Chiremba wako akakuudza here kuti huwandu hwecholesterol yako hwakakwira? Kana zvakadaro, ungangove wakatanga kushandisa statin. Ndiwo mushonga wekutanga wekurapa. Asi dzimwe nguva mushonga iwoyo wega hauna kukwana. Kana kuti vamwe vanhu havagone kushivirira migumisiro yemushonga. Ndosaka vanachiremba vava kutaura nezvemhando itsva yemishonga 'inochinja mutambo'. Idzi dzinonzi PCSK9 Inhibitors. Ngatitaurei nezvadzo nemashoko akareruka nhasi.
Zvichitaurwa zviri nyore, chii chinonzi PCSK9 Inhibitors idzi?
Iyi imhando itsva yemishonga inogona kuderedza zvakanyanya cholesterol 'yakaipa', kana kuti LDL cholesterol , muropa redu. Pari zvino kune mhando mbiri huru dzemishonga dzinotenderwa pasi rose. Idzi `alirocumab (Praluent)` uye `evolocumab (Repatha)`.
Ongororo yakaratidza kuti mishonga iyi, inonzi PCSK9 inhibitors, inoshanda zvinoshamisa. Mune zvimwe zviitiko, inogona kutodzivirira kurwara kwemoyo nekurohwa . Mishonga iyi inogona kutorwa yoga, kana pamwe chete nemushonga westatin waunotora kare. Asi chimwe chinhu chekurangarira ndechekuti inodhura zvakanyanya kupfuura mimwe mishonga yecholesterol.
Zvakanaka, ngationei kuti mushonga uyu unoshanda sei mumuviri.
Kuti tinzwisise izvi, ngatifungei nezvenyaya diki. Nhengo huru inodzora cholesterol mumuviri wedu chiropa.
Fungidzira kuti masero edu echiropa ane "zvinhu zvinobvisa" (receptors) zvidiki zvinobata nekubvisa cholesterol isingadiwe muropa. Idzi ndidzo dzinochengetedza mitsipa yedu yeropa yakachena.
Asi, kune imwe puroteni inonzi PCSK9 inogadzirwa nemiviri yedu. Basa rayo nderekutsvaga nekuparadza "zvinochenesa" zvakanaka. Zvadaro, nekuti hapana munhu anobvisa cholesterol, inoungana muropa uye inosara mumadziro etsinga.
Apa ndipo panobuda mushonga wedu wePCSK9 inhibitor. Zvinoitwa nemushonga uyu ndezvokuti unobata puroteni yePCSK9 yakaipa woimisa kushanda kwayo. Zvakafanana nekubata mwana asina hunhu womuisa pachigaro. Ipapo "vachenesi" vedu vanogona kuita basa ravo pasina chinovadzivisa. Mugumisiro wacho? Huwandu hweLDL cholesterol muropa hunoderera nekukurumidza.
Izvi zvakasiyana sei ne'statins'?
Mishonga inonzi Statins nePCSK9 inhibitors imhando mbiri dzemishonga inoderedza cholesterol, asi inoshanda nenzira mbiri dzakasiyana. Tafura iyi ichakubatsira kunzwisisa izvi.
| Musiyano | Statin | Zvidziviriri zvePCSK9 |
|---|---|---|
| Mashandiro | Inodzivirira kugadzirwa kwecholesterol muchiropa. | Inodzivirira kuparadzwa kwema receptors anobvisa cholesterol kubva muchiropa. |
| Maitiro ekutora | Piritsi rinonwiwa zuva nezuva. | Jekiseni rinopihwa mavhiki maviri kana mana ega ega. |
| Kushandiswa | Kazhinji inoshandiswa yoga, ndiyo sarudzo yekutanga yekudzora cholesterol. | Inogona kushandiswa yoga kana pamwe chete ne statins. Mhedzisiro yacho inotowedzera kusimba. |
Saka ndiani anoda kutora mushonga uyu?
Uyu mubvunzo unokosha nekuti havasi vese vane cholesterol yakakwira vanoda mushonga uyu. Chiremba wako achatanga aedza kudzora cholesterol yako nekushandisa statins. Asi chiremba wako anogona kufunga nezvePCSK9 inhibitor mune zvinotevera:
- Matambudziko emafuta akawandisa mumuviri: Vamwe vanhu vane chirwere chemafuta chinonzi "Familial Hypercholesterolemia." Vanhu ava vane dambudziko pamaitiro emuviri wavo ekudzora cholesterol. Kunyangwe paine statins yakawanda, zvakaoma kuti vanhu ava vaderedze cholesterol yeLDL kusvika padanho rakanaka.
- Kune vanhu vari panjodzi huru yekubatwa nechirwere chemwoyo kana sitiroko: Kana uchitova nechirwere chemwoyo, uye huwandu hwecholesterol yako husingadzoreki zvakakwana nemishonga yakaita se statins, chiremba wako anogona kufunga nezvemushonga uyu.
- Kune avo vasingakwanise kushivirira 'statins': Vanhu vanosvika 10%-20% vanotora statins vanowana migumisiro yakaipa yakadai sekurwadziwa kwetsandanyama, kushaya simba, uye kurwadziwa kwemuviri . Kune vanhu ivavo, iyi ingave sarudzo yakanaka.
Chiremba anopa mushonga uyu rini?
Chiremba haambofi akapa mushonga uyu panguva imwe chete. Pane nzira yekuushandisa.
1. Chekutanga, chinja mararamiro ako: Chiremba anotanga ati kurovedza muviri zvakanaka uye idya chikafu chine hutano chisina mafuta, shuga, uye hupfu .
2. Tevere, 'Statin': Kana shanduko dzemararamiro dzisina kukwana, statin inotanga. Kana cholesterol ikasaderera, dhigiri rinowedzerwa zvishoma nezvishoma.
3. Senzira yekupedzisira: Kana cholesterol yako isingadzoreki kunyangwe kana uine statins yakawanda, kana kana mhedzisiro yacho yakanyanya kuipa, chiremba wako anogona kufunga nezvePCSK9 inhibitor. Sarudzo iyi inogona kuitwa nekuita bvunzo, senge coronary calcium score, kuti uone njodzi yako yechirwere chemwoyo.
Mushonga uyu unoshandiswa sei uye ndeapi mhedzisiro yawo?
Inouya sejekiseni repasi peganda raunopa pasi peganda mavhiki maviri kana mana ega ega . Unogona kuiisa mudumbu, pachidya, kana paruoko. Chiremba wako kana mukoti akadzidziswa achakuratidza maitiro ekuipa nemazvo. Kazhinji hazvirwadzi uye zviri nyore.
Kana zvasvika pamigumisiro yakaipa, inowanzoonekwa idiki.
- Kurwadziwa kwemusana
- Zviratidzo zvakaita sechando (huro inokwenya, kugadzirwa kwemate)
- Kutsvuka, mavanga, kana kurwadziwa kudiki panzvimbo yekubaiwa jekiseni
Zvakakosha: Kashoma kuti pave neallergy yakanyanya. Kana ukangoerekana wava nemapundu akanyanya, kuzvimba kwechiso kana miromo, kana kufema zvakaoma , izvi zvinongoitika nekukurumidza. Kana izvi zvikaitika, unofanira kuenda kuchipatara chiri pedyo (ETU) nekukurumidza .
Chekupedzisira, kana zvasvika pamutengo wemishonga iyi, haina kufanana nemishonga yenguva dzose, uye inodhura zvikuru . Saka, kurapwa uku kungasakwanisika kune wese munhu. Zvakanaka kutaura pachena nachiremba wako nezveizvi uye kukurukura kana uchida, kana kwakakunakira, uye kuti ndeapi mari yaungasarudza.
Mharidzo Yekuenda Nayo Kumba
- Mishonga inodzivirira PCSK9 ine simba zvikuru, mhando itsva yemishonga inoderedza mazinga eLDL ('akaipa') cholesterol.
- Aya haauye semapiritsi ekunwa zuva nezuva, asi sejekiseni rinopihwa mavhiki maviri kana mana ega ega.
- Izvi zvinowanzo kurudzirwa kuvanhu vane zvirwere zvemajini zvecholesterol, avo vari panjodzi huru yechirwere chemwoyo, kana avo vasingakwanise kushivirira mishonga yestatin.
- Mushonga uyu unodhura zvikuru, saka unofanira kusarudza kana wakakunakira mushure mekukurukura nachiremba wako zvakanaka.
- Usambofa wakaita sarudzo nezvemishonga zvichibva pane zvaunonzwa kana zvaunoona pa internet. Gara uchitevera zano rachiremba wako.
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