Chiremba wako akakunyorerera mushonga weBP yakakwira here kana kuti, kana uri murume, wekuwedzera prostate? Kana zvakadaro, zvingangoita kuti mushonga uyu unovhara alpha. Kunyangwe zita racho ringanzwika serakaoma, aya ndiwo mhando yemishonga inoshandiswa zvakanyanya kubatsira kudzora mamwe mamiriro emuviri wedu. Saka nhasi, ngatitaurei nezveaya ma alpha-blockers nenzira iri nyore yaunogona kunzwisisa.
Ma alpha-blockers aya anoshanda sei?
Kuti tinzwisise izvi, ngatifungei nezvehurongwa hwekutaurirana hwemuviri wedu. Hutano hwedu hwetsinga hwakafanana nebasa rekutumira mameseji. Hunotumira mameseji emakemikari (atinodaidza kuti ``Neurotransmitters'') kunhengo dzakasiyana dzemuviri wedu. Kuti tigamuchire mameseji aya, masero edu ane ''receptors'' dzakakosha. Zvakafanana nekiyi nekiyi. Sero iroro rinotanga kushanda chete kana meseji yemakemikari (kiyi) yasvika yopinda mureceptor yakakodzera (kiyi).
Ma-alpha-receptors imhando yema-receptor mumuviri wedu. Anonyanya kuwanikwa mutsinga dzeropa uye munzvimbo dzakadai seprostate gland. Kana ma-alpha-receptor aya agamuchira meseji, masero iwayo anotanga kuomesesa. Semuenzaniso, kana ma-alpha-receptors ari mutsinga dzeropa achishanda, tsinga dzeropa dzinoomesesa uye BP inowedzera.
Saka, zvinoitwa ne alpha-blocker zvakafanana nekuisa kiyi isiriyo mukamba woivhara. Mushonga uyu unoenda wonamatira kune ma alpha-receptors iwayo woadzivisa kuwana meseji chaiyo. Kureva kuti, 'unovhara' ma receptors iwayo. Zvadaro masero iwayo haapindi, anozorora. Kana masero ari mutsinga dzeropa akasununguka, tsinga dzeropa dzinokura, uye BP inodzikira. Kana tsandanyama dziri muprostate dzakasununguka, zvinova nyore kuita weti. Ndizvo zvinoitika.
Mhando dzealpha-receptors uye mabasa avo
Kune mhando mbiri huru dzealpha-receptors: alpha-1 (A1) nealpha-2 (A2). Dzese dzine mabasa akasiyana zvishoma.
| Rudzi rweReceptor | Nzvimbo uye mabasa makuru |
|---|---|
| Alpha-1 (A1) receptor |
|
| Alpha-2 (A2) receptor |
|
Alpha-blockers inoshandiswa mumamiriro api ezvinhu?
Rudzi urwu rwemushonga runonyanya kushandiswa kurapa zvirwere zvakasiyana-siyana.
1. Kukwira kweropa (BP)
Uku ndiko kushandiswa kukuru. Sezvatakambokurukura, mishonga inodzivisa ropa inozorodza mitsipa yeropa uye inoderedza BP. Mishonga yakaita seDoxazosin, Prazosin, uye Terazosin inowanzo shandiswa pachinangwa ichi.
2. Kusashanda zvakanaka kweProstatic Hyperplasia (BPH)
BPH chirwere chinowanzoitika kuvarume pavanenge vachikura. Muchirwere ichi, prostate gland inokura uye inodzvanya urethra, zvichikonzera matambudziko akadai sekuoma kwekuita weti uye kuchengetedza weti. Mishonga yeAlpha-blockers yakaita seTamsulosin, Alfuzosin, uye Silodosin inozorodza tsandanyama dzeprostate nemutsipa wedundira, zvichiita kuti zvive nyore kuti weti ifambe.
3. Mamwe mashandisirwo (Mashandisirwo asina kunyorwa)
Dzimwe nguva, vanachiremba, zvichibva pane zvavakaona uye humbowo hwekurapa, vanonyora mushonga wemamwe mamiriro asiri iwo akatenderwa. Izvi zvinonzi kushandiswa kwe 'off-label'.
- Matombo eItsvo: Mishonga yakaita seTamsulosin inopiwa kubatsira matombo madiki anonamira muweti kuti apfuure zviri nyore.
- Dambudziko rekushushikana mushure mekutambudzika (PTSD): Mushonga wePrazosin dzimwe nguva unoshandiswa kurapa chirwere ichi.
- Pheochromocytoma: Iyi imhando yebundu rinokura muadrenal glands uye rinoburitsa mahormone akawandisa. Alpha-blockers inopiwawo kudzora BP yakakwira inokonzerwa nemabundu aya.
Ndezvipi migumisiro nenjodzi dze alpha-blockers?
Kufanana nemishonga yese, mishonga ye alpha-blockers inogona kuva nemigumisiro yakaipa. Ndosaka vanachiremba vachinyatsochenjerera pavanopa mishonga iyi. Migumisiro yakaipa yaunosangana nayo inogona kusiyana zvichienderana nerudzi rwemishonga yaunotora.
Chinhu chimwe chakakosha ndechekuti "mushonga wekutanga unotorwa." Paunotora piritsi rekutanga re alpha-blocker, BP yako inogona kudonha zvakanyanya. Izvi zvinogona kukonzera dzungu , kuona zvisipo, uye kunzwa sekunge wadonha paunomira (orthostatic hypotension) . Kuti uderedze njodzi iyi, chiremba wako anowanzo kukuudza kuti utore mushonga panguva yekurara wotanga nedosi shoma.
Heano mamwe emigumisiro inowanzoonekwa:
- Dzungu kana kuona zvisipo (kunyanya kana wakamira)
- Musoro
- Kunzwa kuneta
- Kuzara kwemhino
- Kurova kwemoyo nekukurumidza (tachycardia)
- Mhedzisiro pakushanda kwepabonde: Vamwe varume vanogona kusangana nechirwere chinonzi anejaculation. Kashoma, nhengo yekubereka inorwadza inotora maawa anopfuura mana (priapism). Ichi chirwere chinoda kurapwa nekukurumidza.
Zvinhu zvekurangarira kana uchitora mushonga uyu
- Kudyidzana kwemishonga nemimwe mishonga: Mishonga yeAlpha-blockers inogona kudyidzana nemimwe mishonga yeBP, mimwe mishonga inokonzera kusashanda zvakanaka kwepabonde, nemimwe mishonga. Saka, zvakakosha kuudza chiremba wako nezvemishonga yese yauri kutora.
- Kunwa doro: Kunwa doro kunogona kuwedzera migumisiro yakadai sedzungu .
- Kuvhiyiwa kweCataract: Kana uchironga kuvhiyiwa cataract, unofanira kuudza chiremba wemaziso kuti uri kutora alpha-blockers, sezvo mishonga iyi inogona kukonzera matambudziko panguva yekuvhiyiwa.
- Kurega mushonga: Usamborega kutora mushonga uyu kamwe kamwe usina kubvunza chiremba wako. Kuita izvi kunogona kukonzera migumisiro yakaipa, yakadai se rebound hypertension. Kana uchida kurega kutora mushonga, ita izvozvo nenzira yakachengeteka uye zvichienderana nemirairo yachiremba wako.
Unofanira kutsvaga mazano ekurapa rini?
Kana muine mibvunzo nezvemushonga uyu, kana kuti kana migumisiro yacho iri kuita kuti zviomere kuita mabasa ezuva nezuva, taurai nachiremba wenyu.
Zvisinei, kana ukaona chimwe chezviratidzo zvinotevera, enda kuchipatara kuEmergency Department (ETU) nekukasika:
- Kurasikirwa nepfungwa kana kufenda
- Kurwadziwa kwechipfuva (`(Angina)`)
- Kuoma kufema
- Kurova kwemoyo nekukurumidza kana kusina kurongeka (kurova kwemoyo)
- Kumira kunorwadza kunotora maawa anopfuura mana (`(Priapism)`)
- Zviratidzo zvekusawirirana kwakanyanya (semuenzaniso mapundu, kuvaviwa, kuzvimba kwechiso/huro, kuoma kumedza)
Mharidzo Yekuenda Nayo Kumba
- Mishonga yeAlpha-blockers imhando yakakosha yemishonga inorapa zvirwere zvakaita seBP yakakwira uye benign prostatic hyperplasia (BPH).
- Izvi zvinoshanda nekuzorodza tsinga dzeropa netsandanyama dzeprostate gland.
- Paunotanga mushonga, kunyanya mushure memushonga wekutanga, dzungu rinogona kuitika, saka tora mushonga wacho husiku, sezvakarairwa nachiremba wako.
- Udza chiremba wako nezvemimwe mishonga yese yauri kutora.
- Usamborega kutora mishonga iyi kamwe kamwe usina kurairwa nachiremba wako.
- Kana ukasangana nematambudziko akakomba, tsvaga rubatsiro rwechiremba nekukasika.
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