tandukaniro riri hagati ya gigantism?

Imisemburo yo gukura (GH) ni yo igenzura imikurire mu bwana. Ni ukuvuga ko igenzura imikorere y'umubiri mu gihe itera imikurire ifatika mu magufwa, imitsi n'ingingo. Ubusanzwe, imikurire iba ihamye kugeza umwana ageze mu bwangavu.

Mu gihe cy'ubugimbi, imisemburo y'imibonano mpuzabitsina (estrogen na testosterone) irazamuka cyane. Ibi bituma epiphyses (ibice by'igufwa) ku mpera z'amagufwa maremare y'umwana bifunga buhoro buhoro. Iyo epiphyses ifunga burundu, ni ukuvuga iyo ubugimbi burangiye, gukura k'uburebure kurahagarara.

Uburyo umwana akura vuba n'uburebure bwe bwa nyuma nyuma yo kugera mu bwangavu bigenwa n'uruvange rw'uturemangingo twinshi akura ku babyeyi be, ibintu bifitanye isano n'ibidukikije, n'igitsina cye.

Ku bijyanye n’indwara ya gigantism, umwana akura vuba cyane, kandi akaba muremure cyane kurusha abandi bana b’ingeri imwe n’igitsina kimwe. Ariko, ibimenyetso bya gigantism mu ntangiriro bishobora kugaragara nk’ibyiciro bisanzwe by’imikurire y’umwana, bigatuma ababyeyi bigorana kubimenya.

Niba ufite ikibazo cyangwa impungenge ku gipimo cy'imikurire y'umwana wawe, menya neza ko wavuganye na muganga we.

Ni ibihe bimenyetso by'ubugigantime?

Ubwinshi buterwa no kwiyongera k'umusemburo utera gukura (GH). Nanone, ikibyimba cyo mu gasabo k'ubwonko gishobora gushyira igitutu ku bwonko bwegereye n'ingingo z'imitsi, bigatera ibimenyetso bimwe na bimwe. Ikimenyetso nyamukuru cy'ubwinshi ni ukwiyongera gukabije.Abana bafite ubumuga bwo gucika intege bakura vuba cyane.

Uretse kuba umuntu muremure cyane/afite ubunini burenze imyaka ye, imiterere y'umubiri igaragara muri gigantism irimo:

• Agahanga gagaragara cyane n'umusaya ugaragara cyane.
• Kugira icyuho hagati y'amenyo.
• Kubyimba kw'imiterere y'isura.
• Amaboko n'ibirenge binini, n'intoki nini.

Izindi bimenyetso zishobora kugaragara harimo:

• Kwaguka kw'ingingo z'imbere, cyane cyane umutima w'umwana.
• Kubira ibyuya byinshi (hyperhidrosis).
• Kureba kabiri cyangwa kugorana mu kureba impande.
• Umutwe.
• Kubabara ingingo.
• Gutinda mu bugimbi.
• Guhagarara mu buryo butari bwo.
• Urugero, ibibazo byo gusinzira, indwara yo kubura umwuka wo mu mutwe.
• Intege nke z'imitsi.

Niba umwana wawe afite ibi bimenyetso, ni ngombwa cyane kuvugana na muganga vuba bishoboka.

Ni izihe mpamvu zitera ubugiganti?

Ubukana bwa Gigantism bukunze guterwa n'ikibyimba kitari kibi (pituitary adenoma) mu gasabo k'ubwonko k'umwana. Ibi bituma habaho kurekurwa cyane kwa hormone yo gukura (GH). Iyo abana bafite gigantism basuzumwe, hafi ya buri gihe bagira agasabo ka pituitary (ikibyimba gifite uburebure bwa mm 10 cyangwa kirenze), kitwa macroadenoma. Ubukana bwa Gigantism bushobora guterwa no kwiyongera kwa pituitary gland, kitwa pituitary hyperplasia.

Abana benshi bafite indwara ya gigantism bafite ihinduka ry’uturemangingo ritera ikibyimba cy’ubwonko. Ihinduka ry’uturemangingo rikunze kugaragara rijyanye na gigantism ni ihinduka cyangwa gusiba kwa gene ya AIP. Ibi bigira ingaruka ku bantu bagera kuri 29% bafite indwara ya gigantism.

Ubukana bushobora kandi kubaho nk'igice cy'indwara nyinshi zidasanzwe ziterwa n'uturemangingo zongera ibyago byo kurwara ikibyimba cy'ubwonko gitanga imisemburo ikura (GH). Zimwe muri izo ndwara zirimo:

• Carney complex: Iyi ni indwara iterwa n’imiterere y’umubiri ikagira ingaruka ku ibara ry’uruhu kandi igatera ibibyimba by’uruhu, umutima, n’imikorere y’imisemburo. Abantu bagera kuri 10% kugeza kuri 13% bafite Carney complex bakuramo imisemburo ikura mu bwonko (GH), isanzwe ikura buhoro buhoro.
• Indwara ya McCune-Albright:Iyi ni indwara iterwa n’uturemangingo (genetic disorder) igira ingaruka ku magufwa, uruhu, n’imikorere y’imisemburo. Itera uduce twa café-au-lait ku ruhu, inkovu mu magufwa, no kuba mu bwana mbere y’uko umuntu atangira kuba mu bwana. 20% kugeza kuri 30% by’abantu barwaye McCune-Albright syndrome bafite imisemburo ikabije yo gukura (GH). Ibi akenshi biterwa no kwiyongera (hyperplasia) kw’agace ka pituitary, cyangwa adenoma ya pituitary.
• Ubwoko bwa 1 cyangwa 4 bwa Endocrine Neoplasias (MEN): Izi ni indwara zikomoka ku ngirabuzimafatizo. Muri iki gihe, imwe cyangwa nyinshi mu ngirabuzimafatizo zawe zikora cyane, cyangwa ikibyimba kikavuka. Ibi bishobora kuba birimo ikibyimba cya pituitary gisohora imisemburo yo gukura (GH).
• Neurofibromatosis: Iyi ni indwara iterwa n'uturemangingo twitwa neurocutaneous disorders. Izi ndwara zigira ingaruka ku ruhu no ku mitsi. Izi ndwara ziterwa no kwiyongera kudasanzwe kw'uturemangingo. Ibi bishobora gutuma habaho ibibyimba mu mubiri wose. Ibi bishobora kuba birimo ikibyimba gitanga imisemburo ikura (GH).
• Adenomas zo mu bwonko zikomoka ku muryango (FIPA): Iyi ni indwara umuntu avukana mu mizi. Itera indwara zo mu bwonko zikomoka ku bwonko. Izi ndwara zishobora kuba zirimo imisemburo ikura mu bwonko (GH).

Ni gute indwara ya gigantism ipimwa?

Indwara ya Gigantism ishobora kugorana kuyisuzuma kuko ari indwara idakunze kugaragara, kandi kubera ko igipimo cy'iterambere ry'abana gishobora gutandukana cyane bitewe n'imiterere y'umubiri n'ibidukikije.

Ubusanzwe, abaganga bakeka ko uburebure bw'umwana buruta uburebure butatu busanzwe bw'igitsina n'imyaka ye, cyangwa uburebure bubiri buruta uburebure busanzwe bw'ababyeyi be.

Niba muganga w'umwana wawe akeka ko umwana wawe afite indwara ya gigantism, ashobora kukwohereza kwa muganga w'indwara z'imitsi (umuganga wihariye mu ndwara ziterwa n'imisemburo). Muganga azagusuzuma akurikije amateka y'ubuzima bw'umwana wawe, amateka y'ubuzima bw'umuryango, isuzuma ryimbitse ry'umubiri, n'ibizamini byihariye nko gupima amaraso no gupima amashusho.

Ni ibihe bipimo bikoreshwa mu gusuzuma indwara ya gigantism?

Niba muganga w'umwana wawe akeka ko afite indwara ya gigantism, ibizamini bikurikira bishobora gukorwa kugira ngo byemezwe ko afite ikibazo:

• Ibipimo by'amaraso bya Hormone Ikura na IGF-1 (Insulin-like Growth Factor 1): Ibi bizamini bipima urugero rw'imisemburo itandukanye mu maraso yakuwe mu mitsi y'umwana. Iyo urugero ruri hejuru y'ibisanzwe, bishobora kuba ikimenyetso cy'ubugimbi.
• Ikizamini cyo kwihanganira isukari: Iki kizamini gipima uburyo imisemburo y'umwana ikura ikora neza iyo isukari ikoze. Kuri iki kizamini, muganga afata amaraso mu mitsi mu bihe bitandukanye nyuma y'uko umwana anyoye umuti wa sukari.
• Ibizamini byo gupima: Iyo ibipimo by'amaraso byemeza ko umwana wawe afite indwara ya gigantism, muganga wawe akunze kukugira inama yo gupima MRI (Magnetic Resonance Imaging) cyangwa CT (Computed Tomography). Ibi bishobora kureba neza ingano n'aho ikibyimba cy'ubwonko giherereye. Bishobora kandi gufasha kumenya neza uburyo bwo kuvura umwana neza.

Iyo umwana wawe asanzwe afite indwara ya gigantism, muganga ashobora gukora ibindi bipimo kugira ngo arebe niba iyi ndwara yaragize ingaruka ku bindi bice by'umubiri. Ibi bizamini bishobora kuba birimo:

• Echocardiogram yo gusuzuma ibibazo by'umutima.
• Ibizamini byo kwiga ku bijyanye no gusinzira kugira ngo harebwe niba ufite ikibazo cyo guhumeka mu gihe cyo gusinzira.
• Imirasire ya X cyangwa isuzuma rya DEXA/DXA kugira ngo harebwe ubuzima bw'amagufwa yawe.

Indwara ya gigantisme ivurwa ite?

Intego z'ingenzi zo kuvura gigantism ni:

• Kugenzura neza urugero rwa 'growth hormone' (GH) na 'insuline-like growth factor 1' (IGF1).
• Gucunga ikura ry''ikibyimba cy'ubwonko''.
• Kugabanya ingaruka z'ikibyimba cya pituitary ku ngingo z'ubwonko zegereye n'imitsi y'amaso.
• Kuvura cyangwa kugabanya ingaruka za hormone yo gukura (GH) ku zindi ngingo z'umubiri.

Ubusanzwe abaganga bakoresha uburyo butandukanye bwo kuvura indwara ya gigantism , aho kubaga no kuvura hakoreshejwe imirasire ari byo bikunze kuvura.

Nubwo hari imiti ivura imisemburo myinshi ikomoka ku gukura (GH) ku bantu bakuru (acromegaly), ingaruka z'iyi miti ku bana ntiziramenyekana neza.

Kubaga Gigantism

Kubagwa ni bwo buryo bukunze kuvura indwara ya gigantism. Intego ni ugukuraho ikibyimba cya pituitary cyangwa kugabanya ingano yacyo. Kubera ko ikibyimba cya pituitary gitera gigantism akenshi kiba kinini, umwana ashobora gukenera kubagwa inshuro nyinshi kugira ngo agenzure neza urugero rw'imisemburo ikura (GH).

Umuganga w’umwana wawe ashobora gukoresha uburyo bwo kubaga bwitwa transsphenoidal surgery kugira ngo akureho ikibyimba cy’ubwonko. Ibi bikubiyemo kubaga umwana wawe binyuze mu mazuru ye no mu gice cy’ubuhumekero (umwobo uri mu gahanga inyuma y’uruti rw’izuru, munsi y’ubwonko).

Uburyo bwo kuvura indwara ya Gigantism hakoreshejwe imirasire

Iyo kubagwa binaniranye kugabanya urugero rw'imisemburo ikura, ubuvuzi bushingiye ku mirasire bushobora gufasha. Ibi bisaba gukoresha ibikoresho byihariye kugira ngo imirasire igere ku kibyimba. Ubu buryo bukora buhoro. Bushobora gusaba ubuvuzi bwinshi, hagati aho hakabaho igihe kirekire cyo kuruhuka. Bishobora kandi gufata imyaka myinshi kugira ngo haboneke ibisubizo byuzuye.

Ni izihe ngorane zigira mu kuvura?

Bitewe no kubagwa cyangwa kuvurwa hakoreshejwe imirasire, abantu bagera kuri 60% bafite ikibazo cya gigantism barwara indwara yitwa hypopituitarism nyuma yo kuvurwa. Ibi bibaho iyo imisemburo imwe, myinshi, cyangwa yose ikorwa n'agace ka pituitary idakora neza. Hypopituitarism ivurwa n'imiti isimbura imisemburo.

Ingorane zishobora guterwa no kubagwa kugira ngo hakurweho ikibyimba cy'ubwonko kiri mu maraso harimo:

• Kuva amaraso.
• Kuva kw'amazi yo mu bwonko (CSF).
• Meningite (umuriro wo mu bwonko).
• Gutakaza umunyu n'amazi mu mubiri.

Ingaruka mbi zo kuvura hakoreshejwe imirasire zishobora kuba zirimo:

• Uburumbuke budafite ubushobozi bwo kubyara.
• Kutabona neza no kwangirika k'ubwonko (bidakunze kubaho).
• Kuvuka kwa kanseri nyuma y'imyaka myinshi nyuma yo kuvurwa (bikunze kubaho).

Ese indwara ya gigantism ishobora kwirindwa? Ni iki giteganyijwe?

Ikibabaje ni uko nta kintu na kimwe wakora kugira ngo wirinde indwara ya gigantism. Ariko, kuyimenya hakiri kare ni ingenzi cyane. Kuvurwa hakiri kare bishobora gufasha gukumira cyangwa gusubiza inyuma impinduka zituma umwana wawe aba muremure cyane.

Igipimo cy’indwara ya gigantism ku bana n’urubyiruko giterwa n’ibintu byinshi:

• Uko indwara yagaragaye hakiri kare cyangwa nyuma.
• Ni ubuhe buryo bwo kuvura butanga umusaruro mu gucunga urugero rw'imisemburo ikura?
• Niba hari ingorane zijyanye n'ubugiganti.

Muri rusange, abantu bakuze iyo basuzumwe bakunze kugira ingorane nyinshi kurusha abasuzumwe bakiri bato. Ibi bishobora guterwa no kumara igihe kinini bahura n’imisemburo ikura hamwe n’ubwoko bwa insuline bumeze nk’ubwa mbere (IGF1).

Kubwibyo, niba ubonye impinduka zidasanzwe kandi zitunguranye mu mikurire y'umwana wawe cyangwa imiterere ye, ni ngombwa kuvugana na muganga we vuba bishoboka.

Ni ibihe byiringiro by'ubuzima bw'umuntu ufite ubumuga bwo mu mutwe? Ni izihe ngorane z'igihe kirekire?

Gutahura no kuvura indwara ya gigantism hakiri kare ni ingenzi kugira ngo hirindwe uburebure bukabije n'ingorane zijyana na yo no kongera igihe cyo kubaho.

Iyo itavuwe, gigantism ifitanye isano n'ingorane zikomeye kandi igipimo cy'impfu gishobora kugera kuri kabiri ugereranije n'ibisanzwe.

Ingorane z'igihe kirekire bamwe mu bantu bafite ikibazo cya gigantism bahura nazo bitewe n'uburebure bwabo bukabije ndetse n'ingaruka rusange zo kugira imisemburo myinshi yo gukura zirimo:

• Kugorwa no kugenda (Gutembera) bitewe n'intege nke z'imitsi.
• Osteoarthritis (kubyimba ingingo).
• Udukoko tw’imitsi yo mu gice cy’imbere (peripheral neuropathy).
• 'Indwara yo kubura ibitotsi'.
• Ibibazo by'umutima (umutima n'imitsi) n'imitsi y'umutima.
• Ingorane zijyanye na metabolisme nka Diyabete yo mu bwoko bwa 2.

Byongeye kandi, ubuzima bw'abantu bafite ikibazo cy'uburemere bukabije bushobora kugabanuka bitewe n'ibibazo by'imirimo ya buri munsi nko guhaha imyenda no gutembera bitewe no kuba barebire cyane.

Ni ryari wagombye kubonana na muganga w'umwana wawe ku bijyanye n'ubugiganti?

Niba umwana wawe yarasanzwe afite indwara ya gigantism, azakenera kujya kwa muganga we cyangwa/cyangwa umuhanga mu by’ubuvuzi bw’indwara z’imitsi kugira ngo akurikirane aho ubuvuzi bugeze no kureba neza ko urugero rw’imisemburo ye ruri mu buryo bukwiye.

Niba ubonye impinduka mu mikurire y'umwana wawe cyangwa imiterere ye, ni ngombwa kuvugana na muganga w'umwana wawe vuba bishoboka. Nubwo gigantism idashoboka ko ari yo mpamvu, ni ngombwa gukora iperereza ku mpinduka zose zikekwa. Gigantism ni nziza kuyisuzuma hakiri kare, kandi abantu bafite gigantism basanzwe babaho ubuzima bwiza. Niba ufite ikibazo ku mikurire y'umwana wawe, ntutinye kubaza muganga wawe. Barahari kugira ngo bagufashe.

Ibintu by'ingenzi cyane ugomba kwibuka (Ubutumwa bwo kujyana mu rugo)

Indwara ya Gigantism ni indwara idakunze kugaragara ariko ishobora kuba ikomeye. Ikintu cy'ingenzi ni ugushaka inama kwa muganga vuba mu gihe ubonye ikintu kidasanzwe cyangwa giteye amakenga ku mikurire y'umwana wawe, nko gukura vuba kurusha uko byari byitezwe cyangwa kugira amaguru manini.

Wibuke ko gusuzuma no kuvurwa hakiri kare byongera cyane amahirwe yo kubaho ubuzima bwiza kandi busanzwe bw'umwana wawe. Ntugahangayike, abaganga barahari kugira ngo bagufashe wowe n'umwana wawe. Ganira nabo ku mpungenge zose ushobora kuba ufite.

Gigantism , Imisemburo yo Gukura, Indwara y'ubwonko, Ikura mu bana, Ukwiyongera k'uburebure, Acromegaly