Ingakanani inqanaba lakho le-LDH? (LDH - Uvavanyo lweLactate Dehydrogenase) Masifumanise ngale nto ngokulula!

Namhlanje siza kuthetha ngovavanyo olunokusixelela ulwazi oluninzi olubalulekileyo malunga nempilo yemizimba yethu. Usenokuba ukhe weva ngovavanyo lwe-'LDH'. Mhlawumbi ugqirha ukucele ukuba wenze olu vavanyo. Ngoko ke, makhe sibone ukuba yintoni le 'LDH' kunye nento onokuyifunda kolu vavanyo ngokulula.

Yintoni i-lactate dehydrogenase (LDH)?

Ngoko ke, masiqale sibone ukuba yintoni i-'Lactate Dehydrogenase'. Siyibiza ngokuba yi-'(LDH)' ngamafutshane. Ngamafutshane, le yi -enzyme ebaluleke kakhulu emzimbeni wethu. I-enzyme luhlobo lweproteni olukhawulezisayo nolunceda ukusabela kweekhemikhali emzimbeni wethu. Cinga ngayo njengezincedisi ezincinci ezenza umzimba wethu usebenze lula.

Le enzyme ethi `LDH` inceda ngokukodwa ekuphefumleni kweeseli zethu. Oko kukuthi, le `LDH` inceda kwinkqubo ebaluleke kakhulu yokuthatha iglucose (ngokutsho nje, iswekile) ekutyeni esikutyayo nokuvelisa amandla afunekayo kwiiseli zomzimba wethu. Oku kufana nokunceda ukwenza amafutha kwiiseli ezisebenza njengezityalo ezincinci zamandla emzimbeni wethu.

Ubusazi na ukuba le enzyme ethi `LDH` ifumaneka phantse kuzo zonke izicwili zomzimba wethu? Kodwa ifumaneka kakhulu kwimisipha, isibindi, izintso, kunye neeseli ezibomvu zegazi . Xa iiseli ezintsha zisenziwa emzimbeni wethu, iiseli ezindala okanye "ezifileyo" ziyasuswa. Oku kuqhelekile. Xa iiseli ezindala zisuswa, ezinye 'LDH' kwezo zicwili zongezwa egazini lethu okanye kwezinye izicwili zomzimba. Ke ngoko, kuqhelekile ukuba ne-`LDH` ethile kwisampuli yegazi okanye kwenye isampuli yolwelo lomzimba.

Ngoko ke, yintoni le LDH (lactate dehydrogenase) vavanyo?

Kulungile, ngoku unombono omncinci wokuba yintoni i-`LDH`. Uvavanyo lwe-`LDH` lulinganisa ubungakanani be-`LDH` egazini lakho okanye kolunye ulwelo lomzimba. Oku kujongwa ikakhulu ukuba kukho umonakalo kwizicubu zomzimba wakho .

Njengoko besitshilo ngaphambili, kuyinto eqhelekileyo ukuba nomlinganiselo othile we-'LDH' egazini lakho. Nangona kunjalo, ukuba kukho nasiphi na isicwili emzimbeni wakho esonakeleyo okanye esonakeleyo , i-'LDH' engaphezulu kweso sicwili esonakeleyo iya kukhutshwa iye egazini lakho okanye kolunye ulwelo lomzimba. Ngoko ke, ukuba inqanaba lakho le-'LDH' liphezulu kunesiqhelo, oko kuthetha ukuba ezinye izicwili emzimbeni wakho zonakaliswe sisifo esingapheliyo , isifo esibukhali, okanye ukwenzakala .

Kodwa into enye ekufuneka uyikhumbule kukuba kunzima ukufumanisa ukuba zeziphi izicwili ezonakeleyo luvavanyo lwe-'LDH' kuphela. Kuba i-'LDH' ikhona kwiindawo ezininzi emzimbeni wethu. Ke ngoko, oogqirha badla ngokuyalela ezinye iimvavanyo ezininzi kunye novavanyo lwe-'LDH' ukuze bafumanise isifo ngokuchanekileyo.

Olu vavanyo lwe-`LDH` lubizwa nangamanye amagama aliqela:

• Uvavanyo lwe-`LD`
• I-lactic dehydrogenase
• I-lactic acid dehydrogenase

Ndiludinga nini uvavanyo lwe-LDH?

Oogqirha basebenzisa uvavanyo lwe-LDH ukuxilonga nokujonga iimeko ezahlukeneyo zempilo. Ezona zizathu ziphambili zokwenziwa kolu vavanyo zezi:

• Jonga ukuba izicwili zomzimba wakho zonakele na .
• Jonga izifo ezifana ne -anemia , izifo zamalungu angaphakathi (umz. isibindi, izintso), kunye neemeko ezonakalisa izicwili, ezifana nosulelo oluthile.
• Vavanya ubukhali bezinye iintlobo zomhlaza .
• Jonga ukuba unyango lweentlobo ezithile zomhlaza (umz. i-chemotherapy) luphumelele na okanye aluphumeleli.

Ekubeni uvavanyo lwe-`LDH` lwenziwa kwiimeko ezininzi ezahlukeneyo, ukuba uceliwe ukuba wenze olu vavanyo, licebo elihle ukubuza ugqirha wakho ukuba kutheni uvavanywa.

Ngubani owenza olu vavanyo lwe-LDH?

Ngokwesiqhelo, uvavanyo lwegazi lwe-LDH lwenziwa yingcali ye-phlebotomist eqeqeshwe ukutsala igazi . Nangona kunjalo, nawuphi na umntu oqeqeshelwe ukutsala igazi unokukwenza oku. Isampuli yegazi emva koko ithunyelwa kwilabhoratri. Apho, isazinzulu selabhoratri yezonyango sihlola isampuli kwaye sisebenzisa oomatshini abakhethekileyo (ii-analyzers) ukulinganisa inqanaba le-LDH.

Ngamanye amaxesha oogqirha kufuneka balinganise amanqanaba e-LDH kwezinye izinto zomzimba, kungekuphela nje egazini. Umzekelo, ulwelo lwakho lwe-cerebrospinal (CSF), ulwelo lwe-pleural , okanye ulwelo lwe-peritoneal . Kwezi meko, ugqirha oqeqeshwe ngokukhethekileyo uya kuthatha isampuli.

Ndingazilungiselela njani uvavanyo lwe-LDH?

Kwiimeko ezininzi, akufuneki ulungiselele nantoni na ekhethekileyo xa kusenziwa uvavanyo lwegazi lwe-LDH.

Nangona kunjalo, ukuba isampuli ithathwe kolunye ulwelo lomzimba, njengoko bekutshiwo ngaphambili, kungafuneka amalungiselelo athile. Ugqirha wakho uza kukuchazela oku ngelo xesha.

Kwenzeka ntoni ngexesha lovavanyo lwe-LDH?

Ukuba unikela ngegazi, oku kudla ngokwenzeka:

• Uza kuhlaliswa esitulweni. Emva koko umsebenzi wezempilo uza kukhangela umthambo ongalweni yakho okulula ukuwukhupha igazi kuwo. Amaxesha amaninzi, igazi likhutshwa ngaphakathi kwengqiniba yakho.
• Nje ukuba kufunyenwe umthambo, loo ndawo icocekile kakuhle kwaye kufakwe isibulali-ntsholongwane.
• Emva koko, kufakwa inaliti encinci emthanjeni kwaye kutsalwa igazi elincinci. Ngeli xesha, ungaziva ulunywa kancinci, njengokulunywa ziimbovane .
• Emva kokufaka inaliti, igazi elincinci liqokelelwa kwityhubhu yovavanyo.
• Emva kokuba igazi elifunekayo kuvavanyo lithathiwe, inaliti iyasuswa kwaye isiqwenga sekotoni okanye i-gauze sibekwe kwindawo leyo kwaye sifakwe uxinzelelo oluncinci ukuze kumiswe ukopha.
• Emva koko kufakwa iplasta kuloo ndawo. Yiyo leyo.

Le nkqubo yonke idla ngokuthatha ngaphantsi kwemizuzu emihlanu . Ngumsebenzi okhawulezayo kakhulu.

Njengoko besitshilo ngaphambili, ngamanye amaxesha kunokufuneka ezinye iincindi zomzimba ukuze kulinganiswe i-'LDH'. Iimeko ezinjalo ziquka:

• Ulwelo lweCerebrospinal (CSF)
• Ulwelo lwePleural
• Ulwelo lwePeritoneal

Ukuba kufuneka wenze olu hlobo lovavanyo, ungakhathazeki. Ugqirha wakho uza kukuchazela ngokweenkcukacha indlela olu vavanyo lwenziwa ngayo kunye noko kufuneka ukwazi.

Kwenzeka ntoni emva kovavanyo lwe-LDH?

Emva kokuba isampuli yegazi lakho okanye olunye ulwelo lomzimba luthathiwe, luya kuthunyelwa kwilebhu ukuze luvavanywe. Nje ukuba iziphumo zovavanyo zifike, ugqirha wakho uya kuxoxa nawe ngeziphumo.

Ngaba kukho naziphi na iingozi kuvavanyo lwe-LDH?

Ukunikela ngegazi yinkqubo eqhelekileyo kuphando lwezonyango. Ayinawo umngcipheko omkhulu . Kusenokubakho imikrwelo kunye nobuhlungu apho igazi litsalwe khona. Kodwa oko kuya kuphela ngokukhawuleza.

Kuza kuthatha ixesha elingakanani ukuba ndizazi iziphumo zovavanyo lwe-LDH?

Uninzi lwexesha, iziphumo zakho zovavanyo lwe-LDH kufuneka zifumaneke kungekapheli usuku okanye ezimbini , kodwa ngamanye amaxesha kungathatha ixesha elide.

Ukuba olu vavanyo lwenziwa esibhedlele okanye kwigumbi likaxakeka, ungafumana iziphumo kwisithuba seeyure ezimbalwa .

Zithini iziphumo zovavanyo lwe-LDH?

Ingxelo yovavanyo lwegazi, oko kukuthi, ingxelo yovavanyo lwe-`LDH`, idla ngokuqulatha olu lwazi lulandelayo:

• Igama lovavanyo lwegazi, okanye oko kwalinganiswa egazini lakho.
• Ixabiso (oko kukuthi, inani) leziphumo zovavanyo lwakho lwegazi.
• Uluhlu oluqhelekileyo lolo vavanyo.
• Ulwazi olubonisa ukuba iziphumo zakho ziqhelekile, aziqhelekanga, okanye ziphezulu okanye ziphantsi.

Zithini iinqanaba eziqhelekileyo ze-LDH (lactate dehydrogenase)?

Uluhlu oluqhelekileyo lwe-`LDH` lunokwahluka kancinci ukusuka kwilabhoratri ukuya kwenye. Xa ufumana ingxelo yakho yovavanyo lwegazi, iya kuchaza ngokucacileyo ukuba loluphi uluhlu oluqhelekileyo lwe-`LDH` kuloo labhoratri.

Nangona kunjalo, ngokubanzi, amaxabiso aqhelekileyo ovavanyo lwe-LDH ngala alandelayo:

• Kwabesilisa : Iiyunithi ezili-135 – 225 ngelitha (U/L).
• Kwabasetyhini : Iiyunithi ngelitha (U/L) 135 – 214.

Amanqanaba e-LDH aqhelekileyo kubantwana abancinci ngokubanzi aphezulu kunakwabantu abadala.

Ukuba unemibuzo malunga neziphumo zakho, qiniseka ukuba ubuza ugqirha wakho.

Kuthetha ukuthini ukuba inqanaba lam le-LDH liphezulu?

Ukuba inqanaba lakho le-LDH liphezulu kunesiqhelo, kusenokwenzeka ukuba kuthetha ukuba kukho umonakalo kwizicubu ezithile emzimbeni wakho.Kuthetha ukuba kukho into eyenzekileyo. Loo monakalo ungabangelwa kukugula ixesha elide (okungapheliyo), imeko engxamisekileyo (ebukhali), okanye usulelo.

Ezinye zeemeko zonyango ezinokubangela amanqanaba aphezulu e-LDH zezi:

• I-anemia
• Isifo sezintso
• Isifo semiphunga
• Isifo sesibindi
• Ukulimala kwemisipha
• Ukungakwazi kwemisipha
• Ukuqhekeka kwethambo
• Ukuhlaselwa yintliziyo
• I-Pancreatitis
• Ezinye izifo , ezifana ne -meningitis , i-encephalitis , i-mononucleosis (i-mono ), kunye ne-HIV .
• Ezinye iintlobo zomhlaza , umzekelo, i-metastatic melanoma , i-multiple myeloma, i-lymphoma , umhlaza wamasende , kunye ne -leukemia .

Kwakhona, ukuba nenqanaba eliphezulu kuneliqhelekileyo le-LDH kunokuthetha ukuba unyango lomhlaza alusebenzi kakuhle .

Nangona uvavanyo lwe-LDH lunokubonisa ukuba izicubu zomzimba wakho zonakele okanye ukuba unesifo, alunakukuxelela ngqo ukuba umonakalo uphi . Kwakhona, ukuba iiseli ezibomvu zegazi zaphukile ngexesha lesampulu yegazi (i-hemolysis), ixabiso le-LDH ngamanye amaxesha linokuba phezulu ngokungeyonyani . Ngoko ke ukuba iziphumo zakho zibonisa ukuba inqanaba lakho le-LDH liphezulu, ugqirha wakho kuya kufuneka enze uvavanyo oluthe kratya ukuze enze uxilongo oluchanekileyo.

Ngaba kufuneka ndikhathazeke ukuba inqanaba lam le-LDH liphezulu?

Nokuba iziphumo zovavanyo lwakho lwe-LDH zibonisa ukuba inqanaba lakho le-LDH liphezulu, akuthethi ukuba unesifo esinzima . Musa ukukhathazeka.

Kukho ezinye izinto ezininzi ezinokubangela amanqanaba aphezulu e-LDH:

• Ukuzilolonga ngamandla .
• Amanye amayeza , umzekelo i-aspirin , ii-anesthetics , ii-narcotics , kunye ne -procainamide .

Kwakhona, kusenokwenzeka ukuba kubekho impazamo ngexesha lokuqokelelwa kweesampulu, ukuthuthwa, okanye uvavanyo.

Xa esenza isigqibo malunga neziphumo zakho, ugqirha wakho uza kuqwalasela izinto ezininzi, ezifana namayeza owasebenzisayo ngoku, imbali yakho yempilo, kunye neempawu onazo.Uza kukuxelela nokuba ufuna olunye uvavanyo okanye awuludingi.

Ukuba unemibuzo malunga neziphumo zakho, ungoyiki ukuthetha nogqirha wakho.

Kuthetha ukuthini ukuba inqanaba lam le-LDH liphantsi?

Kunqabile kakhulu ukuba iziphumo zovavanyo lwe-`LDH` zibe phantsi kunesiqhelo .

Ukuba nenqanaba eliphantsi kangaka le-LDH kunokubonisa imeko engaqhelekanga kakhulu yemfuza ebizwa ngokuba yi -Lactate Dehydrogenase A deficiency - Glycogen Storage Disease XI, okanye i-Lactate Dehydrogenase B deficiency.

Kwakhona, abantu abatya i-vitamin C eninzi banokuba neziphumo zovavanyo lwe-LDH eziphantsi ngokungeyonyani .

Ndingayibuza yiphi imibuzo ugqirha wam?

Ukuba ukhe wenza uvavanyo lwe-LDH, kunokuba luncedo ukubuza ugqirha wakho imibuzo efana nale:

• Ucinga ukuba yintoni enokubangela ukuba ndibe ne-'LDH' ephezulu?
• Ngaba kufuneka ndenze iimvavanyo ezingaphezulu ukuze ndifumanise unobangela ochanekileyo wamanqanaba am aphezulu e-LDH?
• (Ukuba ungumguli onomhlaza) Ithini inqanaba lam le-'LDH' malunga nobunzima kunye noqikelelo lomhlaza wam?
• (Ukuba unyangelwa isifo) Ithini inqanaba lam le-'LDH' malunga nendlela imeko yam esabela ngayo kunyango?

Eyona nto ibalulekileyo ekufuneka uyikhumbule (Umyalezo Wokuya Ekhaya)

Kuqhelekile ukuba noloyiko kunye nexhala xa ubona iziphumo zovavanyo ezingaqhelekanga. Kodwa khumbula, ukuba nje inqanaba lakho le-'LDH' (lactate dehydrogenase) liphezulu akuthethi ukuba unesifo esinzima kwaye udinga unyango.

Ugqirha wakho ngokuqinisekileyo uza kukuxelela ukuba kufuneka wenze iimvavanyo ezingaphezulu okanye hayi ukuze ufumane unobangela wale meko ingaqhelekanga. Musa ukoyika okanye ungathandabuzi ukubuza ugqirha wakho imibuzo . Bakhona ukukunceda. Thetha naye ngayo yonke into onayo ngempilo yakho.

I- LDH, i-lactate dehydrogenase, i-enzyme, umonakalo kwizicubu, uvavanyo lwegazi, impilo, ukuxilongwa