Uri kuratidzawo zviratidzo zvekukwegura nguva isati yakwana here? Ngatitaurei nezveWerner Syndrome!

Unonzwa sekunge wakura kupfuura zera rako here? Kunyange zvazvo zviri zvakajairika kunzwa saizvozvo dzimwe nguva, kukwegura nguva isati yakwana, kana kuti muviri kukwegura nekukurumidza, zvinogona kukonzerwa nechirwere chemajini chisingawanzoitiki. Chimwe chezvirwere zvakadaro iWerner Syndrome. Ngatitaurei nezvazvo zvakadzama nhasi, nekuti zvakakosha zvikuru kuziva nezvazvo.

Chii chinonzi Werner Syndrome?

Zvichitaurwa zviri nyore, Werner Syndrome chirwere chisingawanzoitika chemajini chinoita kuti muviri wako ukure nekukurumidza kupfuura zvaitarisirwa. Vamwe vanhu vanoti 'adult progeria'. Zviratidzo hazviwanzoonekwa kusvika wasvika pakuyaruka. Izvi zvinoreva kuti unotanga kuona mutsauko paunorega kukura nekukurumidza seshamwari dzako. Zvadaro, mumakore ako ekuma20, unotanga kuona zviratidzo zvekukwegura - uye, nekufamba kwenguva, zvirwere zvinouya nekukwegura.

Asi izvi hazvisi zvekungochena bvudzi uye kudonha kweganda chete. Kukwegura hakusi kungochinja chitarisiko chete. Vanhu vazhinji vane Werner Syndrome vanowana matambudziko anotyisidzira hupenyu hwavo pavanenge vava nemakore ekuma40 ne50.

Zviratidzo izvi ndezvipi?

Kana uine Werner Syndrome, zviratidzo zvinoonekwa zvakanyanya sezvaunokura. Unogona kutanga kuona zviratidzo zvekukwegura usati wasvika kune vamwe vane makore ako ekuma20. Heano mamwe acho:

Kuchinja kwechitarisiko

• Kuchena kwebvudzi uye kurasikirwa nebvudzi: Izvi zvinosanganisira kwete bvudzi riri mumusoro chete, asiwo tsiye nemaziso.
• Inzwi richiva rakakwirira kana kuti rakashoshoma.
• Kuderera kwemafuta ari pasi peganda: Izvi zvinogona kukonzera kuti ganda riite seriri kudonha.
• Kupera kwetsandanyama.
• Kuora kwezino nguva isati yakwana.
• Kusviba kwenzvimbo dzeganda (hyperpigmentation) kana kupenya kwenzvimbo dzimwe (hypopigmentation).
• Kutsvuka kweganda nekuda kwetsinga dzeropa dzakakura.
• Kukora kana kuomarara kweganda: Izvi zvakafanana nechirwere chinonzi scleroderma.
• Chiso chakamanikana uye chakasuruvara.

Mamwe matambudziko ehutano anobva mumuviri

NeWerner Syndrome, haungoratidzike sewakwegura chete. Muviri wako unokwegura nekukurumidza kupfuura zera rako chairo. Izvi zvinoreva kuti unogona zvakare kutanga mamwe matambudziko ehutano nekukurumidza kupfuura zvawaitarisira. Izvi zvinosanganisira:

• Chirwere cheshuga cherudzi rwechipiri: Kutaura zvazviri, vanhu vanosvika 7 pa10 vane Werner Syndrome vanotanga chirwere cheshuga cherudzi rwechipiri pavanosvika makore makumi matatu nemashanu.
• Kusagona kushanda zvakanaka mumazai kana machende.
• Maronda eganda.
• Osteoporosis (kutetepa kwemapfupa).
• Kuora kweropa.
• Kuora kwemaziso kana macular degeneration.
• Kurwadziwa kwechipfuva (angina).
• Kukuvara kwemwoyo.
• Kukundikana kwemoyo `(kutadza kwemoyo)`.

Njodzi yekenza

Vanhu vane Werner Syndrome vane mukana wakawanda wekuva nemamwe marudzi ekenza. Semuenzaniso:

• Kenza yethyroid.
• Melanoma (kenza yeganda).
• Osteosarcoma (kenza yemapfupa).
• Sarcoma yenyama yakapfava.

Chii chinokonzera chirwere cheWerner?

Ichi chirwere chemajini . Kureva kuti, chinokonzerwa nekuchinja kwemajini edu. Werner Syndrome inowanikwa muvanhu vane zvikanganiso zviviri muWRN gene. Kazhinji, rimwe remajini maviri aya ane zvikanganiso rinotorwa kubva kuna amai uye rimwe kubva kuna baba.

Unowana sei izvi? (Kuongororwa)

Chiremba wako achatsvaga zvimwe zvinodiwa kuti aongorore chirwere cheWerner Syndrome. Vanogonawo kuraira bvunzo idzi:

• Kuongororwa kwemajini: Tarisa shanduko dziri mujini dzinokonzera Werner Syndrome.
• X-rays: Tarisa kana paine shanduko mumapfupa kana bundu.

Dzimwe nguva vanachiremba vanogona kuona Werner Syndrome vachiri vadiki semakore gumi nemashanu. Zvisinei, kuongororwa kunowanzoitwa mumakore ekuma30 kana makumi mana. Izvi zvinodaro nekuti zvimwe zvezviratidzo zvechirwere zvinotora nguva yakareba kuti zvionekwe.

Ndezvipi zviri kurapwa?

Werner Syndrome inorapwa zvichienderana nezviratidzo zvinoonekwa. Izvi zvinoreva kuti kurapwa kumwe chete hakushandi kune wese munhu. Nyanzvi dzakasiyana dzinogona kushanda pamwe chete kuronga hurongwa hwenyu hwekurapa. Semuenzaniso:

• Vanachiremba veEndocrinologists (nyanzvi dzemahormone).
• Vanachiremba vemaziso ( nyanzvi dzemaziso).
• Vanachiremba vemapfupa (nyanzvi dzemapfupa nemajoini).

Marapirwo aunowana anogona kusanganisira:

• Mishonga yechirwere cheshuga: Dzora huwandu hweshuga muropa rako.
• Magirazi kana magirazi ekuona: Matambudziko ekuona anogadziriswa.
• Mishonga yezvirwere zvemwoyo:Deredza njodzi yezvinetso nekuderedza atherosclerosis.
• Kuvhiyiwa: Kana paine bundu rekenza, ribvise.

Werner Syndrome inogona kudzivirirwa here?

Nekuti ichi chirwere chemajini, zvinosuwisa kuti Werner Syndrome haigone kudzivirirwa.

Zvisinei, kana iwe nemumwe wako muri vaviri vanotakura jini rechirwere ichi, uye muchidawo kuva nevana, mungada kufunga nezvenzira inonzi preimplantation genetic testing (PGT). PGT musanganiswa we genetic testing ne in vitro fertilization (IVF). Izvi zvinosanganisira kuyedza ma embryo asati aiswa muchibereko kuderedza mukana wekuti vana vagare nhaka iyi genetic defects. Zvisinei, aya maitiro akaoma, saka sarudzo dzinofanira kuitwa chete nekurairwa nachiremba.

Chii chimwe chaungada kubvunza chiremba wako?

Kana uine Werner Syndrome, zvakakosha kubvunza chiremba wako mibvunzo yese yaunayo. Semuenzaniso, unogona kubvunza zvinhu zvakaita se:

• Zvakanaka here kuti ndiedzwe majini eWerner Syndrome?
• Ndezvipi zvingasarudzwa zvekurapa Werner Syndrome?
• Chii chandinofanira kuita kuti ndideredze njodzi yangu yekubatwa nekenza?
• Ndedzipi bvunzo dzandinofanira kuita kuti ndidzivise matambudziko eWerner Syndrome?
• Mikana ipi yekuti vana vangu vagare nhaka yeWerner Syndrome kubva kwandiri?
• Mikana yekuti ndive nemumwe mwana ane Werner Syndrome ndeipi?

Ndezvipi zvimwe zvirwere zvine zviratidzo zvakafanana?

Kuwedzera kune Werner Syndrome, kune zvimwe zvirwere zvakawanda zvinokonzera kupfupika kwehurefu uye kukwegura nguva isati yakwana. Izvi zvinosanganisira:

• De Barsy syndrome
• Gottron syndrome
• Hutchinson-Gilford syndrome (iyi ndiyo mhando yeProgeria inobata vana vadiki)
• Mulvihill-Smith chirwere
• Rothmund-Thomson syndrome
• Dutu remuviri

Zvese izvi zvirwere zvisingawanzoitiki, saka zvakakosha kuti uwane chirwere chakarurama.

Nhoroondo diki nezveWerner Syndrome uye yakajairika sei?

Werner Syndrome yakatanga kuwanikwa pakutanga kwema1900 nachiremba ainzi Otto Werner. Zviratidzo zviviri zvaakatanga kuona muvarwere vadiki zvaive madhaka uye mavanga matema anopenya paganda.

Ichi chirwere chisingawanzoitiki. Kubva pakabudiswa mushumo wekutanga wechirwere muna 1904, vanhu vanosvika mazana masere chete ndivo vakaonekwa mumapepanhau ezvekurapa.

MuUnited States, nyanzvi dzinofungidzira kuti munhu mumwe chete pavanhu 200,000 anogona kunge aine Werner Syndrome. Pasi rose, kuwanda kwechirwere ichi kwakaderera kusvika pamunhu mumwe pavanhu miriyoni.

Zvisinei, izvi zvakajairika muJapan nemunzvimbo yeSardinia muItaly. Ikoko, munhu mumwe chete pavanhu 30,000 kana 50,000 vane chirwere ichi. Chikonzero cheizvi ndechekuti vanhu vazhinji munzvimbo idzodzo vakagara nhaka yekuchinja kwemajini kwakaitika kare kare.

Kuziva kuti iwe kana munhu waunoda ane Werner Syndrome kunogona kuoma. Zvinogona kunetsa nekuti hapana mushonga. Zvisinei, kurapwa kunogona kuderedza njodzi yematambudziko anotyisidzira hupenyu.

Pakupedzisira, meseji yekudzokera nayo kumba

Werner Syndrome chirwere chinonetsa zvechokwadi, asi yeuka, hausi wega.

• Wana rubatsiro rwakakodzera rwechiremba: Izvi zvichakubatsira kudzora zviratidzo zvako uye kuvandudza hupenyu hwako.
• Rarama hupenyu hune hutano: Rara zvakakwana, idya chikafu chinovaka muviri, shandisa mafuta ekudzivirira zuva paunenge uchibuda muzuva, uye edza kuderedza kushushikana. Zvinhu izvi zvichakubatsira kuti urambe uine hutano hwakanaka.
• Tsvaga rutsigiro: Bvunza timu yako yezvekurapa nezvemapoka ekutsigira. Ungave usiri kunzwa kumanikidzwa zvakanyanya parizvino, asi chengeta ruzivo irworwo pedyo. Runogona kubatsira mune ramangwana.

Kurarama nechirwere chisingawanzoitiki chakadai hakusi nyore. Asi neruzivo rwakakodzera, rutsigiro, uye mafungiro akanaka, uchawana simba rekufamba rwendo urwu.

Werner syndrome, zvirwere zvemajini, kukwegura nguva isati yakwana, kukura kwevanhu vakuru, jini reWRN, matambudziko ehutano, njodzi yekenza