Patinonzwa izwi rekuti 'cholesterol', vazhinji vedu tinotya zvishoma, handiti? Kunyanya kana chiremba akati, "Cholesterol yako yakaipa, kureva kuti, LDL level, yakakwira zvishoma," tinotya zvishoma. Zvatinodya uye zvatinonwa, kungave tichirovedza muviri kana kwete, uye dzimwe nguva zvinhu zvemajini zvinokanganisawo izvi. Saka, isu tese takambonzwa nezvemapiritsi erudzi rwe 'statin' anopiwa kudzora cholesterol. Asi kune vamwe vanhu, mishonga iyi yoga haina kukwana, kana kuti haigone kushandiswa. Nhasi tiri kutaura nezvemhando itsva yemushonga wepamusoro-soro unoshandiswa muzviitiko zvakadaro. NdiRepatha.
Chii chinonzi Repatha? Inoderedza sei cholesterol?
Zvichitaurwa zviri nyore, Repatha ijekiseni rinoderedza huwandu hwe "cholesterol" yakaipa, kana kuti LDL (Low-Density Lipoprotein) cholesterol mumiviri yedu. Iri harisi piritsi ratinowanzo nwa, asi jekiseni rinopinzwa pasi peganda.
Zvino tarisa kuti izvi zvinoshanda sei. Fungidzira kuti chiropa chedu ndicho chinobvisa cholesterol yakaipa muropa. Asi muviri wedu unewo puroteni inonzi PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) . Izvi zvakafanana nemunhu anoderedza kushanda kwesefa iyoyo, oikanganisa. Kana puroteni yePCSK9 ikawedzera, kugona kwechiropa kubvisa LDL muropa kunoderera.
Zvinoitwa naRepatha zvinodzivisa kushanda kweproteni yePCSK9 iyoyo 'inokuvadza' . Kana ikamiswa, sefa yechiropa inogona kushanda nesimba zvakare pasina kukanganiswa, kubata nekubvisa cholesterol yakaipa (LDL) muropa. Unonzwisisa here? Izvi zvinoreva kuti mushonga uyu unobatsira maitiro emuviri wedu echisikigo anodzora cholesterol.
Mushonga uyu weRepatha unokurudzirwa ani?
Uyu mushonga hausi wemunhu wese. Chiremba anongokurudzira kuti ushandiswe mune zvimwe zviitiko.
- Kune vakuru vane chirwere chemwoyo chiripo: Mushonga uyu unoshandiswa kuderedza njodzi yekurwara nemoyo, sitiroko, kana chimwe chirwere chemwoyo. Unowanzopihwa pamwe chete nemimwe mishonga yecholesterol, yakadai se statins.
- Kune vanhu vane cholesterol yakakwira kubva muropa: Vamwe vanhu vane cholesterol yakakwira zvakanyanya nekuda kwemamiriro ezvinhu emajini anopfuudzwa kubva kuchizvarwa kuenda kune chimwe. Matambudziko aya anonzi Heterozygous Familyal Hypercholesterolemia (HeFH) uye Homozygous Familyal Hypercholesterolemia (HoFH) . Repatha inokurudzirwa kuvanhu vakuru nevana vane makore anopfuura gumi vane mamiriro aya ekudzora mazinga eLDL.
Chinonyanya kukosha, zvakakosha kutevera kudya kwakanaka uye kurovedza muviri paunenge uchishandisa mushonga uyu.Repatha haisi mashiripiti, ingori chikamu chimwe chete chechirongwa chekurapa.
Ndezvipi zvakanakira uye migumisiro yemushonga uyu?
Zvidzidzo zvekiriniki zveRepatha zvakaratidza mhedzisiro yakanaka. Zvidzidzo izvi zvakaenzanisa Repatha ne placebo (kurapwa kwenhema) uye nemimwe mishonga yecholesterol, yakaita se statins.
Ngatitsanangurei izvi zvakare netafura iri pazasi.
| Mushonga uyu unokurudzirwa kushandisirwa ani? | Mabhenefiti akakosha anoratidzwa nemiedzo |
|---|---|
| Vakuru vane chirwere chemwoyo (pamwe chete nemimwe mishonga yakaita se statins) | Zvinoderedza zvakanyanya njodzi yekurwara nemwoyo, sitiroko, uye kufa nechirwere chemwoyo. |
| Vakuru nevana vane makore anopfuura gumi vane cholesterol yakakwira nekuda kwezvikonzero zvemajini | Zvinobudirira uye nekukurumidza zvinoderedza huwandu hwe "cholesterol" yakaipa (LDL) muropa. |
Unoziva sei kana mushonga wacho uchishanda?
Chiremba wako acharaira kuongororwa kweropa (kuongororwa kwemafuta) nguva nenguva. Mushure mekutanga Repatha, unogona kuona kudzikira kukuru kwemazinga eLDL cholesterol yako mukati memavhiki gumi nemaviri chete .
Ngatidzidzeiwo nezvekushandiswa kweRepatha uye migumisiro yaro.
Ungashandisa sei izvi?
Repatha inouya sesirinji yakazadzwa kare kana peni yejekiseni. Inobayiwa pasi peganda mavhiki maviri ega ega kana kamwe chete pamwedzi, zvichienderana nedoro rawakanyorerwa.
Chinonyanya kukosha: Zvakakosha kutanga wadzidza mashandisirwo chaiwo eizvi kubva kuna chiremba wako. Usati wazvishandisa kekutanga, kumbira kuti vakuratidze zvakajeka mashandisirwo azvo.
Ndezvipi migumisiro yakaipa?
Kufanana nemushonga upi zvawo, Repatha inogona kukonzera migumisiro midiki, kunyange hazvo vasiri vese vanoiwana.
| Migumisiro yakajairika | Mazano ekudzivirira kana kugadzirisa |
|---|---|
| Kutsvuka, kurwadziwa, uye mavanga panzvimbo yekubaiwa jekiseni. | - Gara uchitenderedza nzvimbo yekubaiwa jekiseni (semuenzaniso, rimwe divi redumbu, rinotevera rimwe divi). - Bvisa mushonga wekudzivirira mufiriji, worega ugare kwemaminitsi makumi matatu kusvika makumi mana nemashanu , wobva waubaya kana wasvika patembiricha yemukamuri. |
| Zviratidzo zvakaita sechando (fivha, kurwadziwa kwemuviri). | Izvi zvinowanzova zvenguva pfupi. Kana uine dambudziko, taura nachiremba wako. |
| Kurwadziwa kwemusana, huwandu hweshuga muropa. | Udza chiremba wako kana paine mimwe migumisiro inokunetsa kana kuti inoramba iripo. |
Zvinhu zvekunyanya kutarisisa:
- Kurwara neLatex: Dzimwe tsono dzejekiseni dzinogona kunge dziine latex musheath dzadzo. Kana uine allergy yelatex, iva nechokwadi chekuudza chiremba wako nezvazvo.
- Kubata pamuviri nekuyamwisa: Kana uri nepamuviri, uchiedza kuva nepamuviri, kana kuyamwisa, zvakakosha kuudza chiremba wako usati washandisa mushonga uyu, sezvo pasina ruzivo rwakakwana pamusoro pekuchengetedzeka kwawo mumamiriro ezvinhu akadai.
Ndingawana sei mushonga uyu?
Uyu hausi mushonga waunogona kutenga ku pharmacy. Unofanira kuwana mushonga kubva kuna chiremba.
Kazhinji, chiremba wako mukuru kana chiremba wemwoyo ndiye achasarudza kana uchida mushonga uyu uye oukurudzira. Zvichienderana nezano rachiremba wako, unogona kuuwana kubva kuzvitoro zvemishonga kana kuti kuburikidza nechitoro chemishonga chemunharaunda yako.
Usambofa watanga, wamisa, kana kuchinja mushonga chero upi zvawo usina kupiwa mazano nachiremba. Gara uchibvunza chiremba wako usati waita chero sarudzo.
Mharidzo Yekuenda Nayo Kumba
- Repatha ijekiseni rinopinzwa pasi peganda rinoderedza huwandu hweLDL ("yakaipa") cholesterol.
- Izvi zvinokurudzirwa zvikuru kune avo vari panjodzi huru yekubatwa nechirwere chemwoyo uye avo vane matambudziko eropa.
- Inovhara puroteni inonzi PCSK9, ichibatsira chiropa kubvisa cholesterol yeLDL muropa.
- Izvi zvinongowanikwa chete kana chiremba akakurayira. Zvakakosha zvikuru kutevedzera mirairo yachiremba wako.
- Migumisiro yakadai sekutsvuka uye zviratidzo zvakaita sechando panzvimbo yekubaiwa jekiseni inogona kuitika, uye unofanira kuzivisa chiremba wako nezvazvo.
- Mhedzisiro yakanaka inogona kuwanikwa nekushandisa Repatha pamwe chete nemararamiro ane hutano.
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