Na o kile wa utlwa ka acetylcholine , kapa (ACh)? Mohlomong ngaka ya hao e o boleletse ka yona, kapa o kile wa bala ka yona kaekae. Ke k'hemik'hale e nyane empa e le ya bohlokwa haholo mmeleng wa rona. E tshwana le motho e monyane wa poso ya jarang melaetsa ka hare ho mmele wa rona. Kahoo, kajeno re tla bua ka acetylcholine ka tsela e bonolo eo o ka e utlwisisang.
Hantle-ntle Acetylcholine ke eng?
Ka bokhutšoanyane, acetylcholine ke neurotransmitter . Nahana ka hona, boko ba hao bo hloka ho romela melaetsa e menyenyane ea motlakase ho tsamaisa letsoho la hao, ho nahana, ho hopola ho hong, lintho tsena tsohle. Acetylcholine ke lenģosa la lik'hemik'hale le thusang ho tsamaisa melaetsa eo ka lisele tsa methapo .
Sena se boetse se bitsoa neurotransmitter ea " excitatory " . Na ua tseba hore na seo ke eng? Se "tsosa" sele ea methapo, ke hore, sea e hlasimolla, 'me se etsa hore e "romele" melaetsa kapele. Ho tšoana le ho kokota monyako oa motho ea robetseng 'me u re, "Mona, nka lengolo lena."
Lebitso acetylcholine le tswa dinthong tse pedi tse e etsang. E nngwe ke sehlopha sa acetyl . Sena se tswa motswakong o bitswang acetyl coenzyme A, o entsweng ka glucose ya tswekere. E nngwe ke phepo e bitswang choline . Choline e fumaneha ka tlhaho ho yolk ya lehe, soya, sebete, meroho le dinawa. Choline e boetse e etswa sebeteng sa rona.
Acetylcholine e ameha mesebetsing e mengata ea bohlokoa 'meleng ea rona, haholo-holo ho sisinyeha ha mesifa ka boithatelo.Sena se bapala karolo ea bohlokoa liketsong tsa rona tsa kelello, tse kang ho tsamaisa maoto le maoto a rona le ho tsamaea. Se hlasimolla lisele tsa methapo mesifa ea rona, se etsa hore li honyele. Hase feela seo, empa se boetse se bohlokoa haholo bakeng sa lisele tsa methapo bokong ba rona, le bakeng sa lits'ebetso tse kang mohopolo, ho nahana le ho ithuta.
Acetylcholine (ACh) e sebetsa joang?
Acetylcholine e bolokoa lipheletsong tsa lisele tsa methapo, ho fihlela molaetsa o hloka ho romelloa. Ha "letšoao" le fihla ho romela molaetsa, acetylcholine ena e bolokiloeng ea lokolloa. Hang ha e lokolloa, e tsamaea ka lekhalo le lenyenyane pakeng tsa lisele tse peli tsa methapo. Lekhalo lena le bitsoa synaptic cleft .
Kamora ho tšela lekhalo la synaptic, ho na le mefuta e 'meli ea li-receptor tseo acetylcholine e ka tlamang ho tsona. Ke:
- Li-receptor tsa Nicotinic
- Li-receptor tsa Muscarinic
Kamora ho tlamahana le li-receptor tsena, molaetsa oa lik'hemik'hale o tsamaea ho ea seleng e latelang ea methapo. Kamora hore molaetsa o romeloe, acetylcholine e setseng ka har'a lekhalo la synaptic ha e senyehe feela. Enzyme e 'ngoe e bitsoang acetylcholinesterase ea tla 'me e robe acetylcholine ena likarolong tsa eona, choline le acetate. Ebe likarolo tsena tse robehileng li monngoa hape, li sebelisoa hape, 'me li sebelisoa ho jara molaetsa o mong oa lik'hemik'hale. Sistimi e sebetsang hantle haholo!
Ho etsahala'ng ka acetylcholine (ACh)?
Acetylcholine e na le melemo e mengata bakeng sa 'mele ea rona. A re shebeng tse ka sehloohong.
| Mofuta oa seamoheli | Mesebetsi e ka sehloohong |
|---|---|
| Li-receptor tsa Muscarinic |
|
| Li-receptor tsa Nicotinic (Nicotinic) |
|
Mefuta ena ka bobeli ea li-receptor e ameha mohopolong oa rona. Ke hore, li bohlokoa bakeng sa mohopolo oa nako e telele, mohopolo oa nako e khuts'oane, ho thehoa ha mehopolo, ho kopanngoa ha eona le ho khutlisoa ha eona. Ka hare ho boko, acetylcholine e ameha linthong tse ling. E khothalletsa khothatso, thahasello/tlhokomelo, ho ithuta, le boroko ba REM (mokhahlelo oa boroko oo re lorang ho oona).
Maemo a hlahang ha maemo a acetylcholine (ACh) a theoha ke afe?
Maemo a tlase a acetylcholine, kapa khaello, a ka lebisa mafung a 'maloa. A bohlokoa ka ho fetisisa ho ana ke:
- Lefu la Alzheimer : Batho ba nang le lefu la Alzheimer ha ba na acetylcholine e lekaneng bokong ba bona. Ka lebaka leo, ho lahleheloa ke mohopolo ke letšoao le leholo.
- Lambert-Eaton myasthenic syndrome : Lefu lena le bakoa ke ho fokotseha ha ho lokolloa ha acetylcholine liseleng tsa methapo.
- Myasthenia gravis : Ena ke lefu la autoimmune le etsang hore mesifa ea masapo e fokole kapele ka mor'a ho sebelisoa khafetsa.
Bohlokoa:Haeba o na le matšoao ana, bona ngaka hang-hang. U se ke ua itlhahloba.
Ke meriana efe e hlaselang acetylcholine (ACh)?
Lithibela-cholinesterase ke sehlopha sa meriana e sebetsang ka ho tima enzyme e senyang acetylcholine le ho eketsa ts'ebetso ea li-receptor tsa acetylcholine. Li sebelisetsoa ho phekola lefu la Alzheimer le myasthenia gravis. Donepezil (Aricept®), Rivastigmine (Exelon®), le Galantamine (Razadyne®) ke tse ling tsa meriana ena.
Ke lijo life tse nang le choline, e thusang ho hlahisa acetylcholine (ACh)?
Choline, e leng phepo e fetohang acetylcholine, e fumaneha lijong tse ngata. Mohlala:
- Sebete sa nama ea khomo
- Mahe (haholo-holo li-yolk)
- Potoloho e holimo ea nama ea khomo
- Linaoa tsa soya tse halikiloeng, linaoa tsa liphio tse ka makotikoting
- Lefuba la khoho le besitsoeng
- Tlhapi ea cod `(Cod)`
- Quinoa e phehiloeng
- Li-mushroom tsa shiitake tse phehiloeng, broccoli e phehiloeng le li-Brussels sprouts
- Lebese (1%) `(Lebese (1%)`, yogurt ea vanilla e se nang mafura `(yogurt ea vanilla e se nang mafura)`
Leka ho eketsa lijo tsena lijong tsa hau. Lijo tse leka-lekaneng li bohlokoa haholo bakeng sa bophelo bo botle.
Molaetsa oo u ka o isang hae
Kahoo, mohlomong joale ua utloisisa hore acetylcholine (ACh) ke neurotransmitter e bohlokoa haholo bakeng sa ts'ebetso ea boko ba rona, mohopolo le mesebetsi ea 'mele joalo ka ho honyela ha mesifa. Haeba maemo a eona a fokotseha, mathata a ho hopola le mafu a amanang le mesifa a ka hlaha. Ntho ea bohlokoa ka ho fetisisa ke hore, haeba u na le mathata afe kapa afe a bophelo bo botle, bua le ngaka ka hona. U se ke ua ea kalafong ho latela likhakanyo. Lula u phetse hantle!
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