Chii chinonzi Angioimmunoblastic T-cell Lymphoma (AITL)? Ngatitaurei nezvazvo zviri nyore!

Wakambonzwa nezvechirwere chine zita risinganzwisisike kudaro here? Pamwe iwe kana mumwe munhu waunoziva wakaudzwa zita iri nachiremba. Kunyange zvazvo zvingaita sezvakaoma, ngatiedzei kurinzwisisa zviri nyore. Chinoitika ndechekuti rudzi rwemasero ekudzivirira mumuviri wedu anonzi ``T cells'' anoshanduka kuita masero ekenza.

Chii chinonzi angioimmunoblastic T-cell lymphoma (AITL)?

Zvichitaurwa zviri nyore, Angioimmunoblastic T-cell Lymphoma (AITL) rudzi rwegomarara rinokura mumasero machena eropa muropa redu rinonzi T lymphocytes, kana kuti T cells. Funga nezvazvo senzira yekudzivirira yemuviri wedu. Anorwisa zvinhu zvinokuvadza zvakaita semavhairasi nemabhakitiriya anopinda mumiviri yedu achitidzivirira kubva kuzvirwere. Dzimwe nguva, aya maT cell anogona kutoparadza masero egomarara.

Zvisinei, dzimwe nguva rimwe rema "T cells" aya rinogona kuchinja, kureva kuti, kuchinja, uye kuva sero rekenza. Zvadaro masero aya ekenza akaipa anotanga kupatsanuka nekukurumidza uye kuwanda zvisingadzoreki. Ndipo panoitika chirwere ichi chinonzi `AITL`. Iri igomarara rinowira muboka diki rinonzi `peripheral T-cell lymphoma`, iro riri muboka guru rinonzi `non-Hodgkin T-cell lymphoma`. Gomarara iri rinogona dzimwe nguva kupararira kunzvimbo dzakadai sechiropa, mapapu, kana `bone marrow`.

Chirwere ichi chinonzi AITL chakajairika zvakadii?

Kutaura zvazviri, AITL imhando yakajairika yeT-cell lymphoma, asi zvakazara igomarara risingawanzoitiki . Semuenzaniso, munyika yakaita seUnited States, AITL inongobata 4% chete yevarwere vese vane lymphoma. Inotorawo 1% kusvika 2% yevarwere vese vasiri Hodgkin lymphoma. Inonyanya kuitika kuvanhu vanopfuura makore makumi matanhatu nemashanu .

Ndezvipi zviratidzo zveAITL?

Nekuti AITL igomarara rinokura nekukurumidza, zviratidzo zvinogona kuoneka nekukurumidza. Kana ukasangana nechimwe chezvinotevera, unofanira kunetseka:

• Fivha inouya yoenda pasina chikonzero: Muviri unongopisa uye fivha inouya, yoenda, yodzoka zvakare. Hapana chikonzero chaicho chingawanikwa.
• Kudikitira husiku: Kudikitira zvakanyanya paunenge wakarara zvekuti machira anonyorova.
• Kukwenya kana ganda: Kunogona kuoneka mumuviri wese, mumavanga, kana kuti kunogona kugara kuchikwenya.
• Kutadza kufema: Kunzwa kushaya mweya kunyangwe uchishanda nesimba.
• Kuzvimba kwemajoini: Majoini ari mumakumbo anogona kuzvimba uye pamwe anorwadza.
• Mazamu akazvimba: Anoonekwa semapundu munzvimbo dzakadai semutsipa, muhapwa, uye muzvidya. Izvi hazviwanzo rwadza.
• Kudzikira huremu pasina chikonzero: Kunyangwe ukasadzora kudya kwako kana kurovedza muviri zvakanyanya, unodzikira huremu kamwe kamwe.

Nekuti AITL inokanganisa masoja edu emuviri , vamwe vanhu vane chirwere ichi vanogona kuva nemamiriro ezvinhu anonzi zvirwere zve autoimmune, izvo zvirwere umo masoja edu emuviri anotirwisa. Semuenzaniso, mamiriro akaita se immune thrombocytopenia (low blood platelets) kana autoimmune hemolytic anemia (kuparadzwa kwemasero eropa).

Chii chinokonzera AITL?

AITL inoitika kana masero edu eT anotanga kukura zvisina kujairika uye otanga kukura zvisina kurongeka. Zvisinei, vaongorori havasati vava nechokwadi chekuti nei vamwe vanhu vachikura rudzi urwu rweT-cell lymphoma uye vamwe vasingadaro.

Pane mukana wekuti pangave nekubatana pakati peAITL nehutachiona hwakadai sehutachiona hweEpstein-Barr. Zvisinei, pane rumwe ruzivo runodiwa kuti tinzwisise mashandiro anoita hukama uhwu.

AITL inoonekwa sei?

AITL inowanzoonekwa kuburikidza ne biopsy ye lymph node . Izvi zvinosanganisira kutora sampuli diki yenyama kubva ku lymph node yakazvimba kana nzvimbo inofungirwa woiongorora uchishandisa maikorosikopu. Kana zvabuda muongororo yako zvikaratidza kuti T lymphocytes haina kujairika, vanachiremba vachafungidzira AITL.

Kana chirwere ichi changosimbiswa, chiremba wegomarara achakuongorora uye achakubvunza nezvezviratidzo zvako. Achakubvunzawo nezvenhoroondo yehutano hwako, zvakaita sezvirwere zvawakamborwara nazvo uye mishonga yauri kushandisa pari zvino.

Pamusoro pezvo, chiremba anogonawo kuita bvunzo dzakasiyana siyana, dzakadai se:

• Kuongororwa kweropa.
• Kuongororwa kwemapfupa emumongo.

Unogonawo kuedzwa mifananidzo yakaita seiyi:

• CT scan (CT - computed tomography scans).
• MRI scan (MRI - magnetic resonance imaging scans).
• Kuongororwa kwePET (positron emission tomography scans).

Kungofanana nedzimwe mhando dzelymphoma, AITL inogona kuoma kuona chirwere ichi. Izvi zvinodaro nekuti chirwere ichi chakaoma kunzwisisa, uye zviratidzo zvacho zvinogona kukura zvishoma nezvishoma uye zvinogona kutevedzera zvimwe zvirwere. Nekuda kwezvikonzero izvi, varwere vazhinji veAITL vanoonekwa vaine chirwere ichi padanho rekupedzisira . Zvisinei, vaongorori vari kuramba vachitsvaga nzira dzekuongorora AITL nedzimwe mhando dzelymphoma nekukurumidza.

AITL inorapwa sei?

Kurapwa kweAITL kunoenderana nezvinhu zvakawanda, kusanganisira zviratidzo zvako, kuoma kwechirwere, uye hutano hwako hwese. Mishonga mikuru yeAITL ndeiyi:

• Kurapa nemakemikari:Izvi zvinosanganisira kupa musanganiswa wemishonga yakasiyana-siyana yekuuraya masero egomarara. MaSteroid anowedzerwawo pane izvi. Mishonga inonyanya kushandiswa ndeyeCHOP neBV+CHP. Zita rekuti CHOP ipfupiso yeCytoxan (cyclophosphamide), Hydroxydaunorubicin (hydroxydaunorubicin), Oncovin (vincristine sulfate), uye Prednisone. BV+CHP musanganiswa webrentuximab vedotin, cyclophosphamide, doxorubicin, uye prednisone. Izvi zvakaoma zvishoma, asi chiremba wako achakutsanangurira.

• Kuisirwa masero emuviri: Izvi zvinosanganisira kubvisa masero emuviri ane gomarara woatsiva nemasero emuviri ane hutano. Masero aya ane hutano anogona kutorwa kubva kwauri (`autologous`) kana kuti anogona kupihwa kubva kune mumwe munhu (`allogeneic`).

• Kurapa kwakanangana: Kurapa uku kunongotarisa chete pakuchinja kwemajini kunoshandura masero ane hutano kuita masero ekenza. Izvi zvinoreva kuti mushonga wacho unoenda zvakananga kumasero akaipa uye unoshanda chete pamasero iwayo akaipa.

Ungagara kwenguva yakareba sei neAITL?

AITL igomarara rinotyisa. Tsvagiridzo inoratidza kuti avhareji yekurarama mushure mekuonekwa kwechirwere isingasviki makore matatu . "Avhareji" ndiyo avhareji yepakati mune akasiyana siyana. Izvi zvinoreva kuti vamwe vanhu vanorarama hupenyu hupfupi, nepo vamwe vachirarama kwenguva yakareba.

Asi heino pfungwa inokosha: Vanhu vanosvika 30% kusvika 35% vane AITL vanopindura zvakanaka kana varapwa uye vanogona kutorapwa pasina kenza yadzoka.

Mwero wekurarama kweAITL

Huwandu hwevanhu vanorarama kwemakore mashanu veAITL huri pakati pe30% ne35% . Izvi zvinoreva kuti pavanhu 100 vanoonekwa vaine AITL, vari pakati pe30 ne35 vachiri vapenyu mushure memakore mashanu. Saizvozvowo, huwandu hwevanhu vanorarama kwemakore manomwe hunosvika 29%.

Zvakajairika kuti unzwe kutya uye kunetseka paunoona nhamba idzi. Asi yeuka, idzi ingori fungidziro chete. Dzinobva pane zvakaitika kune vamwe vakamboonekwa vaine chirwere chakafanana newe. Nhoroondo yehutano hwemunhu wese uye majini ake zvakasiyana. Saka, mwero uyu wekurarama haugone kufanotaura kuti uchararama kwenguva yakareba sei kana kuti uchapindura sei pakurapwa.

Kana uchinetseka nezvenhamba idzi, kana kuti uchida kuziva kuti dzingakanganisa sei iwe, iva nechokwadi chekutaura nachiremba wako. Iye/iye anogona kutsanangura mamiriro ako ezvinhu uye kukupa chero rubatsiro rwaunoda.

Ko AITL inogona kudzivirirwa here?

Vanhu vazhinji vane AITL havana zvinhu zvinozivikanwa zvinokonzera chirwere ichi. Hapana nzira chaiyo yekudzivirira AITL kana chero rumwe rudzi rwe lymphoma. Kufanana nekenza zhinji, izvi zvinoitika dzimwe nguva. Hazvirevi kuti pane chawakaita chakaipa.

Ndingaderedza njodzi yangu here?

Kunyangwe usingakwanise kudzivirira angioimmunoblastic T-cell lymphoma, unogona kuita zvinhu izvi kuti uchengetedze dziviriro yemuviri ine hutano :

• Idya chikafu chine mwero: Idya chikafu chine miriwo yakawanda, michero, nyemba, zviyo zvakakwana, uye mapuroteni akadai senyama isina mafuta akawanda nehove.
• Rovedza muviri nguva dzose: Ita chimwe chinhu chakadai sekufamba kana kumhanya kwemaminitsi makumi matatu pazuva.
• Rara zvakanaka: Rara zvakanaka kwemaawa manomwe kusvika masere pazuva.
• Ramba uine huremu hwakanaka hunokunakira.
• Dzivisa kusvuta nekushandisa fodya: Kufanana nefodya nebidis, fodya isina utsi (yakadai sefodya yekutsenga negum) inokuvadzawo. Kuputa fodya nemafuta emuchina wevape hakuna kunakawo.
• Deredza kunwa doro.

Ndinofanira kuona chiremba rini?

Kana ukaona zviratidzo zvakaita semapundu akangoerekana abuda, ma lymph nodes akazvimba, fivha yakanyanya, kana kudzikira uremu usingazive, enda kuna chiremba nekukasika.

Kana watove kurapwa neAITL, zivisa chiremba wako wekenza nekukasika kana ukaona zviratidzo zvitsva kana kana zviratidzo zvako zvikawedzera kamwe kamwe. Zvichienderana nerudzi rwegomarara iri, zvakakosha kutanga kurapwa nekukurumidza.

AITL inobata munhu wese zvakasiyana. Chiremba wako ndiye ega munhu anogona kutsanangura kuti kuongororwa kwako kuchakukanganisa sei. Vamwe vanhu havadi kuziva zvakadzama nezvechirwere ichi, uye hazvina kuipa. Une kodzero yekuita sarudzo nezvekurapa kwako. Iwe chete ndiwe unoziva zvakanakira hutano hwako hwepfungwa, hwemanzwiro, uye hwemweya.

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Zvakajairika kuva nemibvunzo yakawanda mushure mekuonekwa uine AITL. Heano mimwe mibvunzo yaunogona kubvunza chiremba wako wekenza:

• Kenza yangu yakura zvakadii?
• Ko kenza yapararira kune dzimwe nhengo dzangu here?
• Ndedzipi nzira dzekurapa dzandinadzo?
• Ndinofanira kutanga kurapwa kwenguva yakareba sei?
• Ndingaenderera mberi nebasa rangu here ndichirapwa?
• Rubatsiro nerubatsiro rwerudzii rwandichada panguva yekurapwa?
• Ndingabatana nemapoka ekutsigira kana zvimwe zvinhu here?
• Ndingachengetedza sei hutano hwangu hwepfungwa?

Kuongororwa kwegomarara kunogona kuunza manzwiro akasiyana-siyana akaoma, anosanganisira kusuruvara, kuzvidya mwoyo, hasha, uye hasha. Nekuti AITL chirwere chisingawanzoitiki, unganzwa kusurukirwa uye sekunge hapana anokunzwisisa.Asi timu yako yezvekurapa iripo kuti ikubatsire. Vanogona kukuudza nezvezvinhu zvaunoda, uye mapoka ekutsigirana nevanhu vakambosangana nematambudziko akafanana newe. Haufanire kufamba rwendo urwu wega. Wana rutsigiro kubva kune vadikanwi vako nevanachiremba vako.

Mharidzo Yekuenda Nayo Kumba

AITL igomarara rakakomba uye risingawanzoitiki. Zvisinei, zvakakosha kuti uzive nezvaro, unyatsoteerera zviratidzo, uye utsvage rubatsiro rwechiremba nekukasika.

• Ziva zviratidzo: Chenjerera fivha isinganzwisisike, ziya reusiku, zvitsitsinho zvakazvimba, matambudziko eganda, kunetseka kufema, kuzvimba kwemajoini, uye kudzikira kwehuremu.
• Tsvaga mazano echiremba: Kana usina chokwadi, enda kuna chiremba nekukasika. Kuongororwa kwechirwere nekukurumidza uye kurapwa kwakakosha zvikuru.
• Kune nzira dzekurapa: Kune dzimwe nzira dzakadai se chemotherapy, transplantation stem cell, uye nzira dzekurapa dzakanangana. Chiremba wako ndiye achasarudza kuti chii chakakunakira.
• Hausi wega: Rwendo urwu runogona kuoma, asi une mhuri, shamwari, uye timu yezvekurapa kuti vakubatsire. Wana rutsigiro rwavo.
• Ramba uine tariro: Nhamba hadzisi dzese. Munhu wese akasiyana. Ramba uine tariro.

Ndinovimba ruzivo urwu rwakubatsira kunzwisisa chirwere ichi. Yeuka, zvakanaka kutsvaga mazano echiremba kana paine dambudziko rehutano.

` AITL, Angioimmunoblastic T-cell Lymphoma, T-cell lymphoma, kenza, kenza yeropa, zviratidzo zve lymphoma, kurapwa kwekenza