Reka twige byinshi kuri glukagoni, ifasha mu kugenzura urugero rw'isukari mu mubiri wawe.

Ese wigeze wibaza uburyo isukari mu maraso yacu igenzurwa? Hari ikintu cyihariye gifasha iyi yitwa Glucagon. Nk'intwari nto mu mubiri wacu, Glucagon irinda isukari mu maraso yacu kugabanuka cyane. Uyu munsi, turaganira kuri iyi Glucagon mu buryo burambuye kandi bworoshye cyane.

Glucagon ni iki?

Muri make, glucagon ni imisemburo karemano ikorwa n'imibiri yacu . Urabizi, ikorwa n'uturemangingo twa alpha two mu imisemburo yacu. Iyo urugero rwa glucose mu maraso yacu rugabanutse, iyo tutarya igihe kirekire (igihe kirekire cyo kwiyiriza ubusa), iyo dukora siporo cyane, cyangwa iyo turya ifunguro rikungahaye kuri poroteyine, iyi glucagon irarekurwa.

Tekereza kuri ibi, isukari ni yo isukari nyamukuru mu maraso yacu. Iyi sukari tuyikura muri karubohidrati mu byo turya n'ibyo tunywa. Iyi sukari ni yo itanga imbaraga ku ngingo z'umubiri wacu, imitsi, n'imitsi. Ni nk'amavuta ku modoka. Bityo rero, umubiri wacu ubusanzwe ugumana iyi sukari mu maraso ku rugero rukwiye mu buryo bugoye cyane. Yaba iri hejuru cyane cyangwa iri hasi cyane, indwara zitandukanye n'ingorane zishobora kubaho.

Inshinge za Glucagon n'imiti iterwa mu mazuru

Uretse glucagon isanzwe, hari na glucagon zikozwe mu nganda. Izi zishobora gutangwa nk'urushinge cyangwa nk'umuti wumye mu mazuru. Ushobora kuba warabibonye mu bihe byihutirwa, cyane cyane ku bantu barwaye diyabete yo mu bwoko bwa 1 , iyo isukari yabo yo mu maraso igabanutse cyane (hypoglycemia). Glucagon itangwa muri iki gihe irekura isukari ibitse mu mwijima wacu kandi ikongera vuba isukari yo mu maraso yacu. Ni nko kuduha 'imbaraga' nke.

Ni iki glucagon ikora ku mubiri wacu?

Niba pancreas yawe ikora neza, umubiri wawe uzagenzura neza urugero rw'isukari mu maraso yawe. Ibi bikorwa ahanini n'imisemburo ibiri yitwa glucagon na insuline . Urugero, iyo urugero rw'isukari mu maraso yawe rugabanutse cyane (hypoglycemia), pancreas yawe irekura glucagon nyinshi. Iyi glucagon ifasha kuzamura urugero rw'isukari mu maraso yawe mu buryo butandukanye:

• Ubwa mbere, glucagon ijya mu mwijima wacu igahindura glucose yabitswemo – ari yo twita glycogen – ikaba ikintu dushobora gukoresha. Hanyuma umwijima ukayirekura mu maraso.
• Icya kabiri, glucagon ishobora guhagarika umwijima gufata no kubika glucose, bigatuma glucose nyinshi mu maraso isigara.
• Icya gatatu, aside amineGlucagon kandi ifasha umubiri gukora isukari iturutse ku zindi soko, nko:

Wibuke ko bimeze nk'umuti wo guteka. Iyo isukari igabanutse mu maraso, glucagon irakora, kandi iyo isukari izamutse mu maraso, insuline irakora!

Ni izihe ndwara zishobora kuba zifitanye isano n'ibibazo by'imikorere ya glucagon?

Noneho reka turebe ibibazo bishobora kuvuka mu gihe glucagon idakora neza.

Niba urwaye diyabete, umubiri wawe ushobora kudashobora kurekura glukagoni ihagije iyo isukari yo mu maraso yawe iri hasi. Ibi bishobora gutuma ugira isukari nke mu maraso kenshi, cyangwa se isukari nke cyane mu maraso . Izi ngaruka ziba nyinshi cyane iyo ufata imiti igabanya isukari mu maraso nka insuline cyangwa sulfonylureas.

Ku bantu bamwe na bamwe barwaye diyabete yo mu bwoko bwa 2, urugero rwa glucagon rushobora kuba ruri hejuru y’ibisanzwe, ugereranyije n’urugero rw’isukari mu maraso. Iyi ni imwe mu mpamvu ituma urugero rw’isukari mu maraso ruri hejuru.

Ni gake cyane ko ibibazo byo gukora glucagon bibaho nta diyabete, ariko hari ibihe bike bishobora kubaho:

• Pancreatitis: Iyo urwaye diyabete iterwa na pancreatitis hanyuma ugafata insuline, ushobora no kubura glucagon. Ibi byongera ibyago byo kugabanuka kw'isukari mu maraso.
• Glucagonoma: Iki ni ikibyimba kidakunze kugaragara cyane cya pancreas. Gisohora glucagon nyinshi cyane. Ibi bitera ibimenyetso nko kuba isukari nyinshi mu maraso, uduheri ku ruhu, no kugabanya ibiro.
• Indwara nyinshi z'imisemburo (MEN): Iyi nayo ni indwara idakunze kugaragara cyane mu maraso. Muri iyi ndwara, ibibyimba bikura mu tunyangingo turenze kamwe mu maraso yawe. Harimo na pancreas.
• Ingaruka mbi ku icibwa ry’imisemburo: Iyo ku mpamvu runaka igice cya pancreas yawe cyangwa yose ikuweho, uturemangingo dukora glucagon na insuline turabura.

Ni ibihe bimenyetso by'ibibazo bifitanye isano na glukagoni?

Nkuko twabiganiriyeho mbere, kutagira imiterere myiza mu gipimo cya glucagon bishobora gutera isukari nke mu maraso (hypoglycemia) cyangwa isukari nyinshi mu maraso (hyperglycemia). Reka turebere hamwe ibyo bimenyetso.

Ibimenyetso by'isukari nke mu maraso (Hypoglycemia)

Tekereza ko inshuti yawe, Nilanthi, arimo gufata imiti ya diyabete. Umunsi umwe, ahita atangira guhinda umushyitsi, kubira ibyuya, no kumva ameze nk'uzunguza. Asa n'uvuga amagambo make iyo avuga. Ibi bimenyetso biramutse bigaragaye, bishobora gusobanura ko isukari mu maraso ye iri hasi cyane.

Ibimenyetso bisanzwe birimo:

• Gutigita, guhinda umushyitsi
• Kubira ibyuya no kumva bikonje
• Kuzungera, kumva ufite umutwe mwiza
• Umutima utera cyane
• Inzara
• Kugorwa no kwibanda ku bintu, urujijo

Icy'ingenzi: Niba ubonye ibi bimenyetso, ni ngombwa cyane kurya ikintu kirimo isukari, ibiryo cyangwa ikinyobwa gikungahaye kuri karubohidrati vuba bishoboka . Ibi bizafasha isukari yawe mu maraso gusubira ku rugero rusanzwe. Niba ubonye ibi bimenyetso kenshi, ugomba kujya kwa muganga wawe.

Ibimenyetso by'isukari nyinshi mu maraso (Hyperglycemia)

Isukari nyinshi mu maraso (hyperglycemia) ikunze guterwa no kubura insuline, ntabwo ari ikibazo kiri kuri glucagon gusa. Ariko, ibibazo bidasanzwe bya glucagon nabyo bishobora gutera isukari nyinshi mu maraso. Ibimenyetso bya mbere ni ibi bikurikira:

• Inyota ikunze kubaho cyangwa inzara
• Kureba nabi
• Kwihagarika kenshi ( kwihagarika kenshi)
• Umutwe

Niba ufite ibi bimenyetso, ni ngombwa cyane kubonana na muganga.

Ni ibihe bizamini bikorwa kugira ngo harebwe urugero rwa glucagon?

Iyo ufite ibimenyetso bimwe na bimwe, muganga wawe ashobora gutegeka ko upimwa amaraso kugira ngo apime urugero rwa glucagon yawe. Muri iki kizamini, muganga cyangwa umuforomo afata amaraso mu mitsi yawe akoresheje urushinge. Hanyuma ayo maraso akoherezwa muri laboratwari kugira ngo apimwe.

Ingano isanzwe ya glucagon ni iyihe?

Ubusanzwe, ingano ya glucagon tugomba kugira mu maraso yacu iri hagati ya picograms 50 na 100 kuri mililitiro imwe (pg/mL) . Picogram ni kimwe cya tiriyari imwe ya garama! Ni ingano nto cyane, sibyo?

Ariko ibuka ko ibi bipimo bisanzwe bishobora gutandukana gato bitewe na laboratwari. Bishobora kandi gutandukana bitewe n'igihe umaze wiyiriza ubusa n'ingano y'isukari mu maraso yawe igihe wapimwaga. Rero, gereranya ibisubizo byawe n'ibipimo biri kuri raporo y'isuzuma ry'amaraso yawe . Niba ufite ikibazo, vugana na muganga wawe.

Ni ryari nkwiye kujya kwa muganga ku bijyanye n'urugero rwa glucagon mfite?

Niba urwaye diyabete kandi ukaba ukunze kugira ibihe by'isukari nke cyangwa nyinshi mu maraso, ni ngombwa kujya kwa muganga. Igipimo cya Glucagon ntabwo gikunze gupimwa ku bantu barwaye diyabete. Ariko, ushobora gukenera guhindura uburyo bwo gucunga diyabete kugira ngo ugabanye ibyo bihe.

Nubwo izindi ngorane ziterwa na glucagon zidakunze kubaho, niba ufite ibimenyetso, ni ngombwa kumenya impamvu. Rero, menya neza ko wagiye kwa muganga.

Ni irihe tandukaniro riri hagati ya Glucagon na Glycogen?

Ese ibi byombi si bimwe? Glycogen ni ubwoko bwa glucose (isukari) ibikwa mu mwijima.Imibiri yacu ibika glycogen cyane cyane mu mwijima no mu mitsi.

Glucagon ni imisemburo imenyesha umwijima guhindura glycogen mo glucose. Iyo glucose yinjira mu maraso igakoreshwa nk'ingufu n'imibiri yacu.

Ni iki kiba kuri glukagoni mu gihe cyo kwiyiriza ubusa?

Iyo twiyirije ubusa, glukagoni ni ingenzi cyane mu gutuma igipimo cy'isukari mu maraso yacu kitagabanuka cyane. Ibi biterwa nuko imibiri yacu iba itabona isukari mu biribwa muri icyo gihe.

Iyo twiyirije ubusa igihe kirekire, glukagoni ituma umubiri ukora glucose iturutse mu bintu bitari karubohidrati - nka lipide, aside amine na poroteyine. Iyi nzira yitwa glukoneogenesis .

Amaherezo, ngomba kuvuga... (Ubutumwa bwo kujyana mu rugo)

Rero, ushobora kuba usobanukiwe ko glukagoni ari imisemburo y'ingenzi cyane ifasha mu gutuma urugero rw'isukari mu maraso rukomeza kuba rwiza 'muri ruhago'. Ntabwo bishoboka cyane ko waba ufite diyabete cyangwa ibibazo bifitanye isano na glukagoni.

Ariko, niba ukunze kugira ibimenyetso by'isukari nke mu maraso cyangwa isukari nyinshi mu maraso, nyamuneka reba muganga wawe. Hanyuma bashobora kubona impamvu hanyuma bakaguha ubuvuzi ukeneye. Kwita ku buzima bwawe ni cyo kintu cy'ingenzi kurusha ibindi.

` glukagoni, isukari yo mu maraso, hypoglycemia, hyperglycemia, diyabete, pancreas, imisemburo