Chii chinonzi Turcot Syndrome? Inogona kukukanganisa here? Ngatitaurei zvakadzama!

Wakambonzwa nezvechirwere chisingawanzoitika mumajini here? Dzimwe nguva, miviri yedu inogona kuva nematambudziko atisingatombozivi kuti tinawo. Nhasi, tichataura nezvechimwe chirwere chisingawanzoitika chakakosha kuziva nezvacho. Chinonzi Turcot Syndrome.

Chii chinonzi Turcot Syndrome?

Zvichitaurwa zviri nyore, Turcot Syndrome chirwere chisingawanzoitiki chemajini. Chinonyanya kusanganisira kukura kwemajini madiki (anonziwo mapolyps) mudumbu redu, ndiko kuti, muura, uye bundu muuropi kana musana. Fungidzira kuti zvinonetsa sei kuva nematambudziko munzvimbo mbiri panguva imwe chete.

Kana matumbu madiki aya (polyps) akaitika muura, vamwe vanhu vanogona kuona zviratidzo zvakaita sekubuda ropa mudumbu, kuwedzera kwekufamba kwedumbu (manyoka), uye kurwadziwa mudumbu . Zvakare, zvichienderana nehukuru nenzvimbo yebundu muuropi kana musana , zviratidzo zvetsinga zvakaita semusoro, kuona zvisipo, kurasikirwa nepfungwa, uye kudonha kakawanda zvinogona kuitika.

Vamwe vaongorori vezvekurapa vanotenda kuti Turcot Syndrome inogona kunge iri imwe mhando yeFamilial Adenomatous Polyposis (FAP). Zvisinei, izvi hazvisati zvaratidzwa. FAP chirwere chinowanzoita kuti ma polyps madiki akawanda abude muura kenza isati yatanga. Panogona kunge paine hukama pakati pezviviri izvi, sezvo vamwe varwere veTurcot Syndrome vaine shanduko mujini reAPC. Kuchinja kwejini reAPC kunogonawo kukonzera FAP.

Izvi hazviwanzoitiki zvekuti nhamba shoma chete yezviitiko, zvingangoita 150, zvakashumwa muzvinyorwa zvekurapa pasi rose. Saka unogona kufungidzira kuti izvi hazviwanzoitiki sei.

Chirwere ichi chinogara nhaka here? Munhu anochiwana sei?

Ehe, Turcot Syndrome chirwere chemajini chinogara nhaka, zvichireva kuti chinopfuudzwa kubva kuvabereki kuenda kuvana kuburikidza nemajini . Chinokonzerwa nekuchinja kwakasiyana, kana kuti kuchinja kwemajini edu. Chinogona kutikanganisa munzira mbiri huru:

1. Type 1 Turcot Syndrome: Iyi inozivikanwawo se "true" Turcot syndrome. Inogarwa nhaka se autosomal recessive trait. Zvichitaurwa zviri nyore, kuti mwana ave nechirwere ichi, vabereki vese vanofanira kugara nhaka gene mutation. Zvakafanana nekuhwina lottery (asi izvozvo hazvisi zvakanaka!). Rudzi urwu runowanzo kukonzerwa nekuchinja kwemajini `(MLH1)` uye `(PMS2)`.

2. Rudzi rwechipiri rweTurcutt Syndrome:Izvi zvinogara nhaka se "autosomal dominant hunhu." Kureva kuti, mwana anogona kuva nechirwere ichi kunyangwe akagara nhaka gene mutation yakakodzera kubva kumubereki mumwe chete, angave amai kana baba. Izvi zvinokonzerwa nekuchinja kwegene rekuti "(APC)``. Basa regene iri rekuti "(APC)`` nderekudzivirira kuumbwa kwegomarara mumuviri wedu kana kuti kuamisa kukura. Saka kana gene iroro risinganyanyi kushanda zvakanaka, matambudziko anomuka.

Ndezvipi zviratidzo zvikuru zvechirwere ichi?

Zviratidzo zvikuru zveTurcot Syndrome, sezvambotaurwa , mapolyps muura uye bundu rimwe kana akawanda muuropi kana musana. Vamwe vanhu vanogona kuva nemapolyps akawanda aya, zvinoreva kuti anotanga kukura achiri mudiki kwazvo.

Zviratidzo zvemapundu madiki (polyps) mudumbu

Huwandu hwemapundu madiki aya (polyps) anokura mumunhu hunogona kusiyana kubva pamunhu kusvika pamunhu.

• Ma polyps aya anowanikwa muvanhu vane Type 1 Turcotte syndrome ane mukana mukuru wekuva nekenza.
• Vanhu vane Type 2 Turcotte syndrome vane mukana wakakura wekuva nechirwere chataurwa kare chinonzi `Familial Adenomatous Polyposis (FAP)``.

Matumbu madiki aya (intestinal polyps) anoumbwa muura anogona kukonzera zviratidzo zvakaita se:

• Kurwadziwa kwemudumbu
• Kuzvimba
• Manyoka
• Kubuda ropa mutsvina
• Kuderedza uremu, ndiko kuti, kuderedza uremu

Zviratidzo zveMatumbu eUropi/Musana

Mamota anokura muuropi kana mumutsipa anogona kukanganisa sisitimu yedu yetsinga (CNS). Sisitimu yedu yetsinga ndiyo sisitimu inodzora mabasa mazhinji emuviri, kusanganisira uropi nemusana. Izvi zvinogona kukonzera zviratidzo zvakaita se:

• Kurasikirwa nekuenzana, kudonha kakawanda (Matambudziko ekuenzanisa)
• Musoro wakakomba
• Kurasikirwa nekunzwa - kusanzwa zvakanaka mumaoko, makumbo, kana zvikamu zvemuviri
• Kusvotwa kana kurutsa
• Kubatwa nepfari
• Matambudziko ekuona, kusanganisira kuona kaviri kana kuona zvisina kujeka
• Kushaya simba mune imwe nhengo yemuviri wako (semuenzaniso, ruoko rumwe, gumbo rimwe, kana divi rimwe remuviri wako)

Zvimwe zvinhu uye mhando dzekenza dzine njodzi yakakura

Vanhu vane Turcot Syndrome dzimwe nguva vanowana bundu rine mafuta risiri rekenza (lipomas) kana madodzi madiki ebrown (café-au-lait spots) paganda .

Pamusoro pezvo, chirwere ichi chinowedzera njodzi yekubatwa nemamwe marudzi egomarara nemabundu. Zvikuru ndeizvi:

• Kenza yemudumbu
• Astrocytoma (rudzi rwebundu reuropi)
• Ependymoma (rudzi rwebundu rinotanga mumasero ari munzvimbo dzine mvura muuropi nemumusana)
• Glioma (mamota anobva mumasero anotsigira uropi)
• Glioblastoma (rudzi rwekenza yeuropi inorwisa zvakanyanya)
• Medulloblastoma (rudzi rwekenza inokura mucerebellum, ndiko kuti, muchikamu chezasi cheuropi pedyo nedehenya)
• Kansa yeganda reBasal cell

Chirwere ichi chinoonekwa sei? (Kuongororwa)

Kuti aone kana uine Turcot Syndrome, chiremba wako achaita bvunzo dzakasiyana-siyana, achinyanya kutarisa uropi hwako nenzvimbo dzakatenderedza ura hwako.

• Kuongororwa kwakadai seX -rays, MRIs, uye CT scans kunogona kuitwa kuti kuonekwe bundu remuuropi kana kuti mapolyps emudumbu. Mune zvimwe zviitiko zvakakosha, PET scan inogonawo kukurudzirwa.
• Colonoscopy: Izvi zvinosanganisira kuisa chubhu diki, ine chiedza kuburikidza nepaburi kuti uongorore mukati meura hukuru nerectum kuti uone kana paine chero dambudziko.
• Kuongororwa kweBiopsy: Kana bundu rikawanikwa muura kana muuropi, kanyama kadiki kanotorwa koongororwa pasi pemaikorosikopu.

Chinonyanya kukosha ndechekuti kana mumwe wevabereki vako aine Turcot Syndrome, une mukana wekuti uongororwe chirwere chacho.

Muchiitiko chakadaro, chiremba anogona kukurudzira zvinhu zvakaita se:

• Kuongororwa kweDNA: Kuongororwa kwemajini uku kunogona kuona kuvapo kwemajini akachinja anokonzera Turcotte syndrome.
• Sigmoidoscopy: Iyi inoongorora chikamu chezasi cheura hukuru (sigmoid colon). Vechidiki vakagara nhaka gene reTurcotte syndrome vanogona kuramba vachiongororwa ura hukuru kusvika vava nemakore angangoita 35. Izvi zvinoita kuti zvikwanise kuonekwa nekukurumidza uye kurapwa kwezvipuka zvidiki (polyps) muura hukuru.

Ndeapi marapirwo eTurcot Syndrome?

Kurapwa kweTurcot Syndrome kunosiyana zvichienderana nezviratidzo.

Ungangoda kuvhiyiwa polypectomy kubvisa matumbu madiki (polyps) muura hwako. Chiremba wako anogonawo kukurudzira kuvhiyiwa kakawanda kuti amise matumbu aya kuti asaumbe zvakare. Semuenzaniso:

• `Ileoproctostomy`: Ura hukuru hunobviswa uye rectum neura diki zvakabatana.
• `Ileostomy`: Kuvhiyiwa kweIleostomy:Dumbu rinobviswa uye ura hudiki hunobatana nekunze kwedumbu (kuti pave nenzira yakasiyana yekuti tsvina ibude).
• `Ileoanal anastomosis`: Inobatanidza ura hudiki netsvina yemudumbu.
• Kubviswa kwechikamu chedumbu kana ura hwese.
• `Proctocolectomy`: Zvese zviri zviviri ura nerectum zvinobviswa.

Kurapa bundu muuropi kana musana kunogona kusiyana. Vanachiremba vanowanzoedza kubvisa bundu iri. Panguva yekurapwa, vanoedza kuderedza kukuvara kwenyama ine hutano yakaripoteredza. Kuti vaite izvi:

• Kurapa nemakemikari
• Kurapa nemwaranzi
• Kuvhiya

Nzira dzekurapa dzakadai se:

Ndiri panjodzi yekubatwa nechirwere ichi here?

Kana mumwe wevabereki vako aine Turcot Syndrome, une mukana wakakura wekuva nechirwere ichi. Kana kuti, ungave uri mutakuri wemajini. Kuva mutakuri wemajini zvinoreva kuti hauna zviratidzo, asi une jini rinokonzera chirwere ichi, saka vana vako vanogona kuchipfuudza.

Kana uchifungidzira kuti ungave uine Turcot Syndrome, chiremba wako anogona kukurudzira kuongororwa kweDNA. Izvi zvinogona kutarisa kana paine shanduko yemajini inoenderana.

Chii chinoitika kana uchirarama nechirwere ichi? Hachirapiki here?

Zvinosuwisa kuti hapana mushonga weTurcot Syndrome. Kana uine chirwere ichi, chinhu chakakosha kushanda nachiremba wako kuti ugare uchiongororwa bundu remuuropi nekenza yemudumbu. Kana ukakurumidza kuona chimwe chinhu chakaita sekenza, mikana yako yekubudirira inowedzera. Saka, zvakakosha kuti usavhunduke wotevedzera zano rachiremba wako.

Mibvunzo inokosha yekubvunza chiremba wako

Unogona kubvunza chiremba wako mimwe mibvunzo yakaita seiyi:

• Chii chinonyanya kukonzera zviratidzo zvangu?
• Ndedzipi bvunzo dzandinofanira kuita kuti ndizive zvechokwadi kana ndine Turcot Syndrome?
• Ndiri mutakuri wejini rechirwere ichi here?
• Ndedzipi nzira dzekurapa Turcot Syndrome?
• Chii chingaitika kana ndikasawana mushonga?
• Mikana yekuti ndive nemwana ane Turcot Syndrome ndeipi?

Yeukai kuti bundu remuuropi rakaita seglioblastoma harisi renhaka. Zvisinei, vanhu vane zvirwere zvenhaka zvakaita seTurcot Syndrome vanogona dzimwe nguva kukura bundu iri.

Pakupedzisira, zvinhu zvishoma zvekurangarira

Turcot Syndrome chirwere chisingawanzoitiki, chinokonzerwa nemajini chinokonzera kukura kudiki muura (polyps) uye bundu muuropi kana musana. Kurapwa kunosiyana zvichienderana nezviratidzo. Ungangoda kuvhiyiwa kubvisa chikamu cheura kana bundu muuropi kana musana. Kunyangwe pasina mushonga wechirwere ichi, kutarisa zviratidzo zvako, kuongororwa nguva dzose , uye kurapwa nekukurumidza zvinogona kukubatsira kugadzirisa dambudziko rako. Saka, zvakakosha kuchengetedza hutano hwako.

Turcot Syndrome, zvirwere zvemajini, mapolyps emuura, bundu reuropi, njodzi yekenza, kuyedzwa kwemajini