Ngatidzidzei nezvemabundu madiki anoumbwa muura? - Juvenile Polyposis Syndrome (JPS)

Munhu wese angatya zvikuru kana akaona ropa mutsvina yake, kunyanya mumwana mudiki. Kana kuti unonetseka nezvinhu zvakaita sekurwadziwa mudumbu nguva dzose, kuzvimba, uye kunzwa kuneta? Izvi dzimwe nguva zvinogona kuva zviratidzo zvechirwere chemajini chatichataura nezvacho chinonzi Juvenile Polyposis Syndrome (JPS). Usatye kunyangwe zita racho richinzwika serakaoma. Kunyangwe ichi chisiri chirwere chakajairika, zvakakosha kuti uzive nezvacho. Ngatitaurei nezvazvo nenzira iri nyore yaunogona kunzwisisa.

Zvichitaurwa zviri nyore, chii chinonzi Juvenile Polyposis Syndrome (JPS)?

Zvichitaurwa zviri nyore, JPS chirwere chemajini chinokonzera kukura kudiki kunonzi polyps pamadziro emudumbu medu (mudumbu (GI) tract) . Izvi zvakafanana nembeu diki dzakarembera padzinde diki.

Ma polyps aya anogona kukura chero kupi zvako mudumbu, asi anonyanya kuwanikwa mu:

• Colon
• Muromo

Pamusoro pezvo, dzimwe nguva dzinogona kukura mudumbu nemuura hudiki. Munhu ane JPS anogona kunge aine akawanda ema polyps aya, dzimwe nguva anopfuura zana.

Patinoti "vana vadiki," zvinoreva here kuti ichi chirwere chinongobata vana vadiki chete?

Uyu mubvunzo unowanzo fungwa nevanhu vazhinji. Patinonzwa izwi rekuti "vechidiki," tinofunga nezvevana vadiki nevakuru vechidiki. Zvisinei, izwi iri harishandiswi pano kureva zera remurwere. Zita iri rinobva pakuti ma polyps aya anotaridzika sei pasi pe microscope (hunhu hwemasero avo).

Zvisinei, chinonyanya kukosha ndechekuti zviratidzo zveJPS zvinowanzotanga kuoneka munhu asati asvitsa makore makumi maviri , kureva kuti, panguva yehudiki kana kuyaruka. Saka, munhu angafunga kuti zita iri rakakodzera zvishoma.

Kune mhando huru dzeJPS here?

Ehe, JPS inogona kukamurwa kuita mhando nhatu huru. Rudzi rumwe nerumwe rwakasiyana zvishoma nerumwe. Ngationei kuti ndedzipi.

Chirwere ichi chinogara nhaka here?

Ehe, JPS chirwere chinogara nhaka. Chinotapuriranwa nenzira inotonga autosomal . Iye zvino ungave uchishamisika kuti iyi autosomal dominant inorevei.

Varwere vanosvika 75% veJPS vanoiwana kubva kuvabereki vavo nenzira iyi. Asi muzviitiko zvinenge 25% , inokonzerwa nekuchinja kwemajini kutsva uko kusina munhu mumhuri akambova nako. Izvi zvinoreva kuti mumwe munhu anogona kuiwana kunyangwe pasina munhu mumhuri ane chirwere ichi.

Ndezvipi zviratidzo zveJPS?

Chinhu chikuru cheJPS mapolyps atakataura nezvawo kare. Aya anokura mumuviri, saka hatigoni kuaona kubva kunze. Zvisinei, kashoma, mamwe mapolyps anogona kuonekwa kunze kwerectum.

Kazhinji, zviratidzo zvinoonekwa kana mapolyps achikura muhukuru kana huwandu. Ndiwo mapolyps aya atinofanira kunetseka nawo.

Zvimwe zvinhu zvinogona kuva nevamwe vana pakuzvarwa

Vanenge 15% yevarwere veJPS vanogona kunge vaine zvimwe zvirwere zvemuviri panguva yekuzvarwa pamwe chete nemapolyps. Izvi zvinosanganisira:

• Mukanwa wakachekwa
• Kuva neminwe yakawedzerwa pamaoko nemakumbo (Polydactyly)
• Kusashanda zvakanaka kweuropi, moyo, nhengo dzesikarudzi, kana kuti weti
• Kumonyoroka kwedumbu (Malrotation)
• Kuchinja kwetsinga dzeropa paganda (Telangiectasia)

Pane hukama here pakati peJPS nenjodzi yegomarara?

Izvi zvakakosha zvikuru uye chimwe chinhu chatinofanira kungwarira. Mapombi anokonzerwa neJPS anotanga kukura semapundu asina kenza (asina kuipa) . Izvi zvinoreva kuti haasi kenza.

Zvisinei, vanhu vane JPS vane mukana mukuru wekuva nekenza yemudumbu kupfuura vamwe. Ichi ndicho chinhu chine njodzi zvikuru chechirwere ichi. Njodzi yacho inogona kusvika pa30% - 50%.

Kenza dzine njodzi huru:

• Kenza yemudumbu
• Kenza yemudumbu
• Kenza yepancreatic
• Kenza yemudumbu mudiki

Sei JPS ichiitika? Chikonzero chesainzi chii?

JPS inokonzerwa nekuchinja kwemajini maviri ari mumuviri wedu, BMPR1A neSMAD4 .

Funga nezvemajini maviri aya se "vatariri" vaviri vanodzora mashandiro emasero edu. Basa ravo guru nderekuudza masero kuti, "Zvakanaka, patsanura izvozvi" uye "Zvakanaka, rega kupatsanura izvozvi." Aya ndiwo maitiro avanodzora kukura kwemasero.

Chinoitika muJPS ndechekuti kana majini aya akachinja, "mutariri" iyeye haashande nemazvo. Ipapo masero anobva abuda musimba. Anopatsanurana nekukurumidza, oungana pamusoro peumwe neumwe, uye oumba ma polyps atataura.

JPS inoonekwa sei?

Kana uine zviratidzo zveJPS, chiremba wako achatanga akuongorora uye obvunza nezvezviratidzo zvako uye kana paine mumwe munhu mumhuri mako akambova nematambudziko akafanana. Kuti uongororwe kuti une JPS, unofanira kunge uine chimwe chezvinotevera:

Ndedzipi bvunzo dzinoitwa pakuita izvi?

Chiremba anokurudzira bvunzo dzinoverengeka kuti asimbise chirwere ichi:

• Colonoscopy kana Endoscopy: Izvi zvinosanganisira kuisa chubhu yakatetepa, inochinjika ine kamera uye chiedza chinopinda nemutsvina kuti uongorore mukati meura hukuru. Izvi zvinogona kubatsira kuona kana paine ma polyps, ari papi, uye kuti mangani. Kuti uongorore dumbu, chubhu inopinzwa nemuromo (Upper GI Endoscopy).

• Kuongororwa kweropa remajini: Sampuro yeropa inotorwa yoongororwa kuti ione kana paine shanduko dzemajini dzinokonzera JPS.

Ndeapi marapirwo eJPS?

Zvinangwa zvikuru zvekurapa JPS kubvisa mapolyps, kudzora zviratidzo, uye kuderedza njodzi yekenza. Chiremba wako ndiye achasarudza kurapwa kwakanakira iwe zvichienderana nezera rako, hutano, huwandu hwemapolyps, uye nzvimbo yawo.

Kune nzira dzakasiyana-siyana dzekurapa:

• Kubvisa mapolyps panguva yekuongorora colonoscopy: Kana paine mapolyps mashoma chete, anogona kuchekwa nekubviswa uchishandisa michina yakakosha inopfuudzwa nemuchubhu.
• Kubviswa kwemapolyps pakuvhiyiwa: Kana mapolyps acho akakura zvikuru kana ari panzvimbo isingagoni kubviswa panguva ye colonoscopy, kuvhiyiwa kunogona kudiwa.
• Kubviswa kwechikamu chemudumbu kana chedumbu: Kana paine huwandu hwakawanda hwemapolyps munzvimbo imwe chete, vanachiremba vanogona kusarudza kubvisa chikamu chose chemudumbu.

Unoita sei hupenyu hwako mushure mekuonekwa uine chirwere ichi?

Hakuna mushonga weJPS. Saka, kana wangoonekwa, chinhu chakakosha kudzidza kurarama nawo uye kugadzirisa chirwere ichi. Nzira yakanakisisa yekuita izvi ndeyekuongororwa nachiremba nguva dzose.

Ndinofanira kuongororwa kangani?

• Bvunzo yekutanga inofanira kuitwa kana zviratidzo zvatanga kuoneka kana kuti vasati vasvitsa makore gumi nemashanu .
• Kana pasina matambudziko panguva yekuongororwa kwekutanga (pasina ma polyps), zvakakwana kuongororwa makore matatu ega ega .
• Kana wakambova nemapolyps akawanda uye ukabviswa kana kuvhiyiwa, unofanira kuongororwa gore rega rega . Kana pasina polyps akawanikwa zvakare, unogona kuchinja kuenda kunoongororwa makore matatu ega ega, sezvakarayirwa nachiremba wako.

Mushure mekurapwa, unofanira kupa muviri wako nguva yekuti upore. Zvinowanzo tora mavhiki maviri kuti zviratidzo zviderere uye kuti utange kunzwa zviri nani.

Pose paunoda kuona chiremba.

Kana uine zviratidzo zveJPS, kunyanya ropa riri mutsvina yako , usazviregeredza. Enda kuna chiremba nekukurumidza sezvinobvira. Uyewo, kana paine munhu mumhuri yako ane nhoroondo ye polyps kana JPS, iva nechokwadi chekuudza chiremba wako. Nekuti ichi chirwere chinogarwa nhaka, ruzivo irworwo rwakakosha zvikuru pakuongorora chirwere chacho.