Masifunde nge-endothelium - i-powerhouse efihliweyo emzimbeni wakho.

Sonke siyazi ukuba igazi lihamba emizimbeni yethu, akunjalo? Eli gazi alihambi nje kuphela ngenethiwekhi yeetyhubhu ezibizwa ngokuba yimithambo yegazi, ezifana neepayipi zamanzi. Ngaba wakha wazibuza ukuba ingaphakathi lale tyhubhu lijongeka njani? Namhlanje siza kuthetha ngomaleko omangalisayo, obhityileyo weeseli ojikeleze ngaphakathi kwezo tyhubhu. Oku sikubiza ngokuba yi-'endothelium' . Oku akusiyo nje i-lining, yinkqubo yeeseli ezincinci ezenza imisebenzi emininzi ebalulekileyo echaphazela impilo yomzimba wakho wonke.

Kalula nje, yintoni le endothelium?

Khawuthelekelele ukuba yonke imithambo yegazi emzimbeni wakho ine-membrane encinci kakhulu, egudileyo, iseli enye kuphela engqindilili, efana nodonga. Yiyo leyo i-endothelium. Yenziwe ngohlobo oluthile lweseli olubizwa ngokuba zii-endothelial cells.

Le endothelium ifanayo ifumaneka kwezi ndawo emzimbeni wakho:

• Imithambo yegazi: Imithambo yegazi emikhulu ethwala igazi lisuka entliziyweni ukuya kwezinye iindawo zomzimba.
• Imithambo: Imithambo yegazi ethwala igazi lisuka emzimbeni lisiya entliziyweni.
• IiCapillaries: Imithambo yegazi emincinci kakhulu, emincinci.
• Ii-lymph capillaries: Iinqanawa ezikwinkqubo yethu ye-lymphatic.

Ayilulo nje udonga. Isebenza njengesikhungo esikhulu sokutshintshiselana ngolwazi kunye nezondlo phakathi kwegazi lakho kunye nezinye izicwili zomzimba wakho. Kubaluleke kakhulu, izazinzulu ngoku zijonga i-endothelium njengenye yezona zitho zikhulu emizimbeni yethu. Ewe, sisitho, njengesibindi nentliziyo.

Yeyiphi inkonzo enikezelwa yi-endothelium emizimbeni yethu?

Umsebenzi owenziwe yile maleko incinci yeeseli uyamangalisa. Makhe sijonge ezinye zezona ziphambili.

Ilawula ukufinyela nokwandiswa kwemithambo yegazi

Imithambo yakho yegazi kufuneka ivuleke (i-vasodilate) xa kufuneka, ize inciphe (i-vasoconstrict) xa kufuneka. Oku kulawulwa yi-endothelium.

Cinga ngale ndlela.

• Xa uzilolonga: Izihlunu zakho zifuna igazi neoksijini engaphezulu. I-endothelium ithumela imiqondiso yokwandisa imithambo yegazi kuloo ndawo, ivumela igazi ukuba lihambe lula.
• Ngemini ebanda kakhulu: Ufuna ukugcina ubushushu bomzimba wakho buhlala buqinile. Oku kubangela ukuba imithambo yegazi engalweni nasemilenzeni yakho inciphe kancinci, nto leyo enceda ukugcina igazi lihamba liye kumalungu akho aphambili.

Ngale ndlela, inceda kakhulu ekulawuleni uxinzelelo lwegazi lakho nokuqinisekisa ukuba onke amalungu omzimba afumana igazi elifunekayo.

Ilawula ubungakanani bolwelo oluhamba ukusuka egazini ukuya kwizicubu

I-endothelium ifana nesihluzo. Ivumela izondlo kunye neoksijini evela egazini ukuba idlule iye kwiithishu, ngelixa isebenza njengomqobo wokukhusela othintela izinto eziyingozi kunye neetyhefu ukuba zingangeni egazini. Nangona kunjalo, xa unentsholongwane, iiseli zethu zomzimba kufuneka ziphume egazini ziye apho kukho khona isifo. Emva koko i-endothelium ngokwayo ivula indlela yokuba ezo seli zifike apho.

Ithintela ukujiya kwegazi (i-Thrombosis)

Ngokwesiqhelo, amahlwili egazi ngaphakathi kwemithambo yegazi ayingozi kakhulu, akunjalo? Angabangela iimeko ezinzima ezifana nokuhlaselwa yintliziyo kunye nokubetha kwentliziyo. I-endothelium esempilweni ikhupha iikhemikhali ezikhethekileyo ezifana ne-nitric oxide, ezigcina ulwelo lwegazi kwaye zithintele ukujiya kwegazi okungeyomfuneko.

Ingakanani i-endothelium? Iphi emzimbeni wethu?

Ukuba umntu ekubuza ukuba intliziyo yakho iphi, ukhomba esifubeni sakho. Ukuba umntu ekubuza ukuba ingqondo yakho iphi, ukhomba entlokweni yakho. Kodwa ukuba umntu ekubuza ukuba iphi i-endothelium, ukhomba nakweyiphi na inxalenye yomzimba wakho. Ixhaphake kakhulu emzimbeni wonke.

Khawucinge nje, ukuba yonke imithambo yegazi yomntu oqhelekileyo ibibekwe ukusuka ekuqaleni ukuya ekupheleni, ibiya kuba malunga neekhilomitha ezili-100,000 ubude! Oko kwanele ukuhambahamba kabini kwihlabathi liphela. Kwaye obu bude buphela bugqunywe yile endothelium. Ukuba uthatha indawo yayo, idla ngokuba nkulu kuneenkundla ezininzi zetenisi. Kwakhona, le nkqubo yonke yenziwe ngeeseli ze-endothelial ezingaphezu kwe-trillion (1,000,000,000,000).

Yintoni i-Endothelial Dysfunction?

Le yeyona nxalenye ibalulekileyo ekufuneka siyiqwalasele sonke. 'Ukungasebenzi kakuhle kwe-Endothelial' kuthetha ukuba iiseli ze-endothelial zonakele kwaye azikwazi ukwenza umsebenzi wazo ngokufanelekileyo. Kufana nokuba i-asphalt endleleni iphumile, nto leyo eyenza kube nzima ukuba izithuthi ziqhube.

Kwenzeka ntoni xa i-endothelium ngokwayo iba buthathaka?

Xa i-endothelium yonakele, umphezulu wayo ogudileyo uba rhabaxa. I-cholesterol embi (LDL) iqala ukuqokelelana kwezo ndawo zirhabaxa. Ngenxa yoko, iiseli ezivela kwinkqubo yomzimba yokuzikhusela ziyaza ziqokelelane apho. Konke oku kuyaqokelelana, kwaye ngokuhamba kwexesha, kwakheka 'umaleko wamafutha' (iplaque) .

Njengoko olu layer lunamafutha lukhula, umthambo wegazi uyancipha ngaphakathi. Oku ke kuyawuthintela ukuhamba kwegazi. Ukuba ngenye imini olu layer lunokugqabhuka, igazi linokuqhekeka kuloo ndawo lize liwuvale ngokupheleleyo umthambo wegazi.

Ngoko ke, umntu one-endothelium ebuthathaka unokufumana ezi zinto zilandelayo zomngcipheko:

• Ukuhlaselwa yintliziyo
• Istroke
• Isifo semithambo yentliziyo
• Isifo semithambo yegazi ejikeleze umzimba
• Isifo sezintso
• Ukuxhathisa i-insulin

Ngoko ke singayigcina njani le endothelium isempilweni?

Iindaba ezimnandi zezokuba singayikhusela le endothelium ixabisekileyo ngokutshintsha indlela esiphila ngayo.

Ngamafutshane, imizimba yethu ivelisa uhlobo lwesuntswana elibi elibizwa ngokuba yi -'free radicals' . Ezi zonakalisa iiseli zethu ze-endothelial. Izinto ezilungileyo ezinceda ekususeni ezi suntswana zibi zibizwa ngokuba yi -'antioxidants' . Ngoko ke into ekufuneka siyenze kukunciphisa imveliso yee-free radicals ngokutya ukutya okutyebileyo kwii-antioxidants.

Izinto ezilungileyo onokuzenza

Yitya ukutya okuninzi okutyebileyo kwii-antioxidants.

• Imifuno eluhlaza okwesibhakabhaka: ispinatshi, ikale, imifuno eluhlaza.
• Iziqhamo nemifuno enemibala eqaqambileyo: iitumato, iminqathe, iibhithi, iipepile zentsimbi, iiorenji, igrapefruit.
• Iinkozo ezipheleleyo: irayisi emdaka, i-oats, kunye ne-millet.
• Iioyile ezisempilweni: ioyile yomnquma, iavokhado.

Ungathetha nogqirha wakho malunga nolu hlobo lokutya (umz., ukutya kwaseMedithera) uze wenze utshintsho olukufaneleyo.

Izinto ezimbi ekufuneka uziphephe

Ezi zinto zonyusa ii-free radicals emzimbeni wakho.

• Ukutshaya: Olu lutshaba oluphambili. Yeka namhlanje.
• Ukutya okuneswekile eninzi kunye neelekese: Oku kwandisa ukudumba emzimbeni.
• Ukutya okucutshungulweyo: Oku kusenokuba namafutha kunye neekhemikhali eziyingozi.
• Uxinzelelo olugqithisileyo.
• Ukungalali ngokwaneleyo.

Kwakhona, ukuzilolonga rhoqo kubaluleke kakhulu kwimpilo ye-endothelium. Xa uzilolonga, ukuveliswa kwe-nitric oxide kuyanda, nto leyo egcina imithambo yegazi yakho isempilweni. Nokuba yinto elula njengokuhamba imizuzu engama-30 ngosuku inokwenza umahluko omkhulu.

Ukuba sele uneengxaki zempilo ezifana noxinzelelo lwegazi oluphezulu, isifo seswekile, okanye i-cholesterol, kubalulekile ukulandela isicwangciso sonyango sikagqirha wakho ngokuchanekileyo . Injongo yala mayeza kukulawula ezi meko nokunciphisa umonakalo kwi-endothelium yakho.