Ingaba usoloko unxaniwe kwaye uchama rhoqo? Oku kusenokuba kubangelwa yi-Arginine Vasopressin Disorders (Diabetes Insipidus)

Khawucinge nje ukuba nokuba usela amanzi angakanani na, uziva ngathi unxaniwe. Kwangaxeshanye, kufuneka uye kwigumbi lokuhlambela rhoqo. Awukwazi ukulala kakuhle ebusuku, kwaye kufuneka uvuke amaxesha amaninzi. Ayisiyonto iphazamisayo le? Nangona abantu abaninzi becinga ukuba oku kuqhelekile, ngamanye amaxesha kunokuba luphawu lwenye ingxaki emzimbeni wethu. Namhlanje siza kuthetha ngemeko engaqhelekanga, kodwa enokunyangwa. Leyo yi-Arginine Vasopressin Disorders, okanye i-Diabetes Insipidus njengoko abantu abaninzi beyazi ngegama layo lakudala.

Ngamafutshane, zithini iingxaki ze-Arginine Vasopressin?

Nangona eli gama liyinkimbinkimbi kancinci, kulula kakhulu ukuqonda okwenzekayo. Ngamafutshane, le yimeko apho umzimba wethu ungakwazi ukugcina umlinganiselo wamanzi ofunekayo. Ke ngoko, umlinganiselo wamanzi ofunekayo nawo ukhutshwa kumchamo.

Eyona sizathu siphambili sale nto yi-hormone emizimbeni yethu. Ibizwa ngokuba yi -Arginine Vasopressin (AVP) . Abanye oogqirha bayibiza ngokuba yi -Antidiuretic Hormone (ADH) . Le hormone ye-AVP ifana nomphathi onika imiyalelo kwizintso zethu. Nguye oxelela izintso ukuba, "Kulungile, umzimba udinga amanzi ngoku, ngoko ke wonge amanzi kwaye unciphise amanzi akhutshwa njengomchamo."

Kwesi sifo, le nkqubo inokuphazamiseka ngeendlela ezimbini eziphambili:

1. Ukunqongophala kwe-AVP (AVP-D): Oku kwenzeka xa ingqondo yethu ingavelisi i-hormone ye-AVP ngomlinganiselo ofunekayo. Oku kuthetha ukuba akukho mntu uyalela izintso.

2. Ukuxhathisa i-AVP (AVP-R): Kule meko, nangona ingqondo ivelisa i-AVP hormone eyaneleyo, izintso azizamkeli icebiso. Kanye njengokuba umphathi enika icebiso kodwa abasebenzi bayalityeshela.

Nokuba yeyiphi na indlela, isiphumo sokugqibela siyafana: izintso zihluza amanzi njengoko ziwafuna zize ziwakhuphe njengomchamo. Ngenxa yoko, umzimba ulahlekelwa ngamanzi owadingayo.

Zithini iimpawu zale meko?

Iimpawu eziphambili nezicacileyo zale meko zezi:

• Unxano olugqithisileyo (i-polydipsia): Ukuziva ngathi awunxanwanga nokuba usela amanzi angakanani na.
• Ukuchama rhoqo: Imfuneko yokuvuka amaxesha amaninzi ukuze uchame, kungekuphela nje emini, kodwa nasebusuku (nocturia).
• Ukuchama kakhulu: Ubungakanani bomchamo obuveliswayo bukhulu kakhulu. Umchamo awunambala kwaye unamanzi.

Ezi mpawu ziluphawu oluqinileyo lokuba kukho into engasebenzi kakuhle emzimbeni wakho. Ngoko ke, ukuba unezi mpawu, kubaluleke kakhulu ukubona ugqirha ngokukhawuleza.

Ezi mpawu zibonakala njani kubantwana abancinci?

Abantwana abancinci basenokungakwazi ukuthi ngokuchanekileyo "Ndinxaniwe." Ngoko ke ukuba banale meko, iimpawu zisenokubonakala zahlukile kancinci.

• Ukuphelelwa ngamanzi emzimbeni kakhulu
• Ukuqhinwa
• Ukuhlanza
• Umkhuhlane oqhelekileyo
• Ukuhlala ndingaphumli kwaye ndilila
• Ukungaphumeleli ukukhula (ukungatyebi)

Kutheni le meko isenzeka?

Kukho izizathu ezininzi ezinokubangela oku, kuxhomekeke kuhlobo lwemeko.

Izizathu zokunqongophala kwe-Arginine Vasopressin (AVP-D)

Olu lolona hlobo luxhaphakileyo. Lubangelwa kukonakala kweendawo zengqondo ezivelisa i-AVP hormone (i-hypothalamus okanye i-pituitary gland).

• Ukulimala entloko okanye utyando: Ezi ndawo zingonakaliswa lutyando okanye ingozi engqondweni.
• Iithumba: Ngenxa yeethumba ezithile ezikhula engqondweni.
• Ukudumba: Iimeko zokudumba ezibangelwa zizifo ezifana ne-sarcoidosis okanye isifo sephepha.
• Izizathu zemfuza: Utshintsho lwemfuza oluzuzwa njengelifa.
• Idiopathic: Kwezinye iimeko, malunga nesiqingatha sazo zonke iimeko, akukho sizathu sithile sinokufunyanwa .

Izizathu ze-Arginine Vasopressin Resistance (AVP-R)

Akukho ngxaki ngengqondo evelisa le hormone, ingxaki ikwizintso.

• Izizathu zemfuza: Iingxaki zemfuza ezidluliselwa kwizizukulwana ngezizukulwana.
• Amayeza athile: Ingakumbi amanye amayeza okugula ngengqondo, afana ne-lithium.
• Ukuvaleka kwendlela yomchamo.
• Ukwanda kwamanqanaba e-calcium egazini (i-Hypercalcemia).
• Amanqanaba aphantsi e-potassium egazini (i-Hypokalemia).

Iimeko ezikhethekileyo ezenzeka ngexesha lokukhulelwa

Amaxesha amaninzi, abafazi banokukhula kwesi sifo okwethutyana ngexesha lokukhulelwa. Oku kungenxa yokuba i-enzyme eveliswa yi-placenta iqhekeza i-hormone ye-AVP kamama ngexesha lokukhulelwa. Lo mngcipheko uphezulu koomama abakhulelwe amawele kunye nakoomama abaneemeko ezifana ne-preeclampsia, ezichaphazela ukusebenza kwesibindi. Kodwa iindaba ezimnandi zezokuba le meko idla ngokuphela ngokupheleleyo kwiiveki ezimbini ukuya kwezintathu emva kokubeleka.

Zeziphi iingxaki ezinokubangela oku?

Eyona ngxaki iyingozi nenkulu yale meko kukuphelelwa ngamanzi emzimbeni , nto leyo ethetha ukulahleka kwamanzi aneleyo kunye nee-electrolytes ukuze umzimba usebenze.

Ngokwesiqhelo, ungazilungisa iindleko zokulahlekelwa ngamanzi ngokusela amanzi aneleyo ukuze alingane nomlinganiselo womchamo owuvelisayo. Kodwa ukuba ngesizathu esithile awukwazi ukusela amanzi aneleyo, ungaphelelwa ngamanzi emzimbeni ngokukhawuleza.

Ugqirha uyifumana njani le nto?

Kukho ezinye izifo eziqhelekileyo ezinokubangela ukoma rhoqo kunye nokuchama. Umzekelo, isifo seswekile. Ngoko ke, into yokuqala eyenziwa ngugqirha kukujonga ezinye izifo ezifanayo.

Kuyenziwa uvavanyo oluninzi ukuze kufunyaniswe esi sifo ngokuchanekileyo.

• Uvavanyo Lokunqongophala Kwamanzi: Le yeyona ndlela ithembekileyo yokuxilonga le meko. Kolu vavanyo, kuya kufuneka uhlale ungaseli naluphi na ulwelo kangangeeyure ezininzi. Oku kwenziwa esibhedlele phantsi kweliso elithe ngqo likagqirha okanye umongikazi. Oku kungenxa yokuba oku kunokukhokelela ekuphelelweni ngamanzi emzimbeni. Ukuba unale meko, umzimba wakho uya kuqhubeka nokuvelisa umchamo omninzi nangona ungazange usele manzi. Kumntu ophilileyo, ukuphuma komchamo wakho kuya kuncipha, kwaye uya kuvelisa umchamo omncinci otyheli omnyama, oxineneyo.
• Ezinye iimvavanyo:
• Ukujonga amanqanaba eswekile egazini (ukuqinisekisa ukuba awunaso isifo seswekile).
• Uhlalutyo lomchamo - Jonga ubungakanani bomchamo (osmolality).
• Uvavanyo lwegazi - linganisa into ebizwa ngokuba yiCopeptin, enxulumene nehomoni i-AVP.
• I-MRI scan - ukubona ukuba kukho umonakalo kwi-pituitary gland okanye kwi-hypothalamus engqondweni.

Zithini iindlela zonyango zoku?

Iindlela zonyango zixhomekeke ekubeni unayo na i-AVP-D okanye i-AVP-R, kodwa nokuba unyango lunjani na, ukusela amanzi aneleyo kuyimfuneko.

Unyango lwesimo se-AVP-D

Iyeza eliphambili elisetyenziselwa oku yiDesmopressin . Le yihormone yokwenziwa esebenza endaweni yehomoni ye-AVP engekhoyo. Ingathathwa njengepilisi, i-spray yempumlo, okanye inaliti. Ngamanye amaxesha inikwa nakwiimeko zexeshana ezenzeka ngexesha lokukhulelwa.

Unyango lwesimo se-AVP-R

Ukunyanga oku kunzima kancinci. Kuba ingxaki apha asikokunqongophala kweehomoni, kodwa kukuzintso ezingaphenduliyo kuzo. Ke ngoko, unyango olwahlukeneyo kufuneka lusetyenziswe kunye.

• I-Thiazide diuretics: Nangona ezi luhlobo lwamayeza okwandisa ukuphuma komchamo, zisebenza ngendlela eyahlukileyo kule meko kwaye zinciphisa ukuphuma komchamo.
• Amayeza angengowe-steroidal alwa nokuvuvukala (ii-NSAID): Amanye amayeza akudidi lwezithomalalisi zentlungu.
• Ukuba le meko ibangelwa lelinye iyeza olisebenzisayo, ugqirha wakho uza kulitshintsha elo yeza aze akunike elinye iyeza.

Kutheni igama elithi 'Diabetes Insipidus' litshintshiwe ukusuka kwigama elithi 'Diabetes Insipidus' ukuya kwigama elithi 'Diabetes Insipidus'?

Le yingxaki abantu abaninzi abanayo. Kangangexesha elide, esi sifo sasibizwa ngokuba yiDiabetes Insipidus. Kodwa ngo-2022, imibutho emininzi emikhulu yezonyango yadibana yaza yagqiba ekubeni itshintshe eli gama.

Isizathu esiphambili kukudideka okubangelwa ligama elithi "isifo seswekile". Sidla ngokusebenzisa igama elithi "isifo seswekile" ukuthetha iDiabetes Mellitus . Sisifo esixhaphakileyo kwilizwe lethu. Sibonakala ngokwanda kwamanqanaba eswekile egazini. Nangona zombini ezi zifo zineempawu eziqhelekileyo zokunxanwa rhoqo kunye nokuchama, ezi zizifo ezimbini ezahlukeneyo ngokupheleleyo . Unyango lwazo lwahlukile ngokupheleleyo.

Igama elithi "Diabetes Insipidus" likhokelele ekubeni abanye abaguli bachongwe gwenxa njengabanesifo seswekile, kwaneempazamo zonyango. Ukuphelisa oku kudideka, igama elithi "Arginine Vasopressin Disorder" ngoku lisetyenziswa ukubhekisa kwimeko.

Ngaba kunokwenzeka ukuphila ngempumelelo nale meko?

Ewe, kunokwenzeka ngokuqinisekileyo. Ukuba ufumana unyango olufanelekileyo lwesi sifo kwaye usele amanzi aneleyo njengoko ugqirha wakho ecebisa, ngesiqhelo awuyi kuba neengxaki ezinkulu.

Nangona kunjalo, amanye amaqela asemngciphekweni ophezulu kancinci:

• Iintsana ezincinci
• Abantu abangaphezu kweminyaka engama-65 ubudala
• Abantu abaneengxaki ezithile zempilo yengqondo okanye ukukhubazeka kokukhula

Aba bantu banokuba nobunzima bokubona xa benxaniwe okanye becela amanzi ngelo xesha, nto leyo ebabeka emngciphekweni omkhulu wokuphelelwa ngamanzi emzimbeni.

Ukuba uziva ngathi uhlala kwigumbi lokuhlambela, kwaye nokuba usela kangakanani na, awukwazi ukuthomalalisa unxano lwakho, khumbula ukuba le yimeko elawulekayo. Ugqirha wakho uza kuvelisa isicwangciso sonyango esifanelekileyo kuwe. Uza kukuxelela nokuba usele amanzi angakanani ngosuku ukuze uphephe ukopha. Ngoko ke ungoyiki ukufuna ingcebiso kagqirha.