Ko chirwere cheshuga cherudzi rwechipiri chinogona kurapwa zvachose here? Ngationei ruzivo rutsva!

Chirwere cheshuga chave chirwere chakajairika pakati pevanhu vazhinji munyika medu. Pamwe mumwe wemhuri yako, shamwari, kana kuti iwe pachako uri kubatwa nechirwere ichi. Chirwere cheshuga cherudzi rwechipiri kunyanya idambudziko guru rehutano rinobata vanhu vanopfuura mamiriyoni mazana mana pasi rose. Kana rikasadzorwa zvakanaka, rinogona kutungamira kumatambudziko ane njodzi akadai sekukuvara kweitsvo, kurasikirwa nekuona, chirwere chemwoyo, uye kuoma mitezo. Kunyangwe paine mhando dzinopfuura makumi matatu dzemishonga yekudzora chirwere ichi, hapana kana imwe yacho inogona "kurapa" zvachose. Asi ... tsvakiridzo itsva inoratidza kuti mamiriro ezvinhu aya anogona kuchinja. Ngationei kuti sei.

Zvatave tichifunga nezvechirwere cheshuga kwenguva yakareba

Makore angangoita makumi maviri apfuura, kana ukabvunza nyanzvi nezvechirwere cheshuga, yaiti chikonzero chikuru cheizvi 'insulin resistance'. Zvichitaurwa zviri nyore, insulin ihormone inogadzirwa nepancreas yedu. Basa rayo guru nderekutora glucose (shuga) inobva muchikafu chatinodya yoiisa mumasero emuviri wedu. Ndipo apo masero anowana simba.

Funga nezve insulin sekiyi, uye masero semusuwo. Insulin ndiyo kiyi inovhura musuwo kuitira kuti glucose ipinde mumasero.

Asi, masero emunhu ane insulin resistance haapindure insulin iyi nemazvo. Zvakaita seburi rekiyi pamusuwo raita ngura. Zvadaro, nekuti musuwo haugone kuvhurwa, pancreas inofanira kugadzira makiyi e insulin akawanda. Nekufamba kwenguva, pancreas inoshaya simba nekuda kwekushanda nesimba. Ndipo panoitika chirwere cheshuga cherudzi rwechipiri. Iyi ndiyo nyaya yatagara tichiziva kwenguva yakareba.

Kuwanikwa kutsva kwakakosha: Nyaya yemasero e beta

Iye zvino masayendisiti aona kuti dambudziko harisi rekusakwanisa insulin chete. Chimwe chikamu chedambudziko chiri mumasero edu e beta . Aya ndiwo masero ari mukati mepancreas uye akafanana nemafekitori madiki anogadzira insulin.

Masero e beta akawanda anodiwa nemiviri yedu anogadzirwa mumakore mashoma ekutanga ehupenyu hwedu. Asi vamwe vanhu vanoberekwa vaine masero e beta akawanda kupfuura vamwe. Saka, kunyangwe vakazopedzisira vava ne insulin resistance muhupenyu hwavo, mafekitori avo e beta cell anogona kugadzira insulin yakawanda kuti ivabatsire.

Saka, chinangwa chikuru ikozvino ndechekutsvaga mushonga unogona kudzoreredza masero aya e beta ari kufa kana kuwedzera huwandu hwemasero aripo. Kana izvozvo zvikagona kuitwa, chirwere cheshuga cherudzi rwechipiri chinogona kurapwa, kwete kungodzorwa chete.

Mishonga yazvino yakaunza tariro

Masayendisiti pavaiongorora izvi, vakawana mushonga unogona kubatsira kukura kwemasero aya e beta. Unonzi harmine . Mushonga unowanikwa mumiti yakasiyana-siyana pasi rose.

Mushonga uyu, unonzi harmine, unoshanda nekuvhara enzyme inonzi DYRK1A mukati memasero ebeta. Kana izvi zvavharwa, masero ebeta anotanga kupatsanurana, kuwanda, uye kuwedzera saizi. Muongororo dzakaitwa pambeva, mbeva dzine chirwere cheshuga dzakapihwa mushonga uyu dzakawedzera saizi yemasero ebeta katatu ! Panguva imwe chete, huwandu hweshuga muropa ravo hwakadzokerawo pahwakajairika.

Asi, kuti izvi zvibudirire muvanhu, masayendisiti akaona kuti pane chimwe chinhu chaidiwa. Saka, vakaedza mushonga weharmine neimwe mhando yemishonga yatove kushandiswa pakurapa chirwere cheshuga. Mhando iyoyo yemishonga inonzi GLP1R agonists . Kana uri munhu anotora mishonga yechirwere cheshuga, ungave wakambonzwa nezvemazita aya: `(exenatide)`, `(liraglutide)`, `(lixisenatide)` ndemamwe emishonga ari mukirasi iyi. Anoshanda nekukurudzira masero e beta uye kukurudzira kugadzirwa kwe insulin.

Saka, chii chakaitika mishonga iyi miviri payakasanganiswa? Mhedzisiro yacho yaishamisa!

Mhedzisiro iyi yakapa chivimbo chikuru chekuti nzira iyi yekurapa ichabudirirawo kuvanhu.

Dambudziko riri mberi uye nei izvi zvichikosha?

Dambudziko guru ikozvino nderekuti tingaendesa sei musanganiswa uyu zvakananga kumasero e beta. Masayendisiti ari kuti, "Tine pakeji yekurapa masero e beta, asi hatizivi kero chaiyo yekuitumira." Semhinduro, vari kufunga kushandisa chimwe chinhu chinonzi monoclonal antibodies . Izvi zvakafanana nebasa rekutumira mishonga rakangwara rinogona kuendesa pakeji yedu yemishonga zvakananga kumasero e beta.

Sei izvi zvichikosha kudaro?

Fungai, mishonga yechirwere cheshuga iripo parizvino inongodzora huwandu hweshuga muropa chete. Kana ukarega kutora mushonga, chirwere chichadzoka zvakare.

Chinhu chega chave pedyo nemhinduro inogara iripo kusvika pari zvino kuvhiyiwa kwe bariatric . Kureva kuti, kuvhiyiwa kwekuderedza huremu. Izvi zvinowanzoisa chirwere cheshuga mukuderedza uremu. Asi kuvanhu vanosvika mamiriyoni mazana mana pasi rose, kuvhiyiwa hakushandi. Kunodhura, kune njodzi, uye kunotora nguva yakareba kuti kupore.

Asi kana musanganiswa mutsva uyu wemishonga ukabudirira, unogona kuchinja hupenyu hwemamiriyoni evanhu pasi rose. Hausi kungodzivira zviratidzo chete, asi unodzorera chikonzero chikuru chechirwere, icho chiri kurasikirwa nemasero e beta.