Mwana wako ari kukura nekukasika here? Ngatidzidzei nezve gigantism!

Dzimwe nguva vana vedu vanokura nekukurumidza, handiti? Asi hazvisi zvakajairika kuti vangoerekana vareba kupfuura vamwe vana, vaine makumbo makuru. Izvi zvinogona kunge zvichikonzerwa nechirwere chisingawanzoitiki. Nhasi tichataura nezvechirwere chakadaro, icho chinonzi 'Gigantism'.

Chii chinonzi 'Gigantism'?

Zvichitaurwa zviri nyore, gigantism chirwere chisingawanzoitiki apo mwana kana munhu mudiki anoburitsa hormone yekukura yakawandisa (GH) . Ndicho chikonzero nei vana ava vachikura zvakanyanya kupfuura vamwe. Kazhinji, iyi hormone yekukura (GH) inogadzirwa negland diki, rakakura sepizi riri pasi peuropi hwedu. Inonzi pituitary gland. Zvisinei, kana bundu diki rikabuda mugland iyi yepituitary, rinogona kugadzira hormone yekukura yakawanda (GH) kupfuura inodiwa. Ndipo panoitika gigantism.

Gland rePituitary igland diki riri pasi pehuropi, pasi peHypothalamus. Rinoburitsa mahormone angangoita masere. Growth Hormone (GH) ndeimwe yadzo.

Hormone yekukura, inozivikanwawo seHuman Growth Hormone (hGH), inokosha pakukura kwevana. Inokanganisa nhengo dzakawanda dzemuviri uye inobatsira mwana kukura zvakanaka. Zvisinei, kune mamwe marudzi emapundu ekukura mumapfupa edu anonzi Epiphyses/Growth Plates, uye kana avharwa zvachose (kureva mushure mekuyaruka), homoni yekukura (GH) haiwedzere kureba. Chainoita kuchengetedza chimiro uye metabolism yemapfupa, cartilage, nedzimwe nhengo. Homoni iyi yekukura (GH) yakabatana zvakanyanya nehomoni inonzi Insulin-like Growth Factor 1 (IGF1), inogadzirwa nechiropa chedu. Pamwe chete, izvi zviviri zvinobatsira pakukura uye metabolism.

Gigantism chirwere apo muviri unoburitsa hormone yekukura yakawandisa (GH), zvichiita kuti tsandanyama, mapfupa, uye zvinyama zvinobatana zvikure nekukurumidza. Izvi zvinoguma nekureba kusina kujairika uye shanduko dzakawanda munyama dzakapfava dzemuviri. Kana dzikasarapwa, vamwe vanhu vane gigantism vanogona kukura kusvika pakureba kwemamita anopfuura maviri.

Saka, zvakakosha zvikuru kuongorora chirwere ichi uye kutanga kurapwa nekukurumidza kana paine gigantism.

Chii chiri musiyano uripo pakati pe'Gigantism' ne'Acromegaly'?

Gigantism ne acromegaly zvose zvirwere zvinokonzerwa nekuwedzera kwehomoni yekukura (GH). Musiyano uripo ndewekuti ndiani anoiwana. Acromegaly inokanganisa vanhu vakuru. Gigantism inokanganisa vana nevechidiki vachiri kukura, kureva kuti, vasati vasvika pazera rekuyaruka.

Zvichitaurwa zviri nyore, gigantism inoitika kana huwandu hwehormone yekukura (GH) hukawedzera usati wavhara mapundu ekukura mumapfupa evana (kureva kuti, vasati vasvika pazera rekuyaruka).

Kana huwandu hwehormone yako yekukura (GH) hukawedzera mushure mekunge ma plates ako ekukura avharwa, zvinogona kukonzera acromegaly. Hauzokure kureba, asi GH yakawandisa inogona kukanganisa chimiro chemapfupa ako, saizi yenhengo dzako, nezvimwe zvirwere.

Gigantism chirwere chisingawanzoitiki kupfuura acromegaly.

Ndiani anowana gigantism? Yakajairika zvakadii?

Kunyangwe ichi chiri chirwere chisingawanzoitiki, gigantism inogona kuitika mumwana chero upi zvake ane ma "growth plates" asati avhara (kureva kuti, asati apedza kuyaruka). Izvi zvinowanzoitika muvakomana kupfuura muvasikana.

Kurwara kweGigantism chirwere chisingawanzoitiki. Semuenzaniso, vanhu vanosvika zana chete ndivo vakaonekwa muUnited States kusvika pari zvino. Saka unogona kufungidzira kuti hazviwanzoitiki sei.

Kukura kwakajairika kunoitika sei muvana? Musiyano uripi ne gigantism?

Homoni yekukura (GH) ndiyo inodzora kukura kwemuviri panguva yehudiki. Kureva kuti, inodzora kushandiswa kwemuviri uku ichikonzera kukura kunoyerwa mumapfupa, tsandanyama, uye nhengo dzemuviri. Kazhinji, kukura inzira yakagadzikana kusvika mwana asvika pazera rekuyaruka.

Munguva yekuyaruka, kuburitswa kwemahormone epabonde (estrogen ne testosterone) kunowedzera zvakanyanya. Izvi zvinoita kuti maepiphyses (maplates ekukura) ari kumagumo emapfupa marefu emwana avharwe zvishoma nezvishoma. Kana maepiphyses avhara zvachose, kureva kuti, kana kuyaruka kwapera, kukura kwehurefu kunomira.

Kuti mwana anokura nekukurumidza sei uye kuti achava akakura sei mushure mekuyaruka zvinoenderana nemusanganiswa wemajini akawanda aanogara nhaka kubva kuvabereki vake, zvinhu zvakamupoteredza, uye bonde rake.

Kana mwana aine chirwere chegigantism, anokura nekukurumidza, uye anoreba kupfuura vamwe vana vezera rimwe chete uye bonde. Zvisinei, zviratidzo zvegigantism pakutanga zvinogona kutaridzika sekukura kwemwana kwakajairika, zvichiita kuti zvive zvakaoma kuvabereki kuziva.

Kana muine mibvunzo kana zvinokunetsai nezvekukura kwemwana wenyu, iva nechokwadi chekutaura nachiremba wavo.

Ndezvipi zviratidzo zvegigantism?

Kukura kwehomoni (GH) kunokonzerwa nekuwedzera kwehomoni yekukura. Uyewo, bundu riri mugland repituitary rinogona kumanikidza uropi netsinga dziri pedyo, zvichikonzera zvimwe zviratidzo. Chiratidzo chikuru chekukura kwehomoni (gigantism) kukura zvakanyanya.Vana vane gigantism vanokura nekukurumidza muhurefu.

Kuwedzera pakureba/kukura zvakanyanya kupfuura zera remunhu, hunhu hwemuviri hunoonekwa mu gigantism hunosanganisira:

• Huma yakaonekwa zvakanyanya uye muromo weshaya wakaonekwa.
• Kuva nemikana pakati pemazino.
• Kukora kwechiso.
• Maoko netsoka hombe, neminwe mikobvu.

Zvimwe zviratidzo zvinogona kuonekwa zvinosanganisira:

• Kukura kwenhengo dzemukati, kunyanya moyo wemwana.
• Kudikitira zvakanyanya (hyperhidrosis).
• Kuona kaviri kana kuoma kuona zviri padivi pemuviri.
• Musoro.
• Kurwadziwa kwemajoini.
• Kunonoka kuyaruka.
• Kuenda kumwedzi kusingaenderane nenguva.
• Matambudziko ekurara, semuenzaniso, sleep apnea.
• Kushaya simba kwetsandanyama.

Kana mwana wako aine zviratidzo izvi, zvakakosha zvikuru kutaura nachiremba nekukurumidza sezvinobvira.

Ndezvipi zvikonzero zvegigantism?

Kukura kwemwana kunowanzo kukonzerwa nebundu risina njodzi (pituitary adenoma) mugland repituitary remwana. Izvi zvinokonzera kuburitswa kwakanyanya kwehomoni yekukura (GH). Kana vana vane gigantism vakaonekwa kuti vane chirwere ichi, vanowanzova nebundu guru repituitary adenoma (bundu rine 10 mm kana kupfuura), rinonzi macroadenoma. Kukura kwemwana kunogonawo kukonzerwa nekukura kwegland repituitary, rinonzi pituitary hyperplasia.

Vana vazhinji vane gigantism vane majini anochinja anokonzera bundu repituitary. Kuchinja kwemajini kunowanzo batanidzwa negigantism kuchinja kana kubviswa kwejini reAIP. Izvi zvinokanganisa vanhu vanosvika 29% vane gigantism.

Kukura kwehomoni kunogonawo kuitika sechikamu chezvirwere zvisingawanzoitiki zvemajini zvinowedzera njodzi yekuva negomarara repituitary rinoburitsa hormone yekukura (GH). Zvimwe zvezvirwere izvi zvinosanganisira:

• Carney complex: Ichi chirwere chemajini chinokanganisa ruvara rweganda uye chinokonzera bundu risina njodzi reganda, mwoyo, uye endocrine system. Vanhu vanosvika 10% kusvika 13% vane Carney complex vanogadzira growth hormone (GH)-secreting pituitary adenomas, iyo inowanzo kukura zvishoma nezvishoma.
• Chirwere cheMcCune-Albright:Ichi chirwere chemajini chinokanganisa mapfupa, ganda, uye endocrine system. Chinokonzera mavara e café-au-lait paganda, mavanga mumapfupa, uye kuyaruka kwepakutanga. 20% kusvika 30% yevanhu vane McCune-Albright syndrome vane hormone yekukura yakawandisa (GH). Izvi zvinowanzo kukonzerwa nekukura (hyperplasia) kwegland repituitary, kana pituitary adenoma.
• Mhando dzeMultiple Endocrine Neoplasias (MEN) 1 kana 4: Aya ndiwo majini. Muchiitiko ichi, rimwe kana akawanda ema endocrine glands ako anotanga kushanda zvakanyanya, kana kuti bundu rinokura. Izvi zvinogona kusanganisira bundu repituitary rinoburitsa hormone yekukura (GH).
• Neurofibromatosis: Ichi chirwere chemajini chinonzi neurocutaneous disorders. Izvi zvinokanganisa ganda netsinga. Izvi zvinokonzerwa nekuwedzera kusingawanzoitiki kwekukura kwemasero. Izvi zvinogona kutungamira mukuumbwa kwemamota mumuviri wese. Izvi zvinogona kusanganisira bundu rinoburitsa hormone yekukura (GH).
• Mafiro epituitary adenomas emhuri (FIPA): Ichi chirwere chinogara nhaka. Chinosanganisira kukura kwefiroitary adenomas. Izvi zvinogona kusanganisira mafiroitary adenomas anoburitsa hormone yekukura (GH).

Gigantism inoonekwa sei?

Kurwara kweGigantism kunogona kuoma zvishoma kuona nekuti chirwere ichi hachiwanzoitiki, uye nekuti kukura kwevana kunogona kusiyana zvakanyanya nekuda kwemajini uye nharaunda.

Kazhinji, vanachiremba vanofungidzira kuti mwana ane hunhu hwakaipa kana kureba kwake kuri katatu kupfuura kureba kwake zvichienderana nehunhu hwake hwepabonde nezera rake, kana kuti kaviri kupfuura kureba kwakaverengerwa kubva pakukwirira kwevabereki vemwana.

Kana chiremba wemwana wenyu achifungidzira kuti mwana wenyu ane chirwere chegigantism, angangokutumirai kuna chiremba we endocrinologist (chiremba anonyanya kuongorora zvirwere zvine chekuita nemahormone). Chiremba achaita kuti mwana wenyu aonekwe chirwere ichi zvichibva panhoroondo yezveutano hwemwana wenyu, nhoroondo yemhuri yake, kuongororwa kwakanyatsoitwa kwemuviri, uye bvunzo dzakaitwa neunyanzvi dzakadai sekuongororwa kweropa uye bvunzo dzemifananidzo.

Ndezvipi zvidzidzo zvinoshandiswa kuongorora gigantism?

Kana chiremba wemwana wako achifungidzira kuti ane gigantism, bvunzo dzinotevera dzinogona kuitwa kusimbisa chirwere chacho:

• Kuongororwa kweropa kweGrowth Hormone neIGF-1 (Insulin-like Growth Factor 1): Kuongororwa uku kunoyera huwandu hwemahormone akasiyana-siyana muropa rinotorwa kubva mutsinga yemwana. Kana huwandu hwacho hwakakwira kupfuura zvakajairwa, zvinogona kuva chiratidzo chegigantism.
• Kuongororwa kweGlucose Tolerance Test: Kuongororwa uku kunoratidza kuti mahormone emwana anonzwa sei kana abatwa neglucose. Pakuongororwa uku, chiremba anotora ropa kubva mutsinga panguva dzakasiyana-siyana mushure mekunge mwana anwa glucose (shuga).
• Kuongororwa kwemifananidzo: Kana kuongororwa kweropa kukaratidza kuti mwana wako ane gigantism, chiremba wako anowanzo kurudzira kuti apihwe MRI (Magnetic Resonance Imaging) scan kana CT (Computed Tomography). Izvi zvinogona kuona zvakajeka saizi nenzvimbo yegomarara repituitary. Zvinogonawo kubatsira kuona kurapwa chaiko kunodiwa.

Kana mwana wako akaonekwa kuti ane chirwere chegigantism, chiremba anogona kuita mimwe miedzo kuti aone kana chirwere chacho chakanganisa dzimwe nhengo dzemuviri. Miedzo iyi inogona kusanganisira:

• Echocardiogram yekuongorora matambudziko emwoyo.
• Kuongororwa kweongororo yekurara kuti uone kana uine sleep apnea.
• MaX-ray kana DEXA/DXA scan kuti uone hutano hwemapfupa ako.

Kubatwa nechirwere chegigantism kunorapwa sei?

Zvinangwa zvikuru zvekurapa gigantism ndeizvi:

• Kudzora zvakachengeteka mazinga e'growth hormone' (GH) uye 'insulin-like growth factor 1' (IGF1).
• Kutarisira kukura kwe 'pituitary bundu'.
• Kuderedza kukanganiswa kwebundu repituitary patsinga dzeuropi dziri pedyo netsinga dzemaziso.
• Kurapa kana kuderedza migumisiro yehomoni yekukura (GH) pane mamwe masisitimu emuviri.

Vanachiremba vanowanzo shandisa musanganiswa wemishonga yekurapa gigantism , kuvhiyiwa nemwaranzi ndiyo mishonga mikuru.

Kunyangwe paine mishonga inoshanda yekurapa kuwanda kwehomoni yekukura (GH) muvanhu vakuru (acromegaly), mhedzisiro yemishonga iyi pavana haisati yanyatso ongororwa.

Kuvhiyiwa kweGigantism

Kuvhiyiwa ndiyo nzira inonyanya kushandiswa yekurapa gigantism. Chinangwa ndechekubvisa bundu repituitary kana kuderedza saizi yaro. Nekuti bundu repituitary rinokonzera gigantism rinowanzova guru, mwana angangoda kuvhiyiwa kakawanda kuti anyatsodzora huwandu hwemahormone ekukura (GH).

Chiremba wemwana wenyu anogona kushandisa nzira yekuvhiya inonzi transsphenoidal surgery kubvisa bundu repituitary. Izvi zvinosanganisira kuita oparesheni iyi kuburikidza nemhino yemwana wenyu uye kuburikidza nesphenoid sinus (gomba riri kuseri kwemhino, pasi pehuropi).

Kurapa nemwaranzi yeGigantism

Kana kuvhiyiwa kukasaderedza huwandu hwemahormone ekukura, kurapwa nemwaranzi kunogona kubatsira. Izvi zvinosanganisira kushandisa michina yakakosha kunangisa mwenje wemwaranzi pabundu. Kurapa uku kunoshanda zvishoma nezvishoma. Kungada kurapwa kwakawanda, nekuzorora kwenguva refu pakati pako. Zvinogonawo kutora makore akati wandei kuti zvionekwe zvizere.

Ndezvipi zvinetso zvinokonzereswa nekurapwa?

Nekuda kwekuvhiyiwa uye/kana kurapwa nemwaranzi, vanhu vanosvika 60% vane gigantism vanowana chirwere chinonzi hypopituitarism mushure mekurapwa. Izvi zvinoitika kana rimwe, akawanda, kana ese mahormone anogadzirwa nepituitary gland asingagadzirwe zvakakwana. Hypopituitarism inorapwa nemishonga inotsiva mahormone.

Matambudziko anogona kuitika kubva pakuvhiyiwa kubvisa bundu repituitary anosanganisira:

• Kubuda ropa.
• Kubuda kweCerbrospinal Fluid (CSF).
• Meningitis (fivha yeuropi).
• Kurasikirwa nesodium (munyu) uye mvura mumuviri.

Migumisiro yekurapa nemwaranzi inogona kusanganisira:

• Kusakwanisa Kubereka.
• Kurasikirwa nekuona uye kukuvara kwehuropi (zvishoma).
• Kuumbwa kwebundu makore akati wandei mushure mekurapwa (zvisingawanzoitiki).

Kusagona kuita zvepabonde nemurume kunogona kudzivirirwa here? Chii chinonzi fungidziro?

Zvinosuwisa kuti hapana chaunogona kuita kudzivirira gigantism. Zvisinei, kuzivikanwa nekukurumidza kwakakosha. Kurapwa nekukurumidza kunogona kubatsira kudzivirira kana kugadzirisa shanduko dzinoita kuti mwana wako arebe zvakanyanya.

Kufanotaura kwevana nevechidiki vanoonekwa vaine gigantism kunoenderana nezvinhu zvakati wandei:

• Kuti chirwere ichi chakaonekwa nekukurumidza kana kuti kunonoka sei.
• Mishonga inoshanda sei pakugadzirisa huwandu hwemahormone ekukura?
• Kana paine matambudziko ane chekuita negigantism.

Kazhinji, vanhu vakuru vanoonekwa vaine chirwere ichi vanowanzova nematambudziko akawanda kupfuura avo vanoonekwa vachiri vadiki. Izvi zvingangove zvichikonzerwa nekugara kwenguva refu vachishandisa hormone yekukura uye insulin-like growth factor 1 (IGF1).

Saka, kana mukaona shanduko dzisingatarisirwi mukukura kwemwana wenyu uye/kana hunhu hwake, zvakakosha kuti mutaure nachiremba wavo nekukurumidza.

Munhu ane chirwere chegigantism anotarisirwa kurarama kwenguva yakareba sei? Ndezvipi zvinetso zvinotora nguva refu?

Kuonekwa nekukurumidza uye kurapwa kwegigantism kwakakosha kudzivirira kureba kwakanyanya uye matambudziko anokonzerwa nako uye kuwedzera makore ekurarama.

Kana ikasarapwa, gigantism inobatanidzwa nematambudziko makuru uye huwandu hwerufu hunogona kusvika kaviri pane hwakajairika.

Matambudziko enguva refu anosangana nevamwe vanhu vane gigantism nekuda kwekureba kwavo zvakanyanya uye mhedzisiro yekuva nehomoni yekukura yakawandisa anosanganisira:

• Kuomerwa nekufamba-famba (kufamba-famba) nekuda kwekushaya simba kwetsandanyama.
• Osteoarthritis (kuzvimba kwemajoini).
• Kusagadzikana kwetsinga dzemudumbu (peripheral neuropathy).
• 'Kupera kwemhepo pakurara'.
• Matambudziko emwoyo (cardiomegaly) nevharuvhu yemoyo.
• Matambudziko ekugaya chikafu akadai sechirwere cheshuga cherudzi rwechipiri.

Pamusoro pezvo, hupenyu hwevanhu vane chirwere chegigantism chisina kurapwa hunogona kudzikira nekuda kwematambudziko emabasa ezuva nezuva akadai sekutenga mbatya nekufamba nekuda kwekureba zvakanyanya.

Unofanira kuona chiremba wemwana wako rini nezve gigantism?

Kana mwana wako akaonekwa aine chirwere chegigantism, anofanira kugara achiona chiremba wake uye/kana chiremba we endocrinologist kuti vaongorore kufambira mberi kwekurapwa uye kuve nechokwadi chekuti mahormone ake ari mushe.

Kana mukaona shanduko mukukura kwemwana wenyu uye/kana hunhu hwake hwemuviri, zvakakosha kutaura nachiremba wemwana wenyu nekukurumidza. Kunyange zvazvo gigantism isingawanzove iyo inokonzera, zvakakosha kuongorora chero shanduko dzinofungirwa. Gigantism inonyanya kuongororwa nekukurumidza, uye vanhu vane gigantism vanowanzorarama hupenyu hwakanaka. Kana muine mibvunzo nezvekukura kwemwana wenyu, musatya kubvunza chiremba wenyu. Varipo kuti vakubatsirei.

Zvinhu zvakakosha zvekurangarira (Mharidzo Yekuenda Kumba)

Kukura kwemwana mudumbu (Gigantism) chirwere chisingawanzoitiki asi chinogona kunge chakakomba. Chinhu chakakosha ndechekutsvaga rubatsiro rwechiremba nekukasika kana ukaona chimwe chinhu chisina kujairika kana kuti chinofungirwa nezvekukura kwemwana wako, zvakaita sekukura nekukurumidza kupfuura zvaitarisirwa kana kuva nemakumbo makuru.

Yeukai kuti kuongororwa kwechirwere nekukasika uye kurapwa kunowedzera mikana yekuti mwana wenyu ararame hupenyu hwakanaka uye hwakajairika. Musazvidya mwoyo, vanachiremba varipo kuti vakubatsirei imi nemwana wenyu. Taurai navo nezvechero zvinokunetsai.

` Gigantism, Growth Hormone, Pituitary Gland, Kukura muVana, Kuwedzera Kureba, Acromegaly