Xa ugqirha wakho ekuxelela ukuba unomhlaza, unemibuzo emininzi engqondweni yakho, akunjalo? Sivile nge-'chemo' kunye 'nemitha', kodwa ugqirha wakho usenokuba uthetha ngodidi olutsha lwamayeza abizwa ngokuba yi-'Angiogenesis Inhibitors'. Libizwa njani eli yeza lingaqhelekanga? Lenza ntoni ngokwenene? Ungakhathazeki, masithethe ngalo ngokulula.
Okokuqala, masibone, zithini ezi zithinteli ze-angiogenesis?
Ngamafutshane, olu luhlobo lweyeza elithintela ukukhula kwemithambo yegazi emitsha, eyimithambo yegazi enika iithumba. Amanye amagama alo mayeza ngamayeza okulwa ne-angiogenics, amayeza okulwa ne-angiogenics, kunye nonyango olulwa ne-angiogenics.
Cinga ngayo, ukuze nantoni na ikhule, idinga ukutya, izondlo, akunjalo? Iiseli zomhlaza zinjalo kanye. Zikwafuna ukunikezelwa kwegazi okuqhubekayo okuzele zizondlo ukuze zikhule kwaye zisasazeke. Xa iseli yomhlaza incinci, iphila ngokufunxa igazi kwizicubu eziphilileyo ezijikelezileyo. Kodwa xa iseli ikhula ukuya kuthi ga kwi-1-2 millimeters, kufuneka iphuhlise inkqubo yayo entsha yemithambo yegazi. Ngaphandle koko, ayinakukhula ibe nkulu ngakumbi.
Kulapho ke amayeza abizwa ngokuba yi -Angiogenesis Inhibitors angena khona. La mayeza asebenza ngokuthintela inkqubo apho iiseli zomhlaza zikhulisa khona imithambo yegazi emitsha. Kufana nokunqumla umbane oya emthini. Oku kuyacothisa ukukhula komhlaza, kwaye ngamanye amaxesha ithumba linokuncipha. Olu nyango lusenokungawunyangi ngokupheleleyo umhlaza, kodwa lunokulawula ukukhula kwethumba kwaye lukuvumele ukuba ube nabantu obathandayo ixesha elide.
Eli yeza lisebenza njani emzimbeni?
La mayeza aphazamisana nenkqubo ebizwa ngokuba yi -angiogenesis . Le yinkqubo eqhelekileyo emizimbeni yethu. Khawuthelekelele ukuba usika isandla sakho, kufuneka imithambo yegazi emitsha ikhule ukuze iphilise inxeba kwaye izise igazi kuloo ndawo. Oko kubizwa ngokuba yi-angiogenesis. Iiseli ezonakeleyo zithumela isignali, efana nokuthi "Sincede!" Esi signali sibangela ukuba imithambo yegazi emitsha ikhule.
Kodwa ingxaki kukuba, iiseli zomhlaza nazo zisebenzisa le nkqubo inye ukuze zizuze. Iiseli zomhlaza zikwathumela imiqondiso efanayo kwaye zikhulisa imithambo yegazi emitsha. Le mithambo yegazi yiyo enika ithumba izondlo ezifunekayo, ezivumela ukuba likhule kwaye lisasazeke kwamanye amalungu omzimba.
Ii-Angiogenesis Inhibitors zisebenza ngokuphazamisa le nkqubo yokubonisana evela kumhlaza. Uninzi lwala mayeza lusebenza ngokuthintela iproteni ebizwa ngokuba yi -vascular endothelial growth factor (VEGF) . Cinga nge-VEGF njengophawu oluphambili "loncedo" olukhutshwa ziiseli zomhlaza. Xa olu phawu lwe-VEGF lubopha kwii-receptors ze-VEGF kwiiseli zomhlaza, imithambo yegazi emitsha iqala ukwakheka.
Ngoku makhe sibone ukuba eli yeza liyimisa njani le signal.
- Ukuthintela isignali ye-VEGF ekubeni ibotshelelwe kwi-receptor: Amanye amayeza (umzekelo, ii-antibodies ze-monoclonal ezifana ne-Bevacizumab (Avastin®) ziya ngqo kwiproteni ye-VEGF zize zinamathele kuyo. Emva koko azikwazi ukuya kuloo receptor zibotshelelwe kuyo. Kufana nokubamba ileta ngaphambi kokuba ifike kumntu oza kuyifumana.
- Ukuvala imiqondiso evela kwii-receptors ze-VEGF: Amanye amayeza (umzekelo, ii-tyrosine kinase inhibitors ezifana ne-sorafenib (Nexavar®) kunye ne-sunitinib (Sutent®)) athintela i-receptor ekuthumeleni umyalezo kwakhona, nokuba ifumana i-signal.
- Ukuthintela ezinye iinkqubo zokubonisa iimpawu: Amanye amayeza (umzekelo, ii-immunomodulators ezifana ne-thalidomide kunye ne-lenalidomide (Revlimid®)) ziyaphazamisana nezinye iinkqubo zokubonisa iimpawu ezibandakanyekayo kule nkqubo.
Zeziphi iintlobo zomhlaza ezisetyenziselwa eli yeza?
Oogqirha badla ngokunika ezi zithinteli ze-angiogenesis kubantu abanomhlaza osele uqhubekile okanye ophinda ubuye . Ezinye zeentlobo zomhlaza ezicetyiswayo ngolu nyango zezi:
- Umhlaza wobuchopho
- Umhlaza webele
- Umhlaza womlomo wesibeleko
- Umhlaza wamathumbu amakhulu
- Umhlaza wetyhubhu yesibeleko
- Umhlaza wezintso
- Umhlaza wesibindi
- Umhlaza wemiphunga
- I-Lymphoma
- I-myeloma eninzi
- Umhlaza wePancreatic
- Umhlaza wesisu
- Umhlaza wesisu
- Umhlaza we-thyroid
- Umhlaza wesibeleko/we-endometrial
Ukongeza, la mayeza (i-VEGF inhibitors) akwasetyenziselwa ukunyanga izifo ezithile zamehlo apho imithambo yegazi ikhula ngendlela engaqhelekanga emehlweni.
Kwenzeka ntoni ngexesha lonyango?
Oogqirha abadli ngokunika la mayeza odwa. Adla ngokusetyenziswa kunye nezinye iindlela zonyango zomhlaza, ezifana ne -immunotherapy kunye ne-chemotherapy .
Cinga ngayo njengemfazwe. Ii-Angiogenesis Inhibitors zinqumla ukutya kunye neembumbulu (igazi) ezifunyanwa lutshaba (umhlaza). Ezinye iindlela zonyango (ezifana ne-chemotherapy) ziya ngqo kutshaba (iiseli zomhlaza) zize zizihlasele. Xa ezi ndlela zimbini zisebenza kunye, iziphumo zingaphumelela ngakumbi.
Ngokuxhomekeke kuhlobo lwamayeza owanikwayo, unokufuna ukuwasela njengepilisi kanye okanye kabini ngemini, okanye unokufuna ukuwasela njenge-IV (njenge -saline ) emthanjeni rhoqo.
Ithatha ixesha elingakanani le nyango?
Ubude bonyango lwakho buxhomekeke kwizinto ezininzi, kuquka uhlobo lwamayeza owanikwayo kunye nohlobo lomhlaza onawo. Uninzi lwabantu luyaqhubeka nokuwasela la mayeza logama nje esebenza. Ngamanye amaxesha, unyango lunokumiswa ukuba iziphumo ebezingalindelekanga ziba nzima ukuzithwala. Ugqirha wakho uza kuxoxa nawe ngeengenelo kunye neziphumo ebezingalindelekanga zonyango aze enze isigqibo esifanelekileyo.
Zithini iziphumo ebezingalindelekanga kunye neengozi?
Njengayo nayiphi na iyeza, olu nyango lunokuba nemiphumo emibi kunye neengozi. Uninzi lwale miphumo lubangelwa kukopha (ukopha) kunye nokujiya kwegazi. Kwiimeko ezingaqhelekanga, le miphumo emibi inokuba yingozi ebomini. Ngoko ke kubalulekile ukuba uzazi ezi zinto.
Ugqirha wakho uza kujonga impilo yakho rhoqo ukuze anciphise ezi ngozi.
| Isiphumo/umngcipheko onokubakho | Ingcaciso elula |
|---|---|
| Igazi elonyukayo | Uxinzelelo lwegazi oluphezulu. Oku kufanele kuhlolwe kwaye kulawulwe rhoqo. |
| Ukopha ngaphakathi | Ukopha ngaphakathi emzimbeni. |
| Ukuphola kancinci kwenxeba | Ngenxa yokuba iphazamisa ukwakheka kwemithambo yegazi emitsha, inokwandisa ixesha elithathwayo ukuze amanxeba aphole. |
| Ukugqobhoza kwamathumbu | Kunqabile kakhulu ukuba kubekho umngcipheko wokugqobhoka kwesisu okanye amathumbu. |
| Ukuncipha komsebenzi we-thyroid | Ukucothisa isantya se-thyroid gland, elawula iihomoni zomzimba. |
| Umonakalo wesibindi | Ngamanye amaxesha ukusebenza kwesibindi kunokuphazamiseka. |
| Amahlwili egazi | Kukho umngcipheko wokuba amahlwili egazi ayingozi avele kwimithambo yegazi. Oku kunokubangela izifo ezifana nokuhlaselwa yintliziyo okanye isifo sohlangothi. |
Eyona nto ibalulekileyo onokuyenza kukuqonda ezi ziphumo kunye neengozi ngaphambi kokuba uqale unyango. Xa usazi into omawuyilindele, unokuqaphela ngakumbi utshintsho emzimbeni wakho. Ukuba ubona nantoni na engaqhelekanga, yazisa ugqirha wakho ngoko nangoko. Angakufundisa indlela yokulawula iziphumo ebezingalindelekanga okanye alungise umthamo wamayeza akho.
Ngaba kukho izinto ezinokumisa le nkqubo ngokwendalo?
Lo ngumbuzo abantu abaninzi abawubuzayo. Ezinye izidlo ziqulathe izinto ezithintela iimpawu ezithile ezibandakanyeka kwinkqubo ye-angiogenesis. Uninzi lwezi zidlo zifumaneka kukutya kweMeditera. Umzekelo:
- I-asparagus
- Ingcambu yeDandelion
- Iti eluhlaza
- I-oyile ye-olivu
- Iinati
- Isiselo somdiliya esibomvu
- Imidiliya ebomvu
Abaphandi bezonyango bazama ukusebenzisa la mayeza ukwenza amayeza amatsha, kodwa olo phando lusekwinqanaba lokuqala.
Kodwa eyona nto ibalulekileyo ekufuneka uyikhumbule apha kukuba oku kutya akusayi kuze kube yinto ethatha indawo yamayeza omhlaza. Ngamanye amazwi, ukutya iidiliya ezibomvu ezininzi kunye nokusela iti eluhlaza akuyi kuyithintela umhlaza ukuba uvele. Loo ngcamango ayichanekanga kwaphela.
Nangona kunjalo, ukutya ukutya okunesondlo kubaluleke kakhulu ukugcina umzimba wakho unamandla. Kubalulekile ukubonelela ngesondlo esifanelekileyo emzimbeni ngexesha nasemva konyango lomhlaza.
Kufuneka uthethe nini nogqirha?
Ukuba ufumana naziphi na iimpawu ezingalindelekanga ngexesha lonyango, qhagamshelana nogqirha wakho ngoko nangoko.
Ingakumbi ukuba ubona iimpawu zesimo esisongela ubomi, njengokuhlaselwa yintliziyo okanye isifo sohlangothi, yiya kwiSebe leNgxamiseko (ETU) ngoko nangoko.
Izithinteli ze-Angiogenesis lunyango olubaluleke kakhulu oluthintela amandla eeseli zomhlaza okulawula inkqubo yokuphiliswa kwemizimba yethu. Zisenokunganyangeki ngokupheleleyo umhlaza, kodwa zinokunceda ekulawuleni ukusasazeka kwawo kwaye zikunike ixesha elingakumbi lokuphila. Ukuba ugqirha wakho ucebisa eli yeza, qiniseka ukuba uthetha nogqirha wakho ngendima yalo kwisicwangciso sakho sonyango siphela.
Umyalezo Wokuya Ekhaya
- I-Angiogenesis Inhibitors luhlobo lweyeza elithintela ukwakheka kwemithambo yegazi emitsha enika iiseli zomhlaza igazi. Oku kuthintela iiseli zomhlaza ekufumaneni izondlo ezizidingayo kwaye kulawula ukukhula kwazo.
- Nangona oku kungawunyangi ngokupheleleyo umhlaza, kunokulawula ukusasazeka kwesi sifo kwaye kuqhubeke ixesha elide.
- Olu nyango ludla ngokwenziwa kunye nezinye iindlela zonyango, ezifana ne-chemotherapy.
- Kubalulekile ukuba uqaphele iziphumo ebezingalindelekanga ezifana noxinzelelo lwegazi oluphezulu, ukujiya kwegazi, kunye nokuphola kwenxeba okulibazisekayo, kwaye wazise ugqirha wakho ukuba ufumana naziphi na iingxaki.
- Nangona ezinye ukutya kwendalo ziqulethe izinto eziphazamisana nale nkqubo, akufuneki zisetyenziswe endaweni yonyango.
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