Kuongororwa kweropa rako kwazvino kwakaratidza here kuti cholesterol yako yakakwira zvishoma? Wakatya uye wakanetseka here pawakaona kuti "cholesterol yako yakaipa" kana kuti LDL yako yakakwirawo? Kana zvakadaro, chiremba wako angangodaro akakurayira kuti utange kutora mushonga wemhando ye'Statin'. Saka nhasi, ngatitaurei zviri nyore nezve 'Statins', iyo inokosha kuvanhu vazhinji.
Zvakanaka, chii chinonzi 'Statins' idzi?
Muchidimbu, 'Statins' rudzi rwemushonga unonyorerwa navanachiremba kuderedza huwandu hwecholesterol muropa rako, kunyanya cholesterol "yakaipa".
Patinotaura nezve cholesterol, tinogara tichinzwa nezvemhando mbiri dzecholesterol, handiti?
1. LDL (Low-Density Lipoprotein): Izvi ndizvo zvatinodaidza kuti cholesterol "yakaipa" . Funga nezvetsinga dzeropa rako sepombi inotakura mvura. Chinoitwa necholesterol iyi yeLDL kuungana setsvina ine mafuta mukati mepombi iyoyo, zvichiita kuti nzira yeropa ienderere zvishoma nezvishoma. Mamwe marudzi e'statins' anogona kuderedza cholesterol iyi yakaipa ne50% kana kupfuura.
2. HDL (High-Density Lipoprotein): Iyi ndiyo yatinodaidza kuti cholesterol "yakanaka" . Inotora cholesterol yakaipa inenge yaungana mutsinga dzeropa yoiendesa kuchiropa kuti ibviswe mumuviri. Yakafanana nemuchina wekuunganidza marara.
MaStatins haangoderedzi chete cholesterol yakaipa yeLDL, asiwo anobatsira kuderedza triglycerides, imwe mhando yemafuta muropa, uye anowedzera zvishoma mazinga akanaka eHDL cholesterol.
Mishonga iyi inowanzo nyorwa kuti inwe kamwe chete pazuva, panguva imwe chete. Mimwe mishonga yestatin inoshanda zvakanaka kana ikatorwa husiku. Izvi zvinodaro nekuti miviri yedu inogadzira cholesterol yakawanda husiku. Zvisinei, mimwe mishonga mitsva yestatin inoshandawo zvakanaka kana ikatorwa chero nguva yezuva. Chiremba wako achakutsanangurira izvi.
Mushonga uyu unoshanda sei mumuviri?
Iyi inyaya inonakidza zvikuru. Fungidzira kuti chiropa chako ndicho fekitari huru inogadzira cholesterol. Kutaura zvazviri, 75% yecholesterol inodiwa nemuviri wedu inogadzirwa muchiropa chedu. Imwe yacho inobva muzvikafu zvatinodya.
Saka, chiropa chine enzyme inokosha pakugadzira cholesterol iyi. Inonzi `HMG-CoA reductase`. Mushonga we`Statin` unoshanda semuchengeti wegedhi, uchivhara enzyme ye`HMG-CoA reductase` kuti isasvike pachiropa. Ipapo chiropa chinorasikirwa nechinhu chachinoda kuti chigadzire cholesterol. Nekuda kweizvozvo, huwandu hwecholesterol inogadzirwa nechiropa hunoderera zvakanyanya. Unonzwisisa here?
Muchidimbu, 'Statin' mushonga unoderedza huwandu hwecholesterol yakaipa muropa nekuvhiringidza kugadzirwa kwecholesterol muchiropa.
Sei tichida 'Statins'?
Chikonzero chikuru ndechekuderedza njodzi yekurwara nemoyo uye sitiroko.
Sezvandambotaura kare, kana cholesterol yakaipa ikawedzera muropa, inosara pamadziro etsinga dzeropa. Mukurapa, tinodana izvi kuti 'Atherosclerosis' . Cholesterol inoungana nenzira iyi inonzi 'plaque'. Izvi zvinoderedza nzvimbo iri mukati metsinga dzeropa uye zvinotadzisa kufamba kweropa.
Fungidzira kuti chii chinoitika kana tsinga inopa ropa kumoyo ikavharika seizvi? Mwoyo hauwani okisijeni nezvinovaka muviri zvaunoda. Izvi zvinotungamira kuchirwere chemwoyo. Uye kana 'plaque' iyi ikaputika mutsinga inopa ropa kuuropi uye ropa rikagwamba, inokonzera sitiroko.
Statins inoderedza cholesterol, zvichideredza zvakanyanya njodzi yezvirwere izvi zvine njodzi.
Ndedzipi mhando dze'statins' dzinonyanya kushandiswa?
Kune mhando dzakasiyana dze'statins'. Chiremba wako achakupa mhando yakakunakira, achifunga nezvehutano hwako, huwandu hwecholesterol, nezvimwe zvinhu.
| Zita rekuti 'Statin' | Mazita Emhando Dzakajairika |
|---|---|
| Atorvastatin | Lipitor®, Caduet® |
| Rosuvastatin | Crestor®, Ezallor Sprinkle® |
| Simvastatin | Zocor®, Vytorin® (ine ezetimibe) |
| Pravastatin | Pravachol® |
| Lovastatin | Mevacor® |
| Fluvastatin | Lescol® |
Dzimwe nguva 'statin' inouya mupiritsi rimwe chete nemumwe mushonga. Semuenzaniso, mushonga unonzi ezetimibe une simvastatin.
Ndiani anokurudzirwa kutora 'Statins'?
Chiremba achakunyorera mushonga westatin zvichienderana nenjodzi yako yekubatwa nechirwere chemwoyo. Izvi zvinoenderana nezvinhu zvakawanda, zvinosanganisira zera rako, murume kana mukadzi, nhoroondo yemhuri yako, uye kana uchisvuta. Mastatin anowanzo kurudzirwa kuvanhu vanotevera:
- Kune avo vasingakwanise kuderedza huwandu hwecholesterol yavo (kunyanya huwandu hweLDL huri pamusoro pe190 mg/dL) pasinei nekudya uye kurovedza muviri .
- Kune vanhu vane chirwere cheshuga uye vari pakati pemakore 40-75, vane LDL cholesterol inodarika 70 mg/dL.
- Kune avo vakamborwara nechirwere chemwoyo, sitiroko, kana chirwere chetsinga dzeropa (PAD) .
- Kune vanhu vane makore 40-75 vane LDL iri pamusoro pe70 mg/dL, vari panjodzi huru yekubatwa nechirwere chemwoyo.
- Kana mumwe munhu mumhuri (vabereki, vanun'una kana hanzvadzi) akamborwara nechirwere chemwoyo achiri mudiki uye aine cholesterol yakakwira.
Pane migumisiro yakaipa here pane izvi?
Iri idambudziko revanhu vazhinji. Ichokwadi kuti, semushonga upi zvawo, mishonga yemastatin inogona kuva nemigumisiro yakaipa. Asi chinhu chakakosha ndechekuti vanhu vazhinji havasangani nemigumisiro yakaipa. Kunyangwe migumisiro midiki inoitika inozopera kana mushonga uchiramba uchishandiswa.
| Mhedzisiro yedivi | Tsananguro |
|---|---|
| Migumisiro yakajairika (kazhinji haisi yakakomba) | |
| Kurwadziwa kwetsandanyama nemajoini | Uyu ndiwo mhedzisiro inonyanya kutaurwa nezvayo. Inogona kunzwa sekurwadziwa kwakajairika. |
| Musoro | Musoro mudiki ungangoitika. |
| Matambudziko ekugaya chikafu | Kusvotwa, kuzvimba, kufashaira, kana kuvimbiwa zvinogona kuitika. |
| Hazviwanzoonekwi migumisiro yakaipa (inoda mazano echiremba) | |
| Kukuvara kwechiropa | Zviratidzo zvakaita sekuti maziso anotsvuka (jaundice), weti yakasviba, uye kuneta kwakanyanya. |
| Rhabdomyolysis | Ichi chirwere chisingawanzoitiki . Zviratidzo zvinosanganisira kurwadziwa kwakanyanya muhudyu, kushaya simba, uye weti ine ruvara rwakasviba. |
| Kuwedzera kwemazinga eshuga muropa | Njodzi iyi inogona kuwedzera zvishoma kune avo vari panjodzi yekubatwa nechirwere cheshuga. |
Zvakakosha: Kana ukasangana nemigumisiro, usamborega kutora mushonga wako wega. Chinhu chakanakisa chekuita kutaura nachiremba wako nezvazvo. Unogona kugadzirisa dambudziko racho nekuchinja mhando yestatin yauri kutora kana nekugadzirisa chiyero.
Pane vanhu vasingafaniri kutora statins here?
Ehe. Statins hadzikurudzirwi kuvakadzi vane pamuviri, vanaamai vanoyamwisa, nevanhu vane zvimwe zvirwere zvakakomba zvechiropa. Unofanirawo kuudza chiremba wako nezvemimwe mishonga yauri kutora. Majusi emichero, kunyanya grapefruit nepomegranate, anogona kupindirana nemamwe mastatin, saka bvunza chiremba wako nezvazvo futi.
Chii chinoitika kana ukarega kushandisa mushonga wacho?
Kana wangorega kutora statin, huwandu hwecholesterol yako hunodzokera pahwaive huripo. Izvi zvinoreva kuti njodzi yako yekurwara nemoyo nestroke inodzokera padanho repamusoro. Saka kazhinji mushonga wehupenyu hwese.
Nguva yekuona chiremba nekukasika
Kana ukaona chimwe chezviratidzo zvinotevera paunenge uchitora statin, tsvaga rubatsiro rwechiremba nekukasika.
- Kana uchinzwa kurwadziwa kwakanyanya kana kushaya simba kwetsandanyama dzako kana majoini.
- Kana muviri wako uchirwadziwa nefivha .
- YenyuKana maziso ako kana ganda rako richiratidzika seyero (jaundice).
- Kana weti yako ikaita rima, ibva waita semvura inobuda mumashizha etii .
Mumamiriro ezvinhu akadaro, zvakanaka kuenda kuEmergency Treatment Unit (ETU) yechipatara.
Mharidzo Yekuenda Nayo Kumba
- MaStatins imhando yemishonga inoshanda zvikuru inoderedza cholesterol yakaipa (LDL) uye inoderedza njodzi yekurohwa nemoyo uye sitiroko.
- Mushonga uyu unoshanda nekumisa chiropa kugadzira cholesterol.
- Kunyangwe uri kutora statin, zvakakosha kuti urambe uchidya zvine hutano uye uchirovedza muviri. Usafunge kuti nekuda kwekunge uri kutora mushonga, unogona kudya chero chaunoda.
- Kana ukasangana nemigumisiro ipi zvayo, taura nachiremba wako usingaregi mushonga.
- Usamborega kutora statin usina kurairwa nachiremba wako, sezvo izvi zvichawedzera njodzi dzehutano hwako zvakare.
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