Yonke into malunga novavanyo lwe-ACTH Stimulation Test, olulinganisa iihomoni zomzimba wakho!

Ngamanye amaxesha xa izinto ezithile emzimbeni wethu zingasebenzi kakuhle, sinokuba neengxaki ezahlukeneyo zempilo, akunjalo? Ingakumbi ukuba kukho ukungalingani kwinkqubo yehomoni yomzimba wethu, kunokuba nempembelelo enkulu. Kwimeko enjalo, ugqirha wakho unokukucebisa ukuba wenze uvavanyo olukhethekileyo. Olu luvavanyo lwe-'ACTH Stimulation Test'. Masithethe ngale nto ngokulula.

Yintoni uvavanyo lwe-ACTH (uvavanyo lwe-ACTH Stimulation)?

Ngamafutshane, olu luvavanyo olukhethekileyo olujonga indlela amadlala e-adrenal emzimbeni wethu asabela ngayo kwi-hormone ebizwa ngokuba yi-ACTH. Ngamanye amaxesha oku kubizwa ngokuba yi-Cosyntropin Stimulation Test (CST). Olu luvavanyo oluphambili lokufumanisa ukuba kukho imeko ebizwa ngokuba yi-adrenal insufficiency, eyokwehla komsebenzi wamadlala e-adrenal. Oku kungaba yi-primary, secondary okanye tertiary.

Olu vavanyo lubandakanya ukufaka i-hormone ye-ACTH eyenziweyo (i-Synthetic ACTH - i-Cosyntropin) kwizihlunu zakho. Emva koko, rhoqo emva kwesiqingatha seyure okanye ngaphezulu, igazi lakho liyathathwa kwaye inqanaba le-hormone ebizwa ngokuba yi-cortisol liyavavanywa. Oku kwenzelwa ukubona ukuba amadlala akho e-adrenal asebenza kakuhle kangakanani na.

Yintoni i-ACTH kunye ne-Cortisol?

I-'ACTH', emele i-'Adrenocorticotropic Hormone', yi-hormone eveliswa yi-'Pituitary Gland' engqondweni yethu. Inempembelelo enkulu kwindlela umzimba wethu osabela ngayo kuxinzelelo. Xa i-'ACTH' ikhutshwa, ivuselela amadlala e-adrenal ukuba avelise i-'Cortisol', ekwaziwa ngokuba yi -'stress hormone' . I-Cortisol yi-hormone ebalulekileyo echaphazela phantse onke amalungu kunye nezicubu emzimbeni wethu.

Iintlobo zokungabikho kakuhle kwe-adrenal

Oku kunokwenzeka ngeendlela ezintathu eziphambili:

1. Ukungasebenzi kakuhle kwe-adrenal: Oku kwenzeka xa amadlala akho e-adrenal onakele kwaye engakwazi ukuvelisa i-cortisol ngokufanelekileyo. Isizathu esiphambili sesi sifo sisifo sika-Addison. Sisifo esibangelwa kukuzimela komzimba.

2. Ukungasebenzi kakuhle kwe-adrenal secondary: Oku kwenzeka xa i-pituitary gland yakho ingavelisi i-ACTH eyaneleyo. Emva koko i-adrenal glands ayivuselelwa ngokwaneleyo ukwenza i-cortisol.

3. Ukungasebenzi kakuhle kwe-Adrenal Tertiary: Oku kwenzeka xa i-hypothalamus esebuchotsheni ingavelisi i-hormone ethi `CRH (Corticotropin-Releasing Hormone)` ngokufanelekileyo. I-`CRH` yiyo exelela i-pituitary gland ukuba ivelise i-`ACTH`.

Lufuneka nini uvavanyo lwe-ACTH?

Olu vavanyo lunokuqinisekisa ukuba ii-adrenal glands zakho kunye ne-pituitary gland zisebenza kakuhle na ngokubhekiselele ekuveliseni i-cortisol. Ugqirha wakho unokuyalela olu vavanyo ngezizathu ezilandelayo:

• Ukuba olunye uvavanyo lufumanisa ukuba amanqanaba akho e-cortisol aphantsi.
• Ukuba uneempawu zokungasebenzi kakuhle kwe-adrenal (umz., ukudinwa rhoqo, ukwehla kobunzima, isisu esibuhlungu, isicaphucaphu, isiyezi, ulusu olumnyama ).
• Emva kokuba uyekile ukusebenzisa amayeza e-glucocorticoid, afana ne-prednisone, okwethutyana elithile, jonga ukuba i-pituitary glands kunye ne-adrenal glands zibuyele esiqhelweni na.

Ngubani owenza olu vavanyo?

Ngokwesiqhelo, inaliti ye-ACTH yenziwa ngumongikazi. Ukutsalwa kwegazi, oko kukuthi, isampuli yegazi, kwenziwa yingcali ye-phlebotomist, oko kukuthi, umntu ofumene uqeqesho olukhethekileyo ngale njongo. Emva koko ezi sampuli zithunyelwa kwilabhoratri. Apho, isazinzulu selabhoratri yezonyango siyavavanya ezi sampuli.

Olu vavanyo ludla ngokwenziwa esibhedlele okanye eofisini yengcali ye-endocrinologist, ugqirha ogxile kwizifo ezinxulumene neehomoni. Oku kuquka ukujova amayeza kunye nokuthatha iisampuli zegazi. Ingcali ye-endocrinologist ngugqirha ogxile kwizifo ezinxulumene neehomoni.

Ngaba kufuneka ndilungiselele nantoni na ngaphambi kovavanyo?

Ewe, kukho izinto ezithile.

• Usenokucelwa ukuba unciphise umsebenzi wakho kwaye utye ukutya okune-carbohydrate eninzi kwiiyure ezili-12-24 ngaphambi kovavanyo.
• Ungathi uza kuzila ukutya kangangeeyure ezintandathu. Oko kuthetha ukuba awunakutya okanye usele nantoni na ngaphandle kwamanzi.
• Ukuba usela amayeza athile anokuchaphazela uvavanyo lwe-cortisol, unokucelwa ukuba uyeke ukuwasebenzisa okwethutyana.
• Ekubeni amanqanaba e-cortisol ahluka imini yonke (aphezulu kusasa), olu vavanyo lungcono ukwenziwa kusasa ukunciphisa umngcipheko weziphumo ezingezizo.

Nangona kunjalo, ugqirha wakho uza kukunika imiyalelo ethile malunga nendlela yokulungiselela olu vavanyo. Ufanele ulandele loo miyalelo ngokuchanekileyo.

Lwenziwa njani uvavanyo lwe-ACTH?

La ngamanyathelo asisiseko:

1. Okokuqala, kuthathwa isampuli yegazi kumthambo osengalweni yakho. Oku kuya kujonga amanqanaba akho okuqala e-cortisol. Kunokwenziwa nezinye iimvavanyo.

2. Emva koko, umongikazi uza kufaka ihomoni yokwenziwa ebizwa ngokuba yi-'ACTH (Cosyntropin)' kwizihlunu zakho. Le 'ACTH' yokwenziwa isebenza njenge-'ACTH' eveliswa ngumzimba wethu, ivuselela amadlala e-adrenal ukuba avelise i-cortisol.

3. Emva koko, emva kwemizuzu engama-30 nemizuzu engama-60 (ngesiqhelo), iisampuli zegazi ziyathathwa emthanjeni wakho kwakhona kwaye amanqanaba e-cortisol ayajongwa.

4. Ezi sampuli zegazi zithunyelwa kwilabhoratri.

Luhlobo luni lwamava olufumanayo ngexesha lovavanyo?

Nazi ezinye izinto onokuzilindela xa utsalwa igazi lakho:

• Uza kuhlala esitulweni kwaye kuya kufumaneka umthambo ongashukumiyo engalweni yakho. Ngokuqhelekileyo, uza kuba ngaphakathi kwengalo yakho, ngasemva nje kwengqiniba yakho.
• Nje ukuba kufunyenwe umthambo, loo ndawo iyacocwa ize ibulawe iintsholongwane.
• Emva koko kufakwa inaliti encinci emthanjeni kwaye kuthathwa isampuli yegazi. Oku kunokuvakala ngathi kukuhlatywa kancinci.
• Emva kokufaka inaliti, igazi elincinci liya kuqokelelwa kwityhubhu yovavanyo.
• Emva kokuba kuqokelelwe igazi elaneleyo lovavanyo, inaliti iyasuswa kwaye isiqwenga sekotoni okanye i-gauze sibekwe kwindawo leyo size sicinezelwe ukuze kumiswe ukopha.
• Emva koko kufakwa iplasta kuloo ndawo.

Xa ufumana iCosyntropin, idla ngokufakwa engalweni yakho engasentla, ngaphezulu nje kwegxalaba lakho. Usenokuziva uqaqanjelwa okanye utshile xa ufumana inaliti, kodwa oko kuyenzeka okwexeshana.

Kwenzeka ntoni emva kovavanyo?

Emva kokuba iisampulu zegazi zithathwe, zithunyelwa kwilebhu. Xa iziphumo zifunyenwe, ugqirha wakho uza kukuxelela ngazo.

Ngaba kukho naziphi na iingozi ngolu vavanyo?

Uvavanyo lwegazi luyinto eqhelekileyo kakhulu kwezonyango. Iingozi ziphantsi kakhulu. Usenokuziva utyumkile okanye uqaqanjelwe apho igazi litsalwe khona, kodwa oko kuya kuphela ngokukhawuleza. Akukho nto yokukhathazeka ngayo.

Kuthatha ixesha elingakanani ukwazi iziphumo?

Kungathatha ukuya kuthi ga kwiveki ukuba iziphumo zovavanyo lwe-ACTH zibuye, kuba xa iziphumo zelebhu zibuyile, ugqirha kufuneka azifunde ngononophelo aze afikelele kwisigqibo.

Zithini iziphumo?

Iingxelo zovavanyo lwegazi, kuquka neengxelo ze-cortisol ezivela kuvavanyo lwe-ACTH, zihlala ziqulathe ulwazi olufana nolu:

• Igama lovavanyo lwegazi, okanye oko kwalinganiswa egazini.
• Inani okanye umlinganiselo weziphumo zovavanyo lwakho lwegazi.
• Lelo linqanaba eliqhelekileyo lokulinganisa uvavanyo.
• Ulwazi malunga nokuba iziphumo zakho ziqhelekile, aziqhelekanga, ziphezulu, okanye ziphantsi.

Imiphumo eqhelekileyo mayibe njani?

Phantsi kweemeko eziqhelekileyo, amanqanaba akho e-cortisol kufuneka anyuke emva kokukhuthazwa kwe-ACTH. Kwisiphumo esiqhelekileyo, amanqanaba akho e-cortisol kufuneka abe ngaphezulu kwe-12.6 mcg/dL (ii-micrograms nge-deciliter nganye) emva kokukhuthazwa kwe-ACTH.

Khumbula, ezi zigaba ziqhelekileyo zingahluka ukusuka kwilabhoratri ukuya kwilabhoratri, uvavanyo ukuya kuvavanyo, kunye nomntu nomntu. Soloko ujonga uluhlu oluqhelekileyo olunikiweyo kwingxelo yakho.

Kwimeko yovavanyo lwe-ACTH, ugqirha wakho okanye ingcali ye-endocrinologist kuya kufuneka aqonde ngokupheleleyo iziphumo ngaphambi kokuba uzibone. Ukuba unemibuzo malunga neziphumo, qiniseka ukuba ubuza ugqirha wakho.

Zithetha ukuthini iziphumo ezingaqhelekanga?

Ugqirha wakho okanye ingcali ye-endocrinologist iza kuhlalutya ngononophelo iziphumo zakho zovavanyo lwe-ACTH. Zininzi izinto ezinokuchaphazela ukuchaneka kovavanyo. Eyona nto ixhaphakileyo yesiphumo esingalunganga kukusetyenziswa kwakutshanje kwee-corticosteroids.

Iziphumo zovavanyo lwe-ACTH ezingaqhelekanga zihlala zibonisa ukungasebenzi kakuhle kwe-adrenal yokuqala neyesibini.

Ukungasebenzi kakuhle kwe-adrenal

Ukuba unale meko, ii-adrenal glands zakho azikwazi ukwenza i-cortisol okanye aziphenduli ngokufanelekileyo kwi-ACTH. Ngenxa yoko, usenokungaboni ukunyuka okukhulu okanye naluphi na ukunyuka kwamanqanaba akho e-cortisol emva kovavanyo lwe-ACTH. Oku kungenxa yokuba i-ACTH yokwenziwa ayizichaphazeli ii-adrenal glands zakho.

Ukungasebenzi kakuhle kwe-adrenal yesibini

Ukuba i-pituitary gland ayisebenzi kakuhle ixesha elide (hypopituitarism), kwaye imveliso ye-ACTH iyaphazamiseka, oku kukhokelela ekungoneli kwe-adrenal yesibini. Ngenxa yoko, iiseli ezivelisa i-ACTH azivuselelwa, kwaye ii-adrenal glands ziqala ukuwohloka, oko kukuthi, ziqala ukuba buthathaka .

Ngoko ke, ukuba ubune-hypopituitarism kunye nokungasebenzi kakuhle kwe-adrenal ixesha elide, unokubona ukunyuka okuncinci okanye kungakhuphi kwaphela kwamanqanaba akho e-cortisol emva kovavanyo lwe-ACTH.

Nangona kunjalo, ukuba i-hypopituitarism ayiphelelanga (oko kuthetha ukuba i-pituitary gland isavelisa i-ACTH ethile), okanye ukuba imeko isandul' ukwenzeka, ukunyuka kwamanqanaba e-cortisol, oko kuthetha ukuba inqanaba "eliqhelekileyo", kunokubonwa emva kovavanyo lwe-ACTH.

Umyalezo Wokugqibela Wokuya Ekhaya

Uvavanyo lwe-ACTH Stimulation lolona vavanyo lubalulekileyo noluthembekileyo lokufumanisa ukungasebenzi kakuhle kwe-adrenal. Ukulinda iziphumo zovavanyo lokuxilonga kunokuba yinto ekhathazayo. Kodwa khumbula, nokuba zithini na iziphumo, iqela lakho lezonyango likhona ukukunceda. Ungoyiki ukubuza ugqirha wakho malunga novavanyo lwakho okanye iziphumo. Kubalulekile ukwaziswa ngempilo yakho.

Uvavanyo lwe- ACTH, i-cortisol, ii-adrenal glands, i-pituitary gland, iihomoni, ukungasebenzi kakuhle kwe-adrenal, iimvavanyo zonyango