Ngatidzidzei nezvechirwere cheleukemia chisingawanzoitiki chinobuda muropa? (Large Granular Lymphocytic Leukemia - LGL)

Wakambonzwa nezverudzi rweleukemia rusinganzwisisike, asi rusingawanzoitiki runobuda muropa here? Pamwe wakambonzwa nezveshamwari yako ine chirwere ichi. Kana kuti pamwe wakangonzwa nezvacho wobva washamisika nezvacho. Nhasi tichataura nezveimwe yeleukemia isingawanzoitiki, asi inokosha zvikuru. Inonzi Large Granular Lymphocytic Leukemia (LGL). Zita racho ringanzwika serakareba, asi ngatirichengetedzei riri nyore.

Chii chaizvo chinorehwa neLGL?

Zvichitaurwa zviri nyore, LGL rudzi rweleukemia inokura zvishoma nezvishoma mumuviri, isingaperi (zvichireva kuti inogara kwenguva yakareba). Inokanganisa rudzi rwakakosha rwemasero machena eropa muropa redu. Tinodana masero aya kuti lymphocytes . Waizviziva here kuti lymphocytes zvikamu zvakakosha zvemuviri wedu wekudzivirira muviri. Vakafanana nemasoja ari muuto redu. Ndivo vanorwisa utachiona hwakaita semavhairasi anopinda mumuviri wedu, uye ndivo vanogadzira masoja ekudzivirira chirwere anotidzivirira kubva kuzvirwere.

Saka, muLGL, chinoitika ndechekuti aya anonzi lymphocyte cells, kunyanya mhando mbiri dzemasero anonzi Cytotoxic T cells kana Natural Killer cells (NK cells), anochinja zvisina kujairika nekuda kwechimwe chikonzero uye otanga kupatsanurana nekuwanda zvisingadzoreki. Aya masero asina kujairika anonzi masero eLGL.

Chirwere ichi, chinonzi LGL, chinowanzo wedzera zvishoma nezvishoma. Ndosaka chichinzi chirwere cheLeukemia chisingaperi. Chinowanzoonekwa muvanhu vane makore anopfuura makumi matanhatu. Vanachiremba vanogona kurapa LGL. Asi dzimwe nguva chirwere ichi chinogona kudzoka, uye chinogona kuva dambudziko rehutano kwenguva refu.

Kune mhando mbiri huru dzeLGL:

Mhando mbiri huru dzechirwere ichi cheLGL dzakaonekwa. Idzi ndidzo:

1. Sero reT-large granular lymphocytic leukemia (T-LGL)

2. Chirwere chisingaperi chemasero eNK (CLPD-NK)

Muzviitiko zvose izvi, sezvambotaurwa, chinoitika ndechekuti masero eT kana masero eNK anova asina kujairika.

Mamiriro ezvinhu aya anokanganisa sei miviri yedu?

Ungangove uchishamisika kuti chirwere ichi chinonzi LGL chinokanganisa sei miviri yedu. Sezvo iri mhando yeChronic Lymphocytic Leukemia, masero eLGL asina kujairika anoenda kumongo wemapfupa uye anopindira mukugadzirwa kwemasero eropa akajairwa ikoko. Zvakafanana nemuti wakaipa unopinda wotora muti wakanaka.

Izvi zvinogona kukonzera matambudziko makuru maviri:

• Neutropenia : Uku kudzikira kwehuwandu hwemagranulocytes mumuviri wedu.Kuderera kwehuwandu hwemasero machena eropa (granulocytes) (rudzi rwakajairika rwemasero machena eropa). Kana masero aya akadzikira, kugona kwemuviri wedu kurwisa zvirwere, kana kuti dziviriro yemuviri, kunoderera. Izvi zvinowedzera njodzi yekutapukirwa kakawanda.
• Kushaya ropa : Ungave wakambonzwa nezvazvo. Kushaya ropa mumuviri kana muviri wako ukarasikirwa nehuwandu hunodiwa hwemasero matsvuku eropa. Dambudziko iri rinogona kuitika nekuti masero eLGL anokanganisawo kugadzirwa kwemasero matsvuku eropa. Kana ropa rikatanga, unonzwa kuneta uye kuneta zvakanyanya.

Ndiani ane mukana mukuru wekuwana chirwere ichi?

LGL chirwere chisingawanzoitiki . Kana ukatarisa pasi rose, chirwere ichi chinoonekwa muvanhu vanosvika mumwe chete pavanhu miriyoni. Izvi zvinoreva kuti munyika yakaita seSri Lanka, varwere ava vanogona kunge vari vashoma. Kazhinji, kana chirwere ichi chikaonekwa, varwere vanenge vava nemakore ekuma60.

Zviratidzo zvacho chii? Tinozvinzwisisa sei?

Hechino chinoshamisa zvishoma. Vamwe vanhu vane LGL vanogona kugara kwemakore vasina zviratidzo . Imwe ongororo yakawana kuti chikamu chimwe muzvitatu chevanhu vane LGL havana zviratidzo zvachose pavakaonekwa kuti vane chirwere ichi. Vakazongoona kuti vaiva nacho apo kuongororwa kweropa kwechimwe chikonzero kwakaratidza huwandu husina kujairika hwemasero matsvuku eropa kana huwandu hushoma hwemasero machena eropa anonzi neutrophils.

Zvisinei, kune zvimwe zviratidzo zvinowanzoonekwa nevanhu vanowana zviratidzo:

• Kuneta kwakanyanya uye kuneta : Ichi ndicho chiratidzo chinowanzoonekwa cheLGL. Kazhinji, izvi zvinokonzerwa neanemia yataurwa pamusoro apa.
• Kugara uchirwara nefivha uye hutachiona hunodzokororwa : Utachiona hwebhakitiriya hunogona kukonzera fivha. Izvi zvinokonzerwa nekushomeka kwesimba remuviri rekudzivirira chirwere.
• Splenomegaly: Uku kukura kwepleen , iyo nhengo iri mumuviri wedu. Izvi zvinogona kukonzerwa nehutachiona uye mamwe marudzi ekushaya ropa.

Yeuka kuti kungova nezviratidzo izvi hazvirevi kuti une chirwere cheLGL. Izvi zvinogonawo kuva zviratidzo zvezvimwe zvirwere zvakawanda. Saka, kana uri kusangana nechimwe chinhu chakadai, chinhu chakanakisa chekuita ndechekuona chiremba wowana mazano.

Pane zvimwe zvirwere zvine chekuita neLGL here?

Ehe, vanhu vazhinji vane LGL vakaonekwa vaine zvimwe zvirwere zve autoimmune . Kureva kuti, mamiriro ezvinhu apo masoja emuviri wedu anorwisa masero edu ane hutano. Pakati peizvi, rheumatoid arthritis ndiyo inonyanya kuitika.

Mukuwedzera, mamwe mamiriro ezvinhu akawanda anogona kusanganiswa neLGL:

• Anemia : Takambotaura nezvazvo kare. Vamwe vanhu vanoshaya ropa zvakanyanya uye vanoda kuwedzerwa ropa kuti varambe vaine masero matsvuku eropa. Vamwe vanhu vane LGLRudzi rweanemia inonzi hemolytic anemia runogonawo kuitika. Panyaya iyi, pachinzvimbo chekuderedza kugadzirwa kwemasero matsvuku eropa, masero matsvuku aripo anoparadzwa.
• Lymphocytosis : Uku kuwedzera kwehuwandu hwemasero machena eropa anonzi malymphocytes muropa. Kuwedzera uku kwemasero emalymphocytes kunowanzoonekwa muvanhu vane lymphocytic leukemias, lymphomas, kana hutachiona.

Chii chinokonzera LGL?

Ichi chinhu icho vanachiremba vasati vanyatsonzwisisa. Chikonzero chaicho cheLGL hachisati chazivikanwa. Zvisinei, vanotenda kuti pane hukama pakati pechirwere ichi cheleukemia nekushanda kwemasoja edu ekudzivirira muviri, zvirwere zve autoimmune, nedzimwe mhando dzekenza.

• Vanhu vanosvika 30% vane LGL vane zvimwe zvirwere zve autoimmune, zvakaita se rheumatoid arthritis.
• Vamwe 25% kusvika 30% vanogona kunge vaine rumwe rudzi rwe lymphoma kana rumwe rudzi rwekenza.
• Uyewo, vanhu vazhinji vane LGL vane shanduko mumajini avo. Kunyanya, kune shanduko mumajini maviri anonzi STAT3 na STAT5B . Majini maviri aya anoita basa rakakosha mukudzivirira masero uye nzira iyo masero anopatsanurana nekuwanda.

Vanachiremba vanoongorora sei chirwere ichi?

Vanachiremba vanonyanya kushandisa bvunzo dzeropa uye ongororo dzemajini kuti vaone kana chirwere cheLGL chapararira. Heano mamwe ematanho anowanzo shandiswa:

• Kuverengwa kweropa rose (CBC) nemuenzaniso wemusiyano : Izvi zvinoverenga marudzi ese emasero ari muropa rako, kunyanya kuti mangani emhando yega yega yemasero machena eropa aunawo.
• Kuongororwa kweropa rekunze : Izvi zvinosanganisira kutarisa ropa uchishandisa maikorosikopu uye kuverenga huwandu hwemasero eLGL muropa.
• Flow cytometry : Iyi bvunzo yemurabhoritari inoshandiswa kuongorora hunhu hwemasero. Bvunzo iyi inowanzo shandiswa kuona nekuronga mhando dzeleukemia.
• Kuongororwa kwezvirwere zvemuviri : Izvi zvinosanganisira kutora ropa kana kuti tissue samples wozviongorora kuti uone zviratidzo zvakasiyana pamusoro pemasero. Zviratidzo izvi zvinogona kushandiswa kuona mamwe marudzi ezvirwere.
• Kuongororwa kweT-cell receptor (TCR) gene rearrangement : Izvi zvinotora sampuro yeropa kana bone morrow uye zvinotarisa chero matambudziko ane majini anodzora mashandiro eT-cells.
• Kuongororwa kwemajini : Unogona zvakare kuyedza shanduko mumajini eSTAT3 neSTAT5B ambotaurwa.

Kuwedzera kune bvunzo idzi, kushomeka kwemuviri mumuviriMimwe miedzo, yakadai sekuongororwa kwemapfupa, inogona kuitwa kuti pasave nezvimwe zvirwere zvakaita sekushomeka kwemuviri mumuviri, rheumatoid arthritis, myelodysplasia , uye myeloid mutations . Mazinga eImmunoglobulin uye mazinga eprotein yemonoclonal zvinogonawo kuongororwa.

LGL inorapwa sei?

Ngatitii une T-LGL kana CLPD-NK leukemia, asi hauna zviratidzo . Kana zvakadaro, chiremba wako anogona kukurudzira nzira inonzi "waiting waiting." Izvi zvinosanganisira kugara uchitarisa hutano hwako. Kazhinji, unoongororwa ropa mwedzi mishoma yega yega kuti uone kana zviratidzo zvichibuda.

Kune avo vane zviratidzo, mushonga wekudzvanyirira immune system uye mishonga inorwisa mabhakitiriya (steroids) zvinogona kupihwa. Vanachiremba vanogona kutanga kurapwa kwakasiyana-siyana, kana kuti vanogona kutanga kurapwa kwakaderera. Nekuti LGL chirwere chisingawanzoitiki, vanhu vazhinji vanotsvaga chiremba ane hunyanzvi muchirwere ichi.

Hatigone kuderedza kuwanda kwechirwere ichi here?

Zvinosuwisa kuti kwete, hatigone. Vanachiremba havasati vaziva kuti chii chinokonzera izvi. Saka, zvakaoma kutaura kuti vangazvidzivirira sei. Zvisinei, zvakaonekwa kuti vanhu vane zvirwere zve autoimmune vari panjodzi huru yekuva nechirwere ichi. Saka, kana uine chimwe chezvirwere izvi zve autoimmune, zvakanaka kubvunza chiremba wako kana uchifanira kunetseka nezve LGL.

LGL chirwere chinouraya here?

Kazhinji, LGL chirwere chisingaperi, kwete rufu rwechimbichimbi . Vanhu vanosvika 75% vane T-LGL leukemia uye CLPD-LGL leukemia vanorarama kwemakore mashanu mushure mekuonekwa vaine chirwere ichi. Zvisinei, vanhu vanosvika 10% vane rudzi urwu rweleukemia vanofa nezvirwere zvakakomba zvinogona kuitika sedambudziko releukemia. Saka, zvakakosha kuti uzvidzivirire kubva kuzvirwere.

Ndingazvitarisira sei? Ndingararama sei nedambudziko iri?

Kana uine chirwere cheLGL, ungasave nezviratidzo. Zvisinei, zvakakosha kuchengetedza hutano hwako hwese, kusanganisira kuongororwa nguva dzose . Ungave uine zviratidzo kana kuti kwete, mazano aya anogona kubatsira:

• Idya chikafu chine hutano : Idya nyama isina mafuta akawanda, hove, michero, miriwo, uye zviyo zvakakwana.
• Rovedza muviri nguva dzose : Sarudza kurovedza muviri kunonzwa kwakanaka uye kwakakunakira.
• Rara zvakanaka : Zororo rakakwana rakakosha zvikuru.
• Gadzirisa kushushikana.: Ita zvinhu zvinokufadza, fungisisa, ita yoga.
• Dzivirira masoja emuviri wako : Bvunza chiremba wako nezvemajekiseni nezvimwe zvinhu zvaunogona kuita kudzivirira hutachiona. Kunyangwe zvinhu zviri nyore zvakaita sekugeza maoko nesipo uye kusapinda munzvimbo dzine vanhu vakawanda zvinogona kubatsira.

Zvinokwanisika here kurarama hupenyu hwakajairika uine chirwere ichi?

Kazhinji, vanhu vanorapwa chirwere cheLGL vanowanzorarama hupenyu hwakajairika . Vanogona kurarama kwenguva yakareba seyemunhu asina chirwere ichi. Zvisinei, zvakakosha kuyeuka kuti vamwe vanhu vane LGL vanogona kunge vatova nezvirwere zveropa zvakakomba zvinokanganisa hupenyu hwavo.

Ndinofanira kuona chiremba rini?

Kana ukaona zviratidzo zvinoratidza kuti chirwere chako chingave chiri kuwedzera kuipa, unofanira kuona chiremba wako. Kana uri kutorapwa zviratidzo, unofanirawo kuudza chiremba wako nezvekuchinja kwaunoona mumuviri wako (semuenzaniso, zviratidzo zvichiwedzera kuipa).

Ndeipi mibvunzo inokosha yekubvunza chiremba?

Sezvo chirwere cheLGL chisingawanzoitiki, zvakajairika kuva nemibvunzo yakawanda nezvacho. Heano mimwe mibvunzo yatinotarisira kuti ichakubatsira kudzidza zvakawanda nezveLGL:

• Ndine rudzii rweLGL?
• Ndezvipi zvinorapwa izvi?
• Ndichada kurapwa kunopfuura kumwe chete here?
• Ndiri kunzwa zvakanaka izvozvi. Ndicharatidza zviratidzo here?
• Ndine zvimwe zvirwere. LGL ichazviwedzera here?

Usatya kubvunza mibvunzo yakaita seiyi. Chiremba wako aripo kuti akubatsire. Vakazvipira kutsanangura zvese nenzira yaunogona kunzwisisa.

Pakupedzisira, zvinhu zvekurangarira

Large granular lymphocytic leukemia (LGL) igomarara reropa risingawanzoitiki rinokanganisa masero machena eropa. Kunyangwe uine chirwere ichi, ungasaona shanduko mumuviri wako dzinogona kuva zviratidzo zveLGL. Dzimwe nguva, zviratidzo zvinogona kusaonekwa kwemakore.

Vanachiremba havagone kurapa chirwere ichi zvizere. Zvisinei, kune mishonga inogona kubatsira kudzora zviratidzo zvacho. Zvakajairika kunzwa kushamisika uye kutya kana ukanzwa kuti une chirwere chisingarapiki . Vanachiremba vako vachanzwisisa kuti sei uchinzwa saizvozvo.

Vachafara kukutsanangurira zvaunogona kuita kuti utarisire hutano hwako izvozvi, uye zvekutarisira kana zviratidzo zvikaitika. Kuziva zvekutarisira mune ramangwana kuchakupa chivimbo chakawanda nesimba rekurarama neLGL. Saka, taura nachiremba wako nezvemibvunzo yese yaunayo. Wana ruzivo. Ndicho chinhu chakanakisa chaunogona kuita panguva yakaita seiyi.

'LGL leukemia, kenza yeropa, masero machena eropa, lymphocytes, neutropenia, anemia, immune system