Une zviratidzo izvi zvisinganzwisisike here? Ngatitaurei nezveCarcinoid Syndrome!

Dzimwe nguva hatizivi chaizvo zviri kuitika mumiviri yedu, handiti? Makambosangana nekubuda ropa kamwe kamwe, kunetseka kufema, kurwadziwa mudumbu, uye manyoka here? Izvi hazvisi zvinhu zvinongoitika zvega. Dzimwe nguva izvi zvinogona kuva zviratidzo zvechirwere chisingawanzoitiki chinonzi Carcinoid Syndrome. Ngatitaurei nezvazvo zvakadzama nhasi.

Chii chinonzi Carcinoid Syndrome?

Zvichitaurwa zviri nyore, chirwere checarcinoid muunganidzwa wezviratidzo zvinokonzerwa nerudzi rwegomarara rinokura mumuviri wako rinonzi neuroendocrine tumors (NETs) . Aya masero e neuroendocrine imhando yakakosha yemasero anobatanidzwa muhurongwa hwedu hwetsinga nehomoni. MaNET anoitika kana masero aya akangoerekana apatsanuka uye achiwanda nekukurumidza, achigadzira bundu.

Zvino ungave uchishamisika kana ichi chirwere chinobata munhu wese. Kwete, inyaya isingawanzoitiki . Zvidzidzo zvinoratidza kuti munhu mumwe chete pavanhu vashanu vane neuroendocrine tumors (NETs) vanowana carcinoid syndrome. NETs hadzina kuwanda zvakadaro, uye vanhu vashanu pa100,000 muUnited States vanofungidzirwa kuti ndivo vanobatwa nechirwere ichi.

MaNET aya, kunyanya ari mudumbu kana mumapapu, anoburitsa huwandu hwakawanda hwemahormone akaita se serotonin nemamwe makemikari mumuviri panguva imwe chete. Ndipo panoonekwa zviratidzo zvecarcinoid syndrome. Dzimwe nguva, unotanga kuziva kuti une NET mushure mekunge zviratidzo zvechirwere ichi zvaonekwa.

Kashoma, kana chirwere ichi checarcinoid chikasaongororwa zvakanaka uye chikarapwa, chinogona kutungamira kune emergency inotyisidzira hupenyu inonzi 'carcinoid crisis'. Saka, zvakakosha zvikuru kuziva izvi.

Ndezvipi zviratidzo zveCarcinoid Syndrome?

Ngatitarisei zviratidzo zvinonyanya kuzivikanwa zvechirwere ichi. Ona kana uine chimwe chezviratidzo izvi, chimwe nechimwe:

• Kusvina: Izvi zvinogona kushungurudza zvishoma. Zvakafanana nekusvina bvudzi kana uchinyara, asi kana zvikaitika kakawanda pasina chikonzero, unofanira kunetseka.
• Kufema nekushaya mweya (dyspnea): Kunogona kunzwa sekunge zvakaoma kufema, kana kuti sekunge ruzha rwekufema runobva muchipfuva.
• Kurwadziwa kwemudumbu uye manyoka anoputika, anowanzoitika: Kurwadziwa kwemudumbu nechirwere chinogara chichiitika. Dzimwe nguva zvinonetsa kudzora.
• Tsvina ine mafuta inonhuwa zvakaipa: Tsvina yacho inogona kuita seine mafuta uye ine hwema husingawanzoitiki.
• Kuzvimba kwetsoka nemakumbo:Izvi zvinogona dzimwe nguva kuva chiratidzo chekukundikana kwemoyo, saka zvakakosha kutsvaga rubatsiro rwechiremba nekukasika.
• Kuderera kwechido chepabonde kana kusashanda zvakanaka kwepabonde muvarume: Vamwe vanhu vanogona kusangana nematambudziko aya.
• Kutsvuka kweganda uye kuchena kwemaziso (Jaundice): Izvi ndizvo zvatinodaidza kuti 'jaundice'. Inogona kunge iri dambudziko rechiropa.
• Kunzwa dzungu kana kupera simba: Izvi zvinogona kuva chiratidzo cheBP yakaderera.
• Kunzwa sekuti moyo wako uri kurova: Ungangonzwa sekuti chipfuva chako chiri kurova nekukurumidza.

Kana ukaramba uine chimwe chezviratidzo izvi kana kupfuura, iva nechokwadi chekuona chiremba kuti akuudze nezvazvo. Izvi zvinogonawo kuva zviratidzo zvezvimwe zvirwere, asi zvakakosha kuti usimbise kuti une chirwere checarcinoid syndrome.

Sei chirwere ichi checarcinoid chichiitika?

Sezvandambotaura, chirwere checarcinoid chinoitika kana uine neuroendocrine tumors (NETs). Aya maNET tumors anokura kubva mumasero akasarudzika mu neuroendocrine system yako. Masero aya anogadzira nekuburitsa mahormone mumuviri.

Kazhinji, maNET aya anogona kukura munzvimbo dzakadai senzira yako yekugaya, mapapu, uye pancreas. Zvisinei, carcinoid syndrome inowanzo kukonzerwa nemaNET ari munzira yekugaya kana mapapu anongoerekana aburitsa huwandu hwakawanda hwemahormone (kunyanya serotonin) muropa.

Funga nezvazvo sepombi inovhura mvura zvishoma nezvishoma, masero aya anowanzoburitsa mahormone muhuwandu hushoma. Asi kana NET yaumbwa, zvinoita sekunge pombi inovhurika kamwe kamwe, uye mahormone mazhinji anobuda panguva imwe chete. Ndipo panotanga kuoneka zviratidzo zvechirwere ichi.

Ndiani ari panjodzi huru yekubatwa nechirwere checarcinoid?

Chinhu chikuru chinokonzera izvi kuva nebundu re neuroendocrine (NET) mudumbu kana mumapapu . Nemamwe mashoko, carcinoid syndrome haiwanzoitika pasina NET.

Izvi zvinoreva kuti, kana wakamboonekwa uine NETs, ​​unofanirawo kunetseka nezvechirwere ichi. Dzimwe nguva, kana mumwe munhu mumhuri akambova neNETs, ​​izvozvo zvinogonawo kuva chinhu chinokonzera njodzi, asi hazviwanzoitiki.

Ndezvipi zvinetso zvinogona kukonzera Carcinoid Syndrome?

Carcinoid syndrome haisi kungori seti yezviratidzo chete, inogona kutungamira kumatambudziko akawanda akakomba. Chimwe chezvirwere zvakadaro idambudziko recarcinoid rinogona kutyisidzira hupenyu randakambotaura.

Ngatitarisei mamwe matambudziko mashoma:

• Chirwere chemwoyo checarcinoid:Izvi hazviwanzoitiki, asi zvinogona kuisa hupenyu panjodzi. Mahormone anoburitswa neNETs anokanganisa mativi emukati memwoyo wako, mavharuvhu, netsinga dzeropa. Izvi zvinogona kutokonzera kutadza kushanda kwemoyo.
• Mesenteric fibrosis: NETs dzinogona kukonzera kuzvimba uye mavanga emesentery, nyama inobatanidza ura hwako nemadziro edumbu. Izvi zvinogona kukanganisa mashandiro emudumbu.
• Kushungurudzika: Carcinoid syndrome inogona kukanganisa kugona kwemuviri wako kushandisa amino acid inokosha inonzi tryptophan. Tryptophan inobatsira kugadzira serotonin. Serotonin ikemikari yeuropi inodzora zvinhu zvakaita semanzwiro edu, maitiro, uye kurara. Saka huwandu hwakaderera hweserotonin hunogona kukonzera kuora mwoyo.

Dambudziko rine njodzi rinonzi carcinoid crisis

Dambudziko reCarcinoid idambudziko risingawanzoitiki asi rinogona kuisa hupenyu pangozi . Rinogona kuitika nekuda kwekuvhiyiwa, mamwe maitiro ekurapa, kana kukuvara kubva mutsaona.

Hunhu hweizvi ndehu:

• Kuchinja kukuru kweBP: Kumanikidzwa kweropa kunogona kudonha kamwe kamwe kwakanyanyisa (hypotension) kana kukwira zvakanyanya.
• Kusviba kwakanyanya: Muviri wese unongoerekana watsvuka uye unganzwa kupisa.
• Kutadza kufema zvakanaka (Dyspnea): Kushaya mweya zvakanyanya kunogona kuitika.
• Kuvhiringidzika: Unganzwa sekunge pfungwa dzako dziri kukanganiswa.

Zvakakosha kuti munhu ane chirwere checarcinoid syndrome kana neuroendocrine bundu (NET) afambe nekadhi rinotaura mamiriro ake ezvinhu. Izvi zvinogona kubatsira zvikuru kana achida rubatsiro rwechiremba rwekukurumidzira. Zvakare, kana uchizovhiyiwa, zvakakosha kuudza vanachiremba nezvechirwere ichi. Vanogona kukupa mishonga usati wavhiyiwa uye panguva yekuvhiyiwa kuderedza njodzi ye 'carcinoid crisis'.

Carcinoid Syndrome inoonekwa sei?

Vanachiremba vanoshandisa bvunzo dzakasiyana-siyana kuti vaongorore chirwere ichi. Ngationei kuti chii:

• Kuongororwa kweweti: Izvi zvinoongorora huwandu hwemahormone ari muweti yako, kunyanya chinhu chinobva muserotonin chinonzi 5-HIAA (5-hydroxyindoleacetic acid) .
• Kuongororwa kwemuviri uye nhoroondo yezvekurapa: Zviratidzo zvecarcinoid syndrome zvinogona kufanana nezvezvimwe zvirwere zvisina kunyanya kukomba, saka chiremba wako achakubvunza zvakadzama nezvezviratidzo zvako, kuti zvagara kwenguva yakareba sei, uye kana zviri kutowedzera kuipa.
• Kuongororwa kweropa:Izvi zvinoongorora huwandu hwezvinhu zvinoburitswa muropa kubva munhengo dzako nenyama. Kana huwandu hwezvimwe zvinhu hukakwira kana kudzikira kamwe kamwe, zvinogona kuva chiratidzo chechirwere. Semuenzaniso, vanotarisa chiratidzo chinonzi Chromogranin A.
• Kuongororwa kweNeuroendocrine Positron Emission Tomography (PET): Uku kuongorora kwakakosha kunoshandisa dhayi inonzi gallium 68 dotatate kuti ione nzvimbo ine bundu reneuroendocrine (NETs).
• CT scan: CT scan inoshandisa X-rays nekombiyuta kugadzira mifananidzo yezvikamu zvitatu (3D) zvenhengo dzako nemapfupa. Izvi zvinogonawo kubatsira kuona nzvimbo nehukuru hwemapundu.
• Ultrasound scan: Izvi zvinoshandisa mafungu eruzha kugadzira mifananidzo yenhengo dzemuviri.
• Kuongororwa kweMRI (Magnetic Resonance Imaging (MRI): Izvi zvinoshandisa magineti makuru, mafungu eredhiyo, uye komputa kugadzira mifananidzo yakadzama yemukati memuviri.
• Endoscopy: Mubvunzo uyu, chiremba anoisa chubhu refu, yakatetepa ine kamera nechiedza mumuviri wako kuti aongorore. Semuenzaniso, nzira iyi inogona kushandiswa kuongorora dumbu kana ura.

Ndeipi mishonga yekurapa Carcinoid Syndrome?

Carcinoid syndrome inokonzerwa nemabundu e neuroendocrine (NETs). Saka, kana bundu iroro rikarapwa, chirwere ichi chinorapwawo.

Kune nzira dzinoverengeka huru dzekurapa:

• Kuvhiyiwa: Matumbu eNeuroendocrine anogona kubviswa zvachose kana kuderedzwa saizi. Rudzi rwekuvhiyiwa runoenderana nenzvimbo uye saizi yebundu.
• Somatostatin analogues: Iyi imhando yemishonga yakakosha. Mishonga iyi inogona kudzivirira muviri wako kugadzira mahormone akawandisa. Inogonawo kubatsira kudzora kukura kwemabundu kana masero ekenza apararira kune dzimwe nhengo dzemuviri (metastasis). Mienzaniso inosanganisira mishonga inonzi Octreotide neLanreotide .
• Kurapa kwakanangana: Iyi inzira yakakosha yekurapa inoshandiswa kuuraya masero egomarara. Mukuita izvi, mishonga inopiwa kunanga majini chaiwo kana mapuroteni ari mumasero egomarara.
• Kurapa nemakemikari: Izvi zvinoshandisa mishonga kuuraya masero egomarara. Kurapa nemakemikari hakushandi zvakafanana kune marudzi ese eNET.
• Kubvisa ropa: Munzira iyi, tsinga yeropa inoendesa ropa kugomarara inovharika, zvichiita kuti gomarara riparare. Uyu mushonga unonyanya kushandiswa kune maNETs muchiropa.

Carcinoid Syndrome inogona kudzivirirwa here?

Zvechokwadi,Hapana nzira yekudzivirira chirwere checarcinoid nekuti chinobatanidzwa ne neuroendocrine bundu (NETs). Sezvo pasina nzira inozivikanwa yekudzivirira kukura kweNETs, ​​hapana nzira yekudzivirira zviratidzo zvinokonzerwa nazvo.

Zvisinei, kana uchiziva kuti une chirwere chekenza (NET), kuziva zviratidzo zvechirwere chekenza nekukurumidza uye kutanga kurapwa kunogona kuderedza njodzi yematambudziko.

Ndinozvitarisira sei? / Ndingaita sei kuti ndigadzirise zviratidzo?

Kana uine chirwere checarcinoid syndrome, unogona kunge uine bundu re neuroendocrine (NET). Saka, kana uine zviratidzo zvechirwere checarcinoid syndrome, taurira chiremba wako nekukasika. Vanogona kuongorora mamiriro ako uye kukurudzira bvunzo dzinodiwa kuti vaone kana uine chirwere cheNET.

Zviratidzo zvikuru zvitatu zvecarcinoid syndrome kusviba, kufemera panze, uye manyoka. Heano zvinhu zvishoma zvaunogona kuita kuti ubatsire kudzora izvi:

• Kusvina: Uku ndiko kupindura kwetsinga dzako kana uine dambudziko remuviri kana repfungwa. Kuti uderedze izvi, fema zvakadzama, pukuta kumeso kwako nepachipfuva nejira rakanyorova, kana kuwana mhepo itsva panze. Kurega doro kunogonawo kubatsira.
• Kufema: Kana uchitadza kufema zvakanaka, edza kunwa tii yemishonga kana kushandisa mushonga wekufema kana wekupisa . Kana ukasvuta, edza kurega. Kusvuta kunogona kuwedzera kupisa nzira dzekufema.
• Manyoka: Kana manyoka ari dambudziko kwauri, taura nachiremba wako nezvenzira dzekuderedza kuwanda kwawo uye kuoma kwawo. Kune mishonga yakakosha yakagadzirirwa kudzora manyoka anokonzerwa necarcinoid syndrome. Zvakare, chikafu chine mafuta, chine spice, uye chikafu chemukaka zvinogona kuita kuti chirwere ichi chiwedzere kune vamwe vanhu. Saka chenjerera zvaunodya.

Ndinofanira kuona chiremba rini? / Ndinofanira kuenda kuchipatara rini?

Kana zviratidzo zvako zvecarcinoid syndrome zvikawedzera, iva nechokwadi chekuona chiremba. Kana uri kurapwa neNET, udza chiremba wako kana ukaona chero shanduko itsva mumuviri wako dzinganzwa sezviratidzo zveNET. Shanduko idzi dzingasave dzakabatana nekuongororwa kwako neNET, asi nzira yakanakisa yekuziva ndeyekutaura nachiremba wako. Zvakare, kana zviratidzo zvako kana mhedzisiro yekurapwa kwako ikawedzera, udza chiremba wako.

Nguva yekuenda kuEmergency Treatment Unit (ETU)

Kana chirwere checarcinoid chikasarapwa, zviratidzo zvinogona kuipa nekufamba kwenguva zvozokura kuva chirwere chinotyisidzira hupenyu chinonzi 'carcinoid crisis'. Saka, enda kuchipatara nekukurumidza kana uine:

• Kana uine kurova kwemoyo kana kurwadziwa muchipfuva.
• Kana uine manyoka akanyanya kwemazuva akati wandei.
• Kana mudumbu muine kurwadziwa kwakanyanya.
• Kana uchinzwa kupera simba.
• Kana ukangoerekana wabuda ropa zvakanyanya pachiso, mutsipa, uye pachipfuva (kubuda ropa zvakanyanya).

Mibvunzo ipi yandinofanira kubvunza chiremba wangu?

Carcinoid syndrome inogona kuva chiratidzo chekuti une neuroendocrine bundu (NET). Saka kana uine mibvunzo nezve carcinoid syndrome, ungave nemibvunzo yakawanda nezve NETs. Heano mimwe mibvunzo yaunogona kubvunza chiremba wako:

• Kana ndine carcinoid syndrome, ndingaziva sei kana ndine neuroendocrine bundu?
• Kana ndine bundu, riri kupi mumuviri wangu?
• Ndeapi marapirwo egomarara rangu?
• Ndezvipi migumisiro yekurapwa?
• Bundu re neuroendocrine rakakonzera carcinoid syndrome yangu rinogona kurapwa zvizere here?
• Ko chirwere checarcinoid chinogona kudzoka here mushure mekunge bundu rangu re neuroendocrine rapapwa?

Mharidzo Yekupedzisira Yekuenda Kumba

Carcinoid Syndrome chirwere chisingawanzoitiki chinogona kuitika kune munhu ane neuroendocrine bundu (NET). Kazhinji, vanhu vane carcinoid syndrome vanotoziva kuti vane NET. Dzimwe nguva, vanhu vanotanga kuziva kuti vane NET mushure mekunge vaonekwa kuti vane carcinoid syndrome.

Chinhu chakanakisa ndechekuti maNET anorapika. Kuziva kuti une carcinoid syndrome ndiyo nhanho yekutanga yekuziva kana uine kenza uye, kana zvakadaro, maitiro ekuirapa. Saka, kana wakaonekwa uine carcinoid syndrome, usatya kutaura nachiremba wako uchibvunza kuti matanho anotevera ndeapi kuti usimbise kana uine maNET. Chinhu chakakosha ndechekuongororwa uye kurapwa nekukurumidza.

Yeuka kuti hausi wega. Mumamiriro ezvinhu akadai, zvakakosha kutevedzera mazano echiremba uye kutsvaga rutsigiro rwemhuri yako.

` Carcinoid syndrome, neuroendocrine bundu, NETs, ​​​​serotonin, zviratidzo, kenza, mahormone