Pane mumwe munhu mumhuri mako, pamwe amai vako, baba vako, kana ambuya, vanokanganwa zvinhu zvidiki here? Kana usingakwanise kurangarira kunyange zvinhu zvidiki, tinonzwawo kusuruvara uye kutya. Chikonzero chikuru cheizvi chingave chirwere cheAlzheimer. Kutaura zvazviri, hapana mushonga wechirwere ichi parizvino. Zvisinei, kune mishonga mitsva inogona kubatsira kudzora kupararira kwechirwere nekukurumidza uye kunonoka kufambira mberi kwacho. Kisunla ndeimwe yemishonga yakadaro yakaunza tariro itsva. Ngatitaurei nezvazvo zviri nyore uye zvakajeka nhasi.
Chirwere cheAlzheimer uye mashandiro anoita Kisunla
Zvichitaurwa zviri nyore, chirwere cheAlzheimer's chirwere cheuropi chinokura zvishoma nezvishoma nekufamba kwenguva. Ungave wakambonzwa nezvacho sechirwere chekurasikirwa nendangariro chinowanzoitika kuvanhu vakuru. Kana chirwere ichi chikaitika, zvikamu zveuropi hwedu zvinodzora zvinhu zvakakosha zvakaita sekurangarira, kunzwisisa, mutauro, kutarisisa, uye kufunga zvinokuvadzwa. Chikonzero chikuru cheizvi kuunganidzwa kweprotein ine chepfu inonzi amyloid pakati pemasero europi.
Kungofanana nepombi yemvura mumba medu inovharwa nevhu uye inomisa kuyerera kwemvura, kana puroteni iyi yeamyloid ikaungana pakati pemasero europi, masero europi haakwanise kutaurirana uye kushanda zvakanaka.
Ungave wakanzwa kuti chirwere cheAlzheimer rudzi rwechirwere chepfungwa. Dementia izwi rinowanzo reva mamiriro ezvinhu anokonzera kuoma kufunga zvakanaka kusvika pakusakwanisa kuita mabasa ezuva nezuva.
Vanachiremba vanowanzo patsanura chirwere ichi muzvikamu zvakasiyana-siyana. Pakutanga, kurasikirwa nendangariro kwenguva pfupi ndicho chiratidzo chikuru. Sezvo chirwere ichi chichienderera mberi, kunyange mabasa ezuva nezuva akadai sekugadzirira chikafu, kutsvaga nzira yako, uye kutarisira mari anova akaoma. Pazvikamu zvekupedzisira, unogona zvakare kuratidza zviratidzo zvepfungwa zvakaita sekurega kushamwaridzana nevamwe, kurasikirwa nehanya nechimwe chinhu, uye kusagadzikana.
Saka, mushonga mutsva uyu unonzi Kisunla unoita sei? Une mushonga unonzi donanemab-azbt . Chaunoshanda ndechekuti unotarisa mapuroteni e-amyloid andambotaura anoungana muuropi obva aabvisa muuropi. Nenzira iyi, Kisunla inobatsira kuderedza kukuvara kweuropi uye kuderedza mwero wechirwere ichi.
Ungashandisa sei mushonga weKisunla?
Kisunla haisi piritsi. Inopihwa semushonga wemutsinga (IV) . Kungofanana nepatingawana saline, uchafanirwa kurapwa muchipatara kana kukiriniki, izvo zvinotora maminetsi angangoita makumi matatu.
Paunotanga kurapwa, uchapihwa madosi matatu e700 milligrams (700 mg) mavhiki mana ega ega. Mushure meizvozvo, chiremba wako achawedzera dosi kusvika pa1400 milligrams (1400 mg) mavhiki mana ega ega.
Usati watanga kurapwa uku, chiremba wako acharaira kuongororwa kweuropi kunonzi tau positron emission tomography (PET) . Izvi zvinotarisa kuti amyloid yakawanda sei yakaiswa muuropi hwako. Kana kuongororwa kunoratidza kuti huwandu hweamyloid muuropi hwako hwaderera zvakanyanya, chiremba wako anogona kusarudza kurega kurapwa.
Zvinhu zvakakosha zvekuchenjerera uye migumisiro yakaipa
Pane mhedzisiro yakakomba yatinofanira kungwarira zvikuru pakurapa Kisunla. Inonzi ARIA (amyloid-related imaging abnormalities) . Muchidimbu, mushonga uyu unokonzera shanduko dzisina kujairika kuti dzionekwe paMRI scan yeuropi. Izvi hazviwanzo kukonzera zviratidzo.
Zvisinei, kashoma, vamwe vanhu vanogona kuona zviratidzo zvakaita seizvi:
- Musoro
- Kuvhiringidzika
- Kurutsa
- Kuchinja kwemaonero
- Kurasikirwa nekuenzana pakufamba
Dzimwe nguva zviratidzo zveARIA zvinogona kufanana zvikuru nezviratidzo zvestroke. Saka, zvakakosha zvikuru kuudza chiremba wako nezvemishonga yese yauri kutora kuitira kuti agone kuona kana ichikonzerwa neARIA kana chimwe chinhu.
Ndiani ari panjodzi huru ye ARIA?
Vamwe vanhu vane njodzi huru yekubatwa neARIA zvichienderana nekugadzirwa kwemajini avo. Vanhu vane makopi maviri ejini rinonzi apolipoprotein E e4 (ApoE e4) vari panjodzi huru yekubatwa nemhedzisiro yakakomba yakadai sekuzvimba kweuropi kana kubuda ropa muuropi. Saka, chiremba wako angangoraira kuti uedze kuedzwa kwemajini kuti uone njodzi yako yeARIA usati watanga kurapwa neKisunla. Uchafanirawo kuongororwa nguva dzose neMRI kuti utarise chirwere ichi panguva yekurapwa.
Kubudirira kwemushonga weKisunla kwakaongororwa sei?
Ongororo huru yekiriniki yakaitwa kuti ione kuti mushonga uyu unoshanda sei. Huwandu hwakawanda hwevarwere vane chirwere cheAlzheimer's chiri muchikamu chekutanga vakatora chikamu mune izvi.
Vaongorori vakapatsanura vanhu ava mumapoka maviri.
1. Boka rimwe chete rakapihwa: mushonga weKisunla.
2. Rimwe boka: rakapihwa chimwe chinhu chakaita semushonga, asi chisina chinhu chinoshanda (tinoti ichi iplacebo ).
Mhedzisiro yacho inokurudzira zvikuru. Ngatinzwisisei mhedzisiro iyoyo kubva patafura iri pazasi.
| Kubatsirwa | Zvakawanikwa nekudzidza uku |
|---|---|
| Kuderedza kupararira kwechirwere | Mwero wekufambira mberi kwechirwere kune avo vakagamuchira Kisunla waive wakaderera ne20% pane kune avo vakagamuchira placebo. |
| Zviratidzo hazvisi kuipa zvakanyanya | Makumi mana nemanomwe muzana evaya vakapihwa Kisunla havana kumbobvira varwara zvakanyanya mukati megore, zvichienzaniswa ne29% chete yeavo vari muboka re placebo. |
| Kuderera kweamyloid muuropi | Pakupera kwechidzidzo ichi, 76% yeavo vakagamuchira Kisunla vaiva nehuwandu hwakaderera hweamyloid muuropi hwavo. |
Mhedzisiro iyi inoratidza kuti Kisunla inogona kuderedza zvakanyanya kufambira mberi kwechirwere cheAlzheimer.
Zvinotora nguva yakareba sei kuti mushonga ushande uye pane here kupindirana kwemimwe mishonga?
Kana wangogamuchira mushonga wako wekutanga weKisunla, unotanga kushanda nekutarisa amyloid muuropi. Zvisinei, zvinogona kutora mwedzi yakati wandei kuti iwe, vanokuchengeta, nachiremba wako vaone kuti zviratidzo zvako zviri kudzikira uye kuti chirwere chiri kudzikira.
Kudyidzana nemimwe mishonga
Nekuda kwenjodzi yekubuda ropa muuropi neARIA, kungwarira kwakanyanya kunofanira kutorwa pakushandisa Kisunla ine mishonga inobvisa ropa . Kunyangwe pasina humbowo hwakajeka parizvino, kana uri kutora mishonga inobvisa ropa, unofanira kukurukura izvi nachiremba wako usati watanga kurapwa neKisunla.
Chinhu chinonyanya kukosha ndechekuzivisa chiremba wako nezvemishonga yese yauri kutora - ingave yakanyorerwa nachiremba wako, mishonga inotengeswa pasina kunyorerwa chiremba, mavhitamini, mishonga yeAyurvedic kana yeSinhala.
Kana ukaona zviratidzo zvakaita semusoro panguva yekurapwa, usazviregeredza. Izvi zvinogona kunge zviri chiratidzo cheARIA, saka zivisa chiremba wako nekukasika .
Mharidzo Yekuenda Nayo Kumba
- Kisunla mushonga mutsva unoshandiswa kurapa chirwere cheAlzheimer's pakutanga .
- Izvi zvinoshanda nekubvisa puroteni ine chepfu inonzi amyloid inoungana muuropi uye kuderedza mwero wechirwere ichi.
- Uku kurapwa kwekuisirwa mushonga netsinga (IV) uye kunofanira kuitirwa kuchipatara kana kukiriniki.
- Zvakakosha kuziva nezvemhedzisiro yakaipa inonzi ARIA. Izvi zvinoda kuongororwa nguva dzose kweMRI usati warapwa uye panguva yekurapwa.
- Zvakakosha kutaura pachena nachiremba wako nezvemishonga yese yauri kutora (kusanganisira mishonga inobvisa ropa) uye chero zviratidzo zvitsva zvauri kuona.
- Kunyange zvazvo izvi zvisiri mushonga, zvinononotsa zvakanyanya kufamba kwechirwere ichi uye zvinopa tariro itsva kuvarwere nemhuri dzavo.
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