Xa ujonga uvavanyo lwegazi, mhlawumbi unika ingqalelo enkulu kwi-cholesterol, ingakumbi i-cholesterol embi, i-LDL. Kuba sonke siyazi ukuba xa amanqanaba e-LDL enyuka, amathuba okufumana izifo ezifana nokuhlaselwa yintliziyo kunye nokubetha kwentliziyo ayanda. Kodwa ibali alipheli apho. Izifundo zifumanise ukuba ama-50% abantu abaye bahlaselwa yintliziyo babengenawo amanqanaba aphezulu e-LDL. Ngoko ke, oogqirha basebenzisa olunye uvavanyo ukuvavanya ngokuchanekileyo umngcipheko. Yiloo nto siyibiza ngokuba yi-C-Reactive Protein, okanye uvavanyo lwe-CRP.
Yintoni kanye kanye i-CRP?
Ngamafutshane, i-C-Reactive Protein (CRP) yiproteni eveliswa sisibindi sethu. Xa kukho ukudumba , oko kukuthi, ukudumba okubangelwa ngumonakalo othile, kwindawo ethile emzimbeni wakho, eli nqanaba le-CRP liyakhula egazini.
Cinga ngale ndlela. I-cholesterol embi (LDL) ayinamatheli nje kuphela eludongeni lwemithambo yegazi yethu, ikwayonakalisa. Lo monakalo yinto esiyibiza ngokuba kukudumba. Kufana nenxeba elincinci. Xa umzimba uzama ukunyanga lo monakalo, uvelisa iiproteni ezikhethekileyo ezisebenza "njengeqela loncedo." I-CRP yenye yeeproteni ezinjalo. Oko kukuthi, ukuba kukho ukudumba kwindawo ethile emzimbeni, sinokukubona kwinqanaba le-CRP. Kufana nokuba xa sibona umsi, sicinga ukuba kukho umlilo kwenye indawo.
Kutheni ugqirha angacebisa uvavanyo lwe-CRP?
Uvavanyo lwe-CRP lulinganisa ubungakanani beProtein ye-C-Reactive egazini lakho. Oku kunokunika ugqirha wakho umbono olungileyo ngenqanaba lokuvuvukala emzimbeni wakho.
Ezinye izifundo zibonisa ukuba i-CRP yeyona nto ingcono yokuxela umngcipheko wesifo sentliziyo (CVD) kune-LDL cholesterol. Nangona kunjalo, ayilovavanyo oluthile lwesifo sentliziyo. Ibonisa kuphela ukuba kukho ukudumba emzimbeni. Ukudumba kunokubangelwa sisifo sentliziyo okanye enye into.
Kukho nezinye iimeko apho olu vavanyo lusetyenziswa khona:
- Izifo Ezizikhusela Ngokwasemzimbeni: Olu vavanyo lwenziwa nakubantu abanezifo ezifana neLupus okanye iRheumatoid Arthritis. Kuba ezi zifo zikwabangela ukudumba emzimbeni. Olu vavanyo lukwanceda ukubona ukuba amayeza anikiweyo ayakunciphisa na ukudumba. Nangona kunjalo, olu vavanyo alunakuxelela ukuba ukudumba kukuphi emzimbeni.
- Izifo: Olu vavanyo lwenziwa ukuba kukho ukurhanelwa kokuba kukho isifo esibangelwa kukwasulelwa yintsholongwane emzimbeni njenge-sepsis, isifo sefungus, okanye isifo samathambo.
- Umngcipheko wesibini wokuhlaselwa yintliziyo: Ikwasetyenziselwa ukubona ukuba yintoni ingozi yokuba nolunye uhlaselo lwentliziyo kumntu osele ehlaselwe yintliziyo.
- Ezinye izifo:Oku kukwanceda ekuxilongeni izifo ezifana nesifo samathumbu esidumbileyo kunye nesifo semiphunga.
Ungayiqonda njani ixabiso kwingxelo ye-CRP?
Ugqirha wakho unokuyalela olu vavanyo lwe-CRP ukuba uneempawu zosulelo, ezinje ngomkhuhlane, ukubanda, ukubetha kwentliziyo ngokukhawuleza, isantya sokuphefumla esinyukayo, isicaphucaphu, kunye nokuhlanza.
Olu luvavanyo lwegazi olulula kakhulu. Ngokwesiqhelo, igazi elincinci lithathwa kumthambo osengalweni yakho. Alidingi lungiselelo likhethekileyo (njengokuzila ukutya). Akukho ntlungu ngaphandle kwendawo encinci ebuhlungu apho kufakwa khona inaliti. Nangona kunjalo, amanye amayeza owasebenzisayo anokuchaphazela iziphumo zolu vavanyo. Ngoko ke qiniseka ukuba uxelela ugqirha wakho ngawo onke amayeza owasebenzisayo.
Wakuba ufumene iziphumo zakho, itheyibhile engasezantsi iya kukunceda uqonde amaxabiso. Kodwa khumbula, la maxabiso anokwahluka kancinci kwilabhoratri nganye. Ngoko ke qiniseka ukuba ubonisa ugqirha wakho ingxelo yakho kwaye ufumane ingcebiso.
| Inqanaba lokudumba | Ixabiso le-CRP (mg/dL) | Intsingiselo/izizathu ezinokwenzeka |
|---|---|---|
| Ukuphakama Okuphakathi | 1.0 - 10.0 mg/dL | Izifo ezizikhuselayo emzimbeni ezifana ne-rheumatoid arthritis, i-lupus, ukuhlaselwa yintliziyo, i-pancreatitis, i-bronchitis. |
| Ukuphakama Okuphawulweyo | 10.0 - 50.0 mg/dL | Usulelo olukhawulezileyo lwebhaktiriya okanye intsholongwane, ukudumba kwemithambo yegazi (iSystemic Vasculitis), ingozi enkulu okanye ukwenzakala. |
| Ukuphakama Okukhulu | Ngaphezulu kwe-50.0 mg/dL | Idla ngokuba (90%) ibangelwa lusulelo olukhawulezileyo olubangelwa yintsholongwane. Iimeko ezifana nedengue, imalariya, kunye nehepatitis C nazo zinokubangela oku. |
Inqanaba le-CRP elingaphezulu kwe-10 mg/dL lidla ngokuthathwa njengophawu lokuvuvukala okukhulu. Nangona kunjalo, olu vavanyo lodwa alunakuxelela ukuba yintoni ebangela oku. Ugqirha wakho kuya kufuneka enze uvavanyo oluthe kratya ukuze afumanise unobangela.
Uvavanyo olukhethekileyo lwe-CRP (hs-CRP) olujonga umngcipheko wesifo sentliziyo
Kukho uvavanyo olunobuthathaka ngakumbi kunovavanyo oluqhelekileyo lwe-CRP, olusetyenziselwa ukuvavanya umngcipheko wesifo sentliziyo (CVD). Lubizwa ngokuba yi -High-Sensitivity CRP (hs-CRP) .
Olu vavanyo luluncedo kakhulu kubantu abasengozini ye-10%-20% yokuhlaselwa yintliziyo kwiminyaka eli-10 ezayo. Amanqanaba e-CRP, njengamanqanaba e-cholesterol, anokunceda ukuqikelela umngcipheko wesifo sentliziyo. Olunye uphando lufumanise ukuba ukuba namanqanaba aphezulu e-CRP kwandisa kathathu umngcipheko wokuhlaselwa yintliziyo.
Nantsi indlela yokutolika iziphumo ze-hs-CRP:
| Ixabiso le-hs-CRP (mg/L) | Umngcipheko wesifo sentliziyo (CVD) |
|---|---|
| Ngaphantsi kwe-1.0 mg/L | Umngcipheko ophantsi |
| 1.0 mg/L ukuya kwi-3.0 mg/L | Umngcipheko ophakathi |
| Ngaphezulu kwe-3.0 mg/L | Umngcipheko ophezulu |
Ngenxa yokuba amanqanaba e-CRP anokwahluka kancinci imihla ngemihla, kungcono ukuba olu vavanyo lwenziwe kabini, iiveki ezimbini emva kwezinye, ukuze kuvavanywe ngokuchanekileyo umngcipheko wakho wesifo sentliziyo. Kwakhona, ukuba nenqanaba eliphezulu le-hs-CRP akuthethi ukuba unesifo sentliziyo. Ngoko ke kubalulekile ukulithelekisa nenqanaba lakho le-cholesterol ye-LDL ukuze ufumane umfanekiso opheleleyo.
Yintoni omele uyenze ukuba inqanaba lakho le-CRP liphezulu?
Ukuba inqanaba lakho le-CRP liphezulu, unyango luya kuxhomekeka kwisizathu. Ukuba inqanaba lakho le-CRP liphezulu ngenxa yengozi yesifo sentliziyo, kukho izinto ezininzi onokuzenza ukunciphisa loo mngcipheko:
- Yamkela ukutya okunempilo kwentliziyo: Yitya ukutya okunamafutha aphantsi, ityuwa, neswekile, kunye nokutya okuneziqhamo nemifuno eninzi.
- Lawula i-cholesterol.
- Gcina ubunzima bomzimba bufanelekile.
- Zilolonge rhoqo.
- Ukuba unesifo seswekile okanye uxinzelelo lwegazi oluphezulu, zilawule kakuhle.
- Ukuba uyatshaya, yeka ngoko nangoko.
- Nciphisa ukusetyenziswa kotywala.
Iistatin, uhlobo lonyango lokunciphisa i-cholesterol, zinokunceda ukunciphisa umngcipheko wesifo sentliziyo kubantu abanamanqanaba aphezulu e-CRP. Nangona kunjalo, ukuba amanqanaba akho e-cholesterol aqhelekile, ii-statins zisenokungabi sisisombululo esifanelekileyo kumanqanaba aphezulu e-CRP. Kungcono ukuthetha nogqirha wakho malunga nonyango olulungele wena.
Umyalezo Wokuya Ekhaya
- Uvavanyo lwe-CRP lulinganisa ukudumba emzimbeni, kungekhona isifo esithile.
- Oku kuluncedo kakhulu ekuvavanyeni iimeko ezifana nomngcipheko wesifo sentliziyo, usulelo, kunye nezifo zokuzikhusela komzimba.
- Ukuba inqanaba lakho le-CRP liphezulu, ugqirha wakho unokufuna ukwenza uvavanyo oluthe kratya ukuze afumane unobangela.
- Uvavanyo olunobuzaza ngakumbi olubizwa ngokuba yi-hs-CRP lusetyenziswa ukuvavanya ngokukodwa umngcipheko wesifo sentliziyo.
- Utshintsho kwindlela yokuphila lubalulekile ekulawuleni amanqanaba aphezulu e-CRP, kodwa qiniseka ukuba uqhagamshelana nogqirha wakho ngalo naluphi na unyango.
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