Tose tine kutya kumwe chete mumoyo medu kuti vabereki vedu, kana isu pachedu, tichatanga kukanganwa zvinhu sezvatinokura. Pfungwa yekurasikirwa nendangariro dzedu nekukwanisa kufunga zvakajeka inotyisa zvechokwadi. Kunyange hazvo kukwegura kuri iko kunokonzera kurasikirwa nendangariro uku, kana kuti dementia, ikozvino pane imwe nyaya yeimwe njodzi. Ndiko kuti, mimwe yemishonga yatinoshandisa yezvirwere zvakasiyana-siyana.
Ndeipi mishonga iyi yekurwisa cholinergic?
Zvichitaurwa zviri nyore, mishonga inorwisa cholinergics imhando yemishonga. Inogadzirwa kubva mumuti unonzi Belladonna. Muti uyu unogona kuva nechepfu mune mamwe madosi. Zvisinei, mishonga iri mumuti uyu inokwanisa kudzora, kana kudzvinyirira, mashandiro etsinga dzedu kusvika pamwero wakati, saka inoshandiswa kugadzira mishonga inodzorwa.
Fungidzira, sisitimu yedu yetsinga yakaita senetwork yetsinga dzakapararira mumuviri wese. Uropi hwedu ndihwo hukuru. Mirairo inopiwa kubva ipapo inoenda kumuviri wese kuburikidza nemasero aya etsinga. Zvese kubva pakufamba kwedu, kufunga, kurova kwemoyo, kufema, kurara, uye kushanda kwemanzwiro edu mashanu zvinodzorwa nesisitimu iyi yetsinga.
Kune vatumwa vemakemikari vanotumira mashoko kuburikidza netsinga iyi. Tinovadaidza kuti ma neurotransmitters. Acetylcholine imwe yenhunga dzakakosha zvikuru. Saka, zvinoitwa nemishonga ye anticholinergic ndeyekudzivirira nhume iyi inonzi acetylcholine. Kuburikidza neizvozvo, mamwe mabasa etsinga anodzorwa.
Mishonga iyi mizhinji inoshandiswa kurapa zvirwere.
| Nguva yekushandisa mishonga ye anticholinergic | |
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| Kune zvirwere zvinowanzoonekwa | |
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| Panguva yekuvhiyiwa | |
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| Semushonga wekubvisa chepfu | |
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Mimwe mishonga inowanzoshandiswa
Mishonga iyi inouya muchimiro chemapiritsi, madonhwe emaziso, uye majekiseni. Mimwe mienzaniso ndeiyi:
- Diphenhydramine: Uyu mushonga unoshandiswa kurapa allergies. Mushonga wekuSri Lanka unonzi Piriton une mushonga wakafanana unonzi chlorpheniramine. Uyu musanganiswa unowanikwawo muboka rimwe chete remishonga inorwisa cholinergics.
- Benztropine: Inoshandiswa pakurapa zviratidzo zveParkinson.
- Dicycloverine: Inoshandiswa pakurwadziwa kwemudumbu, kunyanya mumamiriro ezvinhu akadai seIrritable Bowel Syndrome (IBS).
- Oxybutynin: Mushonga unopiwa vanhu vane dambudziko rekudzora weti yavo.
- Hyoscyamine: Inoshandiswa pakurwadziwa kwemhasuru dzemudumbu nedzedundira.
Zvichitaurwa zviri nyore, chii chinonzi dementia?
Dementia izwi rinoshandiswa kureva zvirwere zvakasiyana-siyana zvinokanganisa kugona kwemunhu kufunga, kurangarira, kana kuita sarudzo. Rinonyanya kuitika pakati pevanhu vakuru.
Kunyangwe paine mhando dzakasiyana dzechirwere chepfungwa (dementia), 60% - 80% dzacho dzinokonzerwa nechirwere cheAlzheimer .
Chirwere ichi chinogona kukanganisa munhu:
- Kukwanisa kuisa pfungwa pachinhu chimwe chete
- Kutaura nevamwe (kutaurirana)
- Kugona kusarudza zvakanaka kubva pane zvakaipa (kuchenjera kwekusarudza)
- Ndangariro
- Kukwanisa kufunga zvine musoro uye kugadzirisa matambudziko
Dzimwe nguva, mhando dzechirwere chepfungwa dzakadai seAlzheimer's dzinogona kutokonzera shanduko muhunhu hwemunhu nemaitiro ake.
Ndiani ari panjodzi huru yekurwara nepfungwa (dementia)?
- Zera: Kukwegura ndicho chinhu chikuru chinokonzera njodzi.
- Chirwere chemwoyo: Vanhu vane nhoroondo yeBP yakakwira, cholesterol yakakwira, uye sitiroko vari panjodzi huru yekuora mwoyo.
- Majini: Kana nhengo yepedyo yemhuri yakambova nechirwere cheAlzheimer, njodzi yako yekuchibata inogona kuwedzera neinenge 10% - 30%.
- Kukuvara Kwepfungwa Kunokonzerwa Nekukuvara: Kukuvara kwakanyanya kana kuti kunogara kwenguva refu mumusoro kunogonawo kuwedzera njodzi.
Asi dzimwe nguva kurasikirwa nendangariro uku kunogona kuva kwenguva pfupi. Mimwe mishonga, kushomeka kwemavhitamini, uye kusarongeka kwemahormone ethyroid zvinogonawo kukonzera kurasikirwa nendangariro kwenguva pfupi.
Saka mushonga uyu unokonzera dementia zvechokwadi here?
Vaongorori vakaita ongororo yakakura kuti vazive. Iyi yaive ongororo yemakore gumi. Vanhu vanosvika 3,500 vane makore anopfuura 65 vakatora chikamu mune izvi. Hapana kana mumwe wevanhu ava aive nechirwere chepfungwa panguva yekutanga kweongororo iyi.
Vaongorori vakachengeta zvinyorwa zvemishonga yese yakatorwa nevatori vechikamu, iyo yakanyorerwa nachiremba uye iyo yaiwanikwa pasina kunyorerwa chiremba, yakaita sepiridine. Vakaedza hunyanzvi hwekurangarira nekufunga hwevatori vechikamu makore maviri ega ega.
Pakupera kwechidzidzo ichi, vanhu 797 vevakapinda muchidzidzo ichi vakanga vabatwa nechirwere chepfungwa chinonzi dementia. Pavanhu ava, 637 vaiva nechirwere cheAlzheimer.
Pakuongorora ruzivo urwu, vaongorori vakawana chimwe chinhu chinoshamisa. Vakawana hukama hwakakosha pakati pevanhu vaishandisa mishonga yekurwisa cholinergic nevaya vakarwara nedementia . Vakaonawo kuti kana munhu akashandisa mishonga iyi kwenguva yakareba, njodzi yake yekurwara nedementia inowedzera .
Semuenzaniso, zvakaonekwa kuti vanhu vane mukana wepamusoro wekushandisa mushonga uyu kwenguva yakareba, vakaita seavo vaishandisa mushonga uyu nguva dzose kwemakore matatu pachiyero chakajairika chezuva nezuva, vaiva nenjodzi yakakura yekurwara nepfungwa uye chirwere cheAlzheimer kupfuura avo vasina kushandisa mushonga uyu.
Sei izvi zviri kuitika?
Imwe yedzidziso huru ndeyekuti ine chekuita ne neurotransmitter acetylcholine, iyo yakajairika yakaderera muuropi hwevanhu vane chirwere cheAlzheimer. Kutaura zvazviri, mimwe mishonga inoshandiswa kurapa chirwere cheAlzheimer inoshanda nekuwedzera huwandu hweacetylcholine muuropi.
Saka, mishonga yekudzivirira chirwere ichi inovhara acetylcholine messenger, saka vaongorori vanofunga kuti ndicho chikonzero chacho. Asi pane zvakawanda zvinodiwa pakutsvaga ruzivo nezvenyaya iyi.
Mharidzo Yekuenda Nayo Kumba
- Mimwe mishonga inopiwa kune zvirwere zvakajairika zvakaita seallergies, kushungurudzika, kusazvidzora kweweti, uye kurwadziwa kwemudumbu inogona kuwira muchikamu cheanticholinergics.
- Ongororo dzakaratidza kuti kushandisa mishonga iyi kwenguva refu muhuwandu hwakawanda kunowedzera njodzi yekuora mwoyo, kunyanya kune vakwegura.
- Izvi hazvirevi kuti munhu wese anotora mushonga uyu acharwara nepfungwa dzisina kunaka. Ingori njodzi chete.
- Usamborega kutora chero mushonga wawakanyorerwa nachiremba wako wega. Kuita izvi kunogona kuwedzera dambudziko rako.
- Kana muine zvinokunetsai kana mibvunzo nezvemishonga yamuri kunwa, kunyanya mishonga yenguva refu yakaita seiyi, iva nechokwadi chekutaura nachiremba wemhuri yenyu. Iye anogona kuongorora njodzi dzenyu uye, kana zvichidikanwa, anokukurudzirai imwe nzira yakakunakirai.
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