Unowanzo tambura nekurwadziwa kwemajoini , kurwadziwa kwemusana , kana kurwadziwa kwakanyanya kunouya nekuenda kumwedzi here? Tobva tatora mushonga wekurwadziwa nekukasika . Asi waiziva here kuti kune mhando dzakasiyana dzemishonga iyi yekurwadziwa kwemudumbu? Nhasi tichataura nezvemhando yemishonga yekurwadziwa kwemudumbu inotora nzvimbo yakakosha pakati payo, uye inoshanda nenzira yakasiyana zvishoma. Iyo inhibitor yeCOX-2 .
Zvichitaurwa zviri nyore, chii chinonzi COX-2 Inhibitors idzi?
Mishonga inodzivirira COX-2 chaizvoizvo iboka remishonga inoderedza marwadzo uye inoderedza kuzvimba (inoderedza kuzvimba). Zita rekurapa reboka iri ndiNSAIDs, iro rinomiririra Nonsteroidal Anti-inflammatory Drugs. Mishonga yakaita seIbuprofen , Naproxen , uye Diclofenac yaunowanzo kunzwa nezvayo ndeyeboka iri rinonzi NSAIDs .
Zvisinei, rudzi urwu rwemushonga, runonzi COX-2 inhibitors, runoshanda mumuviri nenzira yakasiyana zvishoma neNSAID dzechinyakare dzatinoziva tese. Ngationei musiyano iwoyo.
Mushonga uyu unoshanda sei mumuviri? Inzira inoshamisa kwazvo!
Kuti tinzwisise izvi, tinofanira kutanga tanzwisisa mhando mbiri dzema enzymes mumiviri yedu. Aya ndiwo ma enzymes eCOX-1 neCOX-2 . Ma enzymes ese ari maviri anogadzira makemikari mumiviri yedu anonzi prostaglandins . Ma prostaglandins aya ndiwo anonyanya kukonzera kurwadziwa, kuzvimba, uye fivha.
Fungidzira izvi: Kune vashandi vaviri mukati mefekitori inonzi muviri wedu.
- COX-1 (mushandi wekutanga): Uyu mushandi akanaka. Anogadzira maprostaglandin anokonzera kurwadziwa nekuzvimba. Asi pamusoro pezvo, anoita zvinhu zviviri zvakakosha . Chimwe ndechekudzivirira dumbu redu neura kubva muacid yemudumbu. Chimwe ndechekubatsira pakugwamba kweropa.
- COX-2 (Mushandi 2): Iri ndiro dambudziko chairo. Basa rayo guru kugadzira maprostaglandin anokonzera marwadzo nekuzvimba.
Zvino tarisai, patinotora mishonga inoderedza marwadzo (Non-selective NSAIDs) yakaita seIbuprofen neDiclofenac, mushonga unomisa mishonga yese iyi. Zvadaro, nekuti COX-2 inomiswa, kurwadziwa nekuzvimba zvinodzikira. Asi nekuti mushandi akanaka, kureva COX-1, anomiswa, dziviriro yemudumbu inorasika , uye mikana yechirwere chegastritis, kuzvimba mudumbu, uye pamwe maronda inowedzera.
Asi, mhando iyi yemishonga inonzi COX-2 inhibitors yakangwara zvikuru. Inoenda zvakananga kumushandi wedambudziko, kureva, enzyme yeCOX-2 . Inorega mushandi akanaka (COX-1) achiita basa rayo. Saka kukuvara kwedumbu kushoma. Iyi ndiyo mukana mukuru wemhando iyi yemishonga.
Mishonga inodzivirira COX-2 inoshandiswa pamamiriro ezvinhu api?
Vanachiremba vanokurudzira rudzi urwu rwemushonga wekuderedza marwadzo ari pakati nepakati uye kuzvimba kunokonzerwa nezvirwere zvakasiyana-siyana.
| Dambudziko rehutano | Tsananguro iri nyore |
|---|---|
| Osteoarthritis | Marwadzo nekuomarara kunokonzerwa nekusakara kwemajoini sezvatinokura. |
| Rheumatoid Arthritis | Chirwere chinokonzera kuzvimba nekurwadziwa mumajoini nekuda kwekushanda kwemasoja emuviri. |
| Arthritis yeVechidiki | Arthritis muvana vadiki. |
| Ankylosing Spondylitis | Chirwere apo majoini, kunyanya mumusana, anozvimba uye anogona kubatana nekufamba kwenguva. |
| Marwadzo panguva yekuenda kumwedzi (Dysmenorrhea) | Kurwadziwa kwakanyanya mudumbu panguva yekuenda kumwedzi. |
| Kukuvara kwenguva pfupi, sekukuvara kwemitambo | Kana paine mitsipa, tsandanyama dzakaoma, nezvimwewo. |
Uyezve, chiremba wako anogonawo kunyora mushonga uyu kune zvirwere zvakaita segout uye migraine.
Ndezvipi njodzi nemigumisiro yekushandisa COX-2 Inhibitors?
Pasinei nekudzikira kwemigumisiro yemudumbu, mishonga inodzivirira COX-2 haisi mishonga isina njodzi zvachose. Panogona kunge paine njodzi , kunyanya kana ikashandiswa pamishonga yakawanda uye kwenguva yakareba .
Njodzi huru
- Kurwiswa kwemwoyo nestroke: Zvinodzivirira COX-2 zvakawanikwa zvichibatanidzwa nekuwedzera kwenjodzi yekurwiswa kwemwoyo nestroke. Njodzi iyi yakakura zvakanyanya kune vanhu vatova nechirwere chemwoyo kana zvinhu zvinokonzera chirwere ichi. Nekuda kweizvi, mamwe ma inhibitors eCOX-2, akadai se`Rofecoxib (Vioxx®)` uye`Valdecoxib (Bextra®)`, akabviswa pamusika.
- Matambudziko emudumbu nemudumbu: Kunyangwe kukuvara kwemudumbu kuchiderera, hakuperi zvachose. Vamwe vanhu vanogona kubuda ropa uye kuva nemaronda .
Migumisiro yakajairika
| Rudzi rwemhedzisiro yakaipa | Zviratidzo zvinogona kuitika |
|---|---|
| Sisitimu yekugaya chikafu | Kuzvimba, manyoka, kuzvimba, kuda kurutsa, kurwadziwa mudumbu, kurwadziwa muchipfuva. |
| Mwoyo netsinga dzeropa | Kukwira kweropa, kurwadziwa pachipfuva, kurwara nemoyo, sitiroko. |
| Itsvo | Kusashanda zvakanaka kweitsvo, kuungana kwemvura mumuviri uye kuzvimba (edema). |
| Sisitimu yetsinga | Musoro, dzungu. |
Ndiani asingafaniri kutora COX-2 Inhibitors?
Chiremba wako achaongorora nhoroondo yako yese yehutano kuti aone kana mushonga uyu wakakunakira. Unofanira kudzivisa kutora mushonga uyu kana uine chimwe chezvirwere zvinotevera:
- Kana wakambova nestroke kare.
- Kana wava kuvhiyiwa kana kuti wava kuda kuvhiyiwa ne coronary artery bypass munguva pfupi yapfuura.
- Kana uine chirwere cheitsvo chakakomba kana chirwere chechiropa .
- Kana wakamborwara neasthma kana kuti wakamborwara zvakanyanya ne NSAID, aspirin, kana mushonga unorwisa mabhakitiriya we sulfa.
- Kana uri mumwedzi mitatu yekupedzisira yekuzvitakura .
- Kana uri amai vanoyamwisa (taura nachiremba wako nezveizvi).
Unofanira kuona chiremba nekukasika rini?
Kana ukaona chimwe chezviratidzo zvinotevera paunenge uchitora mushonga uyu, usanonoka uye kurumidza kuona chiremba wako kana kuenda kuchipatara chiri pedyo neEmergency Department (ETU) .
- Zviratidzo zvedambudziko rechiropa: weti yakasviba, kuneta kwakanyanya, ganda kana maziso anotsvuka, tsvina ine ruvara rwakachenuruka, dumbu rinosuruvarisa.
- Zviratidzo zvekubuda ropa: kurutsa ropa kana kurutsa zvinoita sekunge kofi yakakuyiwa, ropa richibuda mutsvina (tsvina nhema kana tsvuku yakasviba), ropa richibuda muweti, matadza achibuda ropa, mavanga asingawanzoitika paganda.
- Zviratidzo zvedambudziko reitsvo: kutadza kuita weti, kuchinja kwehuwandu hweweti inogadzirwa, kuwedzera uremu kamwe kamwe.
- Zviratidzo zvekurwara zvakanyanya: mapundu eganda kana mapundu, kuvaviwa, kufema zvakaoma, kuzvimba kwechiso, miromo, kana rurimi.
- Zviratidzo zvechirwere chemwoyo: kurwadziwa pachipfuva, kushaya mweya, kurwadziwa kunosvika pashaya kana pafudzi.
- Zviratidzo zvestroke: kusanzwa kumeso kune rumwe rutivi rwemuviri, kuoma kutaura, kutetepa kwechiso.
Mharidzo Yekuenda Nayo Kumba
- Mishonga inodzivirira COX-2 imhando yemishonga isingakuvadzi dumbu zvakanyanya kupfuura mishonga inoderedza marwadzo (NSAIDs). Mishonga inonyanya kushandiswa muSri Lanka ndeyeCelecoxib neEtoricoxib.
- Izvi hazvina njodzi zvachose, kunyanya sezvo zvichigona kuwedzera njodzi yekurwara nemoyo uye sitiroko.
- Usamboshandisa mushonga uyu kubva ku pharmacy usina kunyorerwa nachiremba.
- Gara uchishandisa mushonga wakaderera zvikuru unokurudzirwa nachiremba wako, kwenguva pfupi zvikuru .
- Kana uine zvirwere zvakaita sechirwere chemwoyo, chirwere cheitsvo, chirwere chechiropa, kana gastritis, zvakakosha kuti uudze chiremba wako usati watora mushonga uyu.
- Gara uchiziva zviratidzo zvekunyevera zvataurwa pamusoro apa. Kana paine matambudziko, tsvaga rubatsiro rwechiremba nekukasika.
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