Reka twige ku bwoko bushya bw'imiti igabanya cholesterol (PCSK9 Inhibitors)?

Ese muganga wawe yakubwiye ko urugero rwa cholesterol yawe ruri hejuru? Niba ari byo, ushobora kuba waratangiye gufata statin. Ubusanzwe ni wo muti wa mbere. Ariko rimwe na rimwe uwo muti wonyine ntuhagije. Cyangwa hari abantu badashobora kwihanganira ingaruka mbi z'umuti. Niyo mpamvu abaganga ubu bavuga ku bwoko bushya bw'imiti 'ihindura umukino'. Iyi yitwa PCSK9 Inhibitors. Reka tubiganireho mu magambo yoroheje uyu munsi.

Mu magambo make, izi PCSK9 Inhibitors ni iki?

Iyi ni ubwoko bushya bw'imiti ishobora kugabanya neza cholesterol 'mbi', cyangwa cholesterol ya LDL , mu maraso yacu. Kuri ubu hari ubwoko bubiri bw'imiti bwemewe ku isi. Ni `alirocumab (Praluent)` na `evolocumab (Repatha)`.

Ubushakashatsi bwagaragaje ko iyi miti, yitwa PCSK9 inhibitors, igira ingaruka nziza ku buryo butangaje. Hari ubwo ishobora no gukumira indwara z'umutima n'imitsi yo mu bwonko . Iyi miti ishobora gufatwa yonyine, cyangwa ikayinywa hamwe n'umuti wa statin usanzwe ufata. Ariko ikintu kimwe ugomba kuzirikana ni uko ihenze cyane kurusha indi miti ya cholesterol.

Noneho reka turebe uko uyu muti ukora imbere mu mubiri.

Kugira ngo tubisobanukirwe neza, reka dutekereze ku nkuru nto. Urugingo rw'ingenzi rugenzura cholesterol mu mubiri wacu ni umwijima.

Ariko, hari indi poroteyine yitwa PCSK9 umubiri wacu ukora. Akazi kayo ni ugushaka no gusenya ibyo "bisukura" byiza. Hanyuma, kubera ko nta muntu ukuramo cholesterol, yirundanya mu maraso ikajya mu nkuta z'imitsi.

Aha niho umuvuduko wacu, umuti ubuza imiti ya PCSK9, ufasha. Icyo uyu muti ukora ni ugufata iyo poroteyine mbi ya PCSK9 ikayihagarika gukora. Ni nko gufata umwana w'umugome ukamushyira ku ntebe. Hanyuma "abasukura" bacu bashobora gukora akazi kabo nta mbogamizi. Ingaruka zabyo ni izihe? Urugero rwa cholesterol ya LDL mu maraso rugabanuka vuba.

Ibi bitandukanye bite na 'statins'?

Imiti ya Statine na PCSK9 igabanya cholesterol ni ubwoko bubiri bw'imiti, ariko ikora mu buryo bubiri butandukanye. Iyi mbonerahamwe izagufasha kubisobanukirwa.

None se ni nde ushaka gufata uyu muti?

Iki ni ikibazo cy'ingenzi kuko si buri wese ufite cholesterol nyinshi ukeneye uyu muti. Muganga wawe azabanza kugerageza kugenzura cholesterol yawe akoresheje statins. Ariko muganga wawe ashobora gutekereza ku muti ubuza PCSK9 mu bihe bikurikira:

• Indwara za cholesterol nyinshi mu maraso: Hari abantu bafite ikibazo cya cholesterol cyitwa "Familial Hypercholesterolemia." Aba bantu bafite inenge mu buryo umubiri wabo ugenzura cholesterol. Nubwo hari statins nyinshi, biragoye cyane kuri abo bantu kugabanya cholesterol ya LDL ikagera ku rwego rwiza.
• Ku bantu bafite ibyago byinshi byo kurwara indwara z'umutima cyangwa indwara zo mu bwonko: Niba usanzwe ufite indwara z'umutima, kandi urugero rwa cholesterol yawe rudagenzurwa neza n'imiti nka statins, muganga wawe ashobora gusuzuma uyu muti.
• Ku bantu badashobora kwihanganira 'statins': Abantu bagera kuri 10%-20% bafata statins bagira ingaruka mbi nko kubabara imitsi, intege nke, no kubabara umubiri . Kuri abo bantu, iyi ishobora kuba amahitamo meza.

Ni ryari muganga atanga uyu muti?

Muganga ntabwo yatanga uyu muti icyarimwe. Hariho uburyo bwo kuwukoresha.

1. Ubwa mbere, hindura imibereho yawe: Muganga abanza kukubwira gukora imyitozo ngororamubiri neza no kurya ibiryo byiza birimo amavuta make, isukari n'ifu .

2. Hanyuma, 'Statin': Iyo guhindura imibereho bidahagije, statin iratangira. Iyo cholesterol itagabanutse, igipimo cyongerwa buhoro buhoro.

3. Nk'uburyo bwa nyuma: Niba cholesterol yawe idagenzurwa nubwo waba ufite statins nyinshi, cyangwa niba ingaruka mbi ari nyinshi, muganga wawe ashobora kugufasha gufata inhibitor ya PCSK9. Iki cyemezo gishobora gufatwa binyuze mu gukora ikizamini, nk'amanota ya calcium mu mitsi y'umutima, kugira ngo umenye ibyago byo kurwara indwara z'umutima.

Uyu muti ukoreshwa ute kandi ni izihe ngaruka mbi?

Iterwa nk'urushinge rwo munsi y'uruhu utanga buri byumweru bibiri cyangwa bine . Ushobora kuyitera mu ruhu rwo mu nda yawe, mu itako ryo hejuru, cyangwa mu kuboko ko hejuru. Muganga wawe cyangwa umuforomo wabyigiye azakwereka uburyo bwo kuyitanga neza. Akenshi ntabwo ibabaza kandi yoroshye.

Ku bijyanye n'ingaruka mbi, izikunze kugaragara cyane ni ntoya.

• Kubabara umugongo
• Ibimenyetso bisa n'ibicurane (kurya mu muhogo, kubyara ibicurane)
• Gutukura, gukomereka, cyangwa ububabare buto aho umuntu yatewe inshinge

Amaherezo, iyo bigeze ku giciro cy'iyi miti, ntabwo ari nk'imiti isanzwe, kandi irahenze cyane . Kubwibyo, ubu buryo bwo kuvura bushobora kuba budahenze kuri buri wese. Ni byiza kuganira na muganga wawe mu buryo bweruye kuri ibi no kuganira niba ubikeneye, niba bikubereye, n'ibiciro byawe.