Chii chinonzi Castleman Disease? Ngatitaurei nezvazvo zviri nyore!

Wakamboona here kuti une mapundu aya pamutsipa kana muhapwa? Dzimwe nguva anoitika kana uine dzihwa kana furuu. Asi, izvi hazvisi nyore kudaro. Ichi chirwere chisingawanzoitiki asi chakakosha chekuziva. Tinochidana kuti Castleman Disease .

Zvichitaurwa zviri nyore, Castleman Disease chirwere chinoita kuti masoja emuviri wedu ashande zvakanyanya . Fungidzira, kana utachiona hunokonzera chirwere hukapinda mumuviri wedu, masoja edu emuviri anorwisa semusoja ari kuenda kuhondo. Kana chirwere chacho charapwa, musoja iyeye anonyarara zvakare. Asi mumunhu ane Castleman Disease, masoja aya emuviri anogara 'achishanda'. Izvi zvinokonzera kuzvimba kwenguva refu mumuviri, izvo zvinogona kukuvadza nhengo dzedu.

Panguva ino, ma lymph nodes edu - mabundu madiki iwayo ndiwo atinoadaidza kuti - anoita sefirita. Majemusi ese nemasero ekudzivirira muviri zvinoseferwa nepakati pawo. Saka, nekuti immune system iri kushanda nguva dzose, ma lymph nodes aya ari kushandawo nekufamba kwenguva. Zvadaro masero ari maari anokura zvakanyanya, uye ma lymph nodes anokura. Kwete kuzvimba uku chete, asiwo muCastleman Disease, kune shanduko munyama yema lymph nodes aya.

Ichi chirwere chisingawanzoitiki . Semuenzaniso, muUnited States, vanhu vanosvika 4,300 kusvika 5,200 chete ndivo vanoonekwa gore rega rega. Saka vanachiremba vachiri kudzidza zvakawanda nezvechirwere ichi. Zvisinei, kana ukaonekwa uine chirwere ichi, uchawana mishonga chaiyo yakanangana newe.

Ndeapi marudzi makuru eCastleman Disease?

Kune mhando mbiri huru dzechirwere ichi.

Chirwere cheCastleman Chiri Chega Chega (UCD)

Chirwere cheCastleman chinowanikwa muUnicentric (UCD) kana paine lymph nodes shoma munzvimbo imwe chete yemuviri wako dzinokura . Funga nezvemutsipa wako chete, kana kuti mahapwa ako chete. Vanhu vanosvika zvikamu zvitatu muzvina zvevarwere veCastleman vanowira muchikamu ichi.

Chirwere cheCastleman chine vanhu vakawanda (MCD)

Chirwere cheMulticentric Castleman (MCD) chirwere apo ma lymph nodes anozvimba munzvimbo dzakawanda dzemuviri, pane imwe chete. Kutaura chokwadi, vanachiremba vanopatsanura rudzi urwu rweMCD kuita:

• MCD inobatanidzwa neNhetembo: Nhetembo chirwere cheropa chisingawanzoitiki. Dzimwe nguva, Nhetembo dzinogona kuitika pamwe chete neMCD.
• HHV-8-associated MCD: Rudzi urwu rwunokonzerwa nehutachiona hunonzi Human Herpes Virus-8 (HHV-8) . Kana uine hutachiona hweHIV kana kuti uine dziviriro yemuviri, une mukana wekuva nerudzi urwu rweMCD.
• MCD yechikonzero chisingazivikanwe (Idiopathic MCD - iMCD):Iyi ndiyo mhando yeMCD inonyanya kuzivikanwa. 'Idiopathic' zvinoreva kuti chikonzero chaicho hachizivikanwe.

Zvino chikonzero ichi chisingazivikanwe iMCD inewo zvikamu zvitatu:

• iMCD ine chekuita neTAFRO syndrome: Dzimwe nguva iMCD inogona kuperekedzwa nechirwere chinonzi TAFRO syndrome. Zita rekuti TAFRO rinobva pamavara ekutanga ezviratidzo zvayo. Izvi ndeizvi: Thrombocytopenia (maplatelet eropa akaderera), Anasarca (kuzvimba kwemuviri nemvura), Fivha , kusashanda zvakanaka kweitsvo (itsvo), uye Organomegaly (kukura kwepleen kana chiropa).
• iMCD ine Idiopathic Plasmacytic Lymphadenopathy (iMCD-IPL): Muchikamu ichi, maplatelet anogona kunge akakwira. Masero ako machena eropa anogonawo kugadzira ma antibodies akawandisa.
• iMCD haina kutaurwa neimwe nzira (iMCD-NOS): Chikonzero chaicho cherudzi urwu, chinonzi iMCD-NOS, hachizivikanwewo, uye hachina chekuita neTAFRO.

Ndezvipi zviratidzo zveCastleman Disease?

Zviratidzo zvechirwere cheCastleman zvinosiyana zvichienderana nerudzi rwechirwere chaunacho. Kazhinji, kana uine chirwere cheCastleman (UCD) chega chega, ungasava nezviratidzo zvikuru. Ma-lymph nodes akazvimba anogona kunge ari iwo ega chiratidzo chaunoona. Zvisinei, dzimwe nguva zviratidzo zvinogona kuitika kana lymph node yakazvimba ikadzvanya pane imwe nhengo iri pedyo.

Zvisinei, kana uine MCD, zviratidzo zvacho zvinogona kuoneka. Pamusoro pekuzvimba kwema lymph nodes, unogona kuona zviratidzo zvakaita seizvi:

• Kupindwa nechando
• Kuneta (ichi chinogona kuva chiratidzo chekushaya ropa)
• Kudikitira husiku
• Kusvotwa nekurutsa
• Kuderedza uremu pasina chikonzero
• Kuzvimba mutsoka dzako, muzvitsitsinho, kana mudumbu
• Chiropa chakakura (splenomegaly) kana chiropa chakakura (hepatomegaly)
• Kusanzwa zvakanaka mumaoko nemakumbo (peripheral neuropathy)

Chii chinokonzera chirwere cheCastleman?

Chikonzero chaicho chechirwere cheCastleman (UCD) chinozivikanwa hachisati chazivikanwa, asi hutachiona hunonzi HHV-8 hwakawanikwa huri chinhu chinokonzera kukura kwechirwere cheCastleman (MCD) chinokonzerwa nemarudzi akawanda emasero eropa.

Masayendisiti achiri kuferefeta zvimwe zvinokonzera UCD ne iMCD. Semuenzaniso, vari kutsvaga hutachiona husiri HHV-8, majini akachinja , uye maitiro e autoimmune .

Ndiani ari panjodzi huru yekubatwa nechirwere ichi?

Zvinhu zvine njodzi yeUCD kana iMCD hazvisati zvazivikanwa. Zvisinei, kana uine hutachiona hweHIV kana chimwe chirwere chinopedza simba remuviri wako, uri panjodzi yakakura yekubatwa neHHV-8-associated MCD.

Chirwere cheCastleman chinogona kuitika chero pazera ripi zvaro, asi chinonyanya kuonekwa muvanhu vane makore ari pakati pe30 ne60 .

Ndezvipi zvinetso zvinogona kukonzera chirwere cheCastleman?

Chirwere cheCastleman chinowedzera njodzi yako yekubatwa nekenza, kunyanya lymphoma .

Uyewo, kunyange hazvo zvisingawanzoitiki, vanhu vane UCD vari panjodzi yekubatwa nechirwere chakakomba chinonzi Paraneoplastic Pemphigus (PNP) . MCD inowedzerawo njodzi yekuwana hutachiona hunogona kukuvadza nhengo dzemuviri wako. Kukuvara uku kunogona kuisa hupenyu panjodzi kana kukasarapwa zvakanaka.

Usazvidya mwoyo, chiremba wako acharamba achitarisa mamiriro ako ezvinhu uye anokubatsira kudzivirira matambudziko akadaro pese pazvinogoneka.

Vanachiremba vanoongorora sei chirwere cheCastleman?

Zviratidzo zveCastleman Disease zvinogona kufanana nezvezvimwe zvirwere zvakajairika, zvakaita sefuruu kana dzihwa. Saka chiremba wako achatanga abvisa zvirwere izvozvo. Zvadaro, achaita bvunzo dzekuongorora Castleman Disease uye kuona rudzi rwayo.

Miedzo nemaitiro zvinogona kusanganisira:

• Kuongororwa murabhoritari: Chiremba wako achaongorora huwandu hwemasero eropa rako kuti aone kana paine zvisina kumira zvakanaka uye zvimwe zviratidzo zvechirwere cheCastleman zvisingaonekwe. Vanogonawo kuraira kuongororwa kweHIV . Kana uine HHV-8-related MCD, kuongororwa kwako kweHIV kunogona kunge kuri positive.
• Kuongororwa kwemifananidzo: Kuongororwa kwakadai seCT scans nePET scans kunogona kubatsira kuwana lymph nodes dzakazvimba mumuviri wako, pamwe nekutarisa zvimwe zviratidzo zvechirwere cheCastleman, zvakaita sechiropa chakakura kana chirwatata.
• Kuongororwa kwemasero eropa: Nzira chete yekuziva zvechokwadi kana uine chirwere cheCastleman ndeyekuongororwa. Izvi zvinosanganisira kutora chidimbu chidiki chenyama kubva pamasero eropa wochiongorora uchishandisa maikorosikopu. Izvi zvinoona kana paine zviratidzo zvechirwere.

Chirwere cheCastleman chinorapwa sei?

Kurapwa kwechirwere cheCastleman kunosiyana zvichienderana nerudzi rwechirwere chaunacho.

Kurapwa kweUnicentric Castleman Disease (UCD)

Kurapa kukuru kweUCD kubvisa ma lymph nodes akakanganiswa nekuvhiyiwa . Dzimwe nguva ungada kurapwa nemwaranzi kana immunotherapy usati wavhiyiwa. Kurapa uku kunoderedza kukura kwema lymph nodes, zvichiita kuti zvive nyore kubvisa.

Asi kana vanachiremba vakasakwanisa kubvisa lymph node yakakanganiswa, uye iwe usina zviratidzo, chiremba wako anogona kuitarisa pane kuirapa. Kana uine zviratidzo uye usingakwanise kuvhiyiwa, vanogona kukurudzira kurapwa kweMCD.

Kurapwa kwechirwere cheCastleman chine mativi akawanda (MCD)

MCD yakaoma kurapa kupfuura UCD. Nekuti inopararira mumuviri wese, kuvhiyiwa kana kurapwa nemwaranzi hazviwanzo shandiswa. Asi, kurapwa kunoenderana nekuti une hutachiona hweHHV-8 here uye kuti chirwere chacho chakakomba zvakadii.

Chiremba wako anogona kushandisa nzira dzekurapa dzakadai se:

• Corticosteroids: Mishonga iyi inobatsira kuderedza kuzvimba uye inopa zororo kubva pazviratidzo.
• Mishonga yekurapa nemakemikari: Mishonga yekurapa nemakemikari inodzora kukura kwemasero mumuviri wako. Rituximab mushonga unowanzonyorerwa HHV-8-associated MCD.
• Kurapa Nezvirwere Zvinodzivirira Muviri: Kurapa uku kunosanganisira kushandisa zvinhu zvakaita se monoclonal antibodies . Izvi zvinobatsira kudzikamisa mashandiro emuviri wako. Siltuximab (Sylvant®) ndiyo chete nzira yekurapa yakatenderwa neU.S. Food and Drug Administration (FDA) ye iMCD.
• Mishonga inorwisa mavhairasi: Kana uine HHV-8-related MCD, ungangoda mishonga inorwisa mavhairasi yekurapa HIV kana HHV-8.

Ndinofanira kuona chiremba rini?

Kana ukaona bundu kana bundu riri mumutsipa, muhapwa, kana muzvidya, enda kuna chiremba nekukasika . Uyewo, kana uine chimwe chezviratidzo zveCastleman Disease zvataurwa pamusoro apa chisingavandudzike mushure memavhiki mashoma, udza chiremba wako nezvazvo zvakare.

Ungararama kwenguva yakareba sei nechirwere ichi?

Kune vanhu vazhinji vane UCD, fungidziro yacho yakanaka kwazvo. Kubvisa ma lymph nodes akakanganiswa kunogona kurapa chirwere ichi. Nekurapwa, UCD kazhinji haikanganisi makore ekurarama.

Asi tarisiro yevanhu vane MCD inoenderana nerudzi rweMCD yavanayo uye kuoma kwechirwere ichi. Kune vamwe vanhu, zviratidzo zvinogona kungoerekana zvatanga uye zvinoisa upenyu panjodzi. Kune vamwe, zviratidzo zvinogona kugara kwenguva refu. Pakati pe65% ne75% yevanhu vanoonekwa vaine MCD vachiri vapenyu mushure memakore mashanu . Nekurapwa kutsva, pane tariro yekuti mamiriro ezvinhu aya achanaka.

Hapana mhinduro dziri nyore kana zvasvika pachirwere cheCastleman. Zvaunosangana nazvo zvinoenderana nerudzi rwechirwere cheCastleman chaunacho. Zvimwe zvirwere, zvakaita seHIV, kana zvimwe zvirwere zvine chekuita nacho, zvakaita seTAFRO nePOEMS, zvinogonawo kukanganisa zvakaitika kwauri. Mune zvimwe zviitiko, kuvhiyiwa uye kutarisisa zviri pedyo ndizvo chete zvinodiwa. Kana kuti, ungangoda kurapwa kwakasiyana-siyana muhupenyu hwako hwese kudzivirira matambudziko. Bvunza chiremba wako kuti kuongororwa kwako kuchakanganisa sei kurapwa kwako uye maonero ako.

Saka, ndezvipi zvinhu zvinonyanya kukosha zvatinofanira kurangarira kubva pane izvi?

• Chirwere cheCastleman chirwere chisingawanzoitiki asi chinogona kunge chakakomba chemuviri wekudzivirira muviri umo masoja edu emuviri anotanga kushanda zvakanyanya.
• Kune mhando mbiri huru: UCD neMCD. MuUCD, ma lymph nodes anozvimba panzvimbo imwe, nepo muMCD, anozvimba munzvimbo dzakawanda.
• Zviratidzo zvinosiyana. Dzimwe nguva panogona kunge pasina zviratidzo zvachose, kungozvimba bundu. Kana kuti panogona kunge paine zviratidzo zvakaita sefivha, kuneta, uye kudzikira kwehuremu.
• Zvikonzero zvacho hazviwanzojeka, asi hutachiona hweHHV-8 hwakabatana neMCD. Vanhu vane HIV vari panjodzi huru.
• Kuonekwa nekukurumidza uye kurapwa kwakakodzera zvinowanzo kutungamira kumhedzisiro yakanaka. Saka kana ukaona bundu risingawanzoitika, kuzvimba, kana zvimwe zviratidzo zvisingawanzoitika mumuviri wako, tsvaga rubatsiro rwechiremba nekukasika. Chinhu chakakosha kugara uine ruzivo kwete kutya.

` Chirwere cheCastleman, Lymph Nodes, Lymphadenopathy, Immune System, UCD, MCD, HHV-8, Zviratidzo, Kurapwa